Regulation of actin dynamics for phagocytic cup formation
gene
reagent
sample publication
sample review
ABI1
abl interactor 1
total:1
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. 2007 to the paper
Santa Cruz goat Abi antibody (1:2000) was used in western blot to study the role of Abi-1 in morphogenesis and synapse formation.
abl
ABL proto-oncogene 1, non-receptor tyrosine kinase
total:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Calbiochem c-Abl antibody (1:1,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
ACTR2
actin related protein 2
total:4
Mechanisms of Chlamydia trachomatis entry into nonphagocytic cells. 2007 to the paper
Chemicon anti-Arp2 antibody was used to carry out immunofluorescence assays in order to investigate the mechanism of entry for Chlamydia trachomatis into nonphagocytic cells. more
ARPC1A
actin related protein 2/3 complex subunit 1A
ARPC2
actin related protein 2/3 complex subunit 2
total:2
Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms. 2007 to the paper
Santa Cruz anti-Arp2/3 antibody was used to perform immunohistochemistry in order to show that the Hela /-CaD is involved with the migration of endothelial cells/endothelial progenitor cells in human neoplasms. more
ARPC3
actin related protein 2/3 complex subunit 3
ARPC4
actin related protein 2/3 complex subunit 4
beta-actin
actin beta
total:149
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-beta-actin was used to perform western blot in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
BRK1
BRICK1 subunit of SCAR/WAVE actin nucleating complex
CD16
Fc fragment of IgG receptor IIIa
total:42
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 to the paper
AbDSerotec PE-Cy5-conjugated anti-CD16 antibody was used to perform flow cytometry in order to study the role of the EPEC protein NleE in inhibiting NF-kappa B signaling in human dendritic cells. more
CD247
CD247 molecule
total:68
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. 2012 to the paper
eBioscience anti-human CD3 was used to perform blocking or activating experiments in order to show that cancer cell depended on glycine for rapid proliferation. more
CD32
Fc fragment of IgG receptor IIa
total:9
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 to the paper
Upstate anti-IgG antibody was used to perform RNA immunoprecipitation in order to analyze histone methylation at transcription start sites in human-specific prefrontal neurons of brain. more
CD3G
CD3g molecule
total:48
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. 2010 to the paper
eBioscience anti-CD3 antibody was used to perform immunocytochemistry and flow cytometry in order to show that mesenchymal stem cell can be polarized by downstream TLR signaling into two distinctly acting phenotypes. more
CD64
Fc fragment of IgG receptor Ia
total:15
PPAR? controls Dectin-1 expression required for host antifungal defense against Candida albicans. 2010 to the paper
Serotec anti-F4/80 antibody was used in flow cytometry in order to investigate the role of PPARgamma in the regulation dectin-1 expression and host antifungal defense. more
cdc42
cell division cycle 42
total:36
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. 2010 to the paper
Santa Cruz Biotechnology anti-Cdc42 antibody was used in western blot to reveal the effect of slit2 on eosinophil and neutrophil during lung inflammation. more
CFL1
cofilin 1
total:8
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Sigma-Aldrich polyclonal anti-cofilin and anti-phospho-cofilin antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
Crk
CRK proto-oncogene, adaptor protein
total:14
Focal adhesion components are essential for mammalian cell cytokinesis. 2008 to the paper
BD Transduction Laboratories CrkI/II antibody was used to perform western blot in order to study the function of focal adhesion components in mammalian cell cytokinesis. more
ERK1
mitogen-activated protein kinase 3
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
ERK2
mitogen-activated protein kinase 1
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
FAK
protein tyrosine kinase 2
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
Grb2
growth factor receptor bound protein 2
total:36
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. 2009 to the paper
Santa Cruz Biotechnology rabbit polyclonal against Ron antibody was used in western blot in order to demostrate the expression of PAX 5 and the regulation for c-Met transcription in small cell lung cancer. more
HSP90
heat shock protein 90 alpha family class A member 1
total:68
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-HSP90 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
HSP90AB1
heat shock protein 90 alpha family class B member 1
total:8
Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. 2010 to the paper
Millipore anti-H3S28P antibody was used in western blot in order to investigate the mechanism of how the embryonic stem cells chromatin structure change was regulated by condensin complexes during mitotic progression. more
LIMK1
LIM domain kinase 1
total:4
Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer. 2007 to the paper
Transduction Laboratories anti-LIMK1 antibody was used in western blot and immunohistochemistry to study the role of LIM kinase 1 in reversible G1/S phase arrest, chromosomal instability and prostate cancer. more
MYH2
myosin heavy chain 2
total:3
Overexpression of the mitochondrial T3 receptor p43 induces a shift in skeletal muscle fiber types. 2008 to the paper
Alexis Biochemical monoclonal MyHC type IIa antibody was used in immunohistochemistry in order to examine the role of mitochondrial T3 receptor p43 in vivo muscle development and phenotype more
MYH9
myosin heavy chain 9
total:3
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. 2009 to the paper
Sigma anti-NMHC-IIA antibody was used to perform western blot in order to study the assemble of mammalian nonmuscle myosin II in live cells. more
MYO5A
myosin VA
total:1
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. 2007 to the paper
Sigma rabbit polyclonal anti-myosin V antibody was used to carry out western blot analysis in order to investigate the role for UNC-45 in the regulation of tumor cell proliferation and metastasis.
MYO9B
myosin IXB
total:1
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. 2005 to the paper
Genemed anti-myosin IXb antibody made against the C-terminal peptide CSASTESLLEERAVRGAAEE was used in western blot to study the role of BIG1 as a binding partner of myosin IXb to regulate its Rho-GTPase activating protein activity.
PAK1
p21 (RAC1) activated kinase 1
total:29
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Epitomics rabbit monoclonal anti-Pak1 antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
Syk
spleen associated tyrosine kinase
total:12
Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk.. 2008 to the paper
Santa Cruz Biotech anti-Syk antibody was used to perform western blot in order to study the interaction between NS5A and Syk. more
VAV3
vav guanine nucleotide exchange factor 3
total:2
Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. 2008 to the paper
Upstate Biotechnology anti Vav3 antibody was used in western blot and immunohistochemistry to study the activation of estrogen receptor by Vav3 oncogene and Vav3 overexpression in human breast cancer more
WAS
WASP actin nucleation promoting factor
total:1
EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability. 2008 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-WASP antibody was used in western blot to study the role for EspF in pedestal maturation and the disruption of paracellular permeability.
WASF1
WASP family member 1
total:3
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. 2007 to the paper
Chemicon Wave antibody was used in western blot to study the role of Abi-1 in morphogenesis and synapse formation. more
WASF2
WASP family member 2
total:2
Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma. 2006 to the paper
Santa Cruz Biotechnology goat polyclonal anti-human WAVE2 antibody (c-14) was used in protein and paraffin sections from human tumor, and which were used in western blot and immunohistochemistry, to study the relationship between Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 and poor prognosis of hepatocellular carcinoma. more
WASL
WASP like actin nucleation promoting factor
total:2
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. 2005 to the paper
Santa Cruz Biotechnology goat polyclonal Cdc42 antibody was used in western blot and immunoprecipitation to study the role of the adapter protein CrkII in the regulation of N-WASp and Cdc42 activation. more
WIP
WAS/WASL interacting protein family member 1
WIPF2
WAS/WASL interacting protein family member 2
WIPF3
WAS/WASL interacting protein family member 3