Regulation of Hypoxia-inducible Factor (HIF) by oxygen
gene
reagent
sample publication
sample review
ARNT
aryl hydrocarbon receptor nuclear translocator
total:6
CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. 2008 to the paper
Alexis anti-ARNT antibody was used to perform western blot in order to study the roles of the CUL2 in the activity of hypoxia-inducible factor and vasculogenesis. more
CA9
carbonic anhydrase 9
total:4
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. 2007 to the paper
Santa Cruz anti-CAIX antibody was used to perform western blot in order to study the dependency on oxidative phosphorylation during transformation of human mesenchymal stem cells. more
CBP
CREB binding protein
total:38
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. 2009 to the paper
Santa Cruz Biotechnology anti-CBP antbody was used in western blot in order to demonstrate that an HDAC inhibitor induces apoptosis through the FoxO1 acetylation-Bim pathway more
Cul2
cullin 2
total:10
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. 2009 to the paper
Rockland Immunochemicals Inc.anti-Cul2 antibody was used to perform immunoprecipitation in order to identify new components of the CRL family of E3 ligases and elaborate new connections between the CRL and CSN complexes. more
EGLN1
egl-9 family hypoxia inducible factor 1
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD2 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
EGLN2
egl-9 family hypoxia inducible factor 2
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD1 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
EGLN3
egl-9 family hypoxia inducible factor 3
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD3 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
EPAS1
endothelial PAS domain protein 1
total:9
Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha. 2010 to the paper
Novus Biologicals HIF2alpha antibody was used for ChIP assays in order to study HIF-binding and Ets-binding motifs on the PTPRZ1 promoter and show that PTPRZ1 can be activated by HIF-2. more
erythropoietin
total:7
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
R&D Systems anti-Epo antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
HIF-1 alpha
hypoxia inducible factor 1 subunit alpha
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
HIF3A
hypoxia inducible factor 3 subunit alpha
p300
E1A binding protein p300
total:52
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Santa Cruz anti-p300 was used to perform western blot and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
RBX1
ring-box 1
total:5
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. 2008 to the paper
Lab Vision rabbit-anti-RBX1 antibody was used in western blot in order to identify the poxviral motif as a functional F-box more
RPS27A
ribosomal protein S27a
total:5
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 2009 to the paper
Santa Cruz Biotechnology anti-ubiquitin antibody was used in western blot in order to identify a novel complex of erasin-ubiquilin-p97/VCP and its function in ERAD. more
ELOB
elongin B
total:4
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. 2008 to the paper
Santa Cruz anti-Elongin B antibody was used in immunoprecipitation in order to demonstrate that SAP130 may link CRL mediated ubiquitination to gene expression. more
UBC
ubiquitin C
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
UBE2D1
ubiquitin conjugating enzyme E2 D1
total:1
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. 2007 to the paper
Boston Biochem anti-UbcH5 antibody was used to perform immunoprecipitation in order to study the roles of the DET1 during the regulation of the Cul4A activity.
UBE2D3
ubiquitin conjugating enzyme E2 D3
total:1
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. 2010 to the paper
Abcam anti-UbcH5c antibody was used to perform western blot in order to study the mechanism of A20 action in the inhibition of NF-kappaB signaling.
ubiquitin
ubiquitin B
total:34
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. 2009 to the paper
Cell Signaling Technology mouse anti-ubiquitin monoclonal antibody was used in western blot in order to demonstrate that BCL6 interacts with HB-EGF-CTF and that this interaction might induce the cyclin D2 expression in human gastric cancer. more
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
VHL
von Hippel-Lindau tumor suppressor
total:14
The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. 2013 to the paper
GeneTex anti-VHL antibody was used to perform western blot and immunoprecipitation in order to investigate the regulatory effect of HILDA complex on VEGF-A expression. more