Recruitment of repair and signaling proteins to double-strand breaks
gene
reagent
sample publication
sample review
ATM
ATM serine/threonine kinase
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
BRCA1
BRCA1 DNA repair associated
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
H2AX
H2A.X variant histone
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
MDC1
mediator of DNA damage checkpoint 1
total:7
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. 2011 to the paper
Abcam anti-MDC1 was used to perform immunocytochemistry in order to show that chromosomal structural aberrations could be caused by chromosome segregation errors. more
Mre11
MRE11 homolog, double strand break repair nuclease
total:19
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.. 2009 to the paper
Calbiochem rabbit polyclonal Mre11 antibody was used to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2. more
Nbs1
nibrin
total:28
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Novus NBS1 antibody was used to perform immunofluorescence assay in order to study the requirement of RSFI in DSB repair. more
Rad50
RAD50 double strand break repair protein
total:13
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. 2008 to the paper
GeneTex anti-Rad50 antibody was used to perform western blot in order to identify that regions of Nbs1 are differentially required for concatemer formation and inhibition of Ad DNA replication. more
TP53BP1
tumor protein p53 binding protein 1
total:19
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Novus Biologicals polyclonal anti-53BP1 was used to perform immunocytochemistry in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more