Receptor protein-tyrosine kinase
gene
reagent
sample publication
sample review
total:7
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL. 2009 to the paper
Zymed Laboratories mouse anti-ALK (1:4000, 4C5B8) antibody was used to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma. more
total:3
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. 2010 to the paper
R&D System anti-AXL antibody was used to perform flow cytometry in order to study the regulatory function of GAS6/AXL axis in bone marrow niche. more
total:42
Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. 2012 to the paper
NeoMarkers mouse anti-human CD117 monoclonal antibody was used to perform immunohistochemistry in order to analyze the cellular origin of adult functional blood vessels. more
total:30
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues. 2009 to the paper
R&D rabbit anti-pMET antibody was used to perform immunohistochemistry in order to study the function of the fixative in the immunohistochemical detection of phosphoproteins. more
total:7
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. 2006 to the paper
Upstate (Millipore) rabbit anti-human CSF-1 R polyclonal antibody(06-457)was used to perform mmunohistochemistry assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth. more
total:8
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. 2009 to the paper
R&D Systems anti-NEP antibody was used in immunohistochemistry in order to investigate the role of neprilysin in the regulation of pulmonary vascular remodeling in response to chronic hypoxia. more
total:1
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. 2005 to the paper
Regeneron Pharmaceuticals polyclonal anti-DDR2 antibody (R2-JM) was used in western blot to study a novel direct mechanism by which cell contact with fibrillar collagen restricts proliferation.
total:150
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. 2013 to the paper
Santacruz Biotechnology anti-EGFR antibody was used to perform western blot in order to study how ING1a induces senescence. more
total:1
Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. 2006 to the paper
Zymed Laboratories EphA1 antibody was used in western blot to study the role of receptor EphA2 expression in MM cells (MMCs) in the growth and haptotactic migration of MM.
total:13
Anti-EphA2 Antibodies with Distinct In Vitro Properties Have Equal In Vivo Efficacy in Pancreatic Cancer. 2009 to the paper
Santa Cruz Biotechnology anti-EphA2 antibody was used in western blot in order to generate monoclonal antibodies to evaluate therapeutic potential of targeting EphA2 in pancreatic tumor. more
total:5
EphA4 is necessary for spatially selective peripheral somatosensory topography. 2010 to the paper
Santa Cruz rabbit anti-alpha-EphA4 antibody (1:50) was used in immunohistochemistry in order to investigate the role of EphA4 in the regulation of Spatially Selective Peripheral Somatosensory Topography. more
total:1
Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. 2006 to the paper
Zymed Laboratories EphA5 antibody was used in western blot to study the role of receptor EphA2 expression in MM cells (MMCs) in the growth and haptotactic migration of MM.
total:1
Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. 2008 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-human EphA7 antibody (H-55, which is against amino acids of human EphA7) was used in immunohistochemistry to study the correlation between EphA7 and adverse outcome in paraffin sections from glioblastoma multiforme patients.
total:6
EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. 2005 to the paper
Santa Cruz EphB1 antibody was used in western blot to design EphB receptor antagonist more
total:7
The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. 2006 to the paper
Santa Cruz Biotech EphB4 antibody was used in western blot and immunohistochemistry to study the association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. more
total:18
Activation of Stat3 by heregulin/ErbB-2 through the co-option of progesterone receptor signaling drives breast cancer growth. 2009 to the paper
Neomarkers ErbB-3 mouse monoclonal antibody was used to carry out antibody blocking assays in order to investigate the signal cross talk between ErbB2 and PR receptor and the effect on breast cancer growth. more
total:20
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. 2009 to the paper
Santa Cruz Biotechnology anti-ERBB4 antibody was used in immunoprecipitation and western blot in order to characterize the role of ERBB4 mutations in melanoma. more
total:29
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 2011 to the paper
Santa Cruz rabbit anti-ERK antibody was used to perform immunocytochemistry in order to investigate the role of the PKA/AKAP1 complex in the maintenance of mitochondrial integrity and the protection from neuronal injury. more
total:17
Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. 2012 to the paper
Biosource International anti-FGFR-1 (pYpY653/654) antibodies were used to perform western blot and ELISA analyses in order to study the effect of the facilitation of AMPA receptor synaptic delivery on cognitive enhancement. more
total:9
Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. 2008 to the paper
Santa Cruz rabbit polyclonal anti-FGFR2 was used to perform western blot in order to show that VHL tumor supppressor gene has endothelial function through fibroblast growth factor receptor signaling. more
total:7
Transforming fusions of FGFR and TACC genes in human glioblastoma. 2012 to the paper
Santa Cruz mouse anti-FGFR3 was used at 1:1000 to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients. more
total:5
Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-FGFR4 antibody was used to carry out western blot analysis in order to investigate whether FGFR4 plays a role in promoting the progression of hepatocellular carcinoma. more
total:16
The association of vascular endothelial growth factor receptor-1 with the risk of cancer progression following radical prostatectomy. 2008 to the paper
R&D Systems goat anti-human VEGFR-1 polyclonal antibody (catalog number: AF321) was used to perform immunochemistry assays in order to demonstrate that VEGFR-1 expression is not related to the risk of cancer progression following radical prostatectomy. more
total:6
Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation. 2006 to the paper
Santa Cruz Biotechnology anti-FLT3(S18) antibody was used to perform western blot in order to study the mechanism of the decreased proliferation of acute myeloid leukemia (AML) cells treated with arsenic trioxide. more
total:69
Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. 2008 to the paper
Zymed Laboratories anti-c-erbB-2 antibody was used in immunohistochemistry to investigate the relationship between amphiregulin expression and liver metastases of colorectal cancer. more
total:40
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Santa Cruz Biotechnology PE-conjugated anti-IGF-1R antibody was used in flow cytometry to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
total:22
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. 2009 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti subunit of insulin receptors (IR) antibody was used in western blot and immunocytochemistry to test the hypothesis that insulin signaling provides a physiological defense mechanism against the synaptotoxicity of Abeta-derived diffusible ligands. more
total:1
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. 2010 to the paper
R&D System anti-Mer antibody was used to perform flow cytometry in order to study the regulatory function of GAS6/AXL axis in bone marrow niche.
total:14
PDGFRalpha/beta expression correlates with the metastatic behavior of human colorectal cancer: a possible rationale for a molecular targeting strategy. 2008 to the paper
Santa Cruz Biotechnology anti-PDGFRA antibody was used to perform Western Blot and immunohistochemistry in order to prove that the metastatic behavior of human colorectal cancer correlates with PDGFRalpha/beta expression. more
total:27
EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. 2009 to the paper
Abgent anti-p-PDGFR Tyr579 antibody was used in immunohistochemistry in order to investigate the mechanism of how Akt mediates sterol regulatory element-binding protein 1 (SREBP-1) cleavage induced by EGFR. more
total:8
Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. 2006 to the paper
Santa Cruz Biotechnology goat anti-Ret51 antibody was used in western blot and immunoprecipitation to demonstrate that lipid rafts sequester Ret away from the degradation machinery to sustain Ret signaling. more
total:4
The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. 2009 to the paper
Santa Cruz anti-RON antibody was used to perform western blot in order to study the oncogenic behavior of the RON receptor tyrosine kinase in breast epithelial cells. more
total:2
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010 to the paper
Cell SignalingROR2 antibody was used to perform immunocytochemistry in order to investigate ROR2 mediates Wnt5A signaling in metastatic melanoma. more
total:11
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Flk-1 antibody was used in western blot in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
total:27
Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. 2011 to the paper
Upstate anti-TrkA antibody (06-574, 1:100) was used to perform immunostaining in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors. more
total:7
Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. 2008 to the paper
BD Biosciences mouse anti-TrkB antibody was used in western blot in order to study the pathogenesis of Joubert syndrome and the role of the Ahi1-Hap1 complex in early brain development more
total:35
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.. 2010 to the paper
Santa Cruz anti-Flk-1 antibody was used to perform immunoprecipitation in order to reveal the critical role of prorenin receptor and vacuolar H+-ATPase-mediated acidification in Wnt signaling. more
total:15
Expression of VEGF-C and its receptor VEGFR-3 in the bone marrow of patients with acute myeloid leukaemia. 2008 to the paper
Santa Cruz anti-VEGFR-3 (sc-321) antibody was used to perform immunohistochemistry in order to study the expression of VEGF-C and VEGFR-3 in the acute myeloid leukaemia patients' bone marrow. more