RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
gene
reagent
sample publication
sample review
total:5
Targeting A20 decreases glioma stem cell survival and tumor growth. 2010 to the paper
Abcam anti-A20 antibody was used for western blot and flow cytometry to study the function of A20 in glioma stem cell survival and tumor growth. more
total:2
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
Cell Signaling anti-ATG12 antibody was used to perform immunocytochemistry in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
total:3
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. 2010 to the paper
Sigma rabbit polyclonal anti-Atg5 antibody (1:1000) was used in western blot in order to study the regulation of autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. more
total:9
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. 2006 to the paper
R & D Systems anti-caspase-10 antibody was used in human THP-1 cells and in western blot to study the roles for the interaction of the B30.2 domain of pyrin, the familial mediterranean fever protein with caspase-1 in IL-1 production. more
total:73
Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis. 2009 to the paper
R&D systems anti-casp8 antibody was used to carry out western blot analysis in order to investigate the mechanism of DR5 relocalization and its effect on cell apoptosis during adhesion to detachment of EC9706 cells. more
total:38
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. 2009 to the paper
Santa Cruz Biotechnology anti-CBP antbody was used in western blot in order to demonstrate that an HDAC inhibitor induces apoptosis through the FoxO1 acetylation-Bim pathway more
total:1
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 to the paper
ABGENT anti-RIG-I antibody was used to perform western blot in order to study the cellular signaling elicited by human metapneumovirus in airway epithelial cells.
total:1
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 to the paper
ABGENT anti-RIG-I antibody was used to perform western blot in order to study the cellular signaling elicited by human metapneumovirus in airway epithelial cells.
total:19
Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis. 2008 to the paper
Cell Signaling Technology anti-FADD antibody was used to perform western blot in order to assess the effect of Rk1 on cell viability and telomerase activity. more
total:1
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. 2009 to the paper
Santa Cruz anti-Cyclin E antibody was used to perform immunoprecipitation in order to identify new components of the CRL family of E3 ligases and elaborate new connections between the CRL and CSN complexes.
total:2
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 to the paper
IMGENEX anti-MDA-5 antibody was used to perform western blot in order to study the cellular signaling elicited by human metapneumovirus in airway epithelial cells. more
total:2
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling. 2008 to the paper
IMGENEX anti-MDA-5 antibody was used to perform western blot in order to study the cellular signaling elicited by human metapneumovirus in airway epithelial cells. more
total:11
The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.. 2010 to the paper
PBL Laboratories anti-IFNalpha antibody was used in flow cytometry in order to investigate the role of VP35 Protein of Ebola Virus in the regulation of dendritic cell maturation induced by virus and lipopolysaccharide. more
total:9
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 to the paper
Biosource ELISA kit for IFN-beta was used to measure IFN-beta level in order to study the effect of gC1qR on RIG-I and MDA5-dependent antiviral response at mitochondria. more
total:117
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 to the paper
Santa Cruz anti-I-kappa B alpha antibody was used to perform western blot in order to study the role of the EPEC protein NleE in inhibiting NF-kappa B signaling in human dendritic cells. more
total:49
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. 2011 to the paper
Santa Cruz Biotechnology anti-IKKalpha monoclonal antibody was used to perform western blot in order to study that cleveage of NIK leads to noncanonical NF- kB activation more
total:36
A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. 2013 to the paper
Millipore anti-IKK2 antibody was used to perform western blot in order to investigate the structural basis for human IKK2 activation. more
total:21
A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. 2013 to the paper
Santa Cruz Biotechnology anti-NEMO antibody was used to perform western blot in order to investigate the structural basis for human IKK2 activation. more
total:22
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Life Technologies anti-IRF-3antibody was used to perform western blot in order to study IRF-3-dependent innate immunity more
total:4
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. 2006 to the paper
Santa Cruz anti-IRF-7 antibody was used to perform western blot in order to study the mechanism of anti-HCV by TLR7 more
total:7
Mycobacterial disease and impaired IFN-? immunity in humans with inherited ISG15 deficiency. 2012 to the paper
Santa Cruz Biotechnology anti-ISG15 was used to perform flow cytometry and immunocytochemistry in order to show that ISG15 deletion in humans impairs IFN-gamma immunity and results in mycobacterial disease susceptibility. more
total:3
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. 2009 to the paper
BD Biosciences Itch monoclonal antibody was used to perform western blot and immunoprecipitation in order to demonstrate the key mechanisms that regulate p63 protein stability in vivo. more
total:1
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 to the paper
Cell Signaling Technology rabbit polyclonal anti-VISA antibody was used in western blot to study the effect of gC1qR on RIG-I and MDA5-dependent antiviral response at mitochondria.
total:15
Mxi2 promotes stimulus-independent ERK nuclear translocation. 2007 to the paper
Santa Cruz rabbit polyclonal anti-MEK antibody was used in western blot to show that Mxi2 has profound effects on ERK1/2 nucleocytoplasmic distribution, promoting their accumulation in the nucleus. more
total:11
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
New England Biolabs anti-p52/p100 (18D10) monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:7
A critical role for CHIP in the aggresome pathway. 2009 to the paper
Santa Cruz NFKBIB antibody was used for Western blotting in order to study the critical role for CHIP in the aggresome pathway. more
total:52
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Santa Cruz anti-p300 was used to perform western blot and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:146
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Santa Cruz anti-p65 antibody was used to perform immunofluorescence in order to study the role of DNA-dependent protein kinase in the IRF-3-dependent innate immunity. more
total:2
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. 2005 to the paper
Santa Cruz Biotechnology anti-Pin-1 antibody was used in immunoprecipitation to study the interaction of tis21 protein with Pin-1 after phosphorylation of its Ser147 residue by p-Erk1/2. more
total:9
Repression of NF-kappaB and activation of AP-1 enhance apoptosis in prostate cancer cells. 2009 to the paper
Santa Cruz Biotechnology anti-RIP antibody was used in western blot to study the effect of repression of NF-kB and activation of AP-1 on apoptosis in prostate cancer cells. more
total:5
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 2009 to the paper
Santa Cruz Biotechnology anti-ubiquitin antibody was used in western blot in order to identify a novel complex of erasin-ubiquilin-p97/VCP and its function in ERAD. more
total:7
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. 2011 to the paper
Epitomics anti-pTBK1pS172 was used to perform western blot in order to show that Salmonella enterica growth was restricted by phosphorylation of autophagy receptor optineurin. more
total:26
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-TRAF2 (C-20) monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:13
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-TRAF3 (C-20) monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:17
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-TRAF6 (H-274) monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:1
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. 2007 to the paper
Boston Biochem anti-UbcH5 antibody was used to perform immunoprecipitation in order to study the roles of the DET1 during the regulation of the Cul4A activity.
total:1
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. 2007 to the paper
Boston Biochem anti-UbcH5 antibody was used to perform immunoprecipitation in order to study the roles of the DET1 during the regulation of the Cul4A activity.
total:1
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. 2010 to the paper
Abcam anti-UbcH5c antibody was used to perform western blot in order to study the mechanism of A20 action in the inhibition of NF-kappaB signaling.
total:1
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. 2010 to the paper
Abcam anti-UbcH5c antibody was used to perform western blot in order to study the mechanism of A20 action in the inhibition of NF-kappaB signaling.
total:1
A phosphorylation-acetylation switch regulates STAT1 signaling. 2009 to the paper
Abgent UBCH8antibody was used for western blot in order to investigate the role of phosphorylation-acetylation switch in the regulation of STAT1 signaling.
total:1
A phosphorylation-acetylation switch regulates STAT1 signaling. 2009 to the paper
Abgent UBCH8antibody was used for western blot in order to investigate the role of phosphorylation-acetylation switch in the regulation of STAT1 signaling.
total:34
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. 2009 to the paper
Cell Signaling Technology mouse anti-ubiquitin monoclonal antibody was used in western blot in order to demonstrate that BCL6 interacts with HB-EGF-CTF and that this interaction might induce the cyclin D2 expression in human gastric cancer. more