Nuclear Receptor transcription pathway
gene
reagent
sample publication
sample review
total:52
Overcoming mutation-based resistance to antiandrogens with rational drug design. 2013 to the paper
Upstate anti-AR (PG-21) antibody was used to perform ChIP in order to study the rational drug design for castration-resistant prostate cancer without mutation-based resistance to antiandrogens. more
- constitutive androstane receptor antibody
- constitutive androstane receptor gene knockdown
- constitutive androstane receptor cDNA
- constitutive androstane receptor protein
- constitutive androstane receptor inhibitor/activator/substrate/reporter
- constitutive androstane receptor ELISA/assay
- constitutive androstane receptor other
total:112
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-ERa antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:24
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. 2009 to the paper
GeneTex mouse monoclonal anti-ER antibody (C14C8) was used in immunohistochemistry, immunocytochemistry, and immunoprecipitation to study the effect of estrogen receptormediated nuclear interaction between IRS-1 and Rad51 on homologous recombination directed DNA repair in medulloblastoma. more
total:1
Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. 2005 to the paper
Santa Cruz Biotechnologies ER beta H150 antibody was used in Western blot to study the biological function of estrogen receptors in the rapid effects of resveratrol and estradiol.
total:1
Orphan nuclear receptor GCNF is required for the repression of pluripotency genes during retinoic acid-induced embryonic stem cell differentiation. 2005 to the paper
Austin J. Cooney (Baylor College of Medicine) anti-GCNF antibody was used in western blot to study the role of Oct4 in embryonic stem (ES) cell pluripotency and differentiation.
total:20
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. 2009 to the paper
BD rat monoclonal antibodies against mouse Gr-l were used in flow immunocytometry to investigate the role of the migrant cDCs in the regulation of CD11c, MHC II, and CD86. more
total:12
Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes. 2009 to the paper
Santa Cruz anti-HNF4 alpha antibody was used to perform ChIP assays in order to study the roles of PXR in the regulations of CYP4F12 and the coactivation and corepression to a broad range of promoters. more
total:8
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-MED1 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
total:3
Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes. 2009 to the paper
Santa Cruz anti-SHP antibody was used to perform ChIP assays in order to study the roles of PXR in the regulations of CYP4F12 and the coactivation and corepression to a broad range of promoters. more
total:1
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. 2009 to the paper
Cell Signaling anti-REVERB alpha antibody was used to perform western blot in order to study the mechanism of the AMPK's regulation towards the circadian clock.
total:8
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Calbiochem rabbit polyclonal anti-PAR was used to perform immunoprecipitation in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:1
HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. 2009 to the paper
Santa Cruz anti-TR2 was used to perform immunohistochemistry and western blot in order to find out the new function of HDAC3 in shuttling phosphorylated TR2 to PML.
total:2
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. 2006 to the paper
Santa Cruz Biotechnology anti-LRH-1 antibody (catalog number SC-25389x) was used in human 293T cells and in ChIP assay to study the effect of nuclear receptors liver receptor homologue-1 and small heterodimer partner on 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter. more
total:10
Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues. 2008 to the paper
R&D Systems monoclonal anti-Nur77 was used to perform immunocytochemistry in dilution 1:200 in order to show that acetylshikonin and analogues induce apoptosis through orphan nuclear receptor Nur77-mediated apoptotic pathway in cancer cells. more
total:6
Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity. 2005 to the paper
Santa Cruz Biotechnology anti-nurr1 antibody was used in immunocytochemistry to demonstrate that multiple splice variants of nurr1 are produced in rat and human dopamine neurons. more
total:9
Integration of microRNA miR-122 in hepatic circadian gene expression. 2009 to the paper
Abcam rabbit polyclonal antibody PPAR was used for immunoprecipitation in order to study the circadian gene expression of integration of microRNA miR-122 in hepatic. more
total:8
Curcumin suppresses PPARdelta expression and related genes in HT-29 cells. 2009 to the paper
Santa Cruz Biotechnology anti-PPAR5 antibody was used in western blot to investigate the role of curcumin in the regulation of the expression of PPARdelta, 14-3-3epsilon, and VEGF in HT-29 cells. more
total:28
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-PPAR gamma antibody was used to carry out western blot analysis and Ch-IP assays in order to identify the binding sites of PPAR Gramma and RXR in a genome wide manner during adipogenesis. more
total:38
The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. 2009 to the paper
Santa Cruz PR monoclonal antibody was used in immunohistochemistry in order to investigate the role of neurotensin receptor-1 pathway in the regulation of human ductal breast cancer progression. more
total:14
Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network. 2009 to the paper
Santa Cruz Biotechnology anti-RARalpha antibody was used in western blot to test whether derangement of a factor upstream of RARalpha can triggers the repression of a pleiotropic epigenetic network more
total:6
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Abcam anti-Pan-CDH antibody was used to perform western blot in order to study synaptic plasticity. more
total:3
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
Abcam rabbit anti-RORgamma t polyclonal antibody was used to perform immunohistochemistry in order to study the secretion of proinflammatory cytokines and generation of Th17 cells induced by IL-26. more
total:6
Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. 2008 to the paper
Santa Cruz Biotechnologies rabbit polyclonal anti-RXR-gamma antibody was used in immunohistochemistry to determine whether human pregnane X receptor expression profile in localized infiltrative breast cancer is associated with an increased risk of recurrent disease. more
total:14
Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. 2010 to the paper
Santa Cruz Biotechnology polyclonal RXRs antibody was used to perform western blot in order to clarify that retinoic acid could inhibit CYP4F11 expression in human keratinocyte-derived HaCaT cells by multiple signaling pathways including RXR and JNK pathways. more
total:2
Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. 2008 to the paper
Santa Cruz Biotechnologies mouse monoclonal anti-RXR-beta antibody was used in immunohistochemistry to determine whether human pregnane X receptor expression profile in localized infiltrative breast cancer is associated with an increased risk of recurrent disease. more
total:6
Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. 2007 to the paper
Millipore anti-SF1 was used to perform immunoprecipitation in order to study the elements that bind to SF1. more
total:2
The p160 coactivator PAS-B motif stabilizes nuclear receptor binding and contributes to isoform-specific regulation by thyroid hormone receptors. 2009 to the paper
Affinity BioReagents anti-thyroid hormone receptor anti-sera was used in immunoprecipitation in order to investigate the cooperation between thyroid hormone receptor beta2 and p160 coactivator PAS-B through multiple contact surfaces. more
total:3
Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. 2010 to the paper
Cell Signalling Technology anti-TAK1 antibody was used to carry out western blot analysis in order to investigate the role for NF-kB signalling in the interleukin-1 induced expression of C/EBP delta. more
total:15
Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. 2010 to the paper
Affinity BioReagents anti-VDR (MA1-7101, 1:400) monoclonal antibody was used to perform immunocytochemistry in order to show that cathelicidin, a human antimicrobial peptide can be induced by vitamin D in the urinary bladder. more