Nuclear Events (kinase and transcription factor activation)
gene
reagent
sample publication
sample review
total:6
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells. 2009 to the paper
Santa Cruz Biotechnology murine monoclonal anti-ATF-1 antibody was used for western blot in order to show that vasoactive intestinal peptide can promote HCMV MIE gene expression in human NT2 cells. more
total:58
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-CREB1 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:3
(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. 2009 to the paper
Santa Cruz anti-DUSP4 antibody was used for western blot in order to investigate the role of BRAF in the regulation of RAF-MEK signaling pathway. more
total:6
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-MKP3 antibody was used to perform flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
total:13
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz monoclonal anti-p-ELK1 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
total:2
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. 2005 to the paper
Biosource anti-phosphoERK5 antibody was used in western blot to study tissue-specific transcriptional regulation by ERK5 more
total:10
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. 2010 to the paper
Cell Signaling Technologies phospho-specific and total anti-p38antibody was used to perform western blot in order to study the function of phosphodiesterase 6 subunits in idiopathic pulmonary fibrosis. more
total:6
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. 2006 to the paper
Santa Cruz monoclonal anti-MEF2 antibody was used in immunoprecipitation to study a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain.. more
total:3
c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells. 2010 to the paper
Proteintech rabbit anti-Mef2c antibody (10056-1-AP; dilution 1:50) was used to perform immunocytochemistry in order to determine the relationship between the cardiogenic potential of iPS and the nuclear reprogramming. more
total:18
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Cell Signaling Technology anti-MAPKAPK 2 (pT334) was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
total:189
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 to the paper
Biosource International anti-p38 antibody was used to perform western blot in order to study the effect of NFAT5 on hyperosmolar stressed human limbal epithelial cells. more
total:20
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Santa Cruz anti-RSK-1 antibody (1:1,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediates anti-apoptotic effects. more
total:20
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate monoclonal anti-PP2Ac antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
total:7
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate polyclonal anti-PP2A-A antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
total:2
SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. 2007 to the paper
Sigma-Aldrich polyclonal antibody to the PP2APR65 subunit was used to perform western blot in order to investigate the functions of salt-inducible kinase-1. more
total:9
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. 2009 to the paper
Cell Signaling anti-phosphorylated p90RSK antibody was used to perform western blot in order to study the important role of GRK4 in D3 receptor's signaling in human proximal tubule cells. more
total:9
Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection. 2009 to the paper
Santa Cruz anti-RSK2 antibody was used to perform western blot in order to study the role of RSK2 in the cellular antiviral response. more
total:3
Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation. 2009 to the paper
Santa Cruz Biotechnology MSK1 antibody was used in western blot in order to study the role of MSK1 in NF-kB activation and inflammatory diseases more