NRAGE signals death through JNK
gene
reagent
sample publication
sample review
ARHGAP4
Rho GTPase activating protein 4
total:3
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones. 2008 to the paper
Transduction Laboratories p115 antibody was used in western blot and immunocytochemistry in order to investigate the mechanism required for post-Golgi transport of POMC/ACTH vesicles to the plasma membrane for activity-dependent secretion more
ARHGEF7
Rho guanine nucleotide exchange factor 7
total:1
GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization. 2009 to the paper
Santa Cruz Biotechnology anti-beta-PIX antibody was used in western blot to study the role for GM130-dependent control of Cdc42 activity at the golgi in regulating centrosome organization
BAD
BCL2 associated agonist of cell death
total:49
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. 2011 to the paper
Cell Signaling Technology, anti-BAD monoclonal antibody was used to perform western blot in order to study that cleveage of NIK leads to noncanonical NF- kB activation more
Bim
BCL2 like 11
total:31
Control of cellular Bcl-xL levels by deamidation-regulated degradation. 2013 to the paper
Calbiochem anti-Bim antibody was used to perform immunoprecipitation in order to investigate the regulatory effect of deamidation on Bcl-xL degradation. more
ECT2
epithelial cell transforming 2
total:2
CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. 2009 to the paper
Santa Cruz Biotechnology anti-Ect2 antibody was used in western blot in order to study the reguation of the expression of Ect2, MgcRacGAP, and MKLP1 during cell cycle progression more
FGD1
FYVE, RhoGEF and PH domain containing 1
FGD2
FYVE, RhoGEF and PH domain containing 2
FGD4
FYVE, RhoGEF and PH domain containing 4
GRF2
Ras protein specific guanine nucleotide releasing factor 2
JNK
mitogen-activated protein kinase 8
total:193
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-JNK1 monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
MAGED1
MAGE family member D1
total:1
A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. 2010 to the paper
Santa Cruz goat anti-NRAGE antibody was used to perform western blotting in order to determine the role of NRAGE in regulating NF-kappaB activity.
MCF2
MCF.2 cell line derived transforming sequence
total:1
Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1. 2008 to the paper
Santa Cruz rabbit anti-Dbl antibody was used to perform immunoprecipitation and western blot in order to show that Nm23-H1 negatively regulate cell migration and tumor metastasis by modulating the activity of Dbl1.
MCF2L
MCF.2 cell line derived transforming sequence like
NET1
neuroepithelial cell transforming 1
total:1
The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion. 2009 to the paper
Santa Cruz Biotechnology anti-Net1 antibody was used to carry out western blot analysis in order to investigate the regulation of constitutive Vav3 expression along with cell plasticity and migration by dioxin receptor.
NGEF
neuronal guanine nucleotide exchange factor
NGF
nerve growth factor
total:2
NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. 2008 to the paper
Novus monoclone anti-NGF antibody (30 ug/ml) was used in cell culture in order to study the role of NGF or BDNF signaling in neuronal apoptotic death more
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
p75NTR
nerve growth factor receptor
total:17
Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line. 2008 to the paper
Novus Biologicals anti-p75NTR antibody was used to perform immunocytochemistry in order to show that cellular phenotype can be changed after exposure to acid and bile salt in Barrett's epithelial cell line. more
PLEKHG2
pleckstrin homology and RhoGEF domain containing G2
PLEKHG5
pleckstrin homology and RhoGEF domain containing G5
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
Sos
SOS Ras/Rac guanine nucleotide exchange factor 1
total:11
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. 2007 to the paper
Santa Cruz rabbit Sos-1 antibody was used in western blot to study the role of Abi-1 in morphogenesis and synapse formation. more
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2
total:1
The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis. 2005 to the paper
BD Biosciences anti-SOS-2 antibody was used in western blot to study the role of AIF in nuclear phenotype and DNA degradation during apoptosis
Tiam1
TIAM Rac1 associated GEF 1
total:6
Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. 2008 to the paper
Santa Cruz Biotechnology Tiam1 antibody (C-16) was used to perform co-immunoprecipitation analyse and chromatin immunoprecipitation assays in order to demonstrate the mechanism between Rac1 and the canonical Wnt signalling pathway in colorectal cancer cells. more
TRIO
trio Rho guanine nucleotide exchange factor
VAV3
vav guanine nucleotide exchange factor 3
total:2
Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. 2008 to the paper
Upstate Biotechnology anti Vav3 antibody was used in western blot and immunohistochemistry to study the activation of estrogen receptor by Vav3 oncogene and Vav3 overexpression in human breast cancer more
XPLN
Rho guanine nucleotide exchange factor 3