Meiosis
gene
reagent
sample publication
sample review
H2BS1
H2B.S histone 1
ATM
ATM serine/threonine kinase
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
ATR
ATR serine/threonine kinase
total:24
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Santa Cruz human ATR antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
BLM
BLM RecQ like helicase
total:10
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination. 2008 to the paper
Novus anti-BLM antibody (NB100-161) was used to perform immunoprecipitation and western blot in order to study the formation of BLM-53BP1-RAD51 complex. more
BRCA1
BRCA1 DNA repair associated
total:42
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. 2011 to the paper
Calbiochem anti-BRCA1 monoclonal antibody was used to perform immunoprecipitation in order to study the function of apicobasal polarity and regulation of stem cell in breast cancer more
BRCA2
BRCA2 DNA repair associated
total:10
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. 2010 to the paper
EMD anti-BRCA2 antibody was used to carry out immunofluorescence assays in order to investigate the role for FAN1 in promoting DNA interstrand cross-link repair by mono-ubiquitylating FANCI-FANCD2 complex. more
CDK2
cyclin dependent kinase 2
total:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk2 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
Cdk4
cyclin dependent kinase 4
total:44
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 to the paper
Millipore anti-CDK4 antibody was used to perform western blot in order to study the roles of the fragile X mental retardation protein during the regulations of the proliferation and differentiation of adult neural stem/progenitor cells. more
H2AZ1
H2A.Z variant histone 1
total:1
Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin. 2007 to the paper
Dr. Peter Cheung (Ontario Cancer Institute) rabbit H2A.Z-specific antibodies (the H2A.Z-L1 antibody was raised against the peptide sequence KSSRTTSHGR, and the H2A.Z-C antibody was raised against the peptide sequence IPHIHKSLIGKKGQQKTV) was used in western blot and immunocytochemistry to study H2A.Z monoubiquitylation as the marker for its association with euchromatin or facultative heterochromatin
H2AX
H2A.X variant histone
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
H3
H3 clustered histone 14
total:32
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 to the paper
Upstate anti-H3K4 antibody was used to perform RNA immunoprecipitation in order to analyze histone methylation at transcription start sites in human-specific prefrontal neurons of brain. more
H3-3B
H3.3 histone B
total:5
Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. 2005 to the paper
Upstate Biotechnology acetyl-H3 antibody was used in ChIP assay to study 12 (S) Lipoxygenase transcription in A431 cells more
H4
H4 clustered histone 14
total:11
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. 2009 to the paper
Active Motif anti-H4K12Ac antibody 1:1,000 was used for western blot in order to investigate the roles of H3K9Ac and H3K56Ac in the regulation of DNA-damage-responsive in human cells more
H2BC1
H2B clustered histone 1
total:1
Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging. 2007 to the paper
Chemicon International TSH2B antibody was used in western blot to assesse the association of TSH2B with chromatin compaction status.
H2BC5
H2B clustered histone 5
total:1
p53 chromatin epigenetic domain organization and p53 transcription. 2009 to the paper
Abcam anti-histone H2Bantibody was used to perform immunoprecipitation in order to demonstrate that physical barrier due to the folding of chromatin in domain II can give rise to the depletion of RNA polymerase II.
H3C6
H3 clustered histone 6
total:5
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Abcam anti-Histone 3, anti-H3 K9Me, and anti-H3 S10ph antibodies were used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
H2AC20
H2A clustered histone 20
total:6
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. 2009 to the paper
Abcam anti-H2A antibody 1:1,000 was used for western blot in order to investigate the roles of H3K9Ac and H3K56Ac in the regulation of DNA-damage-responsive in human cells more
H2BC21
H2B clustered histone 21
total:10
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Upstate Biotechnologies anti-H2B antibody was used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
H3-4
H3.4 histone
total:17
Transforming fusions of FGFR and TACC genes in human glioblastoma. 2012 to the paper
Millipore rabbit anti-pHH3 was used at 1:500 to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients. more
lamin A/C
total:57
RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. 2013 to the paper
Santa Cruz lamin A/C goat polyclonal (1:1000)was used to perform the immunoblotting to study the translation of a subset of mRNAs encoding secretory proteins potentiated by RanBP2/Nup358. more
lamin B
lamin B1
total:31
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. 2010 to the paper
Santa Cruz anti-lamin-B antibody was used for western blot in order to show that CYLD negatively regulates cell-cycle progression by inactivating HDAC6. more
MLH1
mutL homolog 1
total:24
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men. 2008 to the paper
Calbiochem anti-MLH1 antibody (1:75) was used to perform western blot and immunoprecipitation in order to study the function of small ubiquitin-related modifier (SUMO) 1, SUMO-2/3 and SUMOylation. more
Mre11
MRE11 homolog, double strand break repair nuclease
total:19
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.. 2009 to the paper
Calbiochem rabbit polyclonal Mre11 antibody was used to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2. more
MSH4
mutS homolog 4
total:1
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. 2009 to the paper
BD Biosciences rabbit anti-Msh4 antibody was used for western blot in order to investigate the role of Syce1 in the regulation of Synapsis and DNA Repair.
Nbs1
nibrin
total:28
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Novus NBS1 antibody was used to perform immunofluorescence assay in order to study the requirement of RSFI in DSB repair. more
RAD21
RAD21 cohesin complex component
total:2
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Novus anti-human Rad21 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
Rad50
RAD50 double strand break repair protein
total:13
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. 2008 to the paper
GeneTex anti-Rad50 antibody was used to perform western blot in order to identify that regions of Nbs1 are differentially required for concatemer formation and inhibition of Ad DNA replication. more
RAD51
RAD51 recombinase
total:20
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Calbiochem anti-Rad51 was used to perform immunocytochemistry in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
RBBP8
RB binding protein 8, endonuclease
total:3
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. 2012 to the paper
Abcam anti-SAE2 was used to perform western blot in order to show that Myc-dependent cancer needs SUMOylation for tumorigenesis. more
REC8
REC8 meiotic recombination protein
total:1
Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe. 2006 to the paper
Santa Cruz Biotechnology anti-REC8 antibody was used in western blot and immunocytochemistry to study the upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe.
RPA2
replication protein A2
total:12
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. 2010 to the paper
GeneTex anti-RPA32 monoclonal antibody was used to perform immunofluorescence in order to study the interactions of ATR and ATRIP in gene expression and production of virus during HSV-1 infection. more
Smc1
structural maintenance of chromosomes 1A
total:14
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. 2011 to the paper
Bethyl anti-SMC1 was used to perform western blot in order to show that RHINO is important for ATR activation during DNA damage responses. more
SMC1B
structural maintenance of chromosomes 1B
SMC3
structural maintenance of chromosomes 3
SPO11
SPO11 initiator of meiotic double stranded breaks
STAG1
stromal antigen 1
total:2
Mutational inactivation of STAG2 causes aneuploidy in human cancer. 2011 to the paper
Santa Cruz anti-STAG1 was used to perform western blot in order to show that aneuploidy in tumor cells is associated with STAG2 inactivation. more
STAG2
stromal antigen 2
total:1
Mutational inactivation of STAG2 causes aneuploidy in human cancer. 2011 to the paper
Santa Cruz anti-STAG2 was used to perform western blot and immunohistochemistry in order to show that aneuploidy in tumor cells is associated with STAG2 inactivation.
STAG3
stromal antigen 3
total:1
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. 2009 to the paper
Upstate Biotechnology rabbit anti-STAG3 antibody was used for western blot in order to investigate the role of Syce1 in the regulation of Synapsis and DNA Repair.
SUN1
Sad1 and UNC84 domain containing 1
total:1
Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7. 2010 to the paper
Sigma/Atlas Antibodies rabbit anti-Sun1 antibody was used in immunohistochemistry in order to investigate the effects of the expression of human LBR disease mutants on cellular structure.
SYCE1
synaptonemal complex central element protein 1
total:1
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. 2009 to the paper
Abcam rabbit anti-SYCE1 antibody was used for western blot in order to investigate the role of Syce1 in the regulation of Synapsis and DNA Repair.
SYCE2
synaptonemal complex central element protein 2
total:1
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. 2009 to the paper
Abcam rabbit anti-SYCE2 antibody was used for western blot in order to investigate the role of Syce1 in the regulation of Synapsis and DNA Repair.
SYCP1
synaptonemal complex protein 1
total:2
Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men. 2008 to the paper
Santa Cruz Biotechnology anti-SCP1 antibody (1:100) was used to perform western blot and immunoprecipitation in order to study the function of small ubiquitin-related modifier (SUMO) 1, SUMO-2/3 and SUMOylation. more
SYCP3
synaptonemal complex protein 3
total:1
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. 2009 to the paper
Abcam mouse anti-SYCP3 antibody was used for western blot in order to investigate the role of Syce1 in the regulation of Synapsis and DNA Repair.
SYNE1
spectrin repeat containing nuclear envelope protein 1
total:2
Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. 2009 to the paper
Santa Cruz Biotechnology Nesprin-1 antibody was used in immunohistochemistry in order to demonstrate that lamin A/C-mediated NMJ defects contribute to the AD-EDMD disease phenotype more
SYNE2
spectrin repeat containing nuclear envelope protein 2
TEX12
testis expressed 12
total:1
Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair. 2009 to the paper
Abcam rabbit anti-TEX12 antibody was used for western blot in order to investigate the role of Syce1 in the regulation of Synapsis and DNA Repair.
TRF1
telomeric repeat binding factor 1
total:5
Functional dissection of human and mouse POT1 proteins. 2009 to the paper
Sigma rabbit anti-mouse TRF1 (644) antibody was used in immunofluorescence in order to investigate the function of single-stranded telomeric DNA associated protein-POT1 in human and mice. more
TRF2
telomeric repeat binding factor 2
total:16
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. 2009 to the paper
Millipore anti-TRF2 antibody was used to perform immunohistochemistry in order to study the function of HP1 proteins in the alternative lengthening of telomeres-associated PML bodies by p53/p21. more
UBE2I
ubiquitin conjugating enzyme E2 I
total:10
The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. 2010 to the paper
Santa Cruz anti-UBC9 antibody was used in western blot in order to find the counterpart of forkhead transcription factor- FOXL2 and elucidate the role of its sumoylation more