MPS IIIB - Sanfilippo syndrome B
gene
reagent
sample publication
sample review
ABCC5
ATP binding cassette subfamily C member 5
aggrecan
total:4
Expression of ZIC family genes in meningiomas and other brain tumors. 2010 to the paper
Sigma anti-chondroitin sulfate proteoglycan antibody was used to perform immunohistochemistry in order to study the expression of the ZIC family genes in different type of brain tumors. more
alpha L iduronidase
alpha-L-iduronidase
total:1
Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. 2006 to the paper
BioMarin Pharmaceutical rabbit polyclonal IDUA antibody was used in immunohistochemistry (1:3000) to determine the expression level of IDUA in the brain after AAV vectors.
B3GALT6
beta-1,3-galactosyltransferase 6
total:1
Impairment of glycosaminoglycan synthesis in mucopolysaccharidosis type IIIA cells by using siRNA: a potential therapeutic approach for Sanfilippo disease. 2010 to the paper
Abnova anti-B3GALT6(M06) mouse monoclonal antibody was used to perform western blot in order to study the efficiency of using the small interfering RNA(siRNA) to control expression of particular genes involved in GAG synthesis for the treatment of mucopolysaccharidosis type III.
B3GNT2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
total:1
How do human cells react to the absence of mitochondrial DNA?. 2009 to the paper
Invitrogen anti-Core1 antibody was used for western blot to study the reaction of human cells to the absence of mitochondrial DNA.
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B3GNT7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
B4GALT7
beta-1,4-galactosyltransferase 7
total:1
Impairment of glycosaminoglycan synthesis in mucopolysaccharidosis type IIIA cells by using siRNA: a potential therapeutic approach for Sanfilippo disease. 2010 to the paper
Proteintech Group anti-B4GALT7 rabbit polyclonal antibody was used to perform western blot in order to study the efficiency of using the small interfering RNA(siRNA) to control expression of particular genes involved in GAG synthesis for the treatment of mucopolysaccharidosis type III.
CD44
CD44 molecule (Indian blood group)
total:49
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. 2013 to the paper
Millipore rat anti-heparan sulfate proteoglycan monoclonal antibody was used to perform immunohistochemistry in order to investigate the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models. more
CD57
beta-1,3-glucuronyltransferase 1
total:9
Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival. 2008 to the paper
Becton Dickinson anti-CD57 antibody was used in immunohistochemistry to investigate the relationship between IDO expression and tumor-infiltrating lymphocytes in endometrial cancer. more
chondroitin 6 sulfotransferase
carbohydrate sulfotransferase 3
total:2
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. 2005 to the paper
ICN Biomedicals 20-HSD antiserum (1:1000) was used in western blot to determine the relative contribution of 20alpha-HSD to progesterone metabolism and Stat5 function during pregnancy and parturition. more
CHST7
carbohydrate sulfotransferase 7
CHST9
carbohydrate sulfotransferase 9
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
total:1
Comparison between human fetal and adult skin. 2010 to the paper
Sigma anti-chondroitin sulfate was used to perform immunohistochemistry in dilution 1:500 in order to show that dermal components express differentially between human fetal and adult skin and play important roles in fetal scarless healing.
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
DSEL
dermatan sulfate epimerase like
GLB1
galactosidase beta 1
total:7
Conditional knockout of NMDA receptors in dopamine neurons prevents nicotine-conditioned place preference. 2010 to the paper
Invitrogene anti-beta-Galactosidase antibody was used in immunocytochemistry for immunofluorescent staining to investigate the role of the NMDA receptors in the regulation of nicotine-conditioned place preference in dopamine neurons. more
glucuronyl C5 epimerase
glucuronic acid epimerase
total:1
Decreased expression of human D-glucuronyl C5-epimerase in breast cancer. 2008 to the paper
GenScript Corporation anti-GLCE antibody was used to perform western blot in order to study the GLCE expression in human breast cancer.
GPC3
glypican 3
total:1
Differential expression of syndecans and glypicans in chronically inflamed synovium. 2008 to the paper
Santa Cruz Biotechnologies anti-glypican-3 antibody was used in immunohistochemistry to investigate which HSPGs are expressed in knee joint synovia from patients with different forms of arthritis and normal individuals.
HAS1
hyaluronan synthase 1
total:1
Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant indicator of poor outcome in multiple myeloma. 2005 to the paper
Washington Biotechnology rabbit polyclonal anti-HAS1 antibody was used in western blot to study the intronic splicing of hyaluronan synthase 1 (HAS1).
heparanase
total:6
Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery. 2009 to the paper
Abgent anti-HPSE rabbit antibody (1:200) was used to perform western blot in order to study how to modulate gene expression and develop new drugs by short chain fatty acid (SCFA) hexosamine molecules. more
HPSE2
heparanase 2 (inactive)
total:1
Heparanase expression in circulating lymphocytes of breast cancer patients depends on the presence of the primary tumor and/or systemic metastasis. 2007 to the paper
Santa Cruz Biotechnology HPA2 antibody was used in immunocytochemistry (1:100) to demonstrate that heparanase was expressed in lymphocytes of breast cancer PBMC.
HS3ST1
heparan sulfate-glucosamine 3-sulfotransferase 1
HS3ST2
heparan sulfate-glucosamine 3-sulfotransferase 2
HS3ST3A1
heparan sulfate-glucosamine 3-sulfotransferase 3A1
HS3ST3B1
heparan sulfate-glucosamine 3-sulfotransferase 3B1
HS3ST4
heparan sulfate-glucosamine 3-sulfotransferase 4
HS3ST5
heparan sulfate-glucosamine 3-sulfotransferase 5
HS3ST6
heparan sulfate-glucosamine 3-sulfotransferase 6
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
LYVE 1
lymphatic vessel endothelial hyaluronan receptor 1
total:7
Altered regulation of Prox1-gene-expression in liver tumors. 2008 to the paper
Reliatech rabbit polyclonal anti-Lyve-1 (1:500) antibody was used in immunohistochemistry to study Prox1-gene-expression in liver tumors more
NG2
chondroitin sulfate proteoglycan 4
total:12
Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. 2010 to the paper
Chemicon anti-NG2 antibody (1:1500) was used in immunocytochemistry in order to investigate the roles of Nkx2.2 and Nkx6.2 in the regulation of myelin sheath formation. more
PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
total:2
Oxysterols are substrates for cholesterol sulfotransferase. 2007 to the paper
Dr. Charles A. Strott (National Institute of Child Health and Human Development) PAPSS1 (1:2,000; HL4004) antibody was used in western blot to identify oxysterols as substrates for cholesterol sulfotransferase more
PAPST2
solute carrier family 35 member B3
perlecan
heparan sulfate proteoglycan 2
total:5
WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. 2006 to the paper
Chemicon monoclonal anti-perlecan antibody (MAB 1948) was used in frozen sections from mouse and in immunohistochemistry to study the identification of WARP as a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. more
PRELP
proline and arginine rich end leucine rich repeat protein
SDC2
syndecan 2
total:2
Syndecan-4 is required for thrombin-induced migration and proliferation in human vascular smooth muscle cells. 2005 to the paper
Seikagaku HSPG neo-epitope (exposed after heparitinase III digestion, clone 3G10) antibody was used in western blot to study thrombin-induced human vascular smooth muscle cell migration and proliferation more
SDC3
syndecan 3
total:1
Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue. 2006 to the paper
Zymed Laboratories rabbit anti syndecan-3 antibody was used in immunohistochemistry to study its expression in human uterine tissue during prolonged labour
SDC4
syndecan 4
total:3
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. 2008 to the paper
Santa Cruz Biotechnology anti-syndecan-4 antibody was used in immunocytochemistry to study the effect of heparanase on cell adhesion and spreading. more
ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
syndecan
syndecan 1
total:26
Heparanase regulates levels of syndecan-1 in the nucleus. 2009 to the paper
Cell Sciences B-A38 (Syndecan-1) antibody was used in western blot in order to demonstrate that heparanase can promote expression of syndecan-1 in the nucleus. more
VCAN
versican
total:4
Expression of ZIC family genes in meningiomas and other brain tumors. 2010 to the paper
Sigma-Aldrich anti-chondroitin sulfate proteoglycan antibody was used to perform immunohistochemistry in order to investigate the expression profiles of ZIC genes in brain tumors. more