Late Phase of HIV Life Cycle
gene
reagent
sample publication
sample review
CCNH
cyclin H
total:3
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. 2005 to the paper
Santa Cruz Biotechnology cyclin H antibody was used in western blot to study the role of Dmp1 in Ras-Raf-Arf signaling. more
CCNT1
cyclin T1
total:5
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. 2008 to the paper
Santa Cruz anti-cyclin T1 antibody was used to perform western blot in order to study the association between ING4 and the activity of NF-kappa B molecules bound with target gene promoters. more
cdk7
cyclin dependent kinase 7
total:8
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-CDK7 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
cdk9
cyclin dependent kinase 9
total:11
MED23 mutation links intellectual disability to dysregulation of immediate early gene expression. 2011 to the paper
Santa Cruz polyclonal anti-CDK9 was used to perform ChIP assay and western blot in order to show that immediate early gene expression is disrupted by MED23 mutation and results in intellectual disability. more
CHMP2B
charged multivesicular body protein 2B
total:1
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. 2011 to the paper
Abcam antibody mouse rabbit anti-CHMP2B antibody was used to perform immunohistochemistry in order to study quantification of CHMP2B on intercellular bridges at different stages.
CHMP3
charged multivesicular body protein 3
total:1
Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. 2005 to the paper
Bethyl Laboratory Inc. rabbit anti-Vps24 antibody was used in western blot to study the interaction of the mammalian endosomal sorting complex required for rransport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1
CHMP4A
charged multivesicular body protein 4A
total:2
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-CHMP4A was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
CHMP4B
charged multivesicular body protein 4B
total:2
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-CHMP4B was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
CypA
peptidylprolyl isomerase A
total:9
Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection. 2010 to the paper
Proteintech anti-CypA monoclonal antibody was used to perform western blot in order to study the role of HBV small surface protein(SHBs) in promoting the pathogenesis of HBV infection. more
ELL
elongation factor for RNA polymerase II
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit
total:3
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-XPD was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit
total:5
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. 2012 to the paper
Santa Cruz anti-XPB was used to perform western blot and immunoprecipitation in order to show that DNA metabolism and genomic integrity were maintained by MMS19. more
FCP1
CTD phosphatase subunit 1
total:4
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat. 2013 to the paper
Abcam RNA polymerase II CTD repeat YSPTSPS peptide-phospho S2 antibody was used to perform western blot in order to study the structure and function of the tripartite complex containing P-TEFb,AFF4HIV and HIV Tat. more
GTF2A1
general transcription factor IIA subunit 1
GTF2A2
general transcription factor IIA subunit 2
total:1
Human La is found at RNA polymerase III-transcribed genes in vivo. 2005 to the paper
Santa Cruz Biotechnology TFIIA antibody was used in ChIP assay to study the association of human autoantigen La with pol III-transcribed genes in vivo
GTF2E1
general transcription factor IIE subunit 1
total:2
Identification of novel functional TBP-binding sites and general factor repertoires. 2007 to the paper
Santa Cruz TFIIEa antibody was used in ChIP assay to identify novel functional TBP-binding sites and general factor repertoires. more
GTF2E2
general transcription factor IIE subunit 2
GTF2F1
general transcription factor IIF subunit 1
total:3
Papillomavirus E2 proteins and the host BRD4 protein associate with transcriptionally active cellular chromatin. 2009 to the paper
Santa Cruz anti-TFIIF antibody was used to perform ChIP assays in order to study the association between the papillomavirus E2 proteins, the host Brd4 protein and the transcriptionally active cellular genes. more
GTF2F2
general transcription factor IIF subunit 2
GTF2H3
general transcription factor IIH subunit 3
total:1
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. 2009 to the paper
Santa Cruz Biotechnology TFIIH antibody was used in western blot to study the regulation of aromatase transcription and estrogen biosynthesis in adipose stromal cells (ASCs).
MNAT1
MNAT1 component of CDK activating kinase
total:2
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". 2006 to the paper
Santa Cruz monoclonal anti-Mat1 antibody (F-6) was used in human T98G cells and in western blot to study the role for cyclins and CDK "inhibitors" in Thr172 phosphorylation of CDK4. more
NCBP1
nuclear cap binding protein subunit 1
total:2
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. 2009 to the paper
Protein-Tech anti-CBP80 antibody was used in western blot in order to investigate the function of surveillance complex associated with ribosome during nonsense-mediated mRNA decay (NMD). more
NCBP2
nuclear cap binding protein subunit 2
total:1
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. 2009 to the paper
Abgent CBP20 antibody was used in western blot in order to study the regulatory mechanism of SMG-1 kinase in nonsense-mediated mRNA decay.
NELFA
negative elongation factor complex member A
NELFCD
negative elongation factor complex member C/D
NELFE
negative elongation factor complex member E
NMT1
N-myristoyltransferase 1
total:1
Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. 2005 to the paper
BD Transduction Laboratories anti-NMT1 antibody was used in western blot to detect NMT1 in SK-OV-3 cells treated with NMT1-1 siRNA or NMT2-4 siRNA.
NMT2
N-myristoyltransferase 2
total:1
Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. 2005 to the paper
BD Transduction Laboratories anti-NMT2 antibody was used in western blot to detect NMT2 in SK-OV-3 cells treated with NMT1-1 siRNA or NMT2-4 siRNA.
nucleoporin p62
nucleoporin 62
total:8
Fractionation of the Coxiella burnetii parasitophorous vacuole. 2008 to the paper
BD Biosciences mouse anti-human nuclear pore protein nucleoporin p62 antibody was used to perform western blot in order to develope a method to separate intact parasitophorous vacuole from host cell material. more
NUP133
nucleoporin 133
total:1
The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. 2009 to the paper
Covance anti-nucleoporin antibody was used to perform western blot in order to study the roles of Nup153 plays in mitosis.
NUP153
nucleoporin 153
total:2
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Abcam monoclonal anti-NUP was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
NUP88
nucleoporin 88
total:1
Caspases target only two architectural components within the core structure of the nuclear pore complex. 2006 to the paper
BD Biosciences monoclonal Nup88 antibody was used in western blot to identify caspase targets in the core structure of nuclear pore complex in Hela cells
PDCD6IP
programmed cell death 6 interacting protein
total:2
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. 2010 to the paper
Cell Signaling ALIX antibody was used to perform western blot in order to indicate an important role for the ubiquitin ligase activity of HOIP in CD40 signaling. more
POLR2B
RNA polymerase II subunit B
total:1
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. 2009 to the paper
Santa Cruz anti-the large subunit of RNA polymerases II antibody (N20) was used in western blot to study the role for the STAGA subunit ADA2b in regulating human GCN5 catalysis.
POM121
POM121 transmembrane nucleoporin
RAE1
ribonucleic acid export 1
total:1
The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response. 2008 to the paper
R&D Systems anti-RAE-1 antibody was used in flow cytometry in order to study the role of immune responses in the tumorigenicity of embryonic stem cells
Ran
RAN, member RAS oncogene family
total:17
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
BD Biosciences mouse anti-RAN antibody was used to perform western blot in order to investigate the role of PVRL4 in tumor progression. more
RANBP2
RAN binding protein 2
total:4
Nitric oxide destabilizes Pias3 and regulates sumoylation. 2007 to the paper
Santa Cruz polyclonal anti-RanBP2 was used to perform western blot in order to show that global sumoylation and Pias3 stabilization could be regulated by nitric oxide. more
RCC1
regulator of chromosome condensation 1
total:3
A survivin-ran complex regulates spindle formation in tumor cells. 2008 to the paper
Santa Cruz Biotechnology anti-human RCC1 antibody was used to perform western blot in order to study the role of survivin-Ran signaling in spindle formation in tumor cells. more
RNA polymerase II
RNA polymerase II subunit A
total:69
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. 2011 to the paper
Santa Cruz anti-Rpb1 was used to perform western blot and ChIP assay in order to show that histone mRNA 3 end processing needs the phosphorylation of RNAP II CTD Thr4. more
RPS27A
ribosomal protein S27a
total:5
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 2009 to the paper
Santa Cruz Biotechnology anti-ubiquitin antibody was used in western blot in order to identify a novel complex of erasin-ubiquilin-p97/VCP and its function in ERAD. more
SSRP1
structure specific recognition protein 1
total:2
FACT facilitates chromatin transcription by RNA polymerases I and III. 2009 to the paper
Abcam anti-SSRP1 was used to perform immunoprecipitation in order to to determine whether indeed FACT associates with Pol I complexes. more
SUPT4H1
SPT4 homolog, DSIF elongation factor subunit
SUPT5H
SPT5 homolog, DSIF elongation factor subunit
total:2
Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression. 2007 to the paper
Santa Cruz Biotechnology anti-Spt5 (sc-28678) antibody was used in western blot to study the role of transcription termination factor Pcf11 on the processivity of Pol II more
TAF1
TATA-box binding protein associated factor 1
total:7
Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. 2012 to the paper
Santa Cruz anti-TAF1 antibody was used to perform Chip in order to show that in human embryonic stem cells there are non-canonical TAF complexes regulate active promoters. more
TAF10
TATA-box binding protein associated factor 10
total:2
SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation. 2009 to the paper
Upstate Biochemistry amti-RNA polymerase II antibody was used for immunoprecipitation in order to indicate that SUMOylation is mediated through reduced CDK7-induced phosphorylation of SF-1. more
TAF11
TATA-box binding protein associated factor 11
total:2
Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. 2012 to the paper
Santa Cruz anti-TAF11 antibody was used to perform Chip or Web in order to show that in human embryonic stem cells there are non-canonical TAF complexes regulate active promoters. more
TAF12
TATA-box binding protein associated factor 12
total:2
Identification of novel functional TBP-binding sites and general factor repertoires. 2007 to the paper
Irwin Davidson TAF12 antibody was used in ChIP assay to identify novel functional TBP-binding sites and general factor repertoires. more
TAF13
TATA-box binding protein associated factor 13
TAF4
TATA-box binding protein associated factor 4
total:1
Identification of novel functional TBP-binding sites and general factor repertoires. 2007 to the paper
Irwin Davidson TAF4 antibody was used in ChIP assay to identify novel functional TBP-binding sites and general factor repertoires.
TAF5
TATA-box binding protein associated factor 5
total:1
Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. 2012 to the paper
Sigma-Aldrich anti-TAF5 antibody was used to perform Chip in order to show that in human embryonic stem cells there are non-canonical TAF complexes regulate active promoters.
TAF6
TATA-box binding protein associated factor 6
TAF9
TATA-box binding protein associated factor 9
total:1
Core promoter binding by histone-like TAF complexes. 2005 to the paper
Santa Cruz Biotechnology anti-TAF9 antibody was used in western blot, immunoprecipitation, and EMSA to study histone-like TAF complexes
TAFII105
TATA-box binding protein associated factor 4b
TBP
TATA-box binding protein
total:14
Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. 2012 to the paper
Santa Cruz anti-TBP antibody was used to perform Chip or Web in order to show that in human embryonic stem cells there are non-canonical TAF complexes regulate active promoters. more
ELOB
elongin B
total:4
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. 2008 to the paper
Santa Cruz anti-Elongin B antibody was used in immunoprecipitation in order to demonstrate that SAP130 may link CRL mediated ubiquitination to gene expression. more
TFIIB
general transcription factor IIB
total:8
Papillomavirus E2 proteins and the host BRD4 protein associate with transcriptionally active cellular chromatin. 2009 to the paper
Santa Cruz anti-TFIIB antibody was used to perform ChIP assays in order to study the association between the papillomavirus E2 proteins, the host Brd4 protein and the transcriptionally active cellular genes. more
TPR
translocated promoter region, nuclear basket protein
TSG101
tumor susceptibility 101
total:15
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Abcam monoclonal anti-Tsg101 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
UBC
ubiquitin C
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
ubiquitin
ubiquitin B
total:34
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. 2009 to the paper
Cell Signaling Technology mouse anti-ubiquitin monoclonal antibody was used in western blot in order to demonstrate that BCL6 interacts with HB-EGF-CTF and that this interaction might induce the cyclin D2 expression in human gastric cancer. more
VPS4A
vacuolar protein sorting 4 homolog A
total:1
Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. 2005 to the paper
Bethyl Laboratory Inc. rabbit anti-SKD1 antibody was used in western blot to study the interaction of the mammalian endosomal sorting complex required for rransport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1
XPO1
exportin 1
total:7
Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. 2009 to the paper
Santa Cruz Biotechnology CRM-1 antibody was used for Western blotting in order to investigate the effect of LKB1 on nucleocytoplasmic transport. more