Hemostasis
gene
reagent
sample publication
sample review
14 3 3 protein zeta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
total:6
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest. 2008 to the paper
Santa Cruz 14-3-3zeta antibody was used in western blot at dilution of 1/1000 in order to identify 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins released from degenerating neurons more
abl
ABL proto-oncogene 1, non-receptor tyrosine kinase
total:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Calbiochem c-Abl antibody (1:1,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
ACTN2
actinin alpha 2
total:3
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?. 2008 to the paper
Sigma monoclonal anti-alpha-actinin-2 antibody was used in immunohistochemistry to study the role for the binding of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) with alpha-actinin 1 in skeletal muscle. more
ACTN4
actinin alpha 4
total:3
The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3. 2008 to the paper
Sigma mouse monoclonal anti-alpha-actinin clone BM-75.2 was used to perform western blot and immunoprecipitation in order to study the interaction function between parafibromin and muscle alpha-actinins. more
Akt
AKT serine/threonine kinase 1
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
AKT3
AKT serine/threonine kinase 3
total:4
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. 2008 to the paper
Millipore anti-Akt3 was used to perform western blot in order to show that PTEN-null tumors is promoted to autophagy and more sensitive to lysosomotropic agents after Akt inhibition. more
albumin
total:11
Human microglial cells synthesize albumin in brain. 2008 to the paper
R&D system mouse anti-human-albumin antibody was used in immunohistochemistry and immunocytochemistry in order to study the expression of albumin in human microglial cells and brain tissues. more
alpha 2 macroglobulin
alpha-2-macroglobulin
total:1
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. 2013 to the paper
Invitrogen rabbit IgG was used to perform immunohistochemistry in order to investigate the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models.
alpha-actinin
actinin alpha 1
total:13
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. 2009 to the paper
Santa Cruz anti-ACTN1 antibody was used for western blot in order to investigate the role of CaMKII in the regulation of pressure overload-induced cardiac hypertrophy to heart failure in mice. more
alpha-tubulin
tubulin alpha 4a
total:19
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. 2009 to the paper
GeneTex mouse anti-tubulin antibody was used in western blot to study the role for the binding and interaction of ferroportin with Jak2 in hepcidin-induced internalization of ferroportin. more
angiopoietin 2
total:5
Expression of angiopoietin-2 is correlated with vascularization and tumor size in human colorectal adenocarcinoma. 2007 to the paper
Santa Cruz Biotechnology rabbit-derived polyclonal Ang-1 antibody was used in immunohistochemistry to study angiopoietin-2 expression in human colorectal adenocarcinoma more
antithrombin
serpin family C member 1
total:5
Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1. 2008 to the paper
R&D Systems polyclonal ATIII antibody was used to perform western blot in order to investigate the relations between proteolytic activity of matriptase and secreted serpins. more
APBB1IP
amyloid beta precursor protein binding family B member 1 interacting protein
apoA-I
apolipoprotein A1
total:13
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. 2008 to the paper
Abcam polyclonal rabbit anti-apoA-I antibody (1:10,000) was used for western blot in order to investigate the distinct roles of apolipoprotein components in a transgenic mouse model. more
apolipoprotein B
total:14
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. 2010 to the paper
Abcam anti-ApoB100 antibody was used in western blot to study the formation requirement of efficient hepatitis C virus particle. more
APP
amyloid beta precursor protein
total:81
Identification of beta-secretase (BACE1) substrates using quantitative proteomics. 2009 to the paper
Chemicon anti-APP was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics. more
ARRB1
arrestin beta 1
total:7
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. 2010 to the paper
Santa Cruz Biotechnology beta-arrestin1/2 rabbit polyclonal antibody (21-B1) was used to perform western blot in order to clarify that the arrestin-2/STAM-1 complex modulates CXCR4 lysosomal sorting by ubiquitination of HRS. more
ARRB2
arrestin beta 2
total:3
Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. 2006 to the paper
Affinity BioReagents polyclonal anti-beta arrestin 2 antibody was used in human embryonic kidney (HEK) 293 cells and in western blot to study the role of G protein-coupled receptor kinase site serine cluster in beta-arrestin-dependent beta2AR internalization and desensitization. more
ATP1B3
ATPase Na+/K+ transporting subunit beta 3
total:5
Control of chemokine gradients by the retinal pigment epithelium. 2008 to the paper
Abcam Na, K-ATPase antibody was used in immunocytochemistry in order to examine the physiological responses of human fetal retinal pigment epithelia (hfRPE) after polarized activation of proinflammatory cytokine receptors in vitro more
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
total:4
Increased nitration of sarcoplasmic reticulum Ca2+-ATPase in human heart failure. 2005 to the paper
Affinity Bioreagents mouse monoclonal anti-SERCA2a antibody was used in western blot to study the role of SERCA2a nitration in heart failure in tissue from normal and failing human hearts. more
ATP2A3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
total:2
Regulation of the nitric oxide pathway genes by tetrahydrofurandiols: microarray analysis of MCF-7 human breast cancer cells. 2008 to the paper
Santa Cruz Biotechnologies ATP2A3 antibody was used in western blot in order to study the role of THF-diols in the regulation of the nitric oxide pathway genes more
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
total:5
Plasma membrane Ca2+-ATPase isoforms in frog crista ampullaris: identification of PMCA1 and PMCA2 specific splice variants. 2007 to the paper
Affinity BioReagents mouse monoclonal PMCA1 (1:200 1:600) antibody was used in immunohistochemistry to determine the identity and distribution of PMCA isoforms in frog crista ampullaris. more
ATP2B2
ATPase plasma membrane Ca2+ transporting 2
total:3
Plasma membrane calcium pumps in mouse olfactory sensory neurons. 2006 to the paper
Affinity BioReagents anti-PMCA2 antibody was used in immunocytochemistry in order to elucidate the isoforms of plasma membrane calcium pumps (PMCAs) are not identical in different places. more
ATP2B3
ATPase plasma membrane Ca2+ transporting 3
total:2
Plasma membrane calcium pumps in mouse olfactory sensory neurons. 2006 to the paper
Affinity BioReagents anti-PMCA3 antibody was used in immunocytochemistry in order to elucidate the isoforms of plasma membrane calcium pumps (PMCAs) are not identical in different places. more
ATP2B4
ATPase plasma membrane Ca2+ transporting 4
total:3
Topology of the yeast fatty acid transport protein Fat1p: mechanistic implications for functional domains on the cytosolic surface of the plasma membrane. 2007 to the paper
Dr. Guenther Daum mouse anti-Pma1p antibody was used in western blot to define the role of Fat1p in the transport of exogenous fatty acids. more
beta1 integrin
integrin subunit beta 1
total:85
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD29-FITC antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
Bip
heat shock protein family A (Hsp70) member 5
total:47
RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. 2013 to the paper
Abcam GRP78/BiP rabbit polyclonal (1:25) was used to perform the immunoblotting to study the translation of a subset of mRNAs encoding secretory proteins potentiated by RanBP2/Nup358. more
BRPF3
bromodomain and PHD finger containing 3
C1QBP
complement C1q binding protein
total:2
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 to the paper
CHEMICON International mouse monoclonal anti-gC1qR antibody was used in western blot to study the effect of gC1qR on RIG-I and MDA5-dependent antiviral response at mitochondria. more
CAP1
cyclase associated actin cytoskeleton regulatory protein 1
total:1
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. 2009 to the paper
Abnova mouse anti-CAP1 antibody was used for immunoprecipitation in order to study the effect of DC ehrlichiae on cell signaling, transcriptional regulation, and vesicle trafficking.
CAPZA1
capping actin protein of muscle Z-line subunit alpha 1
CAPZA2
capping actin protein of muscle Z-line subunit alpha 2
CAPZB
capping actin protein of muscle Z-line subunit beta
CAR
CXADR Ig-like cell adhesion molecule
total:7
Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications. 2008 to the paper
Santa Cruz Biochemicals rabbit monoclonal anti-CAR antibody (CAR H300) was used in immunohistochemistry to evaluate the clinical significance of CAR expression in endometrial adenocarcinoma in paraffin sections from human tumor. more
caveolin-1
caveolin 1
total:60
Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature. 2009 to the paper
Epitomics anti-calveolin-1 antibody was used for immunohistochemistry in order to show that a novel translocation involving chromosome 19 causes Xp11.2 translocation renal cell carcinoma. more
CBX5
chromobox 5
total:7
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 to the paper
Santa Cruz anti-HP1 antibody was used to perform western blot in order to study the DNA damage and response by UV. more
CD11b
integrin subunit alpha M
total:46
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Beckman-coulter PE-conjugated anti-CD11b was used to perform flow cytometry in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
CD11c
integrin subunit alpha X
total:25
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. 2012 to the paper
BioLegend anti-CD11c monoclonal antibody was used to perform FACS in order to study novel HIV-1 capture mechanism. more
CD147
basigin (Ok blood group)
total:15
Upregulation of EMMPRIN after permanent focal cerebral ischemia. 2008 to the paper
Serotec rat anti-EMMPRIN monoclonal antibody (1:200) was used in immunohistochemistry in order to examine potential association between EMMPRIN and MMP-9 expre more
CD177
CD177 molecule
total:1
Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1. 2009 to the paper
Anti-HNA antibody from Chemicon was used for immunohistochemistry in order to study the relationship between the activation of TERT and NOTCH1 and tumorigenic potential of human adult neural stem cells from olfactory bulb.
CD18
integrin subunit beta 2
total:23
CBFbeta is critical for AML1-ETO and TEL-AML1 activity. 2009 to the paper
eBioscience allophycocyanin (APC), phycoerythrin (PE), or PerCPcy5.5 conjugated anti Mac-1 (clone M1/70) antibody was used in flow cytometry in order to determine whether CBFbeta is required for AML1-ETO and TEL-AML1 activity more
CD2
CD2 molecule
total:12
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. 2012 to the paper
BD Pharmingen anti-CD2 monoclonal antibody was used to perform FACS in order to study novel HIV-1 capture mechanism. more
CD244
CD244 molecule
total:2
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. 2009 to the paper
eBioscience, CD244 antibody was used for flow cytometry in order to clarify that ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. more
CD36
CD36 molecule
total:16
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. 2010 to the paper
eBioscience anti-CD36 antibody was used to perform immunocytochemistry and flow cytometry in order to show that mesenchymal stem cell can be polarized by downstream TLR signaling into two distinctly acting phenotypes. more
CD41
integrin subunit alpha 2b
total:13
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Biolegend anti-CD41 was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
CD44
CD44 molecule (Indian blood group)
total:49
Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. 2013 to the paper
Millipore rat anti-heparan sulfate proteoglycan monoclonal antibody was used to perform immunohistochemistry in order to investigate the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models. more
CD47
CD47 molecule
total:4
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
BD Biosciences anti-CD47 was used in 2ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
CD48
CD48 molecule
total:1
CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. 2007 to the paper
Santa Cruz Biotechnology CD48 antibody was used in western blot to study the role of flotillin-1 in chemokine receptor signaling and receptor partitioning with lipid rafts.
CD58
CD58 molecule
total:6
Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. 2005 to the paper
Immunotech/Coulter anti-CD58 antibody was used in flow cytometry immunophenotyping to study the function of fibromodulin which serves as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL) to enable the expansion of specific CD8+ autologous T lymphocytes more
CD62L
selectin L
total:14
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 2010 to the paper
BD Biosciences anti-CD62L antibody was used in flow cytometry in order to investigate the roles of Fas ligand and TRAIL in the regulation of murine thymic graft-versus-host disease. more
CD63
CD63 molecule
total:18
Acid sphingomyelinase activity triggers microparticle release from glial cells. 2009 to the paper
Santa Cruz Goat polyclonal anti-CD63/LAMP3 Ab (clone M-13, 1:50) was used in western blot in order to study the activation of acid sphingomyelinase in microparticle release from glial cells. more
CD9
CD9 molecule
total:7
Expression and function of CD9 in melanoma cells. 2010 to the paper
Abcam anti-CD9 antibody was used to perform western blot in order to study the expression and function of CD9. more
cdc42
cell division cycle 42
total:36
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. 2010 to the paper
Santa Cruz Biotechnology anti-Cdc42 antibody was used in western blot to reveal the effect of slit2 on eosinophil and neutrophil during lung inflammation. more
CDK2
cyclin dependent kinase 2
total:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk2 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
Cdk5
cyclin dependent kinase 5
total:8
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 to the paper
Santa Cruz Biotechnology anti-Cdk5 (SC-173), Cdk5-pTyr-15 (SC-12918), and Cdk5-pSer-159 (SC-12919) antibodies were used to perform western blot in order to investigate the molecular mechanisms underlying CRMP2 function in CXCL12-induced T lymphocyte migration. more
CENPE
centromere protein E
total:3
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Abcam monoclonal anti-CENP-E antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
CFD
complement factor D
total:1
De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Adipsin antibody was used to carry out western blot analysis in order to identify the binding sites of PPAR Gramma and RXR in a genome wide manner during adipogenesis.
CFL1
cofilin 1
total:8
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Sigma-Aldrich polyclonal anti-cofilin and anti-phospho-cofilin antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
CLU
clusterin
total:6
Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney. 2009 to the paper
Oncogene antibodies against clusterin were used in western blot to investigate the role of endothelin systems in the regulation of physiologic renal growth and development. more
Crk
CRK proto-oncogene, adaptor protein
total:14
Focal adhesion components are essential for mammalian cell cytokinesis. 2008 to the paper
BD Transduction Laboratories CrkI/II antibody was used to perform western blot in order to study the function of focal adhesion components in mammalian cell cytokinesis. more
CSK
C-terminal Src kinase
total:7
Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase. 2006 to the paper
Santa Cruz anti-Csk antibody was used in immnoprecipitation to study the role of leukocyte-associated Ig-like receptor-1. more
Cu Zn superoxide dismutase
superoxide dismutase 1
total:16
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. 2009 to the paper
Stressgen anti-SOD1 antibody was used in western blot in order to demonstrate that locomotor defect associated with aggregation can be found in an ALS-linked mutant SOD1. more
CypA
peptidylprolyl isomerase A
total:9
Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection. 2010 to the paper
Proteintech anti-CypA monoclonal antibody was used to perform western blot in order to study the role of HBV small surface protein(SHBs) in promoting the pathogenesis of HBV infection. more
DGKQ
diacylglycerol kinase theta
total:1
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. 2005 to the paper
BD Biosciences mouse monoclonal antibody to DGK theta theta was used in western blot to provide evidence in vitro and in vivo for a major role for PKCepsilon and/or PKCeta activation in the regulation of DGKdelta translocation to the plasma membrane.
E-selectin
selectin E
total:5
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. 2008 to the paper
R&D monoclonal anti-E-selectin antibody (BBIG-E4) was used in immunohistochemistry to determine whether the heterogeneous clinical response to tumour necrosis factor (TNF) alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. more
EGF
epidermal growth factor
total:9
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. 2008 to the paper
Santa Cruz Biotechnology rabbit anti-EGF antibody was used in immunohistochemistry to study whether the expression of tyrosine kinase growth factor receptors is constant or varies between and within individual colon cancer neoplasms. more
EHD1
EH domain containing 1
total:1
A role for EHD4 in the regulation of early endosomal transport. 2008 to the paper
AnaSpec rabbit polyclonal anti-EHD1 antibody was used to carry out western blot analysis and immunoprecipitation assays in order to investigate the role for EHD4 in the control of trafficking at the early endosome.
EHD2
EH domain containing 2
total:2
Molecular composition and ultrastructure of the caveolar coat complex. 2013 to the paper
Abcam goat anti-EHD2 antibody was used to perform western blot in order to investigate the structural composition of caveolar coat complex. more
eNOS
nitric oxide synthase 3
total:36
Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. 2009 to the paper
Upstate Laboratories anti-eNOS antibody was used for western blot in order to investigate the role of purinergic in the regulation of endothelial nitric oxide synthase activity in endothelial cells. more
ERK1
mitogen-activated protein kinase 3
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
ERK2
mitogen-activated protein kinase 1
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
F2RL2
coagulation factor II thrombin receptor like 2
total:2
Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. 2005 to the paper
Upstate Biotechnologies Par-3 antibody was used in western blot and immunocytochemistry to study the role of Par-3 in epithelial cell polarization in mammals. more
F8
coagulation factor VIII
total:4
Expression of CD74, the receptor for macrophage migration inhibitory factor, in non-small cell lung cancer. 2009 to the paper
DAKO anti-Factor-VIII antibody (DAKO-EPOS) was used in immunohistochemistry to demonstrate whether the expression of CD74 is associated with the angiogenic activity and level of CXC chemokine expression in human specimens of non-small cell lung cancer. more
factor V
coagulation factor V
total:4
Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation. 2009 to the paper
Affinity Biologicals sheep anti-factor V antibody was used to carry out immunofluorescence assays in order to investigate the association for increased expression of urokinase plasminogen activator and megakaryocyte differentiation in Quebec platelet disorder. more
FAK
protein tyrosine kinase 2
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
FCER1G
Fc fragment of IgE receptor Ig
total:3
High-affinity IgE receptor-beta chain expression in human mast cells. 2008 to the paper
Upstate Biotechnology rabbit anti-FcepsilonRI-gamma polyclonal antibody was used in western blot in order to clarify beta-chain protein expression in human mast cells more
FGB
fibrinogen beta chain
total:1
Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation. 2009 to the paper
Behring rabbit anti-fibrinogen antibody was used to carry out immunofluorescence assays in order to investigate the association for increased expression of urokinase plasminogen activator and megakaryocyte differentiation in Quebec platelet disorder.
fibrinogen
fibrinogen alpha chain
total:4
Biomarkers for ragwort poisoning in horses: identification of protein targets. 2008 to the paper
Affiland rabbit (polyclonal) anti-(equine) fibrinogen antibody was used in western blot in order to investigate whether pyrrole toxins induce specific modifications of equine blood proteins that are detectable by proteomic methods more
fibronectin
fibronectin 1
total:39
Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. 2010 to the paper
Sigma Aldrich anti-fibronectin antibody was used to perform immunocytochemistry and western blot in order to study the mechanism by which Angiotensin-(1-7) inhibited CAF growth and reduced tumour fibrosis in orthotopic breast tumors. more
VEGFD
vascular endothelial growth factor D
total:3
Correlation of vascular endothelial growth factor-D expression and VEGFR-3-positive vessel density with lymph node metastasis in gastric carcinoma. 2008 to the paper
R&D Systems goat polyclonal anti-VEGF-D antibody was used in immunohistochemistry to study the clinical value of VEGF-D expression and VEGFR-3 positive vessel density in gastric carcinoma with regard to lymphangiogenesis in paraffin sections from human tumor. more
FLNA
filamin A
total:9
Identification of a filamin docking site on PTP-PEST. 2006 to the paper
Chemicon International monoclonal antibody against filamin-A was used in immunocytochemistry to detect filamin-A expression in HeLa cells more
Fyn
FYN proto-oncogene, Src family tyrosine kinase
total:19
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-FYN antibody was used for immunoprecipitation in order to study the effect of DC ehrlichiae on cell signaling, transcriptional regulation, and vesicle trafficking. more
Galpha13
G protein subunit alpha 13
total:7
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. 2011 to the paper
Abcam anti-BAFF monoclonal antibody was used to perform western blot in order to study that cleveage of NIK leads to noncanonical NF- kB activation more
GATA-1
GATA binding protein 1
total:15
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 to the paper
Santa Cruz anti-GATA-1 antibody (sc-265) was used in ChIP assay to study the recruitment of DOT1L and the patterning of mono-, di-, and trimethylation of H3K79 under dynamic conditions in human HEK293T cells. more
GATA-4
GATA binding protein 4
total:7
Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). 2008 to the paper
Santa Cruz Biotechnology goat anti-mouse GATA4 antibody was used in immunohistochemistry at 1:200 dilution in order to demonstrate that that cyt b5 is upregulated during gonadectomy-induced adrenocortical neoplasia and is a marker of androgen synthetic potential in these tumors more
GATA3
GATA binding protein 3
total:4
Lhx2 maintains stem cell character in hair follicles. 2006 to the paper
Santa Cruz mouse anti-Gata3 antibody was used in immunohistochemistry to study a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors. more
GATA6
GATA binding protein 6
total:3
Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. 2008 to the paper
Santa Cruz Biotechnology polyclonal rabbit anti-human GATA-6 antibody (sc-9055, dilution 1:50) was used in immunohistochemistry to study GATA-4 and GATA-6 expression in normal and neoplastic human gastrointestinal mucosa. more
GNA12
G protein subunit alpha 12
total:6
G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. 2005 to the paper
Santa Cruz Biotechnology polyclonal anti-Galpha12 antibody (which recognizes N-terminal peptides of Galpha12 proteins) was used in western blot and immunocytochemistry to study the effects of interaction between G 12 and SNAP on VE-cadherin localization at endothelial junctions and barrier function. more
GNAI2
G protein subunit alpha i2
total:5
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 to the paper
Abcam rabbit anti-GNAI2 antibody was used to carry out immunoprecipitation assays in order to investigate the role for the stereochemistry of beta2-adrenoceptor agonist fenoterol in determining receptor-G protein selectivity and downstream signaling. more
GNAI3
G protein subunit alpha i3
total:6
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-GNAI3 antibody was used to carry out immunoprecipitation assays in order to investigate the role for the stereochemistry of beta2-adrenoceptor agonist fenoterol in determining receptor-G protein selectivity and downstream signaling. more
GNAQ
G protein subunit alpha q
total:11
Caveolin-1 alters Ca(2+) signal duration through specific interaction with the G alpha q family of G proteins. 2008 to the paper
Santa Cruz rabbit anti-Galphaq antibody was used in immunocytochemistry to study the effect of the interaction between caveolin-1 and the Galphaq family of G proteins on Ca2+ signal duration. more
GNAS
GNAS complex locus
total:4
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 to the paper
United States Biological rabbit anti-GNAS antibody was used to carry out immunoprecipitation assays in order to investigate the role for the stereochemistry of beta2-adrenoceptor agonist fenoterol in determining receptor-G protein selectivity and downstream signaling. more
GNAT3
G protein subunit alpha transducin 3
total:1
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-Galphagust antibody (I-20, sc-395) was used in immunohistochemistry to study the association of alpha-subunit of gustducin with PYY and GLP-1 in histological sections of the human colon.
GNB5
G protein subunit beta 5
total:1
Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. 2007 to the paper
Dr. W. Simonds (NINDK) rabbit anti-VAChT antibody was used in western blot to study the localization and differential interaction of R7 RGS proteins with R7BP and R9AP in neurons of vertebrate retina.
GP5
glycoprotein V platelet
total:3
Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. 2006 to the paper
Diagnostica Stago antibody against soluble glycoprotein V (sGPV) was used in ELISA to measure sGPV levels in plasma samples and eluates obtained from patients more
Grb2
growth factor receptor bound protein 2
total:36
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. 2009 to the paper
Santa Cruz Biotechnology rabbit polyclonal against Ron antibody was used in western blot in order to demostrate the expression of PAX 5 and the regulation for c-Met transcription in small cell lung cancer. more
GRB7
growth factor receptor bound protein 7
total:4
The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. 2007 to the paper
Santa Cruz Biotechnology anti-Grb7 antibody was used in western blot to identify Grb7 as a new RNA-binding protein that serves as the molecular adaptor for transmitting Netrin-1 signals. more
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
total:1
Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. 2008 to the paper
Santa Cruz Biotechnology Inc anti-Gucy1a3 antibody was used for western blot in order to investigate the roles of elenium and isoflavones in the regulation of androgen-regulated gene expression in healthy rat dorsolateral prostate.
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
total:1
Characterization of a novel type of endogenous activator of soluble guanylyl cyclase. 2005 to the paper
Dr. David L. Garbers anti-1 subunit of sGC antibody was used in western blot and immunohistochemistry to identify a novel type of endogenous activator of soluble guanylyl cyclase.
H-Ras
HRas proto-oncogene, GTPase
total:26
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
Calbiochem/Merck anti-H-Ras antibody was used to perform western blot in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
H3
H3 clustered histone 14
total:32
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 to the paper
Upstate anti-H3K4 antibody was used to perform RNA immunoprecipitation in order to analyze histone methylation at transcription start sites in human-specific prefrontal neurons of brain. more
H3-3B
H3.3 histone B
total:5
Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. 2005 to the paper
Upstate Biotechnology acetyl-H3 antibody was used in ChIP assay to study 12 (S) Lipoxygenase transcription in A431 cells more
HBG1
hemoglobin subunit gamma 1
total:1
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. 2011 to the paper
Invitrogen FITC-conjugated monoclonal anti-HbF was used to perform flow cytometry in order to show that sickle cell disease could be corrected by BCL11A inactivation to keep human fetal hemoglobin expression.
HDAC1
histone deacetylase 1
total:54
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Upstate Biotechnology anti-HDAC1 antibody was used to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
HDAC2
histone deacetylase 2
total:24
High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo. 2009 to the paper
Abcam anti-HDAC2 antibody was used to perform immunohistochemistry in order to study the association between the high class I HDAC activity and RelA/p65 activation in pancreatic cancer. more
hepatocyte growth factor
total:9
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
R&D Systems monoclonal anti-human HGF antibody (MoAb) was used in blocking or activating expriments to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
H3C6
H3 clustered histone 6
total:5
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Abcam anti-Histone 3, anti-H3 K9Me, and anti-H3 S10ph antibodies were used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
IFNA1
interferon alpha 1
total:11
The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.. 2010 to the paper
PBL Laboratories anti-IFNalpha antibody was used in flow cytometry in order to investigate the role of VP35 Protein of Ebola Virus in the regulation of dendritic cell maturation induced by virus and lipopolysaccharide. more
IFNB1
interferon beta 1
total:9
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 to the paper
Biosource ELISA kit for IFN-beta was used to measure IFN-beta level in order to study the effect of gC1qR on RIG-I and MDA5-dependent antiviral response at mitochondria. more
IGF-1
insulin like growth factor 1
total:13
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. 2009 to the paper
Abcam rabbit anti-IGF-1 antibody was used in western blot to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis. more
iNOS
nitric oxide synthase 2
total:38
Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-iNOS antibody was used in western blot to study the role for elevated arginase expression in HCV associated HCC more
integrin alpha v
integrin subunit alpha V
total:24
TGFBI expression is associated with a better response to chemotherapy in NSCLC. 2010 to the paper
Chemicon Interational anti-integrin alphavbeta3 monoclonal was used to perform flow cytometry in order to determine if this integrin influences TGFBI-mediated NSCLC cell susceptibility to chemotherapy. more
integrin alpha2
integrin subunit alpha 2
total:15
Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. 2006 to the paper
Chemicon monoclonal anti-integrin alpha2 antibody (clone P1E6) was used in western blot to study the role of TEM5 in angiogenesis in human umbilical vein endothelial cells. more
integrin alpha3
integrin subunit alpha 3
total:16
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 to the paper
Millipore anti-integrin alpha 3 antibody was used to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas. more
integrin alpha5
integrin subunit alpha 5
total:30
The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis. 2008 to the paper
Chemicon monoclonal anti-alpha5 was used to perform blocking experiments in order to show that integrins could interact with CXCL4 and play a role in angiogenesis. more
integrin beta3
integrin subunit beta 3
total:28
Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. 2010 to the paper
Santa Cruz Biotechnology mouse monoclonal integrin beta3 antibody (1:1000) was used in western blot in order to study the role of activated state of p42/44 and p38 in MMP-13 expression. more
IRAG
murine retrovirus integration site 1 homolog
IRF-1
interferon regulatory factor 1
total:14
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 to the paper
Santa Cruz Biotechnology anti-IRF-1 antibody was used to perform western blot and immunohistochemical in order to study epstein-barr virus (EBV) infection of human B lymphocytes with interferon regulatory factor 4 (IRF-4). more
IRF-2
interferon regulatory factor 2
total:7
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 to the paper
Santa Cruz Biotechnology anti-IRF-2 antibody was used to perform western blot and immunohistochemical in order to study epstein-barr virus (EBV) infection of human B lymphocytes with interferon regulatory factor 4 (IRF-4). more
ITGA1
integrin subunit alpha 1
total:11
Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. 2006 to the paper
Chemicon monoclonal anti-integrin alpha1 antibody (clone FB12) was used in western blot to study the role of TEM5 in angiogenesis in human umbilical vein endothelial cells. more
ITGA4
integrin subunit alpha 4
total:7
Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. 2009 to the paper
eBioscience antibodies against alpha4beta1 were used in immunohistochemistry to investigate MuPAR and plasmin in the regulation of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and HSCs. more
ITGA6
integrin subunit alpha 6
total:20
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD49f-PE antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
total:5
Molecular alterations in the cerebellum of the plasma membrane calcium ATPase 2 (PMCA2)-null mouse indicate abnormalities in Purkinje neurons. 2007 to the paper
Calbiochem IP3R1 antibody was used in western blot and immunohistochemistry to study the role of molecular alterations in the cerebellum of the PMCA2-null in Purkinje neurons. more
ITPR2
inositol 1,4,5-trisphosphate receptor type 2
total:2
Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression. 2005 to the paper
Santa Cruz Biotechnology goat anti-IP3R2 antibody was used in western blot to study the binding of phospholipid scramblase 1 to the promoter region of the inositol 1, 4, 5-triphosphate receptor type 1 more
Jak2
Janus kinase 2
total:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
Upstate anti-JAK2 antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
JAM3
junctional adhesion molecule 3
total:1
Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit. 2010 to the paper
Michel Aurrand-Lions anti-myc monoclonal antibody was used to perform western blot in order to study that during germinal zone exit siah regulation of Pard3A controls neuronal cell adhesion
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
total:3
Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss. 2007 to the paper
Alomone large conductance voltage and bk channel alpha-subunit antibody (1:100) was used in immunohistochemistry to study the physiological function and the contribution of type II transmembrane serine protease to the auditory function. more
KCNMB1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
KCNMB2
potassium calcium-activated channel subfamily M regulatory beta subunit 2
KCNMB3
potassium calcium-activated channel subfamily M regulatory beta subunit 3
KCNMB4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
KDM1A
lysine demethylase 1A
total:4
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 to the paper
Abcam rabbit anti-LSD1 antibody was used to carry out immunoprecipitation assay and ChIP assays in order to investigate the role for long intergenic noncoding RNAs as scaffolds to regulate histone modification complexes and gene expression. more
KIF23
kinesin family member 23
total:6
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 to the paper
Abcam anti-MKLP2 antibody was used in immunocytochemistry in order to investigate the spatial and temporal coordination of subunit-Mps one binding (Mob) 1 and chromosomal passenger complex during mitosis. more
KIF2C
kinesin family member 2C
total:1
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. 2010 to the paper
Abnova mouse monoclonal anti-MCAK antibody was used to carry out immunoblotting assays in order to investigate the mechanism for Haspin-mediated histone H3 thr-3 phosphorylation regulating chromosomal passenger complex accumulation at centromeres.
KIF3A
kinesin family member 3A
total:3
Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules. 2009 to the paper
Sigma anti-KIF3A antibodies were used to perform immunofluorescence assays in order to demonstrate that KSHV tegument protein play a crucial role in cellular transport of viral particles. more
KIF3C
kinesin family member 3C
total:1
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2. 2008 to the paper
BD-Biosciences KIF3C antibody was used in western blot (1:500) to investigate the role of kinesin-2 in pVHL mobility.
KIF5A
kinesin family member 5A
total:1
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. 2005 to the paper
Abcam anti-KIF5A (1007 1027) antibody was used in western blot to characterize GRIF-1 and OIP106 and to study their associaiton with kinesin
KIF5B
kinesin family member 5B
total:5
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 to the paper
Abcam anti-KIF5B antibody ab5629 was used in western blot to study the role for kinesin 5B in cancer cells. more
KIF5B
kinesin family member 5B
total:5
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 to the paper
Abcam anti-KIF5B antibody ab5629 was used in western blot to study the role for kinesin 5B in cancer cells. more
KIF5C
kinesin family member 5C
total:4
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones. 2008 to the paper
Santa Cruz KHC antibody was used in western blot and immunocytochemistry in order to investigate the mechanism required for post-Golgi transport of POMC/ACTH vesicles to the plasma membrane for activity-dependent secretion more
KIFAP3
kinesin associated protein 3
total:3
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2. 2008 to the paper
BD-Biosciences KAP3 antibody was used in western blot (1:500) to investigate the role of kinesin-2 in pVHL mobility. more
KLC1
kinesin light chain 1
total:2
Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. 2009 to the paper
Chemicon anti-KLC antibody was used to perform western blot in order to show that the mutant SOD1 can sequester KAP3 and then reduce the axonal transport of choline acetyltransferase and acetylcholine release. more
KNG1
kininogen 1
total:1
Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated. 2010 to the paper
DAKO anii-CKH antibody was used to carry out immunohistochemistry assays in order to investigate the regulation of Estrogen receptor beta activated apoptosis and the role of its agonist in cancer treatment.
Lamp-2
lysosomal associated membrane protein 2
total:24
Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. 2012 to the paper
Abcam rabbit anti-LAMP2 was used to perform immunocytochemistry in order to show that ciliogenesis was regulated by an evolutionarily assembled cis-regulatory module more
LAT
linker for activation of T cells
total:11
CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. 2007 to the paper
Upstate Biotechnology LAT antibody was used in western blot to study the role of flotillin-1 in chemokine receptor signaling and receptor partitioning with lipid rafts. more
Lck
LCK proto-oncogene, Src family tyrosine kinase
total:18
CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. 2007 to the paper
Upstate Biotechnology Lck antibody was used in western blot to study the role of flotillin-1 in chemokine receptor signaling and receptor partitioning with lipid rafts. more
LFA-1
integrin subunit alpha L
total:14
Altered gene expression in early atherosclerosis is blocked by low level apolipoprotein E. 2008 to the paper
eBioscience CD11a antibody was used in immunohistochemistry in order to study the linkage between changes of adhesion molecules/cofactors and atherosclerosis more
CARMIL1
capping protein regulator and myosin 1 linker 1
Lyn
LYN proto-oncogene, Src family tyrosine kinase
total:20
Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors. 2009 to the paper
Santa Cruz anti-Lyn 44 antibody was used to perform western blot in order to study the roles of the lipid raft-dependent Fc secre tRI ubiquitination in the regulation of receptor endocytosis. more
MAFK
MAF bZIP transcription factor K
total:3
Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. 2007 to the paper
Santa Cruz Biotechnology MafG/K antibody was used in western blot to study the molecular events mediating cellular responses to Cr (VI). more
MERTK
MER proto-oncogene, tyrosine kinase
total:1
GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. 2010 to the paper
R&D System anti-Mer antibody was used to perform flow cytometry in order to study the regulatory function of GAS6/AXL axis in bone marrow niche.
MMP-1
matrix metallopeptidase 1
total:13
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 to the paper
Calbiochem anti-MMP-1 monoclonal antibody was used to perform western blot in order to study the role of CD147 promoted myofibroblast differentiation in tissue remodeling. more
MRP4
ATP binding cassette subfamily C member 4
total:2
Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. 2008 to the paper
Novus Biologicals anti-Abcc4 antibody was used for western blot in order to investigate the roles of elenium and isoflavones in the regulation of androgen-regulated gene expression in healthy rat dorsolateral prostate. more
mSin3A
SIN3 transcription regulator family member A
total:15
Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex. 2010 to the paper
Abcam anti-Sin3a trimethyl was used to perform western blot in order to study the role of deacetylase inhibitors to ING2 subunit from the Sin3 complex. more
MYB
MYB proto-oncogene, transcription factor
total:7
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-c-Myb antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
myelin associated glycoprotein
total:3
Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. 2010 to the paper
Chemicon anti-mouse MAG antibody (1:5000) was used in immunocytochemistry in order to investigate the roles of Nkx2.2 and Nkx6.2 in the regulation of myelin sheath formation. more
NF E2
nuclear factor, erythroid 2
total:5
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. 2010 to the paper
Santa Cruz Biotechnology anti-p45 antibody was used in immunoprecipitation in order to investigate the role of NF-E2 in the regulation of ROS accumulation and megakaryocytic maturation. more
nNOS
nitric oxide synthase 1
total:8
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. 2009 to the paper
Zymed Laboratories anti-nNOS antibody was used for western blot in order to investigate the role of Estradiol in the regulation of nitric oxide formation in primary neuronal cultures. more
NRAS
NRAS proto-oncogene, GTPase
total:4
Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3. 2007 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-Ras antibody was used in western blot to study mechanism mtHSV was targeted for treating tumors but not other organs. more
P-selectin
selectin P
total:8
Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept. 2008 to the paper
Santa Cruz Biotechnology anti-P-selectin antibody was used in immunohistochemistry at 1:500 in order to evaluate an in vivo role of TNF-alphaR1 on the pathogenesis of inflammatory diseases more
p110
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
p130Cas
BCAR1 scaffold protein, Cas family member
total:9
Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. 2010 to the paper
Santa Cruz Biotechnology Inc anti-p130CAS antibody was used for immunoblotting in order to illustrate the mechanism of silencing SCARA5 in HCC tumorigenesis and metastasis. more
P2Y1
purinergic receptor P2Y1
total:2
Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments. 2008 to the paper
Alomone Labs anti-P2Y1 antibody was used in western blot to study the role for extracellular nucleotides in ectopic ossification of human spinal ligaments in human cells. more
p38
mitogen-activated protein kinase 14
total:189
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 to the paper
Biosource International anti-p38 antibody was used to perform western blot in order to study the effect of NFAT5 on hyperosmolar stressed human limbal epithelial cells. more
p53
tumor protein p53
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
p85
phosphoinositide-3-kinase regulatory subunit 1
total:43
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Upstate anti-p85 pAb was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
PAI-1
serpin family E member 1
total:16
Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. 2010 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to investigate the interaction between leptospiral endostatin-like protein A and human plasminogen. more
PAR-1
coagulation factor II thrombin receptor
total:7
Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. 2007 to the paper
Santa Cruz Biotechnology PAR1 antibody was used in immunohistochemistry to determine the expression and functions of PARs in the gallbladder epithelium. more
PDE10A
phosphodiesterase 10A
total:1
Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase. 2006 to the paper
Abcam PDE10A mouse monoclonal antibody was used in western blot andimmunohistochemistry to study Cellular and subcellular localization of PDE10A.
PDE11A
phosphodiesterase 11A
total:1
Expression of PDE11A in normal and malignant human tissues. 2005 to the paper
FabGennix anti-Cyclic nucleotide phosphodiesterase 11A antibody was used in immunohistochemistry and western blot to study the expression of PDE11A in normal and malignant human tissues.
PDE1B
phosphodiesterase 1B
total:2
Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase. 2006 to the paper
Chemicon PDE1B1 antibody was used in western blot to study Cellular and subcellular localization of PDE10A. more
PDE3B
phosphodiesterase 3B
total:1
Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. 2005 to the paper
Santa Cruz Biotech anti-PDE3B antibody was used in western blot to study the suppression of cyclic GMP-specific phosphodiesterase 5 promoting apoptosis and inhibiting growth in HT29 cells.
PDE5A
phosphodiesterase 5A
total:3
Expression of the PDE5 enzyme on human retinal tissue: new aspects of PDE5 inhibitors ocular side effects. 2008 to the paper
Abcam PDE5 antibody was used in western blot and immunohistochemistry to test the effect of PDE5 inhibitors on ophthalmic artery (OA) blood flow velocity. more
PDGFA
platelet derived growth factor subunit A
total:5
Antiangiogenic characteristics of astrocytes from optic nerve heads with primary open-angle glaucoma. 2008 to the paper
Santa Cruz Biotechnology anti-PDGF-A polyclonal antibody was used to perform western blot in order to study the role of astrocytes on angiogenesis. more
PDGFB
platelet derived growth factor subunit B
total:5
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. 2008 to the paper
Santa Cruz Biotechnology rabbit anti-PDGF-B antibody was used in immunohistochemistry to study whether the expression of tyrosine kinase growth factor receptors is constant or varies between and within individual colon cancer neoplasms. more
PECAM 1
platelet and endothelial cell adhesion molecule 1
total:125
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Millipore anti-mouse CD31 antibody was used to perform immunohistochemistry in order to study the inhibition of antifungal drug thiabendazole to tumor growth in a mouse xenograft model. more
PF4
platelet factor 4
total:3
Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. 2009 to the paper
Santa Cruz Biotechnology Mouse anti-platelet factor-4 polyclonal antibody was used to carry out western blot analysis in order to investigate the functionality of platelet TLR2 in the immune and inflammatory response. more
PFN1
profilin 1
total:4
Self-assembly of filopodia-like structures on supported lipid bilayers. 2010 to the paper
Axxora anti-profilin antibody was used to carry out immunofluorescence assays in order to investigate the mechanism for how filopodia-like structures is self-assembled. more
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
total:6
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Santa Cruz polyclonal anti-p110beta antibody was used to perform immunoprecipitation to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
total:11
Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation. 2006 to the paper
Santa Cruz Biotechology anti-p110 gamma antibody was used in western blot in order to investigate the mechanism of the PI3K-IA (phosphatidylinositol 3-kinase Class IA) lipid kinase activity was affected by high NaCl and ionizing radiation. more
PIK3R2
phosphoinositide-3-kinase regulatory subunit 2
total:11
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Millipore polyclonal anti-human p85 antibody was used to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
PIK3R6
phosphoinositide-3-kinase regulatory subunit 6
PKC alpha
protein kinase C alpha
total:50
A male with unilateral microphthalmia reveals a role for TMX3 in eye development. 2010 to the paper
Santa Cruz Biotechnology rabbit anti-PKCAalpha antibody was used in western blot in order to study the function of TMX3 in eye development. more
PKC beta
protein kinase C beta
total:27
Protein kinase C in porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. 2009 to the paper
Santa Cruz Biotechnology mouse monoclonal anti-beta-actin antibody (1:5000) was used for western blot in order to investigate the role of PKC in the regulation of porcine retinal ischemia-reperfusion. more
PKC delta
protein kinase C delta
total:35
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. 2009 to the paper
Santa Cruz Biotechnology anti-PKCdelta antibody was used in western blot to study the mechanism underlying PKCalpha suppressing tumor in the intestine. more
PKC epsilon
protein kinase C epsilon
total:20
GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. 2010 to the paper
Santa Cruz Biotechnology goat anti-PKC epsilon antibody was used to perform western blot and immunocytochemistry in order to show that NSF and PKC epsilon could regulate GABAA receptor trafficking to affect synaptic inhibition. more
PKC zeta
protein kinase C zeta
total:25
Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. 2010 to the paper
Invitrogen anti-PKC-zeta (1:500) antibody was used in western blot in order to investigate the role of PKM-zeta on neuropathic pain hypersensitivity in cortex. more
PLA2G4A
phospholipase A2 group IVA
total:8
Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport.. 2009 to the paper
Santa Cruz Biotechnology anit-cPLA2a antibody was used to perform western blot and immunocytochemistry to study the role of cPLA2a in the formation of intercisternal tubular continuities and transport through the Golgi complex. more
plasminogen
total:4
Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. 2009 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to study human plasminogen binding surface proteins ErpP, ErpA, and ErpC in Borrelia burgdorferi infection. more
PLAT
plasminogen activator, tissue type
total:2
Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. 2008 to the paper
Santa Cruz tPA antibody was used in western blot in order to demonstrate that lithium suppresses Smad3/4-dependent TGF-beta-responsive gene transactivation more
PLC-gamma1
phospholipase C gamma 1
total:32
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Santa Cruz Biotechnology polyclonal anti-PLCG1 antibody was used to carry out western blot analysis and immunoprecipitation assays in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
pleckstrin
total:1
Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling. 2007 to the paper
Sigma-Aldrich anti pleckstrin monoclonal antibody was used in western blot to obtain insights into the abnormal platelet mechanisms and CBFA2-regulated genes.
PP2AC
protein phosphatase 2 catalytic subunit alpha
total:20
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate monoclonal anti-PP2Ac antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
PPBP
pro-platelet basic protein
total:2
Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H. 2010 to the paper
Santa Cruz goat polyclonal anti-PBP was used to perform western blot in order to show that function of factor H is defective in patients with systemic sclerosis and sclerodermatous GVHD. more
PPP2R1A
protein phosphatase 2 scaffold subunit Aalpha
total:7
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. 2008 to the paper
Upstate polyclonal anti-PP2A-A antibody was used in western blot in order to study the abnormal hyperphosphorylation of tau and its possible causes in adult DS brains more
PPP2R1B
protein phosphatase 2 scaffold subunit Abeta
total:2
SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. 2007 to the paper
Sigma-Aldrich polyclonal antibody to the PP2APR65 subunit was used to perform western blot in order to investigate the functions of salt-inducible kinase-1. more
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
total:20
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells. 2009 to the paper
Santa Cruz Biotechnology polyclonal rabbit anti-PKA catalytic subunit antibody was used for western blot in order to show that vasoactive intestinal peptide can promote HCMV MIE gene expression in human NT2 cells. more
PRKACG
protein kinase cAMP-activated catalytic subunit gamma
total:4
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. 2006 to the paper
Santa Cruz Biotechnology anti-the catalytic D subunit of PKA antibody C-20 was used in human fibrosarcoma HT1080 cells and in western blot to study the role for tyrosine phosphorylation in full-scale activation of the eIF2alpha RNA-dependent protein kinase. more
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
total:9
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 to the paper
EMD Biosciences monoclonal antibody specific for RIalpha was used in immunohistochemistry to detect the PKA subunit RIalpha in human adrenal samples more
PRKAR2A
protein kinase cAMP-dependent type II regulatory subunit alpha
total:9
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. 2008 to the paper
Santa Cruz Biotechnology anti-PKA RII antibody was used in immunoprecipitation in order to study the role of PP2A in limiting PKA phosphorylation of phospholamban and TnI for myocyte contraction responses under beta1AR stimulation more
PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
total:3
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 to the paper
EMD Biosciences monoclonal antibody specific for RIIbeta was used in immunohistochemistry to detect the PKA subunit RIIbeta in human adrenal samples more
PRKCG
protein kinase C gamma
total:12
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. 2007 to the paper
Cell Signaling Technology phospho-Pan-PKC antibody (1:1,000) was used in western blot to study melanoma cell motility by the Wnt5A/protein kinase C pathway through the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition more
PRKCH
protein kinase C eta
total:5
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. 2006 to the paper
Cell Signaling Technology anti-phospho-PKC-eta antibody was used in western blot to demonstrate that CCL2 induces brain endothelial hyperpermeability via Rho/PKCalpha signal pathway interactions. more
PRKCQ
protein kinase C theta
total:10
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. 2006 to the paper
Cell Signaling Technology anti-phospho-PKCtheta antibody was used in western blot to demonstrate that CCL2 induces brain endothelial hyperpermeability via Rho/PKCalpha signal pathway interactions. more
PRKG1
protein kinase cGMP-dependent 1
total:7
Hsp90/Hsp70 chaperone machine regulation of the Saccharomyces MAL-activator as determined in vivo using noninducible and constitutive mutant alleles. 2008 to the paper
Molecular Probes anti-PGK antibody was used in western blot in order to study the roles of Hsp90, Hsp70, and Sti1 in the regulation of the Saccharomyces MAL-activator more
Rab5
RAB5A, member RAS oncogene family
total:19
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. 2009 to the paper
BD anti-Rab5 antibody was used in immunocytochemistry in order to investigate the mechanism of the autonomous cholesterol regulation activated by adenovirus membrane protein RID-alpha. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
RAC2
Rac family small GTPase 2
total:3
In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. 2009 to the paper
Proteintech Rac2 antibody was used to perform western blot in order to investigate the role of Rac2 in lymphoma progression more
RACGAP1
Rac GTPase activating protein 1
total:3
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 to the paper
Abcam anti-RacGAP antibody was used in immunocytochemistry in order to investigate the spatial and temporal coordination of subunit-Mps one binding (Mob) 1 and chromosomal passenger complex during mitosis. more
RAD51C
RAD51 paralog C
total:3
Role of RAD51C and XRCC3 in genetic recombination and DNA repair. 2007 to the paper
Dr. Stephen C. West (London Research Institute) monoclonal (2H11) and polyclonal (SWE31 and SWE68) RAD51C antibodies (raised against purified denatured full-length RAD51C protein) and polyclonal RAD51C antibody (SWE72) (raised against a synthetic peptide corresponding to residues 41-80 of RAD51C) were used in western blot (2H110), immunohistochemistry (2H110, SWE72, SWE31, and SWE68), and ChIP assay (SWE72 and SWE68) on mouse testicular cells to study the role of RAD51C and XRCC3 in genetic recombination and DNA repair more
Raf-1
Raf-1 proto-oncogene, serine/threonine kinase
total:46
MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. 2010 to the paper
Santa Cruz Biotechnology anti-RAF1 antibody was used to perform western blot in order to study the role of microRNA-7 in tongue squamous cell carcinoma cells. more
RAPGEF3
Rap guanine nucleotide exchange factor 3
total:3
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. 2007 to the paper
Santa Cruz Biotechnology anti-EPAC antibody was used in western blot to determine whether the PDE4 sequestered by DISC1 is released after cAMP elevation. more
RAPGEF4
Rap guanine nucleotide exchange factor 4
total:4
An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. 2012 to the paper
Santa Cruz anti-Epac2 monoclonal antibody was used to perform coimmunoprecipitations in order to study the role of Epac2 coupleing with Ras signaling in controlling basal dendrite maintenance. more
Ras
KRAS proto-oncogene, GTPase
total:20
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Oncogene Ras antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
RCOR1
REST corepressor 1
total:3
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 to the paper
Upstate rabbit anti-CoREST antibody was used to carry out western blot analysis in order to investigate the role for long intergenic noncoding RNAs as scaffolds to regulate histone modification complexes and gene expression. more
RhoA
ras homolog family member A
total:49
Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo. 2010 to the paper
Santa Cruz anti-RhoA antibody was used to perform immunohistochemistry in order to study the effect of silencing of RhoA and RhoC expression on human colorectal carcinoma growth in vivo. more
RhoB
ras homolog family member B
total:10
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
Santa Cruz Biotechnology anti-RhoB antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
SELPLG
selectin P ligand
total:5
Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function. 2008 to the paper
BD Bioscience anti-PSGL-1 antibody (PL1) was used in blocking or activating expriments to study the effect of the role for Anaplasma phagocytophilum in increasing cathepsin L activity on neutrophil function. more
SERCA2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
total:10
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. 2007 to the paper
Affinity BioReagents mouse anti-SERCA-2a antibody was used in western blot (1:1,000) to study the role of polycystin-2 in regulating ryanodine receptor-dependent calcium signaling. more
SERPINA1
serpin family A member 1
total:5
Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum. 2010 to the paper
Abcam anti-alpha-1 antitrypsin antibody was used to perform western blot in order to study the identification of candidate biomarkers by iTRAQ® analysis in ovarian cancer serum. more
SERPINF2
serpin family F member 2
total:2
Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1. 2008 to the paper
R&D Systems a2AP polyclonal antibody was used to perform western blot in order to investigate the relations between proteolytic activity of matriptase and secreted serpins. more
SERPING1
serpin family G member 1
total:2
Molecular and functional characterization of a ToxR-regulated lipoprotein from a clinical isolate of Aeromonas hydrophila. 2006 to the paper
Cedarlane polyclonal goat anti-human C1-INH antibody was used in western blot to investigate C1-INH cleavage in vitro, and in immunocytochemistry to detect C1-INH on the bacterial surface of A. hydrophila SSU more
SH2B1
SH2B adaptor protein 1
total:1
SLAM-associated protein as a potential negative regulator in Trk signaling. 2005 to the paper
BD Biosciences SH2B antibody was used in western blot and immunoprecipitation to study the role of SLAM-associated protein in Trk signaling
SH2B3
SH2B adaptor protein 3
total:1
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. 2010 to the paper
Abcam anti-human Lnk antibody was used for immunoblotting in order to demonstrate that Lnk leads to stabilization of thrombus development in vivo through regulating integrin alphaIIbbeta3 outside-in signaling in mouse platelets.
Shc
SHC adaptor protein 1
total:20
Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. 2012 to the paper
Cell Signalling anti-ShcA and anti-phospho-ShcA (Tyr239/240) antibodies were used to perform western blot in order to study the effect of the facilitation of AMPA receptor synaptic delivery on cognitive enhancement. more
SHIP
inositol polyphosphate-5-phosphatase D
total:11
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. 2008 to the paper
Santa Cruz mouse anti-SHIP1 was used to perform western blot in order to show that IRAK-1 blockade is important for tolerance of human DCs induced by TLR2 and TLR4 stimulation. more
SHP-1
protein tyrosine phosphatase non-receptor type 6
total:16
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. 2009 to the paper
Santa Cruz Biotechnology anti-SHP-1 polyclonal antibody was used in western blot in order to demonstrate that Lyn can inhibit osteoclast formation. more
SHP-2
protein tyrosine phosphatase non-receptor type 11
total:34
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. 2010 to the paper
Santa Cruz Biotechnology polyclonal anti-Shp2 antibody was used to perform western blot in order to study Notch signaling auto-amplification in macrophages which was regulated by TLR and RBP-J. more
SLC7A6
solute carrier family 7 member 6
SLC8A1
solute carrier family 8 member A1
total:1
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. 2007 to the paper
Affinity BioReagents monoclonal anti-NCX antibody was used in western blot in order to investigate the cellular and molecular basis of heart failure (HF) caused by aberrant Ca2+ handling.
SLC8A3
solute carrier family 8 member A3
total:1
Ontogeny of NHE8 in the rat proximal tubule. 2007 to the paper
Santa Cruz Biotechnology Na+/Ca2+ exchanger (NCX) antibody (1:200) was used in immunocytochemistry to study the developmental expression of NHE8 in rat proximal tubules.
SLP 76
lymphocyte cytosolic protein 2
total:4
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
BD Biosciences anti-SLP-76 (BLNK)(pY128) was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
Sos
SOS Ras/Rac guanine nucleotide exchange factor 1
total:11
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation. 2007 to the paper
Santa Cruz rabbit Sos-1 antibody was used in western blot to study the role of Abi-1 in morphogenesis and synapse formation. more
SPARC
secreted protein acidic and cysteine rich
total:11
Aberrant promoter methylation of SPARC in ovarian cancer. 2009 to the paper
Santa Cruz Biotechnology anti-human SPARC antibody was used for western blot and immunohistochemistry in order to study the role of SPARC in therapeutic process for ovarian cancer. more
Src
SRC proto-oncogene, non-receptor tyrosine kinase
total:120
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Calbiochem anti-SRC antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
STIM1
stromal interaction molecule 1
total:4
The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels. 2010 to the paper
Abnova anti-STIM1 antibody was used to carry out western blot analysis in order to investigate the role for STIM1 in coordinating Voltage- and store-operated calcium channels to generate coherent calcium signals. more
STX4
syntaxin 4
total:5
A role for VAMP8/endobrevin in surface deployment of the water channel aquaporin 2.. 2010 to the paper
Synaptic Systems rabbit anti-syntaxin 4 antibody was used for western blot in order to investigate the role of VAMP8/Endobrevin in the regulation of the surface deployment of the water channel AQP2. more
Syk
spleen associated tyrosine kinase
total:12
Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk.. 2008 to the paper
Santa Cruz Biotech anti-Syk antibody was used to perform western blot in order to study the interaction between NS5A and Syk. more
Talin
talin 1
total:10
Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms. 2007 to the paper
Serotec anti-talin antibody was used to perform immunohistochemistry in order to show that the Hela /-CaD is involved with the migration of endothelial cells/endothelial progenitor cells in human neoplasms. more
TGF-beta1
transforming growth factor beta 1
total:35
Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. 2011 to the paper
R&D Systems anti-TGFbeta antibody was used for intraperitoneal injection in order to study the role of transforming growth factor-beta signaling in aortic disease in Marfan syndrome mice. more
TGFB2
transforming growth factor beta 2
total:4
trans-3,4'-Dimethyl-3-hydroxyflavanone, a hair growth enhancing active component, decreases active transforming growth factor beta2 (TGF-beta2) through control of urokinase-type plasminogen activator (uPA) on the surface of keratinocytes. 2008 to the paper
TECHNE anti-TGF-b2 antibody (which is in a ELISA assay kit) was used in ELISA to study the mechanism of hair growth enhancement by t-flavanone in human cells. more
TGFB3
transforming growth factor beta 3
total:5
Transforming growth factor-beta regulates in vitro heart valve repair by activated valve interstitial cells. 2008 to the paper
Abcam rabbit anti-TGF-beta3 antibody (1:100) was used in immunocytochemistry in order to investigate the regulatory role of transforming growth factor-beta in valve interstitial cell function during wound repair more
thrombomodulin
total:8
IL-32-dependent effects of IL-1beta on endothelial cell functions. 2009 to the paper
R&Dsystems anti-human CD141/TM antibody was used in western blot to study the role for IL-32 in the effect of IL-1 on endothelial cell functions. more
thrombospondin 1
total:20
Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling. 2009 to the paper
Acbam mouse monoclonal antibody against human and mouse thrombospondin-1 was used in immunohistochemistry to investigate the role of transforming growth factor Beta signaling in the regulation of tumor growth. more
tie-2
TEK receptor tyrosine kinase
total:11
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
Santa Cruz Biotechnology anti-Flk-1 antibody was used in western blot in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
TIMP-1
TIMP metallopeptidase inhibitor 1
total:16
Matrix metalloproteinase activity in pediatric acute lung injury. 2009 to the paper
R/D Systems TIMP-1 antibody was used to perform immunoblots in order to study the role of matrix metalloproteinase in pediatric acute lung injury. more
tissue factor
coagulation factor III, tissue factor
total:5
Versican G3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1. 2006 to the paper
BD Biosciences tissue factor antibody (CD142, clone number HTF-1) was used in western blot to detect its expression in culture medium and cell lysate from versican G3- or vector-transfected astrocytoma cell line U87 more
tissue factor pathway inhibitor
total:2
Versican G3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1. 2006 to the paper
American Diagnostica Inc mouse anti-human TFPI monoclonal antibody and rabbit anti-human TFPI polyclonal antibody were in western blot and immunoprecipitation to study its interation with versican G3 domain in astrocytoma cell line U87 more
titin
total:2
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. 2007 to the paper
Siegfried Labeit (Universit tsklinikum Mannheim) anti-titin N2B (1:200) antibody was used in immunohistochemistry to study the role of the titin N2B region in systole and diastole of the heart. more
transferrin
total:17
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. 2009 to the paper
Stressgen anti-transferrin antibody was used for immunohistochemistry in order to demonstrate that in Parkinson's disease, a novel transferrin/TfR2-mediated mitochondrial iron transport system was disrupted more
TRPC3
transient receptor potential cation channel subfamily C member 3
total:6
Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. 2006 to the paper
Santa Cruz Biotechnology TRPC3 goat polyclonal antibody was used in western blot and immunohistochemistry to study the expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. more
TRPC6
transient receptor potential cation channel subfamily C member 6
total:7
Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. 2006 to the paper
Santa Cruz Biotechnology TRPC6 goat polyclonal antibody was used in western blot and immunohistochemistry to study the expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells. more
TRPC7
transient receptor potential cation channel subfamily C member 7
total:1
Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. 2005 to the paper
Santa Cruz anti-TRPC7 antibody was used in western blot to study the role of endogenous TRPC6 channels in Ca2+ signal generation.
VAV3
vav guanine nucleotide exchange factor 3
total:2
Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. 2008 to the paper
Upstate Biotechnology anti Vav3 antibody was used in western blot and immunohistochemistry to study the activation of estrogen receptor by Vav3 oncogene and Vav3 overexpression in human breast cancer more
VEGF
vascular endothelial growth factor A
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
VEGF-C
vascular endothelial growth factor C
total:10
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Epitomics anti-VEGF antibody (1:1000) was used in western blot to study the effects of curcumin on the expression of peroxisome proliferator-activated receptor delta (PPARdelta) and related genes in HT-29 cells. more
VEGFB
vascular endothelial growth factor B
total:1
Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia. 2009 to the paper
R&D Systems anti-VEGFb antibody was used to quantify the mount of VEGFb by ELISA assays in order to investigate the role for VEGF165b as trimester predictive marker for pre-eclampsia.
vinculin
total:54
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
Sigma mouse anti-vinculin antibody was used to perform western blot in order to investigate the role of PVRL4 in tumor progression. more
von Willebrand factor
total:32
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. 2009 to the paper
Serotec sheep anti-VWF was used to test von Willebrand factor (VWF) in order to research Rab27a and MyRIP's regulation to the amount and multimeric state of VWF released from endothelial cells. more
WEE1
WEE1 G2 checkpoint kinase
total:2
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-WEE1 antibody was used to carry out western blot analysis in order to investigate the mechanism of FANCM degradation during mitosis. more
YES1
YES proto-oncogene 1, Src family tyrosine kinase
total:6
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 to the paper
Upstate rabbit anti-Yes1 (06.514) polyclonal antibody was used to perform western blot and immunocytochemistry in order to investigate the molecular mechanisms underlying CRMP2 function in CXCL12-induced T lymphocyte migration. more
ZFPM1
zinc finger protein, FOG family member 1
total:1
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. 2006 to the paper
Santa Cruz Biotechnology anti-GATA-1 N6 antibody was used in EMSA and ChIP to study a gain-of-function regulatory single-nucleotide polymorphism (rSNP) in a nongenic region between the alpha-globin genes and their upstream regulatory elements.
ZFPM2
zinc finger protein, FOG family member 2