Factors involved in megakaryocyte development and platelet production
gene
reagent
sample publication
sample review
total:35
c-Abl tyrosine kinase regulates cardiac growth and development. 2010 to the paper
Calbiochem c-Abl antibody (1:1,000) was used for western blot in order to investigate the role of c-Abl tyrosine kinase in the regulation of cardiac growth and development. more
total:7
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 to the paper
Santa Cruz anti-HP1 antibody was used to perform western blot in order to study the DNA damage and response by UV. more
total:36
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. 2010 to the paper
Santa Cruz Biotechnology anti-Cdc42 antibody was used in western blot to reveal the effect of slit2 on eosinophil and neutrophil during lung inflammation. more
total:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk2 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
total:8
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 to the paper
Santa Cruz Biotechnology anti-Cdk5 (SC-173), Cdk5-pTyr-15 (SC-12918), and Cdk5-pSer-159 (SC-12919) antibodies were used to perform western blot in order to investigate the molecular mechanisms underlying CRMP2 function in CXCL12-induced T lymphocyte migration. more
total:3
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Abcam monoclonal anti-CENP-E antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
total:1
A role for EHD4 in the regulation of early endosomal transport. 2008 to the paper
AnaSpec rabbit polyclonal anti-EHD1 antibody was used to carry out western blot analysis and immunoprecipitation assays in order to investigate the role for EHD4 in the control of trafficking at the early endosome.
total:2
Molecular composition and ultrastructure of the caveolar coat complex. 2013 to the paper
Abcam goat anti-EHD2 antibody was used to perform western blot in order to investigate the structural composition of caveolar coat complex. more
total:15
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. 2008 to the paper
Santa Cruz anti-GATA-1 antibody (sc-265) was used in ChIP assay to study the recruitment of DOT1L and the patterning of mono-, di-, and trimethylation of H3K79 under dynamic conditions in human HEK293T cells. more
total:7
Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). 2008 to the paper
Santa Cruz Biotechnology goat anti-mouse GATA4 antibody was used in immunohistochemistry at 1:200 dilution in order to demonstrate that that cyt b5 is upregulated during gonadectomy-induced adrenocortical neoplasia and is a marker of androgen synthetic potential in these tumors more
total:4
Lhx2 maintains stem cell character in hair follicles. 2006 to the paper
Santa Cruz mouse anti-Gata3 antibody was used in immunohistochemistry to study a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors. more
total:3
Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. 2008 to the paper
Santa Cruz Biotechnology polyclonal rabbit anti-human GATA-6 antibody (sc-9055, dilution 1:50) was used in immunohistochemistry to study GATA-4 and GATA-6 expression in normal and neoplastic human gastrointestinal mucosa. more
total:32
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 to the paper
Upstate anti-H3K4 antibody was used to perform RNA immunoprecipitation in order to analyze histone methylation at transcription start sites in human-specific prefrontal neurons of brain. more
total:5
Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. 2005 to the paper
Upstate Biotechnology acetyl-H3 antibody was used in ChIP assay to study 12 (S) Lipoxygenase transcription in A431 cells more
total:1
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. 2011 to the paper
Invitrogen FITC-conjugated monoclonal anti-HbF was used to perform flow cytometry in order to show that sickle cell disease could be corrected by BCL11A inactivation to keep human fetal hemoglobin expression.
total:54
Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. 2010 to the paper
Upstate Biotechnology anti-HDAC1 antibody was used to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs. more
total:24
High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo. 2009 to the paper
Abcam anti-HDAC2 antibody was used to perform immunohistochemistry in order to study the association between the high class I HDAC activity and RelA/p65 activation in pancreatic cancer. more
total:5
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Abcam anti-Histone 3, anti-H3 K9Me, and anti-H3 S10ph antibodies were used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:11
The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide.. 2010 to the paper
PBL Laboratories anti-IFNalpha antibody was used in flow cytometry in order to investigate the role of VP35 Protein of Ebola Virus in the regulation of dendritic cell maturation induced by virus and lipopolysaccharide. more
total:9
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. 2009 to the paper
Biosource ELISA kit for IFN-beta was used to measure IFN-beta level in order to study the effect of gC1qR on RIG-I and MDA5-dependent antiviral response at mitochondria. more
total:14
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 to the paper
Santa Cruz Biotechnology anti-IRF-1 antibody was used to perform western blot and immunohistochemical in order to study epstein-barr virus (EBV) infection of human B lymphocytes with interferon regulatory factor 4 (IRF-4). more
total:7
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. 2008 to the paper
Santa Cruz Biotechnology anti-IRF-2 antibody was used to perform western blot and immunohistochemical in order to study epstein-barr virus (EBV) infection of human B lymphocytes with interferon regulatory factor 4 (IRF-4). more
total:34
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
Upstate anti-JAK2 antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
total:4
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 to the paper
Abcam rabbit anti-LSD1 antibody was used to carry out immunoprecipitation assay and ChIP assays in order to investigate the role for long intergenic noncoding RNAs as scaffolds to regulate histone modification complexes and gene expression. more
total:6
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 to the paper
Abcam anti-MKLP2 antibody was used in immunocytochemistry in order to investigate the spatial and temporal coordination of subunit-Mps one binding (Mob) 1 and chromosomal passenger complex during mitosis. more
total:1
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. 2010 to the paper
Abnova mouse monoclonal anti-MCAK antibody was used to carry out immunoblotting assays in order to investigate the mechanism for Haspin-mediated histone H3 thr-3 phosphorylation regulating chromosomal passenger complex accumulation at centromeres.
total:3
Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules. 2009 to the paper
Sigma anti-KIF3A antibodies were used to perform immunofluorescence assays in order to demonstrate that KSHV tegument protein play a crucial role in cellular transport of viral particles. more
total:1
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2. 2008 to the paper
BD-Biosciences KIF3C antibody was used in western blot (1:500) to investigate the role of kinesin-2 in pVHL mobility.
total:1
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. 2005 to the paper
Abcam anti-KIF5A (1007 1027) antibody was used in western blot to characterize GRIF-1 and OIP106 and to study their associaiton with kinesin
total:5
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 to the paper
Abcam anti-KIF5B antibody ab5629 was used in western blot to study the role for kinesin 5B in cancer cells. more
total:5
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. 2009 to the paper
Abcam anti-KIF5B antibody ab5629 was used in western blot to study the role for kinesin 5B in cancer cells. more
total:4
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones. 2008 to the paper
Santa Cruz KHC antibody was used in western blot and immunocytochemistry in order to investigate the mechanism required for post-Golgi transport of POMC/ACTH vesicles to the plasma membrane for activity-dependent secretion more
total:3
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2. 2008 to the paper
BD-Biosciences KAP3 antibody was used in western blot (1:500) to investigate the role of kinesin-2 in pVHL mobility. more
total:2
Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3. 2009 to the paper
Chemicon anti-KLC antibody was used to perform western blot in order to show that the mutant SOD1 can sequester KAP3 and then reduce the axonal transport of choline acetyltransferase and acetylcholine release. more
total:3
Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. 2007 to the paper
Santa Cruz Biotechnology MafG/K antibody was used in western blot to study the molecular events mediating cellular responses to Cr (VI). more
total:15
Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex. 2010 to the paper
Abcam anti-Sin3a trimethyl was used to perform western blot in order to study the role of deacetylase inhibitors to ING2 subunit from the Sin3 complex. more
total:7
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. 2010 to the paper
Upstate Biotechnology anti-c-Myb antibody was used for coimmunoprecipitation in order to illustrate the role of c-Myb in MLL-associated leukemogenesis. more
total:5
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. 2010 to the paper
Santa Cruz Biotechnology anti-p45 antibody was used in immunoprecipitation in order to investigate the role of NF-E2 in the regulation of ROS accumulation and megakaryocytic maturation. more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:20
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells. 2009 to the paper
Santa Cruz Biotechnology polyclonal rabbit anti-PKA catalytic subunit antibody was used for western blot in order to show that vasoactive intestinal peptide can promote HCMV MIE gene expression in human NT2 cells. more
total:4
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. 2006 to the paper
Santa Cruz Biotechnology anti-the catalytic D subunit of PKA antibody C-20 was used in human fibrosarcoma HT1080 cells and in western blot to study the role for tyrosine phosphorylation in full-scale activation of the eIF2alpha RNA-dependent protein kinase. more
total:9
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 to the paper
EMD Biosciences monoclonal antibody specific for RIalpha was used in immunohistochemistry to detect the PKA subunit RIalpha in human adrenal samples more
total:9
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. 2008 to the paper
Santa Cruz Biotechnology anti-PKA RII antibody was used in immunoprecipitation in order to study the role of PP2A in limiting PKA phosphorylation of phospholamban and TnI for myocyte contraction responses under beta1AR stimulation more
total:3
17q22-24 chromosomal losses and alterations of protein kinase a subunit expression and activity in adrenocorticotropin-independent macronodular adrenal hyperplasia. 2006 to the paper
EMD Biosciences monoclonal antibody specific for RIIbeta was used in immunohistochemistry to detect the PKA subunit RIIbeta in human adrenal samples more
total:19
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. 2009 to the paper
BD anti-Rab5 antibody was used in immunocytochemistry in order to investigate the mechanism of the autonomous cholesterol regulation activated by adenovirus membrane protein RID-alpha. more
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
total:3
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosis. 2010 to the paper
Abcam anti-RacGAP antibody was used in immunocytochemistry in order to investigate the spatial and temporal coordination of subunit-Mps one binding (Mob) 1 and chromosomal passenger complex during mitosis. more
total:3
Role of RAD51C and XRCC3 in genetic recombination and DNA repair. 2007 to the paper
Dr. Stephen C. West (London Research Institute) monoclonal (2H11) and polyclonal (SWE31 and SWE68) RAD51C antibodies (raised against purified denatured full-length RAD51C protein) and polyclonal RAD51C antibody (SWE72) (raised against a synthetic peptide corresponding to residues 41-80 of RAD51C) were used in western blot (2H110), immunohistochemistry (2H110, SWE72, SWE31, and SWE68), and ChIP assay (SWE72 and SWE68) on mouse testicular cells to study the role of RAD51C and XRCC3 in genetic recombination and DNA repair more
total:3
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 to the paper
Upstate rabbit anti-CoREST antibody was used to carry out western blot analysis in order to investigate the role for long intergenic noncoding RNAs as scaffolds to regulate histone modification complexes and gene expression. more
total:1
SLAM-associated protein as a potential negative regulator in Trk signaling. 2005 to the paper
BD Biosciences SH2B antibody was used in western blot and immunoprecipitation to study the role of SLAM-associated protein in Trk signaling
total:1
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. 2010 to the paper
Abcam anti-human Lnk antibody was used for immunoblotting in order to demonstrate that Lnk leads to stabilization of thrombus development in vivo through regulating integrin alphaIIbbeta3 outside-in signaling in mouse platelets.
total:2
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-WEE1 antibody was used to carry out western blot analysis in order to investigate the mechanism of FANCM degradation during mitosis. more
total:1
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. 2006 to the paper
Santa Cruz Biotechnology anti-GATA-1 N6 antibody was used in EMSA and ChIP to study a gain-of-function regulatory single-nucleotide polymorphism (rSNP) in a nongenic region between the alpha-globin genes and their upstream regulatory elements.