DNA Damage/Telomere Stress Induced Senescence
gene
reagent
sample publication
sample review
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
total:14
CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. 2009 to the paper
Santa Cruz Biotechnology anti-cyclin A antibody was used in western blot in order to study the reguation of the expression of Ect2, MgcRacGAP, and MKLP1 during cell cycle progression more
total:4
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. 2013 to the paper
Epitomics anti-CYCE2 antibody was used to perform western blot assay in order to investigate the interaction of CYCE2 with SCML2 more
total:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk2 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
total:39
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Santa Cruz Biotechnology monoclonal anti-cyclin A antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
total:55
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-cyclin E antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:1
p400 is required for E1A to promote apoptosis. 2005 to the paper
Santa Cruz Biotechnology anti-E1A antibody was used in western blot and immunoprecipitation to study that p400 is required for E1A to promote apoptosis.
total:3
DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. 2009 to the paper
Santa Cruz anti-histone H1 antibody was used for western blot in order to illustrate the new functions of SAP30L and SAP30 in mediating key protein-protein and protein-DNA interactions involved in chromatin remodeling and transcription. more
total:1
Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin. 2007 to the paper
Dr. Peter Cheung (Ontario Cancer Institute) rabbit H2A.Z-specific antibodies (the H2A.Z-L1 antibody was raised against the peptide sequence KSSRTTSHGR, and the H2A.Z-C antibody was raised against the peptide sequence IPHIHKSLIGKKGQQKTV) was used in western blot and immunocytochemistry to study H2A.Z monoubiquitylation as the marker for its association with euchromatin or facultative heterochromatin
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:11
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. 2009 to the paper
Active Motif anti-H4K12Ac antibody 1:1,000 was used for western blot in order to investigate the roles of H3K9Ac and H3K56Ac in the regulation of DNA-damage-responsive in human cells more
total:3
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 to the paper
Abcam anti-histone H1 antibody was used to perform western blot in order to study the DNA damage and response by UV. more
total:1
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. 2009 to the paper
Abcam anti-histone H1.4K26me2 was used to perform western blot in order to show the effects of G9a/KMT1C and jumonji-C type histone demethylases in histone H1 isotype 4 methylation and demethylation.
total:2
The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C. 2012 to the paper
Chemicon mouse anti-pan-histone antibody was used to perform immunostaining in order to study the cell cycle timing of CID assembly in mitosis and meiosis. more
total:1
Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging. 2007 to the paper
Chemicon International TSH2B antibody was used in western blot to assesse the association of TSH2B with chromatin compaction status.
total:1
p53 chromatin epigenetic domain organization and p53 transcription. 2009 to the paper
Abcam anti-histone H2Bantibody was used to perform immunoprecipitation in order to demonstrate that physical barrier due to the folding of chromatin in domain II can give rise to the depletion of RNA polymerase II.
total:6
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. 2009 to the paper
Abcam anti-H2A antibody 1:1,000 was used for western blot in order to investigate the roles of H3K9Ac and H3K56Ac in the regulation of DNA-damage-responsive in human cells more
total:10
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Upstate Biotechnologies anti-H2B antibody was used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:17
Transforming fusions of FGFR and TACC genes in human glioblastoma. 2012 to the paper
Millipore rabbit anti-pHH3 was used at 1:500 to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients. more
total:7
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. 2007 to the paper
Santa Cruz mouse anti-Histone H1 monoclonal antibody(1:100) was used to perform immunofluoresence in order to study the mechanism of genetic disease ataxia telangiectasia (AT) in the nucleus of human Purkinje neurons. more
total:3
HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. 2009 to the paper
Santa Cruz anti-HMGA1 antibody was used to perform western blot in order to study the role of HMGA2 in maintaining the oncogenic RAS-induced epithelial-mesenchymal transition. more
total:1
HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. 2009 to the paper
Santa Cruz anti-HMGA2 antibody was used to perform western blot in order to study the role of HMGA2 in maintaining the oncogenic RAS-induced epithelial-mesenchymal transition.
total:19
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.. 2009 to the paper
Calbiochem rabbit polyclonal Mre11 antibody was used to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2. more
total:28
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Novus NBS1 antibody was used to perform immunofluorescence assay in order to study the requirement of RSFI in DSB repair. more
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
total:118
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-p27CDKN1B antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:13
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. 2008 to the paper
GeneTex anti-Rad50 antibody was used to perform western blot in order to identify that regions of Nbs1 are differentially required for concatemer formation and inhibition of Ad DNA replication. more
total:5
Functional dissection of human and mouse POT1 proteins. 2009 to the paper
Sigma rabbit anti-mouse TRF1 (644) antibody was used in immunofluorescence in order to investigate the function of single-stranded telomeric DNA associated protein-POT1 in human and mice. more
total:16
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. 2009 to the paper
Millipore anti-TRF2 antibody was used to perform immunohistochemistry in order to study the function of HP1 proteins in the alternative lengthening of telomeres-associated PML bodies by p53/p21. more