Class B/2 (Secretin family receptors)
gene
reagent
sample publication
sample review
adrenomedullin
total:5
Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. 2005 to the paper
Accurate Chemical AMBP-1 antibody was used in western blot to study the role of adrenomedullin binding protein-1 in vascular hyporesponsiveness to adrenomedullin after hemorrhage. more
calcitonin
calcitonin related polypeptide alpha
total:6
Role of FNA cytology and immunochemistry in the diagnosis and management of medullary thyroid carcinoma: report of six cases and review of the literature. 2007 to the paper
Dako calcitonin antibody (1:200) was used in immunohistochemistry to study the role of FNA cytology and immunochemistry in the diagnosis and management of medullary thyroid carcinoma. more
calcitonin
calcitonin related polypeptide alpha
total:6
Role of FNA cytology and immunochemistry in the diagnosis and management of medullary thyroid carcinoma: report of six cases and review of the literature. 2007 to the paper
Dako calcitonin antibody (1:200) was used in immunohistochemistry to study the role of FNA cytology and immunochemistry in the diagnosis and management of medullary thyroid carcinoma. more
CD55
CD55 molecule (Cromer blood group)
total:14
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium. 2008 to the paper
Serotec monoclonal anti-CD55 antibody (67) was used in immunohistochemistry to determine whether the heterogeneous clinical response to tumour necrosis factor (TNF) alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. more
ADGRE5
adhesion G protein-coupled receptor E5
total:2
Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. 2010 to the paper
Imgenex rabbit polyclonal CD97 antibody was used in western blot in order to investigate the function of CD97 in intestinal epithelial cells. more
CRH
corticotropin releasing hormone
total:4
Corticotropin-releasing hormone, its binding protein and receptors in human cervical tissue at preterm and term labor in comparison to non-pregnant state. 2006 to the paper
Santa Cruz Biotechnology rabbit polyclonal antibody against CRH was used in immunohistochemistry to detect the localization of CRH in human cervix. more
CRHR1
corticotropin releasing hormone receptor 1
total:6
Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells. 2005 to the paper
Santa Cruz Biotechnology polyclonal goat anti-human/mouse/rat CRH-R1 antibody (V-14 sc-12381) was used in immunocytochemistry to study the expression of CRH-R1 and CRH-R2 n human cord blood-derived cultured mast cells. more
CRHR2
corticotropin releasing hormone receptor 2
total:3
Evidence for the presence of the type 2 corticotropin releasing factor receptor in the rodent cerebellum. 2006 to the paper
Santa Cruz Biotechnology CRF-RII antibody was used in western blot and immunohistochemistry to demonstrate that the CRF family of peptides modulates cerebellar output by binding to multiple CRF receptors. more
ADGRE1
adhesion G protein-coupled receptor E1
total:3
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. 2010 to the paper
Santa Cruz Biotechnology anti-F4/80 antibody was used to carry out immunohistochemistry assays in order to investigate the role for Sfrp5 as anti-inflammatory adipokine in the modulation of metabolic dysfunction in obesity. more
GHRH
growth hormone releasing hormone
total:1
Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines. 2008 to the paper
Santa Cruz Biotechnology anti-GHRH antibody was used to perform western blot in order to study inhibition of the GHRH gene expression affects proliferation of human cancer cell lines.
GHRHR
growth hormone releasing hormone receptor
total:1
Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel. 2006 to the paper
Dr.Andrew V. Schally (Veterans Affairs Medical Center) pGHRH-R antibody (1:2,000) was used in western blot to study the effect of antagonists of growth hormone-releasing hormone (GHRH) MZ-J-7-138 and JV-1-92 on H460 human non-small cell lung carcinoma (NSCLC) xenografted orthotopically into nude mice.
GLP1R
glucagon like peptide 1 receptor
total:2
Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r). 2007 to the paper
Abcam GLP-1R antibody was used in western blot to study protein expression of GLP-1R to reveal tissue-specific strain differences in pancreas (congenic>B6) and stomach (B6>congenic). more
glucagon
total:13
Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. 2009 to the paper
Sigma anti-glucagon antibody was used to perform immunohistochemistry in order to study the role of mitochondrial flavoprotein apoptosis inducing factor. more
GNAS
GNAS complex locus
total:4
Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. 2009 to the paper
United States Biological rabbit anti-GNAS antibody was used to carry out immunoprecipitation assays in order to investigate the role for the stereochemistry of beta2-adrenoceptor agonist fenoterol in determining receptor-G protein selectivity and downstream signaling. more
GNB5
G protein subunit beta 5
total:1
Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. 2007 to the paper
Dr. W. Simonds (NINDK) rabbit anti-VAChT antibody was used in western blot to study the localization and differential interaction of R7 RGS proteins with R7BP and R9AP in neurons of vertebrate retina.
PTCH1
patched 1
total:3
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
Santa Cruz Biotechnology rabbit anti-Ptch-1 was used to perform immunocytochemistry in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
PTH1R
parathyroid hormone 1 receptor
total:3
Effect of parathyroid-hormone-related protein on human platelet activation. 2007 to the paper
Santa Cruz Biotechnology affinity-purified mouse monoclonal anti-PTH1R antibody was used in western blot to determine the content of PTH1R in platelets from patients during AMI and patients in the absence of AMI, and Santa Cruz Biotechnology FITC conjugated anti-PTH1R antibody was used in flow cytometry to detect PTH1R expression on the platelet surface obtained from patients during AMI and patients with similar cardiovascular risk factors without AMI. more
secretin
total:2
Application of light microscopical and ultrastructural immunohistochemistry in the study of goblet cell carcinoid in the appendix. 2008 to the paper
BioGenex Laboratories rabbit anti-human secretin antibody was used in immunohistochemistry in order to develop a combined histochemical and immunohistochemical procedure to reveal the dual nature of goblet cell carcinoide more
secretin receptor
total:1
Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. 2007 to the paper
AbD Serotec rabbit anti-secretin receptor polyclonal antibody (1:1000) was used in western blot and immunohistochemistry to study secretin-receptor and secretin-receptor-variant expression in gastrinomas
SMO
smoothened, frizzled class receptor
total:3
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. 2011 to the paper
Abcam rabbit anti-Smo was used to perform western blot in order to show that blood-brain barrier integrity and CNS immune quiescence were promoted by sonic hedgehog pathway. more
WNT1
Wnt family member 1
total:4
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. 2009 to the paper
Abcam antibodies against WNT1 were used in western blot and immunohistochemistry to investigate the role of WISP1 in the regulation of ATII cell hyperplasia and plasticity. more
WNT10B
Wnt family member 10B
total:1
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. 2010 to the paper
Santa Cruz Biotechnology anti-Nrf2 antibody was used in immunoprecipitation in order to investigate the role of NF-E2 in the regulation of ROS accumulation and megakaryocytic maturation.
WNT3A
Wnt family member 3A
total:1
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. 2008 to the paper
Zymed Laboratories/Invitrogen Wnt3a antibody was used in immunohistochemistry in order to quantify and localize the expression and activity of the Wnt/beta-catenin pathway in IPF
WNT4
Wnt family member 4
total:2
Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. 2008 to the paper
Santa Cruz Biotechnology affinity-purified polyclonal Wnt-4 antibody was used in western blot in order to demonstrate that integration beta-catenin/Lef-1/Tcf-3 signaling with ERalpha is necessary for estrogen-dependent endogenous gene regulation in uterine biology more
WNT5A
Wnt family member 5A
total:4
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. 2010 to the paper
R&D Wnt5A antibody was used to perform western blot in order to investigate the effection of Wnt5A to ROR2 more
WNT7A
Wnt family member 7A
total:1
The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. 2008 to the paper
Santa Cruz Biotechnology wnt7a antibody was used in western blot in order to demonstrate that the transcription factor p53 regulates PC12 neuronal differentiation following NGF treatment
WNT7B
Wnt family member 7B
total:1
The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. 2008 to the paper
Santa Cruz Biotechnology wnt7b antibody was used in western blot in order to demonstrate that the transcription factor p53 regulates PC12 neuronal differentiation following NGF treatment