Cellular responses to stress
gene
reagent
sample publication
sample review
total:5
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Santa Cruz Biotechnology anti-14-3-3epsilon antibody (1:2000) was used in western blot to study the effects of curcumin on the expression of peroxisome proliferator-activated receptor delta (PPARdelta) and related genes in HT-29 cells. more
total:4
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. 2011 to the paper
Cell Signaling Technology anti-phospho-PRAS40 was used to perform western blot in order to show that how growth factor signaling is inhibited by mTOR through mTOR-regulated phosphoproteome. more
total:1
Meningiomas exhibit loss of heterozygosity of the APC gene. 2008 to the paper
Calbiochem monoclonal mouse anti-human APC-1 antibody (1:50) was used to perform immunohistochemistry in order to study the adenomatous polyposis coli (APC) gene's loss of heterozygosity in meningiomas.
total:1
Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. 2005 to the paper
Santa Cruz Biotechnology anti-human APC7 antibody was used in western blot and immunohistochemistry to study the clinical significance and the involvement of APC in tumorigenesis.
total:6
CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. 2008 to the paper
Alexis anti-ARNT antibody was used to perform western blot in order to study the roles of the CUL2 in the activity of hypoxia-inducible factor and vasculogenesis. more
total:11
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. 2006 to the paper
Santa Cruz Biotechnology ASK1 antibody was used in western blot and immunohistochemistry to demonstrate direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. more
total:50
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore anti-phospho-ATM-S1981 antibody was used to perform immunofluorescence assay in order to detect the requirment of RSF1 for the recruitment of CENPS/MHF1, CENPX/MHF2, FANCD2, and FANCI to IRIF. more
total:5
Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells. 2008 to the paper
Santa Cruz Biotechnology goat anti-ATP7A antibody was used in immunocytochemistry in order to assess the relevance of sub cellular localization of the copper efflux transporters ATP7A and ATP7B for acquired cisplatin resistance in vitro. more
total:24
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Santa Cruz human ATR antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:7
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
Upstate Biotechnology anti-Bmi-1 antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
total:41
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. 2010 to the paper
Santa Cruz Biotechnology rabbit anti-c-Fos antibody was used to carry out immunohistochemistry assays in order to investigate the effect of lossing BDNF receptor in different neurons on control of cocaine reward. more
total:100
Plasma membrane contributes to the formation of pre-autophagosomal structures. 2010 to the paper
Abcam anti-AP1-A1 antibody was used to perform western blot in order to study the role of plasma membrane in the formation of preautophagosomal structures. more
total:26
IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. 2009 to the paper
Santa Cruz Biotechnology C/EBPbeta antibody was used in ChIP assay to study the regulation of aromatase transcription and estrogen biosynthesis in adipose stromal cells (ASCs). more
total:4
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. 2007 to the paper
Santa Cruz anti-CAIX antibody was used to perform western blot in order to study the dependency on oxidative phosphorylation during transformation of human mesenchymal stem cells. more
total:13
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. 2009 to the paper
Affinity Bioreagents anti-phospho-CaMKII antibody was used for western blot in order to investigate the role of CaMKII in the regulation of pressure overload-induced cardiac hypertrophy to heart failure in mice. more
total:10
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. 2010 to the paper
Santa Cruz anti-phos-CaMKII antibody was used to perform western blot in order to study the role of cGMP-dependent protein kinase and RGS2 in local antihypertrophic effects of cardiac atrial natriuretic peptide. more
total:8
Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma. 2009 to the paper
Calbiochem rabbit polyclonal anti-catalase was used to perform western blot in order to show that ROS production and PDK2 upregulation induced by mitochondrial ND2 mutation lead to HIF1alpha accumulation in head and neck squamous cell carcinoma. more
total:38
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. 2009 to the paper
Santa Cruz Biotechnology anti-CBP antbody was used in western blot in order to demonstrate that an HDAC inhibitor induces apoptosis through the FoxO1 acetylation-Bim pathway more
total:2
The polycomb repressive complex 2 is a potential target of SUMO modifications. 2008 to the paper
Upstate mouse anti-Cbx4 was used to perform western blot in order to show that the polycomb repressive complex 2 could be sumoylated post-translationally. more
total:14
CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes Ect2, MgcRacGAP, and MKLP1 in S phase. 2009 to the paper
Santa Cruz Biotechnology anti-cyclin A antibody was used in western blot in order to study the reguation of the expression of Ect2, MgcRacGAP, and MKLP1 during cell cycle progression more
total:4
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. 2013 to the paper
Epitomics anti-CYCE2 antibody was used to perform western blot assay in order to investigate the interaction of CYCE2 with SCML2 more
total:8
Host factors required for modulation of phagosome biogenesis and proliferation of Francisella tularensis within the cytosol. 2010 to the paper
Abcam anti-CDC27 antibody was used to perform western blot in order to study the modulation of intracellular F. tularensis phagosome biogenesis and proliferation. more
total:53
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase. 2010 to the paper
Santa Cruz anti-human Cdk2 antibody was used to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase. more
total:44
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. 2010 to the paper
Millipore anti-CDK4 antibody was used to perform western blot in order to study the roles of the fragile X mental retardation protein during the regulations of the proliferation and differentiation of adult neural stem/progenitor cells. more
total:20
Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA. 2010 to the paper
Abcam anti-Cdk6 antibody was used to carry out western blot analysis in order to investigate the role for Herpesvirus saimiri Noncoding RNA HSURs in the regulation of host cell microRNAs. more
total:1
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 to the paper
Santa Cruz anti-p15 was used to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma.
total:1
Cyclin K and cyclin D1b are oncogenic in myeloma cells. 2010 to the paper
Santa Cruz anti-p18 was used to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma.
total:16
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. 2009 to the paper
Stressgen anti-SOD1 antibody was used in western blot in order to demonstrate that locomotor defect associated with aggregation can be found in an ALS-linked mutant SOD1. more
total:10
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. 2009 to the paper
Rockland Immunochemicals Inc.anti-Cul2 antibody was used to perform immunoprecipitation in order to identify new components of the CRL family of E3 ligases and elaborate new connections between the CRL and CSN complexes. more
total:39
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 2010 to the paper
Santa Cruz Biotechnology monoclonal anti-cyclin A antibody was used to perform immunoblotting in order to study the critical effect of Pcid2 on B cell survival through the regulation of MAD2 expression. more
total:55
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Santa Cruz anti-cyclin E antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
total:48
Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. 2010 to the paper
BD PharMingen anti-cytochrome c antibody was used to perform western blot in order to study the interaction between F1L and endogenous Bak. more
total:37
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. 2010 to the paper
Santa Cruz E2F1 antibody was used to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence. more
total:3
The polycomb repressive complex 2 is a potential target of SUMO modifications. 2008 to the paper
Upstate mouse anti-EED AA19 was used to perform western blot in order to show that the polycomb repressive complex 2 could be sumoylated post-translationally. more
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD2 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD1 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
total:1
Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. 2007 to the paper
Novus Biologicals rabbit polyclonal PHD3 antibody was used in immunohistochemistry to demonstrate the expressions of three isoforms of PHD and their distributions in different kidney regions.
total:3
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. 2010 to the paper
Upstate G9a antibody (#07-551) was used to perform ChIP assays in order to clarify that a KRAB domain-containing ZNF is involved in recruitment of the KAP1 and SETDB1 to specific regions of the human genome. more
total:1
p400 is required for E1A to promote apoptosis. 2005 to the paper
Santa Cruz Biotechnology anti-E1A antibody was used in western blot and immunoprecipitation to study that p400 is required for E1A to promote apoptosis.
total:9
Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha. 2010 to the paper
Novus Biologicals HIF2alpha antibody was used for ChIP assays in order to study HIF-binding and Ets-binding motifs on the PTPRZ1 promoter and show that PTPRZ1 can be activated by HIF-2. more
total:252
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Millipore anti-ERK1/2 polyclonal antibody (1:10,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediated anti-apoptotic effects. more
total:490
IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. 2010 to the paper
Santa Cruz Biotechnology anti-ERK1/2 antibody and anti-p-ERK1/2 antibody were used to perform western blot, immunohistochemistry and flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10. more
total:2
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. 2005 to the paper
Biosource anti-phosphoERK5 antibody was used in western blot to study tissue-specific transcriptional regulation by ERK5 more
total:7
Covering a broad dynamic range: information processing at the erythropoietin receptor. 2010 to the paper
R&D Systems anti-Epo antibody was used to carry out immunoprecipitation assay and western blot analysis in order to determine the receptor property of erythropoietin receptor during receptor signaling activation. more
total:13
Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activation. 2009 to the paper
Santa Cruz anti-Ets-1 antibody was used in western blot in order to identify factors for reactivating latent HIV-1 without inducing global T cell activation more
total:11
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. 2009 to the paper
Abcam anti-EZH2 was used to perform western blot in order to show the effects of G9a/KMT1C and jumonji-C type histone demethylases in histone H1 isotype 4 methylation and demethylation. more
total:11
Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import. 2007 to the paper
Assay Designs anti-FKBP52 antibody was used in western blot in order to investigate the functions of Hsp40-related J-domain proteins DJA1, DJA2, and DJA4 during mitochondrial import. more
total:2
Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis. 2008 to the paper
Calbiochem Cdh1 antibody was used in western blot in order to study the role of Cdh1/APC in tumorigenesis more
total:3
The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. 2009 to the paper
Affinity BioReagents ATP synthase antibody was used for western blot in order to investigate the role of mitochondria in endothelial cell dysfunction. more
total:1
Differential profiling of breast cancer plasma proteome by isotope-coded affinity tagging method reveals biotinidase as a breast cancer biomarker. 2010 to the paper
Abcam anti-GPX3 antibody was used to perform western blot in order to reveal that biotinidase was a breast cancer biomarker by isotope-coded affinity tagging method.
total:79
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. 2012 to the paper
Santa Cruz Biotechnology anti-GSK3 beta antibody was used to perform western blot in order to investigate the role of GSK3-TIP60-ULK1 signaling pathway in autophagy. more
total:9
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. 2009 to the paper
Sigma mouse GG-7 Fc-specific anti-human IgG antibody was used to confirm the presence of the Fc fragment of human IgG in order to illustrate that Toll-like receptor 4 (TLR4) plays a fundamental role in the sensing of LPS from Gram-negative bacteria. more
total:3
Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. 2009 to the paper
Santa Cruz goat anti-GW182 antibody (1:100) was used to perform immunofluorescence in order to prove that the association of AKAP350A and CCAR1 with RNA stress granules is microtubule dependent. more
total:3
DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. 2009 to the paper
Santa Cruz anti-histone H1 antibody was used for western blot in order to illustrate the new functions of SAP30L and SAP30 in mediating key protein-protein and protein-DNA interactions involved in chromatin remodeling and transcription. more
total:1
Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin. 2007 to the paper
Dr. Peter Cheung (Ontario Cancer Institute) rabbit H2A.Z-specific antibodies (the H2A.Z-L1 antibody was raised against the peptide sequence KSSRTTSHGR, and the H2A.Z-C antibody was raised against the peptide sequence IPHIHKSLIGKKGQQKTV) was used in western blot and immunocytochemistry to study H2A.Z monoubiquitylation as the marker for its association with euchromatin or facultative heterochromatin
total:62
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Millipore Gamma-H2AX antibody was used to perform western blot assay in order to study the requirement of RSFI in DSB repair. more
total:32
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. 2012 to the paper
Upstate anti-H3K4 antibody was used to perform RNA immunoprecipitation in order to analyze histone methylation at transcription start sites in human-specific prefrontal neurons of brain. more
total:5
Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. 2005 to the paper
Upstate Biotechnology acetyl-H3 antibody was used in ChIP assay to study 12 (S) Lipoxygenase transcription in A431 cells more
total:11
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. 2009 to the paper
Active Motif anti-H4K12Ac antibody 1:1,000 was used for western blot in order to investigate the roles of H3K9Ac and H3K56Ac in the regulation of DNA-damage-responsive in human cells more
total:9
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. 2010 to the paper
Santa Cruz rabbit anti-HDAC6 antibody (WB, 1:2000; IF, 1:500) was used to perform western blot and immunofluorescence in order to study knockdown of TDP-43 mediated HDAC6 downregulation. more
total:63
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. 2010 to the paper
BD Transduction Laboratories anti-HIF-1a antibody was used to carry out western blot analysis in order to investigate the role for CHBP protein from Burkholderia pseudomallei as a potent inhibitor of the eukaryotic ubiquitination pathway. more
total:3
Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. 2011 to the paper
Abcam anti-histone H1 antibody was used to perform western blot in order to study the DNA damage and response by UV. more
total:1
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. 2009 to the paper
Abcam anti-histone H1.4K26me2 was used to perform western blot in order to show the effects of G9a/KMT1C and jumonji-C type histone demethylases in histone H1 isotype 4 methylation and demethylation.
total:2
The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C. 2012 to the paper
Chemicon mouse anti-pan-histone antibody was used to perform immunostaining in order to study the cell cycle timing of CID assembly in mitosis and meiosis. more
total:1
Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging. 2007 to the paper
Chemicon International TSH2B antibody was used in western blot to assesse the association of TSH2B with chromatin compaction status.
total:1
p53 chromatin epigenetic domain organization and p53 transcription. 2009 to the paper
Abcam anti-histone H2Bantibody was used to perform immunoprecipitation in order to demonstrate that physical barrier due to the folding of chromatin in domain II can give rise to the depletion of RNA polymerase II.
total:5
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Abcam anti-Histone 3, anti-H3 K9Me, and anti-H3 S10ph antibodies were used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:6
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. 2009 to the paper
Abcam anti-H2A antibody 1:1,000 was used for western blot in order to investigate the roles of H3K9Ac and H3K56Ac in the regulation of DNA-damage-responsive in human cells more
total:10
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. 2010 to the paper
Upstate Biotechnologies anti-H2B antibody was used to carry out western blot analysis in order to investigate the mechanism for AMP-activated protein kinase regulating cellular responses to metabolic stress. more
total:17
Transforming fusions of FGFR and TACC genes in human glioblastoma. 2012 to the paper
Millipore rabbit anti-pHH3 was used at 1:500 to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients. more
total:7
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. 2007 to the paper
Santa Cruz mouse anti-Histone H1 monoclonal antibody(1:100) was used to perform immunofluoresence in order to study the mechanism of genetic disease ataxia telangiectasia (AT) in the nucleus of human Purkinje neurons. more
total:3
HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. 2009 to the paper
Santa Cruz anti-HMGA1 antibody was used to perform western blot in order to study the role of HMGA2 in maintaining the oncogenic RAS-induced epithelial-mesenchymal transition. more
total:1
HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. 2009 to the paper
Santa Cruz anti-HMGA2 antibody was used to perform western blot in order to study the role of HMGA2 in maintaining the oncogenic RAS-induced epithelial-mesenchymal transition.
total:25
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. 2010 to the paper
Stressgen monoclonal anti-Hsc70 antibody was used to carry out western blot analysis in order to determine the atomic structure of human adenovirus. more
total:6
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. 2006 to the paper
Stressgen monoclonal anti-HSF1 antibody was used in human HeLa cells and in western blot, EMSA to study the role for the effects of MK2 on the regulation of HSF1 in inhibiting transcriptional activity and promotes HSP90 binding. more
total:10
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. 2009 to the paper
Biosciences Hsp40 rabbit polyclonal antibody was used for western blot in order to investigate the role of SRPK1 in the regulation of SR protein phosphorylation. more
total:68
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. 2012 to the paper
Santa Cruz Biotechnology anti-HSP90 was used to perform western blot in order to show that cell abscission mediated by Aurora B was regulated by ESCRT-III. more
total:8
Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. 2010 to the paper
Millipore anti-H3S28P antibody was used in western blot in order to investigate the mechanism of how the embryonic stem cells chromatin structure change was regulated by condensin complexes during mitotic progression. more
total:1
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. 2010 to the paper
Santa Cruz Biotechnology Inc anti-GRP78 antibody was used for western blot in order to investigate the role of C/EBPB in the regulation of ER stress and pancreatic beta cell failure.
total:8
BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1. 2005 to the paper
Santa Cruz polyclonal anti-Id1 was used to perform western blot in order to show that in mature human B cells BMP-6 could regulate Smad phosphorylation, Id1 expression, and cell growth. more
total:2
Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. 2009 to the paper
Santa Cruz Biotechnology mouse monoclonal anti-IGFBP7 antibody was used to carry out immunofluorescence assays in order to investigate the role for AEG1 in regulating Hepatocellular carcinoma pathogenesis. more
total:43
IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. 2012 to the paper
R&D Systems anti-IL-6 mAb was used to perform cell stimulation in order to study the secretion of proinflammatory cytokine and generation of Th17 cell induced by IL-26. more
total:46
Spatial coupling of mTOR and autophagy augments secretory phenotypes. 2011 to the paper
R&D systems anti-IL8 antibody was used to perform immunocytochemistry in order to study the role of spatial coupling of cells' catabolic and anabolic machinery in facilitating the synthesis of secretory proteins. more
total:5
Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. 2006 to the paper
R & D Systems monoclonal anti-human IL-1alpha antibody was used in human SSc fibroblasts and in immunocytochemistry, immunoprecipitation to study the effect of intracellular IL-1alpha-binding proteins on biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts. more
total:193
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-JNK1 monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
total:22
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. 2008 to the paper
Cell Signaling Technologies anti-phospho-SAPK antibody was used to perform western blot in order to show that neovessel development can be regulated by fibronectin fibrillogenesis. more
total:9
Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. 2010 to the paper
Assay Designs anti-manganese superoxide dismutase antibody was used to perform western blot in order to study the interaction between F1L and endogenous Bak. more
total:2
NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. 2005 to the paper
SCBT NIK antibody wase used in western blot to characterize a NIK and IKKbeta binding protein more
total:4
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. 2008 to the paper
Abgent rabbit anti-JNK3 antibody was used to perform western blot in order to study the effect of TNF-alpha on gamma-secretase. more
total:10
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. 2010 to the paper
Cell Signaling Technologies phospho-specific and total anti-p38antibody was used to perform western blot in order to study the function of phosphodiesterase 6 subunits in idiopathic pulmonary fibrosis. more
total:38
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 2010 to the paper
Calbiochem anti-Hdm2 antibody was used for western blot in order to investigate the role of TGFB1 in the regulation of Mdm2 expression and late-stage breast cancer metastasis. more
total:1
TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens. 2010 to the paper
ProteinTech Trx 2 antibody (1:1000) was used to perform western blot and immunocytochemistry in order to clarify a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract.
total:18
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
Cell Signaling Technology anti-MAPKAPK 2 (pT334) was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
total:15
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. 2008 to the paper
Cell Signaling Technology polyclonal rabbit MKK3 with phosphorylated serine 189 antibody was used in western blot in order to demonstrate that ATM undergoes an activating phosphorylation in syncytia elicited by the envelope glycoprotein complex (Env) of human immunodeficiency virus-1 (HIV-1) in vitro more
total:9
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. 2008 to the paper
Cell Signaling Technology polyclonal rabbit MKK6 with phosphorylated serine 207 antibody was used in western blot in order to demonstrate that ATM undergoes an activating phosphorylation in syncytia elicited by the envelope glycoprotein complex (Env) of human immunodeficiency virus-1 (HIV-1) in vitro more
total:2
Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity. 2010 to the paper
Proteintech Group anti-Mov10 antibody was used to perform western blotting in order to study if overexpression of Mov10 in cells would inhibit HIV-1 infectivity. more
total:19
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.. 2009 to the paper
Calbiochem rabbit polyclonal Mre11 antibody was used to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2. more
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
total:28
The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins. 2014 to the paper
Novus NBS1 antibody was used to perform immunofluorescence assay in order to study the requirement of RSFI in DSB repair. more
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:49
Constitutive activation of Raf-1 induces glioma formation in mice. 2008 to the paper
Santa Cruz Biotechnology anti-p19 antibody was used to perform western blot in order to study the role of Raf-1 in glioma formation. more
total:178
Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1. 2012 to the paper
Abcam mouse anti-p21 antibody was used to perform western blot in order to study the mechanism through which doxorubicin suppressed tumor growth. more
total:118
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. 2012 to the paper
BD Pharmingen anti-p27CDKN1B antibody was used to perform western blot in order to show that p53-dependent cell proliferation and survival could be regulated by atg7. more
total:52
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. 2011 to the paper
Santa Cruz anti-p300 was used to perform western blot and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis. more
total:189
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 to the paper
Biosource International anti-p38 antibody was used to perform western blot in order to study the effect of NFAT5 on hyperosmolar stressed human limbal epithelial cells. more
total:81
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. 2010 to the paper
Santa Cruz Biotechnology anti-p50 antibody was used to perform ChIP assay in order to show that viral replication was inhibited by the elevated IL-32 levels during influenza virus infections. more
total:250
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. 2014 to the paper
Abcam anti-p53 antibody was used to perform western blotting in order to study JMJD6 promotes colon carcinogenesis through negative regulation of p53. more
total:146
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. 2012 to the paper
Santa Cruz anti-p65 antibody was used to perform immunofluorescence in order to study the role of DNA-dependent protein kinase in the IRF-3-dependent innate immunity. more
total:20
{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. 2009 to the paper
Santa Cruz anti-RSK-1 antibody (1:1,000) was used to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediates anti-apoptotic effects. more
total:4
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. 2009 to the paper
Abcam anti-Prdx1 antibody was used for western blot in order to investigate the role of Prdx1 in the regulation of tumorigenesis. more
total:2
Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. 2007 to the paper
Abcam Prx II antibody was used in western blot to map the differences in protein expression in BaP (1 microM) and quercetin (5 microM) treated 22Rv1 human prostate cancer cells. more
total:1
Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress. 2008 to the paper
Lab Frontier Prdx3 antibody was used in western blot in order to characterize the complex changes in Prdxs induced by oxidant stress in rat myocardium
total:1
Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress. 2008 to the paper
Lab Frontier Prdx5 antibody was used in western blot in order to characterize the complex changes in Prdxs induced by oxidant stress in rat myocardium
total:1
Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress. 2008 to the paper
Lab Frontier Prdx6 antibody was used in western blot in order to characterize the complex changes in Prdxs induced by oxidant stress in rat myocardium
total:6
Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe. 2010 to the paper
Abcam anti-PDIA1 antibody was used to perform western blot in order to study the role of non-directed activity-based protein profiling plays in the identification of enzymes that are either predominantly or exclusively labeled in living cells. more
total:5
High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. 2010 to the paper
Thermo Fisher anti-p23 antibody was used for performing immunoblotting and immunohistochemistry in order to study the effect of high levels of Hsp90 cochaperone p23 on tumor progression and prognosis in breast cancer. more
total:13
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. 2008 to the paper
GeneTex anti-Rad50 antibody was used to perform western blot in order to identify that regions of Nbs1 are differentially required for concatemer formation and inhibition of Ad DNA replication. more
total:8
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. 2011 to the paper
Cell Signaling anti-raptor was used to perform western blot in order to show that vacuolar H+-ATPase is involved in mTOR pathway for mTORC1 translocation and activation. more
total:6
CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. 2006 to the paper
Abcam RbAp46 antibody was used in immunoprecipitation to study the molecular mechanism (s) by which CTIP2 contributes to T cell development and axonal. more
total:8
The polycomb repressive complex 2 is a potential target of SUMO modifications. 2008 to the paper
Upstate rabbit anti-RbAp48 13D10 was used to perform western blot in order to show that the polycomb repressive complex 2 could be sumoylated post-translationally. more
total:5
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. 2008 to the paper
Lab Vision rabbit-anti-RBX1 antibody was used in western blot in order to identify the poxviral motif as a functional F-box more
total:3
Histone ubiquitination associates with BRCA1-dependent DNA damage response. 2009 to the paper
MBL anti-RING1B antibody was used in immunoprecipitation in order to confirm that histone ubiquitination cause DNA damage. more
total:12
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. 2010 to the paper
GeneTex anti-RPA32 monoclonal antibody was used to perform immunofluorescence in order to study the interactions of ATR and ATRIP in gene expression and production of virus during HSV-1 infection. more
total:5
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 2009 to the paper
Santa Cruz Biotechnology anti-ubiquitin antibody was used in western blot in order to identify a novel complex of erasin-ubiquilin-p97/VCP and its function in ERAD. more
total:9
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor. 2009 to the paper
Cell Signaling anti-phosphorylated p90RSK antibody was used to perform western blot in order to study the important role of GRK4 in D3 receptor's signaling in human proximal tubule cells. more
total:9
Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection. 2009 to the paper
Santa Cruz anti-RSK2 antibody was used to perform western blot in order to study the role of RSK2 in the cellular antiviral response. more
total:13
SIRT6 promotes DNA repair under stress by activating PARP1. 2011 to the paper
Abcam anti-SIRT1 was used to perform western blot in order to show that DNA repair could be promoted by SIRT6 through PARP1 activation under oxidative stress. more
total:70
Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. 2010 to the paper
Santa Cruz anti-Sp1 antibody was used to perform ChIP assay in order to study the regulatory function of Sp1 and KLF15 on basal transcription of the human LRP5 gene. more
total:9
Long noncoding RNA as modular scaffold of histone modification complexes. 2010 to the paper
Abcam rabbit anti-SUZ12 antibody was used to carry out ChIP assays in order to investigate the role for long intergenic noncoding RNAs as scaffolds to regulate histone modification complexes and gene expression. more
total:4
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. 2008 to the paper
Santa Cruz anti-Elongin B antibody was used in immunoprecipitation in order to demonstrate that SAP130 may link CRL mediated ubiquitination to gene expression. more
total:1
Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner. 2005 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-DP-1 antibody was used in western blot to identify and Characterize the novel isoforms of human DP-1.
total:15
TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens. 2010 to the paper
Abcam Trx 1 antibody (1:1000) was used to perform western blot and immunocytochemistry in order to clarify a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract. more
total:1
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
BD Biosciences anti-TNIK monoclonal antibody was used to perform immunoprecipitation and immunoblotting in order to find out TNIK play what's role and how it play the role for canonical NF-kB and JNK Signaling in B-Cells.
total:5
Functional dissection of human and mouse POT1 proteins. 2009 to the paper
Sigma rabbit anti-mouse TRF1 (644) antibody was used in immunofluorescence in order to investigate the function of single-stranded telomeric DNA associated protein-POT1 in human and mice. more
total:16
Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. 2009 to the paper
Millipore anti-TRF2 antibody was used to perform immunohistochemistry in order to study the function of HP1 proteins in the alternative lengthening of telomeres-associated PML bodies by p53/p21. more
total:2
Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. 2009 to the paper
Santa Cruz Biotechnology anti-TrxR1 antibody was used in western blot in order to show that adiponectin haploinsufficiency can promote mammary tumorigenesis through inhibition of PTEN activity and activation of PI3K/Akt signalling pathway. more
total:7
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. 2014 to the paper
Enzo Life Sciences anti-Ubiquitin antibody was used to perform western blot in order to study synaptic plasticity. more
total:3
Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. 2009 to the paper
Boston Biochem anti-UbcH10 antibody was used to perform immunohistochemistry in order to study the regulation of ubiquitin-conjugating enzyme H7 in S phase of the cell cycle. more
total:1
Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. 2007 to the paper
Boston Biochem anti-UbcH5 antibody was used to perform immunoprecipitation in order to study the roles of the DET1 during the regulation of the Cul4A activity.
total:1
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. 2010 to the paper
Abcam anti-UbcH5c antibody was used to perform western blot in order to study the mechanism of A20 action in the inhibition of NF-kappaB signaling.
total:34
BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. 2009 to the paper
Cell Signaling Technology mouse anti-ubiquitin monoclonal antibody was used in western blot in order to demonstrate that BCL6 interacts with HB-EGF-CTF and that this interaction might induce the cyclin D2 expression in human gastric cancer. more
total:14
The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97. 2008 to the paper
Progen Biotechnik GmbH anti-VCP/p97 monoclonal antibody was used to perform Western Blot in order to study the possible role of VCP/p97 in myelomonocytic differentiation and retrodifferentiation. more
total:81
DLC1 negatively regulates angiogenesis in a paracrine fashion. 2010 to the paper
Santa Cruz biotechnology anti-VEGF antibody was used for performing immunohistochemistry in order to explore the effect of DLC1 on angiogenesis. more
total:14
The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. 2013 to the paper
GeneTex anti-VHL antibody was used to perform western blot and immunoprecipitation in order to investigate the regulatory effect of HILDA complex on VEGF-A expression. more