Cell-Cell communication
gene
reagent
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sample review
ACTN2
actinin alpha 2
total:3
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) binds to alpha-actinin 1: novel pathways in skeletal muscle?. 2008 to the paper
Sigma monoclonal anti-alpha-actinin-2 antibody was used in immunohistochemistry to study the role for the binding of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) with alpha-actinin 1 in skeletal muscle. more
ACTN3
actinin alpha 3 (gene/pseudogene)
total:4
Functional cardiomyocytes derived from human induced pluripotent stem cells. 2009 to the paper
Sigma monoclonal anti actinin was used to perform immunolabeling in order to study functional cardiomyocytes derived from human induced pluripotent stem cells. more
ACTN4
actinin alpha 4
total:3
The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3. 2008 to the paper
Sigma mouse monoclonal anti-alpha-actinin clone BM-75.2 was used to perform western blot and immunoprecipitation in order to study the interaction function between parafibromin and muscle alpha-actinins. more
AF6
afadin, adherens junction formation factor
total:6
AF6 negatively regulates Rap1-induced cell adhesion. 2005 to the paper
Transduction Laboratories monoclonal anti-AF6 antibody was used in western blot to detect AF6 in Jurkat cells stably expressing Epac (HB6 cells) cotransfected with empty vector or HA-AF6. more
alpha-actinin
actinin alpha 1
total:13
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. 2009 to the paper
Santa Cruz anti-ACTN1 antibody was used for western blot in order to investigate the role of CaMKII in the regulation of pressure overload-induced cardiac hypertrophy to heart failure in mice. more
alpha-catenin
catenin alpha 1
total:24
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. 2010 to the paper
BD Biosciences anti-a-catenin antibody was used to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression. more
beta-catenin
catenin beta 1
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
beta1 integrin
integrin subunit beta 1
total:85
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD29-FITC antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
CASK
calcium/calmodulin dependent serine protein kinase
total:6
SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. 2008 to the paper
Santa Cruz rabbit polyclonal anti-CASK was used to perform western blot in order to show that dendritic spinogenesis is regulated by SUMOylation of the MAGUK protein CASK. more
CD2AP
CD2 associated protein
total:2
Clues to CD2-associated protein involvement in cytokinesis. 2005 to the paper
Santa Cruz Biotechnology polyclonal antibodies against CD2AP (H-290) were used in western blot and immunoprecipitation to present several clues for the involvement of CD2AP in cytokinesis. more
CD47
CD47 molecule
total:4
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. 2011 to the paper
BD Biosciences anti-CD47 was used in 2ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry. more
CDH15
cadherin 15
total:1
Long-term survival of transplanted stem cells in immunocompetent mice with muscular dystrophy. 2008 to the paper
Santa Cruz Biotechnology rabbit polyclonal anti-M-cadherin antibody was used in flow cytometry at 1:50 in order to study the role of duchenne muscular dystrophy in the long-term survival of transplanted stem Cells
CDH6
cadherin 6
total:1
Cadherin-6 function in zebrafish retinal development. 2008 to the paper
Covance Research Products anti-cadherin-6 antibody was used in western blot at 1:500 and immunohistochemistry at 1:300 in order to study the role of Cadherin-6 in the formation of the retina
claudin-1
claudin 1
total:13
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. 2008 to the paper
Novus anti-CLDN1 antibody 1C5-D9 was used in immunocytochemistry to study the role for protein kinase signaling in HCV infection more
CLDN11
claudin 11
total:2
MMP-28 as a regulator of myelination. 2008 to the paper
Santa Cruz anti-Claudin-11 antibody was used in immunocytochemistry to study the role for MMP-28 in myelination. more
CLDN19
claudin 19
total:1
Renal localization and function of the tight junction protein, claudin-19. 2007 to the paper
Zymed polyclonal claudin-19 antiserum was used in western blot (1:1,000) and immunohistochemistry (1:100) to study the distribution and possible functional role of claudin-19 in the renal tubule.
CLDN3
claudin 3
total:7
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. 2010 to the paper
Labvision rabbit anti-Claudin-3 (clone WN1 222-5) polyclonal antibody was used to perform immunohistochemistry in order to shown that in the absence of SIV infection, PTM have damage to their gastrointestinal tract and increased basal levels of microbial translocation and immune activation. more
CLDN4
claudin 4
total:6
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. 2005 to the paper
Zymed Laboratories mouse anti-claudin-4 monoclonal antibody was used in western blot and immunoprecipitation to study that phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction carrier function in ovarian cancer cells. more
CLDN5
claudin 5
total:3
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. 2006 to the paper
Zymed Laboratories mouse anti-claudin-5 antibody was used in western blot and immunohistochemistry to demonstrate that CCL2 induces brain endothelial hyperpermeability via Rho/PKCalpha signal pathway interactions. more
CLDN7
claudin 7
total:5
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 to the paper
Invitrogen anti-claudin-1 antibody was used to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas. more
CRB3
crumbs cell polarity complex component 3
DAP12
transmembrane immune signaling adaptor TYROBP
DCC
DCC netrin 1 receptor
total:2
Netrin-1 inhibits leukocyte migration in vitro and in vivo. 2005 to the paper
Santa Cruz Biotechnology goat anti-mouse DCC antibody was used in immunocytochemistry to study the effect of netrin-1 on leukocyte migration more
E-cadherin
cadherin 1
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
FAK
protein tyrosine kinase 2
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
FLNA
filamin A
total:9
Identification of a filamin docking site on PTP-PEST. 2006 to the paper
Chemicon International monoclonal antibody against filamin-A was used in immunocytochemistry to detect filamin-A expression in HeLa cells more
Fyn
FYN proto-oncogene, Src family tyrosine kinase
total:19
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-FYN antibody was used for immunoprecipitation in order to study the effect of DC ehrlichiae on cell signaling, transcriptional regulation, and vesicle trafficking. more
gamma-catenin
junction plakoglobin
total:17
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells. 2010 to the paper
BD Biosciences anti-plakoglobin antibody was used to carry out western blot and immunostaining assays in order to investigate the role of the T-box transcription factor Brachyury in tumor cells epithelial-mesenchymal transition and and tumor progression. more
Grb2
growth factor receptor bound protein 2
total:36
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. 2009 to the paper
Santa Cruz Biotechnology rabbit polyclonal against Ron antibody was used in western blot in order to demostrate the expression of PAX 5 and the regulation for c-Met transcription in small cell lung cancer. more
PATJ
PATJ crumbs cell polarity complex component
integrin linked kinase
total:19
The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. 2010 to the paper
Spring Bioscience anti SMA antibody (1:100) was used to perform immunohistochemistry in order to study the function of pAkt on posterior capsule. more
IQGAP1
IQ motif containing GTPase activating protein 1
total:6
The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. 2006 to the paper
Santa Cruz Biotechnology polyclonal anti-IQGAP1 antibody was used in human A549 cells and in immunocytochemistry to study the interaction between the receptor protein-tyrosine phosphatase PTP and IQGAP1. more
ITGA6
integrin subunit alpha 6
total:20
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. 2010 to the paper
Biolegend anti-CD49f-PE antibody was used to perform flow cytometry in order to study the properties induced by cell signaling by urokinase-type plasminogen activator receptor (uPAR) in breast cancer cells. more
ITGB4
integrin subunit beta 4
total:12
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
BD Biosciences mouse anti-ITGB4 antibody was used to perform western blot in order to investigate the role of PVRL4 in tumor progression. more
JNK
mitogen-activated protein kinase 8
total:193
The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor. 2012 to the paper
Santa Cruz Biotechnology anti-JNK1 monoclonal antibody was used to perform western blot in order to study TNIK plays what role and how it play this role for canonical NF-kB and JNK signaling in B-cells. more
KIRREL3
kirre like nephrin family adhesion molecule 3
LAMA3
laminin subunit alpha 3
total:3
Nephrotic syndrome and aberrant expression of laminin isoforms in glomerular basement membranes for an infant with Herlitz junctional epidermolysis bullosa. 2005 to the paper
Chemicon monoclonal anti-laminin alpha3 chain antibody P3H9 was used in immunohistochemistry to study the association of laminin isoforms with herlitz junctional epidermolysis bullosa in a case complicated by nephrotic syndrome. more
LAMC2
laminin subunit gamma 2
total:6
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 to the paper
Millipore anti-laminin gamma 2 chain antibody was used to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas. more
LIMS2
LIM zinc finger domain containing 2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
MAPK11
mitogen-activated protein kinase 11
total:10
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. 2010 to the paper
Cell Signaling Technologies phospho-specific and total anti-p38antibody was used to perform western blot in order to study the function of phosphodiesterase 6 subunits in idiopathic pulmonary fibrosis. more
MAPK13
mitogen-activated protein kinase 13
total:2
Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. 2005 to the paper
Cell Signaling Technology polyclonal anti-p38 delta antibody was used in human umbilical vein endothelial cells (HUVECs) and in western blot to study the effect of enhanced p38 MAPK activity on endothelial cell function. more
MPP5
membrane palmitoylated protein 5
total:1
Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. 2005 to the paper
Upstate Biotechnologies Pals1 antibody was used in western blot to study the role of Par-3 in epithelial cell polarization in mammals.
N-cadherin
cadherin 2
total:26
Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. 2010 to the paper
Abcam rabbit anti-N-cadherin antibody was used to carry out western blot analysis in order to investigate the role of forward trafficking of connexin 43 in gap junction coupling and ischemia-related cardiac arrhythmias therapy. more
nectin 4
nectin cell adhesion molecule 4
total:2
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
R&D Systems mouse anti-human PVRL4 IgG2B was used to perform cell culture in order to investigate the role of PVRL4 in tumor progression. more
nephrin
NPHS1 adhesion molecule, nephrin
total:3
The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes. 2007 to the paper
Progen Biotechnik polyclonal guinea pig anti-nephrin antibody was used in western blot in order to demonstrate cultured human podocytes express the CCR2 receptor and the MCP-1/CCR2 system can induce a migratory response in this cell type. more
p110
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
p120ctn
catenin delta 1
total:23
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Santa Cruz Biotechnology polyclonal anti-p120-catenin antibody was used to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
p38
mitogen-activated protein kinase 14
total:189
NFAT5 induction and its role in hyperosmolar stressed human limbal epithelial cells. 2008 to the paper
Biosource International anti-p38 antibody was used to perform western blot in order to study the effect of NFAT5 on hyperosmolar stressed human limbal epithelial cells. more
p85
phosphoinositide-3-kinase regulatory subunit 1
total:43
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Upstate anti-p85 pAb was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
PAK1
p21 (RAC1) activated kinase 1
total:29
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Epitomics rabbit monoclonal anti-Pak1 antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
PARD6G
par-6 family cell polarity regulator gamma
PARVA
parvin alpha
total:1
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. 2008 to the paper
Sigma-Aldrich rabbit anti-PARVA antibody was used for western blot in order to investigate the role of ILK in the regulation of mitotic spindle organization.
paxillin
total:51
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. 2008 to the paper
Upstate mouse monoclonal anti-paxillin was used to perform immunocytochemistry in order to show that Rho/ROCK/MLC pathway could be inhibited by DCL1 in hepatocellular carcinoma. more
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
total:6
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Santa Cruz polyclonal anti-p110beta antibody was used to perform immunoprecipitation to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
PIK3R2
phosphoinositide-3-kinase regulatory subunit 2
total:11
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Millipore polyclonal anti-human p85 antibody was used to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
PINCH
LIM zinc finger domain containing 1
total:1
Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. 2010 to the paper
BD Transduction Laboratories anti-PINCH antibody was used for western blot in order to investigate the role of ILK in the regulation of human intestinal cells migration and proliferation.
PLEC
plectin
total:5
Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. 2009 to the paper
Epitomics rabbit monoclonal anti-plectin antibody was used to carry out western blot analysis and immunofluorescence assays in order to investigate the function for beta3 integrin-mediated vimentin IF recruitment to the cell surface. more
NECTIN1
nectin cell adhesion molecule 1
total:3
A role for PVRL4-driven cell-cell interactions in tumorigenesis. 2013 to the paper
R&D Systems goat anti-human PVRL1 antibody was used to perform cell culture and western blot in order to investigate the role of PVRL4 in tumor progression. more
NECTIN3
nectin cell adhesion molecule 3
total:1
A double mutation in glycoprotein gB compensates for ineffective gD-dependent initiation of herpes simplex virus type 1 infection. 2010 to the paper
R&D anti-nectin-3 monoclonal antibody was used to pretreat CHO-K1 cells in vitro to investigate the compensation by mutated-gB for initiation of HSV-1 Infection.
PYK2
protein tyrosine kinase 2 beta
total:27
Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. 2009 to the paper
BD Biosciences monoclonal mouse anti-phospho-focal adhesion kinase (FAK) antibody was used in immunocytochemistry to study the role of supervillin (SV) in the function of tumor cell actin-rich protrusions. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
SHP-1
protein tyrosine phosphatase non-receptor type 6
total:16
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. 2009 to the paper
Santa Cruz Biotechnology anti-SHP-1 polyclonal antibody was used in western blot in order to demonstrate that Lyn can inhibit osteoclast formation. more
SHP-2
protein tyrosine phosphatase non-receptor type 11
total:34
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. 2010 to the paper
Santa Cruz Biotechnology polyclonal anti-Shp2 antibody was used to perform western blot in order to study Notch signaling auto-amplification in macrophages which was regulated by TLR and RBP-J. more
Src
SRC proto-oncogene, non-receptor tyrosine kinase
total:120
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Calbiochem anti-SRC antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
T cadherin
cadherin 13
total:5
Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A. 2008 to the paper
Calbiochem anti-pan-cadherin antibody was used in western blot in order to identify NS5A-associated target molecules more
TESK1
testis associated actin remodelling kinase 1
TSLL1
cell adhesion molecule 3
total:1
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. 2005 to the paper
Immunex antibody anti-hNecl1 (M170) was used in flow cytometry to identify a subset of T-cell zone dendritic cells by nectin-like protein 2
VASP
vasodilator stimulated phosphoprotein
total:10
Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function. 2009 to the paper
Chemicon International rabbit polyclonal anti-VASP antibody was used to carry out western blot analysis and immunofluorescence assays in order to investigate the roles of ADMA and DDAH in the regulation of pulmonary endothelial barrier function. more
VE cadherin
cadherin 5
total:19
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. 2009 to the paper
eBioscience anti-CD144 antibody was used in immunohistochemistry in order to demonstrate that vasculogenesis in human MM may develop from tumoral production of pleiotrophin, which induces the transdifferentiation of monocytes into VECs. more
WASL
WASP like actin nucleation promoting factor
total:2
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. 2005 to the paper
Santa Cruz Biotechnology goat polyclonal Cdc42 antibody was used in western blot and immunoprecipitation to study the role of the adapter protein CrkII in the regulation of N-WASp and Cdc42 activation. more