CD28 co-stimulation
gene
reagent
sample publication
sample review
Akt
AKT serine/threonine kinase 1
total:423
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-phospho-Ser473Akt polyclonal antibody was used to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival. more
AKT3
AKT serine/threonine kinase 3
total:4
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. 2008 to the paper
Millipore anti-Akt3 was used to perform western blot in order to show that PTEN-null tumors is promoted to autophagy and more sensitive to lysosomotropic agents after Akt inhibition. more
CD28
CD28 molecule
total:25
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. 2012 to the paper
eBioscience anti-human CD28 was used to perform blocking or activating experiments in order to show that cancer cell depended on glycine for rapid proliferation. more
CD80
CD80 molecule
total:24
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
Beckman anti-CD80 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
CD86
CD86 molecule
total:23
CD4CD8?? lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. 2014 to the paper
Beckman anti-CD86 antibody was used to perform flow cytometry in order to study how gut microbiota regulate immunesystem. more
cdc42
cell division cycle 42
total:36
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. 2010 to the paper
Santa Cruz Biotechnology anti-Cdc42 antibody was used in western blot to reveal the effect of slit2 on eosinophil and neutrophil during lung inflammation. more
Fyn
FYN proto-oncogene, Src family tyrosine kinase
total:19
An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. 2009 to the paper
Santa Cruz Biotechnology rabbit anti-FYN antibody was used for immunoprecipitation in order to study the effect of DC ehrlichiae on cell signaling, transcriptional regulation, and vesicle trafficking. more
GRAP2
GRB2 related adaptor protein 2
total:3
T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76. 2005 to the paper
Upstate Cell Signaling Solutions anti-Gads polyclonal antibody was used in western blot to demonstrate T-cell receptor-induced activation of phospholipase C-gamma1 by a sequence-independent function of the P-I region of SLP-76. more
Grb2
growth factor receptor bound protein 2
total:36
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. 2009 to the paper
Santa Cruz Biotechnology rabbit polyclonal against Ron antibody was used in western blot in order to demostrate the expression of PAX 5 and the regulation for c-Met transcription in small cell lung cancer. more
Lck
LCK proto-oncogene, Src family tyrosine kinase
total:18
CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. 2007 to the paper
Upstate Biotechnology Lck antibody was used in western blot to study the role of flotillin-1 in chemokine receptor signaling and receptor partitioning with lipid rafts. more
Lyn
LYN proto-oncogene, Src family tyrosine kinase
total:20
Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors. 2009 to the paper
Santa Cruz anti-Lyn 44 antibody was used to perform western blot in order to study the roles of the lipid raft-dependent Fc secre tRI ubiquitination in the regulation of receptor endocytosis. more
MAP3K8
mitogen-activated protein kinase kinase kinase 8
total:4
Proteomics analysis of immunoprecipitated proteins associated with the oncogenic kinase cot. 2008 to the paper
Santa Cruz anti-Cot antibody (N17) and anti-Cot antibody (H212) were used in immunoprecipitation and anti-Cot antibody (M20) was used in western blot to study the potential binding partners to Cot and their region of association by separating proteins that were pulled-down with various Cot constructs following immunoprecipiation in human HEK293 cells and Hela cells. more
mTOR
mechanistic target of rapamycin kinase
total:33
A gene signature-based approach identifies mTOR as a regulator of p73. 2008 to the paper
Santa Cruz polyclonal anti-mTOR (N-19 (alpha-FRAP) was used to perform western blot in order to show that mTOR is identified as a regulator of p73 by a gene signature-based approach. more
p110
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
total:26
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Cell Signalling anti-p110alpha was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
p85
phosphoinositide-3-kinase regulatory subunit 1
total:43
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. 2013 to the paper
Upstate anti-p85 pAb was used to perform immunoprecipitation to the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival more
PAK1
p21 (RAC1) activated kinase 1
total:29
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. 2009 to the paper
Epitomics rabbit monoclonal anti-Pak1 antibody was used in western blot to identify Pak4 as a novel Gab1-interacting protein downstream from the Met receptor and to study its function. more
Pak2
p21 (RAC1) activated kinase 2
total:6
Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death. 2009 to the paper
Santa Cruz Biotechnology anti-PAK-2 antibody was used for western blot in order to investigate the role of PAK-2 in the regulation of anticancer drug-induced cell apoptosis. more
PIK3R2
phosphoinositide-3-kinase regulatory subunit 2
total:11
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. 2009 to the paper
Millipore polyclonal anti-human p85 antibody was used to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation. more
Rac1
Rac family small GTPase 1
total:55
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. 2009 to the paper
Millipore anti-Rac1 monoclonal antibody (1:1,000) was used to perform immunoblot in order to study the metastasis suppressed by Rho GDP dissociation inhibitor 2 (RhoGDI2) through Rho GTPases. more
RICTOR
RPTOR independent companion of MTOR complex 2
total:3
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. 2010 to the paper
Cell Signaling Technology anti-rictor antibody was used to carry out western blot analysis in order to investigate the precise contribution of 4E-BPs to mTORC1 signaling. more
Src
SRC proto-oncogene, non-receptor tyrosine kinase
total:120
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. 2012 to the paper
Calbiochem anti-SRC antibody was used to perform western blot in order to study the estrogen sensitivity and the acquisition of antiestrogen resistance in luminal breast cancer. more
YES1
YES proto-oncogene 1, Src family tyrosine kinase
total:6
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. 2009 to the paper
Upstate rabbit anti-Yes1 (06.514) polyclonal antibody was used to perform western blot and immunocytochemistry in order to investigate the molecular mechanisms underlying CRMP2 function in CXCL12-induced T lymphocyte migration. more