Apoptotic cleavage of cellular proteins
gene
reagent
sample publication
sample review
total:11
A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. 2009 to the paper
Calbiochem anti-APC was used to perform immunocytochemistry in order to show that MRP protein plays an important role in adherens junction formation and tumorigenesis more
total:154
Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. 2012 to the paper
Millipore anti-beta-catenin was used to perform ChIP assay in order to show that telomerase was regulated by Wnt/beta-catenin signaling. more
total:15
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. 2011 to the paper
Alexis anti-cIAP1 was used to perform western blot in order to show that autoubiquitination could be promoted by conformational change of cIAP1 induced by antagonists. more
total:212
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. 2012 to the paper
Abcam Caspase-3 antibody was used to perform immunohistochemistry in order to study theeffect of thiabendazole on proliferation and apoptosis of human cells. more
total:12
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. 2010 to the paper
Abcam monoclonal anti-caspase-6 antibody was used for western blot in order to investigate the role of DJ-1 mutations in the regulation of Parkinson disease pathology. more
total:23
Analysis of changes in the proteome of HL-60 promyeloid leukemia cells induced by the proteasome inhibitor PSI. 2008 to the paper
Santa Cruz Caspase-7 antibody was used in western blot in order to analyze changes in a subproteome of ~800 proteins in the promyelocytic leukemia cell line HL-60 upon treatment with the proteasome inhibitor PSI more
total:73
Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis. 2009 to the paper
R&D systems anti-casp8 antibody was used to carry out western blot analysis in order to investigate the mechanism of DR5 relocalization and its effect on cell apoptosis during adhesion to detachment of EC9706 cells. more
total:6
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. 2009 to the paper
Bethyl Laboratories rabbit anti-Claspin antibody was used to carry out western blot analysis in order to investigate the mechanism of FANCM degradation during mitosis. more
total:11
Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. 2008 to the paper
Serotec anti-desmoplakin was used to perform western blot in order to investigate the role of the tetraspanin TM4SF5 in contact inhibition and tumorigenesis. more
total:5
The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. 2006 to the paper
Research Diagnostics monoclonal anti-Dsg1 antibody (clone P124, which recognizes N-terminal extracellular domain of Dsg1) was used in parental A431 human vulvar epidermoid carcinoma cells and in western blot to study the function for Dsg1 in facilitating apoptotic elimination of damaged cells. more
total:3
Limbal epithelial crypt: a model for corneal epithelial maintenance and novel limbal regional variations. 2008 to the paper
Zymed Laboratories anti-desmoglein 3 antibody was used to perform immunohistochemistry in order to study the distribution of cell membrane proteins and extracellular matrix proteins in human corneoscleral limbus rims. more
total:129
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Invitrogen rat anti-E-Cadherin (ECCD-2; 13-1900) was used to perform western blot in order to study the role for TRAF4, a novel phosphoinositide-binding protein in modulating tight junctions and promoting cell migration. more
total:101
Increased levels of active c-Src distinguish invasive from in situ lobular lesions. 2009 to the paper
Santa Cruz Biotechnology anti-Fak antibody (1:1000) was used to carry out immunofluorescence assays in order to study whether c-Src kinase contributes the progression from atypical lobular hyperplasia, and lobular carcinoma in situ to invasive lobular carcinoma. more
total:1
The calpain system is involved in the constitutive regulation of beta-catenin signaling functions. 2005 to the paper
Sigma anti-Gas2 antibody was used in western blot to study constitutive regulation of beta-catenin signaling functions
total:8
Hela l-CaD is implicated in the migration of endothelial cells/endothelial progenitor cells in human neoplasms. 2007 to the paper
Sigma anti-gelsolin antibody was used to perform immunohistochemistry in order to show that the Hela /-CaD is involved with the migration of endothelial cells/endothelial progenitor cells in human neoplasms. more
total:57
RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins. 2013 to the paper
Santa Cruz lamin A/C goat polyclonal (1:1000)was used to perform the immunoblotting to study the translation of a subset of mRNAs encoding secretory proteins potentiated by RanBP2/Nup358. more
total:31
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. 2010 to the paper
Santa Cruz anti-lamin-B antibody was used for western blot in order to show that CYLD negatively regulates cell-cycle progression by inactivating HDAC6. more
total:21
Inhibition of NF-?B signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE. 2010 to the paper
Santa Cruz anti-occludin antibody was used to perform immunocytochemistry in order to study the role of the EPEC protein NleE in inhibiting NF-kappa B signaling in human dendritic cells. more
total:35
PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. 2009 to the paper
Santa Cruz Biotechnology anti-PKCdelta antibody was used in western blot to study the mechanism underlying PKCalpha suppressing tumor in the intestine. more
total:5
Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength. 2009 to the paper
Epitomics rabbit monoclonal anti-plectin antibody was used to carry out western blot analysis and immunofluorescence assays in order to investigate the function for beta3 integrin-mediated vimentin IF recruitment to the cell surface. more
total:10
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. 2006 to the paper
Cell Signaling Technology anti-phospho-PKCtheta antibody was used in western blot to demonstrate that CCL2 induces brain endothelial hyperpermeability via Rho/PKCalpha signal pathway interactions. more
total:8
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. 2009 to the paper
Santa Curz anit-ROCK1 antibody was used to perform western blot to study the different roles of ROCK1 and ROCK2 in regulating keratinocyte adhesion and terminal differentiation. more
total:2
Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. 2009 to the paper
Santa Cruz Biotechnology acetylated SATB1 antibody was used in western blot in order to study the role of SATB1-CtBP1 interaction in the repression and derepression of SATB1 target genes during Wnt signaling in T cells more
total:45
p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance. 2010 to the paper
Proteintech Group MAPT antibody (1:1500) was used to perform western blot in order to clarify that YB-1, GST, ABCB5, and ERK3 could be potential targets against drug resistant breast cancer cells. more
total:3
EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability. 2008 to the paper
Zymed Laboratories rabbit polyclonal anti-ZO-2 antibody was used in western blot and immunocytochemistry to study the role for EspF in pedestal maturation and the disruption of paracellular permeability. more
total:76
Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells. 2008 to the paper
Santa Cruz Biotechnology anti-vimentin (C-20 and H-84, 1:1000) antibody was used to perform western blot in order to study the formation mechanism of tubulin-based microtentacles in detached breast tumor cells. more
total:55
TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. 2013 to the paper
Zymed mouse anti-ZO-1 (1:1,000) antibody was used to perform immunofluorescence in order to study the role for TRAF4, a novel phosphoinositide-binding protein, in modulating tight junctions and promoting cell migration. more