Activation of Matrix Metalloproteinases
gene
reagent
sample publication
sample review
CTSV
cathepsin V
total:2
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. 2006 to the paper
R&D Systems monoclonal mouse-anti-human CTSV antibody was used in immunohistochemistry to study cystatin M/E as a high affinity inhibitor of cathepsin V and cathepsin L through a reactive site that is distinct from the legumain-binding site more
ELANE
elastase, neutrophil expressed
total:11
Mycobacterial disease and impaired IFN-? immunity in humans with inherited ISG15 deficiency. 2012 to the paper
Abcam anti-elastase antibody was used to perform western blot and immunocytochemistry in order to show that ISG15 deletion in humans impairs IFN-gamma immunity and results in mycobacterial disease susceptibility. more
MMP-1
matrix metallopeptidase 1
total:13
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. 2008 to the paper
Calbiochem anti-MMP-1 monoclonal antibody was used to perform western blot in order to study the role of CD147 promoted myofibroblast differentiation in tissue remodeling. more
MMP-2
matrix metallopeptidase 2
total:37
Suppression of matrix metalloproteinase-2 via RNA interference inhibits pancreatic carcinoma cell invasiveness and adhesion. 2009 to the paper
Santa Cruz monoclonal MMP-2 antibodies were used in western blot in order to investigate the role of matrix metalloproteinase-2 (MMP-2) gene in invasiveness and adhesion of human pancreatic cancer cell line, BxPC-3. more
MMP-3
matrix metallopeptidase 3
total:8
Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. 2010 to the paper
Santa Cruze Biotechnology anti-human MMP-3 polyclonal antibody was used for western blot in order to investigate the role of PGE2 on matrix metalloproteinase synthesis in chondrocytes. more
MMP-7
matrix metallopeptidase 7
total:9
Characterization of a candidate tumor suppressor gene uroplakin 1A in esophageal squamous cell carcinoma. 2010 to the paper
Santa Cruz Biotechnology anti-MMP7 antibody was used in immunohistochemistry to investigate the function of UPK1A in esophageal squamous cell carcinoma. more
MMP-8
matrix metallopeptidase 8
total:6
Matrix metalloproteinase activity in pediatric acute lung injury. 2009 to the paper
Chemicon MMP-8 antibody was used to perform immunoblots in order to study the role of matrix metalloproteinase in pediatric acute lung injury. more
MMP-9
matrix metallopeptidase 9
total:45
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. 2009 to the paper
Epitomics anti-MMP-9 antibody was used in immunohistochemistry to study the mechanism of protein kinase D1 for inhibiting breast tumour cell invasion. more
MMP10
matrix metallopeptidase 10
total:5
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes. 2010 to the paper
R&D Systems anti-MMP-10 antibody was used to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas. more
MMP13
matrix metallopeptidase 13
total:7
Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. 2010 to the paper
Santa Cruze Biotechnology anti-human MMP-13 polyclonal antibody was used for western blot in order to investigate the role of PGE2 on matrix metalloproteinase synthesis in chondrocytes. more
MMP15
matrix metallopeptidase 15
total:3
Opposing effects of interferon-alpha and interferon-gamma on the expression of major histocompatibility complex class I chain-related A in tumors. 2008 to the paper
Santa Cruz Biotechnology anti-MT2-MMP antibody was used to perform western blot in order to study the differential effects of IFN-alpha and IFN-gamma on tumor cells. more
MMP16
matrix metallopeptidase 16
total:1
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. 2006 to the paper
Triple Point Biologics MT3-MMP antibody was used in western blot in order to demonstrate that tumor cells require coordinate regulation of LPA/S1P receptors and Rho GTPases to migrate, and additionally, require MT1-MMP in order to invade collagen matrices during neoplastic progression.
MMP25
matrix metallopeptidase 25
total:1
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis. 2009 to the paper
Sigma-Aldrich Co. MMP-25 antibody was used in paraffin-embeded tissue specimens in immunostaining in order to research the role of MMP-8 in Porphyromonas gingivalis-induced periodontitis.
MT1-MMP
matrix metallopeptidase 14
total:15
Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer. 2008 to the paper
Acris anti-MMP14(113-5B7) antibody was used to perform immunohistochemistry in order to study the expression of cytokeratin 7 and 19 are related with genomic stability and favorable prognosis in clear cell renal cell cancer. more
plasminogen
total:4
Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. 2009 to the paper
Novus Biologicals goat anti-human plasminogen antibody was used to perform ELISA in order to study human plasminogen binding surface proteins ErpP, ErpA, and ErpC in Borrelia burgdorferi infection. more
stromelysin 3
matrix metallopeptidase 11
total:4
Matrix metalloproteinase activity in pediatric acute lung injury. 2009 to the paper
Chemicon MMP-11 antibody was used to perform immunoblots in order to study the role of matrix metalloproteinase in pediatric acute lung injury. more
TIMP-1
TIMP metallopeptidase inhibitor 1
total:16
Matrix metalloproteinase activity in pediatric acute lung injury. 2009 to the paper
R/D Systems TIMP-1 antibody was used to perform immunoblots in order to study the role of matrix metalloproteinase in pediatric acute lung injury. more
TIMP-2
TIMP metallopeptidase inhibitor 2
total:12
Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism. 2008 to the paper
Chemicon International mouse anti-human TIMP-2 antibody was used to perform western blot in order to investigate the role of MT1-MMP-TIMP-2 interaction in controlling cell functions. more
tryptase
tryptase alpha/beta 1
total:11
Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis. 2010 to the paper
Abcam anti-tryptase was used to perform immunohistochemistry and immunocytochemistry in order to show that the levels of human neutrophil peptides 1-3 secretion is inhibited by tumor necrosis factor and norepinephrine in mixed synovial tissue cultures from osteoarthritis and rheumatoid arthritis patients. more