Activated NOTCH1 Transmits Signal to the Nucleus
gene
reagent
sample publication
sample review
total:10
S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. 2009 to the paper
Chemicon ADAM-10 antibody was used for western blot in order to indentify new biomarker of Alzheimer's disease. more
total:13
TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. 2008 to the paper
Santa Cruz Biotechnology anti-TACE antibody was used to perform Western Blot in order to show that TACE has a inhibitory role in EGFR axis in colorectal cancer. more
total:7
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. 2010 to the paper
Santa Cruz Biotechnology beta-arrestin1/2 rabbit polyclonal antibody (21-B1) was used to perform western blot in order to clarify that the arrestin-2/STAM-1 complex modulates CXCR4 lysosomal sorting by ubiquitination of HRS. more
total:3
Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. 2006 to the paper
Affinity BioReagents polyclonal anti-beta arrestin 2 antibody was used in human embryonic kidney (HEK) 293 cells and in western blot to study the role of G protein-coupled receptor kinase site serine cluster in beta-arrestin-dependent beta2AR internalization and desensitization. more
total:2
Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. 2005 to the paper
Santa Cruz Biotechnology polyclonal anti-Delta1 antibody (sc-8155) was used in immunohistochemistry to study the effect of Delta1 versus Jagged1 on T-cell progenitors at specific developmental stages in sections from human thymic tissue. more
total:1
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. 2007 to the paper
I. B. Lobov (Regeneron Pharmaceuticals) Dll4 antibody was used in immunohistochemistry to study the role of Dll4 during vascular growth and differentiation.
total:2
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. 2010 to the paper
Santa Cruz Biotechnologies Biosystems anti-JAGGED2 antibody was used to perform immunocytochemistry and flow cytometry in order to show that mesenchymal stem cell can be polarized by downstream TLR signaling into two distinctly acting phenotypes. more
total:12
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. 2010 to the paper
R&D Systems anti-Jagged1 antibody was used to perform flow cytometry in order to study Notch signaling auto-amplification in macrophages which was regulated by TLR and RBP-J. more
total:10
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. 2008 to the paper
Calbiochem rabbit anti-nicastrin antibody was used to perform western blot in order to study the effect of TNF-alpha on gamma-secretase. more
total:17
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. 2010 to the paper
Epitomics anti-Notch1 antibody was used to carry out western blot analysis in order to investigate the regulation of Notch signaling and cell differentiation by mTOR signaling. more