This is a review about Ins2, based on 50 published articles (read how Labome selects the articles), using Ins2 antibody in all methods. It is aimed to help Labome visitors find the most suited Ins2 antibody.
Ins2 synonym: AA986540; Ins-2; InsII; Mody; Mody4; proinsulin

Invitrogen
rabbit polyclonal
  • IHC-F; mouse; 1:1000
  • IP; mouse; 1:500
In order to investigate the role of Fbxo2 in regulating NMDAR subunits in the brain, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in immunohistochemistry - frozen section on mouse samples at 1:1000 and in immunoprecipitation on mouse samples at 1:500. J Neurosci (2015) ncbi
rabbit polyclonal
  • WB; human; 1:500
In order to examine the aggregation and toxicity of melittin and pancreatic polypeptide, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on human samples at 1:500. PLoS ONE (2015) ncbi
rabbit polyclonal
  • dot; human; 1:1000
In order to study neuroinflammation-related gene regulation during normal aging and in sporadic Alzheimer disease in mice, Invitrogen Ins2 antibody (Invitrogen Thermo-Fisher, AHB0052) was used in dot on human samples at 1:1000. J Neuropathol Exp Neurol (2015) ncbi
rabbit polyclonal
  • WB; human
In order to investigate the link between metabolic and epigenetic deficits on reduced mitochondrial function, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on human samples. ACS Chem Neurosci (2015) ncbi
rabbit polyclonal
  • IC; rat; 1:1000; fig 3
In order to test if DT-diaphorase has a protective role in alpha synuclein neurotoxicity, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in immunocytochemistry on rat samples at 1:1000 (fig 3). Toxicol Sci (2015) ncbi
rabbit polyclonal
  • WB; human
In order to assess the effect of carnosic acid on apoptosis induced by Abeta42 or Abeta43 in human neuroblastoma cells, Invitrogen Ins2 antibody (Invitrogen, #AHB0052) was used in western blot on human samples. Neurosci Res (2015) ncbi
rabbit polyclonal
  • IC; rat; 1:200
In order to characterize the structure of human islet polypeptide or amylin, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in immunocytochemistry on rat samples at 1:200. Eur J Med Chem (2014) ncbi
rabbit polyclonal
  • WB; mouse; 1 ug/ml
  • IC; mouse
In order to study the role of the amyloid core of the acrosomal matrix in sperm-zona pellucida interactions, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on mouse samples at 1 ug/ml and in immunocytochemistry on mouse samples. Mol Cell Biol (2014) ncbi
rabbit polyclonal
  • IP; mouse
In order to study the role of the Reelin pathway in Alzheimer's disease pathogenesis, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in immunoprecipitation on mouse samples. Nat Commun (2014) ncbi
rabbit polyclonal
  • WB; mouse; fig 7a
In order to show that RanBP9 overexpression accelerates loss of synaptic proteins in the murine brain, Invitrogen Ins2 antibody (Life Technologies, AHB0052) was used in western blot on mouse samples (fig 7a). PLoS ONE (2014) ncbi
rabbit polyclonal
  • WB; human; 1:1000; fig 5
In order to study cellular inclusions in the Krabbe brain, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on human samples at 1:1000 (fig 5). J Pathol (2014) ncbi
rabbit polyclonal
  • WB; mouse; 1:1000
In order to study Abeta agggregation and oligomerization induced in a murine model of Alzheimer's disease by experimental traumatic brain injury, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on mouse samples at 1:1000. J Neurotrauma (2014) ncbi
rabbit polyclonal
  • WB; mouse; fig 5
In order to characterize the novel autophagy inducer, GTM-1, and assess its effect in an Alzheimer's disease model, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on mouse samples (fig 5). PLoS ONE (2013) ncbi
rabbit polyclonal
  • dot; human; fig 8
In order to study interaction between prion protein and amyloid-beta, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in dot on human samples (fig 8). FASEB J (2013) ncbi
rabbit polyclonal
  • dot; human; 1:4000; fig 2
In order to compare the aggregation of amyloid-beta peptide variants, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in dot on human samples at 1:4000 (fig 2). FEBS Lett (2012) ncbi
rabbit polyclonal
  • IC; human; 1:100; fig 8
In order to study the contribution of macroautophagy to lysosomal Abeta accumulation, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in immunocytochemistry on human samples at 1:100 (fig 8). Autophagy (2011) ncbi
rabbit polyclonal
  • WB; rat; fig 2
In order to identify an actin-mediated and cholesterol-dependent mechanism for selective uptake and clearance of amylin oligomers, Invitrogen Ins2 antibody (Invitrogen, AHB0052) was used in western blot on rat samples (fig 2). J Biol Chem (2011) ncbi
rabbit polyclonal
  • WB; mouse; fig 4
In order to examine the ability of an antibody-profiling technology to characterize and diagnose Alzheimer's disease, Invitrogen Ins2 antibody (Biosource, AHB0052) was used in western blot on mouse samples (fig 4). Ann Neurol (2011) ncbi
rabbit polyclonal
  • IHC-Free; mouse; 1:50; fig 3
In order to examine the Reelin accumulation of Reelin in amyloid-like deposits during ageing, Invitrogen Ins2 antibody (BioSource, AHB0052) was used in immunohistochemistry - free floating section on mouse samples at 1:50 (fig 3). Neurobiol Aging (2009) ncbi
Abcam
guinea pigs polyclonal
  • IHC-P; mouse; 1:100
In order to determine the effect of liraglutide on beta cell fate and function, Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - paraffin section on mouse samples at 1:100. PLoS ONE (2015) ncbi
guinea pigs polyclonal
  • IHC-F; mouse
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - frozen section on mouse samples. PLoS ONE (2014) ncbi
guinea pigs polyclonal
  • IHC-F; mouse; 100 ul/section
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - frozen section on mouse samples at 100 ul/section. PLoS ONE (2014) ncbi
guinea pigs polyclonal
  • IHC-P; mouse; 1:1000
Abcam Ins2 antibody (Abcam, AB7842) was used in immunohistochemistry - paraffin section on mouse samples at 1:1000. Diabetes (2014) ncbi
guinea pigs polyclonal
  • IHC; human
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry on human samples. Hum Gene Ther Methods (2014) ncbi
guinea pigs polyclonal
  • IHC-P; mouse
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - paraffin section on mouse samples. J Leukoc Biol (2014) ncbi
guinea pigs polyclonal
  • IHC-P; mouse
  • IP; mouse
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - paraffin section on mouse samples and in immunoprecipitation on mouse samples. Mol Biol Cell (2014) ncbi
guinea pigs polyclonal
  • IHC-P; pig
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - paraffin section on pig samples. Islets (2013) ncbi
guinea pigs polyclonal
  • IHC-F; mouse; 1:3000
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - frozen section on mouse samples at 1:3000. Aging Cell (2014) ncbi
guinea pigs polyclonal
  • FC; human
  • IC; human; 1:50
In order to evaluate a novel nanotube in the promotion of insulin production from pancreatic beta cells, Abcam Ins2 antibody (Abcam, ab7842) was used in flow cytometry on human samples and in immunocytochemistry on human samples at 1:50. Int J Nanomedicine (2013) ncbi
guinea pigs polyclonal
  • IHC-F; mouse; 1:100
In order to investigate the effect of histidine-rich glycoprotein on tumor progression and its mechanism, Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - frozen section on mouse samples at 1:100. Angiogenesis (2013) ncbi
guinea pigs polyclonal
  • IHC-P; mouse; 1:200
  • IHC-P; rat
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 and on rat samples. J Diabetes Res (2013) ncbi
not indicated
  • IC; mouse
Abcam anti-proinsulin mouse monoclonal antibody was used to perform immunocytochemistry in order to study the role for PICK1 and ICA69 in regulating the formation and maturation of insulin granules.PLoS Biol (2013) ncbi
guinea pigs polyclonal
  • IC; human; 1:100
Abcam Ins2 antibody (Abcam, ab7842) was used in immunocytochemistry on human samples at 1:100. Cell Stem Cell (2013) ncbi
guinea pigs polyclonal
  • IC; mouse
In order to , Abcam Ins2 antibody (Abcam, ab7842) was used in immunocytochemistry on mouse samples. Cancer Res (2013) ncbi
guinea pigs polyclonal
  • IC; mouse
Abcam Ins2 antibody (Abcam, ab7842) was used in immunocytochemistry on mouse samples. FASEB J (2013) ncbi
guinea pigs polyclonal
  • IHC-P; mouse; 1:400
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry - paraffin section on mouse samples at 1:400. Cell Transplant (2012) ncbi
guinea pigs polyclonal
  • IHC; mouse; 1:100
Abcam Ins2 antibody (Abcam, ab7842) was used in immunohistochemistry on mouse samples at 1:100. Exp Diabetes Res (2012) ncbi
Santa Cruz Biotechnology
rabbit polyclonal (H-86)
  • IHC-P; mouse; 1:100
  • ChIP; mouse; 1:100
In order to examine the impact of vitamin D deficiency on insulin resistance and abnormal glucose homeostasis in obesity, Santa Cruz Biotechnology Ins2 antibody (Santa Cruz, sc-9168) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 and in chromatin immunoprecipitation on mouse samples at 1:100. Mol Nutr Food Res (2016) ncbi
rabbit polyclonal (H-86)
  • IHC-P; mouse; 1:200
Santa Cruz Biotechnology Ins2 antibody (Santa Cruz Biotechnology, sc-9168) was used in immunohistochemistry - paraffin section on mouse samples at 1:200. Biochim Biophys Acta (2015) ncbi
goat polyclonal (N-20)
  • IC; human
Santa Cruz Biotechnology Ins2 antibody (Santa Cruz Biotechnology, SC-7838) was used in immunocytochemistry on human samples. PLoS ONE (2015) ncbi
rabbit polyclonal (H-86)
  • IHC-F; mouse
Santa Cruz Biotechnology Ins2 antibody (Santa Cruz, SC-9168) was used in immunohistochemistry - frozen section on mouse samples. Islets (2014) ncbi
rabbit polyclonal (H-86)
  • IHC; mouse; 1:250
Santa Cruz Biotechnology Ins2 antibody (Santa Cruz Biotechnology, sc-9168) was used in immunohistochemistry on mouse samples at 1:250. Mol Cell Biol (2014) ncbi
rabbit polyclonal (H-86)
  • IHC-P; mouse
Santa Cruz Biotechnology Ins2 antibody (Santa Cruz, SC-9168) was used in immunohistochemistry - paraffin section on mouse samples. PLoS ONE (2013) ncbi
rabbit polyclonal (H-86)
  • IHC-P; human; 1:100
  • IHC-P; mouse; 1:100
  • IHC-P; rat
Santa Cruz Biotechnology Ins2 antibody (Santa Cruz Biotechnology, sc-9168) was used in immunohistochemistry - paraffin section on human samples at 1:100, on mouse samples at 1:100, and on rat samples. J Diabetes Res (2013) ncbi
rabbit polyclonal (H-86)
  • IC; rat; 1:100
In order to evaluate the isolation and culture of adult salivary gland-derived stem/progenitor cells, Santa Cruz Biotechnology Ins2 antibody (Santa Cruz Biotechnology, sc-9168) was used in immunocytochemistry on rat samples at 1:100. J Tissue Eng Regen Med (2014) ncbi
ImmunoStar
rabbit polyclonal
  • IHC-F; human; 1:1000
ImmunoStar Ins2 antibody (Immunostar, 20056) was used in immunohistochemistry - frozen section on human samples at 1:1000. PLoS ONE (2014) ncbi
GeneTex
guinea pigs polyclonal
  • IHC-F; human; 1:200
  • IHC-F; mouse; 1:200
  • WB; human
GeneTex Ins2 antibody (GeneTex, GT X27842) was used in immunohistochemistry - frozen section on human samples at 1:200 and on mouse samples at 1:200 and in western blot on human samples. J Biol Chem (2014) ncbi
R and D Systems
not indicated
  • WB; mouse
R&D systems anti-proinsulin mouse monoclonal antibody was used to perform western blot in order to study the role for PICK1 and ICA69 in regulating the formation and maturation of insulin granules.PLoS Biol (2013) ncbi
Cell Signaling Technology
rabbit polyclonal
  • IHC-P; rat; 1:100
In order to determine if Reg3alpha improves islet engraftment, Cell Signaling Technology Ins2 antibody (Cell Signaling Technology, 4590S) was used in immunohistochemistry - paraffin section on rat samples at 1:100. Mol Med (2014) ncbi
rabbit polyclonal
  • IHC; mouse; 1:300; fig 2, 4, 5
Cell Signaling Technology Ins2 antibody (Cell Signaling, 4593) was used in immunohistochemistry on mouse samples at 1:300 (fig 2, 4, 5). J Biol Chem (2015) ncbi
Dako
not indicated
  • IHC; mouse
DAKO Guinea Pig anti-insulin was used to perform immunohistochemistry in order to study the mechanism by which the small molecule inhibitor of TGF-beta receptor I (Alk5) reverses beta cell de-differentiation.elife (2014) ncbi
not indicated
  • IHC; mouse
DAKO anti-Insulin was used to perform immunohistochemistry in order to show that specific myeloid cells derived from the yolk sac.Science (2012) ncbi
Mercodia
not indicatedMercodia rat/mouse proinsulin-specific ELISA kits were used to measure total proinsulin content in order to study the role for PICK1 and ICA69 in regulating the formation and maturation of insulin granules.PLoS Biol (2013) ncbi
Articles Reviewed
  1. Celina Carvalho Borges et al. (2016). "Adverse effects of vitamin D deficiency on the Pi3k/Akt pathway and pancreatic islet morphology in diet-induced obese mice".PMID 26446269
  2. Angela Vinue et al. (2015). "Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling".PMID 26022372
  3. Kanako Tamura et al. (2015). "Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice".PMID 25938469
  4. Graham Atkin et al. (2015). "Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity".PMID 25878288
  5. Ying Ding et al. (2014). "Reg3α Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome".PMID 25826674
  6. Pradeep K Singh et al. (2015). "Cytotoxic helix-rich oligomer formation by melittin and pancreatic polypeptide".PMID 25803428
  7. Irene López-González et al. (2015). "Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species".PMID 25756590
  8. Diego Mastroeni et al. (2015). "Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function".PMID 25668062
  9. Patricia Munoz et al. (2015). "DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity".PMID 25634539
  10. Sudhanshu P Raikwar et al. (2015). "Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice".PMID 25629318
  11. Pengfei Meng et al. (2015). "Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells".PMID 25510380
  12. Steven E Trasino et al. (2015). "Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass".PMID 25451926
  13. Lijie Liu et al. (2014). "Chromanol 293B, an inhibitor of KCNQ1 channels, enhances glucose-stimulated insulin secretion and increases glucagon-like peptide-1 level in mice".PMID 25437377
  14. Haruka Nagasaki et al. (2014). "Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb".PMID 25397325
  15. Jimmy Masjkur et al. (2014). "Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release".PMID 25371201
  16. Lilia Maneva-Radicheva et al. (2014). "Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1".PMID 25259810
  17. Barak Blum et al. (2014). "Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway".PMID 25233132
  18. Lindsey E Nicol et al. (2014). "Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys".PMID 25207967
  19. Sarah A Tersey et al. (2014). "12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets".PMID 25071151
  20. Benjamin N Ediger et al. (2014). "Islet-1 Is essential for pancreatic β-cell function".PMID 25028525
  21. Marianna Flora Tomasello et al. (2014). "Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: a comparative study with the respective full-length parent polypeptides".PMID 24859763
  22. Masayuki Shimoda et al. (2014). "A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1".PMID 24845703
  23. Benoît Guyonnet et al. (2014). "Functional amyloids in the mouse sperm acrosome".PMID 24797071
  24. Kristin A Sauter et al. (2014). "Pleiotropic effects of extended blockade of CSF1R signaling in adult mice".PMID 24652541
  25. Lluís Pujadas et al. (2014). "Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease".PMID 24599114
  26. Hongjie Wang et al. (2014). "RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain".PMID 24454876
  27. Benjamin R Smith et al. (2014). "Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease".PMID 24415155
  28. Jill M Fritz et al. (2014). "Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects".PMID 24336520
  29. Carina Kuehn et al. (2013). "Young porcine endocrine pancreatic islets cultured in fibrin show improved resistance toward hydrogen peroxide".PMID 24262980
  30. Yaiza Diaz-De-Durana et al. (2013). "IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes".PMID 24205242
  31. Nirinjini Naidoo et al. (2014). "Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism".PMID 24102714
  32. Patricia M Washington et al. (2014). "Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model".PMID 24050316
  33. Ioana Ilie et al. (2013). "Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway".PMID 24039418
  34. Jessica Cedervall et al. (2013). "HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment".PMID 23793459
  35. Lesya Novikova et al. (2013). "Variations in rodent models of type 1 diabetes: islet morphology".PMID 23762878
  36. Cheng Chu et al. (2013). "Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits".PMID 23750258
  37. Mian Cao et al. (2013). "PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance".PMID 23630453
  38. Asmin Tulpule et al. (2013). "Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction".PMID 23602541
  39. Buddha Gurung et al. (2013). "Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome".PMID 23580576
  40. Nadine D Younan et al. (2013). "The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers".PMID 23335053
  41. Katarzyna A Cieslik et al. (2013). "Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels".PMID 23303205
  42. Robert B Vernon et al. (2012). "Reversal of diabetes in mice with a bioengineered islet implant incorporating a type I collagen hydrogel and sustained release of vascular endothelial growth factor".PMID 23231959
  43. Kevin Farmer et al. (2012). "KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability".PMID 23197975
  44. Annelies Vandersteen et al. (2012). "A comparative analysis of the aggregation behavior of amyloid-β peptide variants".PMID 23103738
  45. Hyunjung Baek et al. (2014). "Autonomous isolation, long-term culture and differentiation potential of adult salivary gland-derived stem/progenitor cells".PMID 22915381
  46. Christian Schulz et al. (2012). "A lineage of myeloid cells independent of Myb and hematopoietic stem cells".PMID 22442384
  47. Lin Zheng et al. (2011). "Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells".PMID 22108004
  48. Saurabh Trikha et al. (2011). "Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol".PMID 21865171
  49. Lucas Restrepo et al. (2011). "Application of immunosignatures to the assessment of Alzheimer's disease".PMID 21823156
  50. Irene Knuesel et al. (2009). "Age-related accumulation of Reelin in amyloid-like deposits".PMID 17904250