This is a review about Cdkn2a, based on 34 published articles (read how Labome selects the articles), using Cdkn2a antibody in all methods. It is aimed to help Labome visitors find the most suited Cdkn2a antibody.
Cdkn2a synonym: ARF-INK4a; Arf; INK4a-ARF; Ink4a/Arf; MTS1; Pctr1; p16; p16(INK4a); p16INK4a; p19; p19ARF; CDK4I; alternative reading frame; cdkn2a; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; mitochondrial smARF; p16-INK4; p16-INK4a

Santa Cruz Biotechnology
mouse monoclonal (F-12)
  • WB; human; 1:500; fig 5
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology, sc-1661) was used in western blot on human samples at 1:500 (fig 5). Cell Cycle (2015) ncbi
mouse monoclonal (F-12)
  • WB; human
In order to show that subcellular targeting bolsters the cardioprotective effects of Pim1 in primary human cardiac progenitor cells, Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz, sc-1661) was used in western blot on human samples. J Biol Chem (2015) ncbi
mouse monoclonal (F-12)
  • WB; human
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology, SC-1661) was used in western blot on human samples. Cancer Prev Res (Phila) (2015) ncbi
mouse monoclonal (F-12)
  • IHC-F; mouse
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz, sc-1661) was used in immunohistochemistry - frozen section on mouse samples. Clin Exp Pharmacol Physiol (2014) ncbi
mouse monoclonal (F-12)
  • WB; human; 1:500
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz, sc-1661) was used in western blot on human samples at 1:500. PPAR Res (2014) ncbi
mouse monoclonal (F-12)
  • WB; human
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology, sc1661) was used in western blot on human samples. J Cell Physiol (2014) ncbi
mouse monoclonal (2D9A12)
  • IHC-P; human; 1:100
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology, sc-81157) was used in immunohistochemistry - paraffin section on human samples at 1:100. Cancer (2013) ncbi
mouse monoclonal (F-12)
  • IHC-P; mouse; 1:250
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology Inc, sc-1661) was used in immunohistochemistry - paraffin section on mouse samples at 1:250. J Clin Invest (2013) ncbi
mouse monoclonal (F-12)
  • IHC-P; human; 1:100
Santa Cruz Biotechnology Cdkn2a antibody (Santa Cruz Biotechnology, sc-1661) was used in immunohistochemistry - paraffin section on human samples at 1:100. Int J Cancer (2014) ncbi
mouse monoclonal (F-12)
  • WB; mouse; fig 2
Santa Cruz Biotechnology Cdkn2a antibody (Santa, SC-1661) was used in western blot on mouse samples (fig 2). Mol Cell Biol (2013) ncbi
not indicated
  • IHC; mouse
Santa Cruz Biotechnology p16 antibody was used in immunohistochemistry in order to show the importance of protection of the ATM-mediated DDR-p53 signaling pathway for breast cancer prevention.Proc Natl Acad Sci U S A (2010) ncbi
not indicated
  • WB; mouse
  • IP; mouse
Santa Cruz p19Arf antibody was used in immunoblotting and immunoprecipitation to study the role of Sei1 in pancreatic beta-cells and the link between Sei1 and the core cell cycle regulators.PLoS ONE (2010) ncbi
not indicated
  • WB; mouse
Santa Cruz anti-p16 antibody was used to perform western blot in order to show that the absence of p53 can result in tumourgenesis in those mesenchymal stem cells lacking p21.Neoplasia (2009) ncbi
not indicated
  • WB; mouse
Santa Cruz anti-Ink4a antibody was used to perform western blot in order to show that the loss of Faf1 resulted in aberrant NF-kB signaling and tumor progression.Proc Natl Acad Sci U S A (2009) ncbi
not indicated
  • WB; mouse
Santa Cruz Biotechnology anti-p16INK4a antibody was used for western blot in order to demonstrate that cold-inducible RNA-binding protein bypassed replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation.Mol Cell Biol (2009) ncbi
not indicated
  • IHC; mouse
Santa Cruz p16INK4a rabbit polyclonal antibody was used to perform immunohistochemistry in order to reveal the importance of Bmi1 for tumor cell expansion.PLoS ONE (2009) ncbi
not indicated
  • WB; mouse
Santa Cruz Biotechnologies antibody against p16 (M-156) was used in western blot to detect p16 in mouse embryo fibroblasts (MEFs).Genes Dev (2008) ncbi
rabbit polyclonal (M-156)
  • WB; mouse
Santa Cruz Biotechnology rabbit anti-Cdkn2a polyclonal antibody (Catalog #: sc-1207) was used to perform western blot assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth..Adv Drug Deliv Rev (2006) ncbi
not indicated
  • WB; mouse
  • IHC; mouse
Santa Cruz anti-p16 Ink4 (M-156) was used in western blot and immunohistochemistry to detect p16 Ink4 expression patterns in brain and spinal cord of human P301S tau-transgenic mice and age-matched controls.Am J Pathol (2006) ncbi
not indicated
  • IC; mouse
Santa Cruz anti-P16Ink4A antibody was used in immunocytochemistry to study the function of forkhead box M1 to regulate the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.Mol Cell Biol (2005) ncbi
rabbit polyclonal (M-156)
  • WB; mouse
Santa Cruz Biotechnology anti-p16 antibody was used in western blot to detect p16 in mouse hepatocellular carcinoma cell lines 223 infected with adIKK-2 or adGFP.Mol Cancer Res (2005) ncbi
Invitrogen
rabbit polyclonal
  • WB; human; fig 3
In order to use transgenic mice to show that CDK5 activity is crucial for cell cycle progression and medullary thyroid carcinoma proliferation, Invitrogen Cdkn2a antibody (Pierce, PA5-20379) was used in western blot on human samples (fig 3). Oncotarget (2015) ncbi
rabbit polyclonal
  • IHC-P; mouse
In order to elucidate how GREM1 contributes to hereditary mixed polyposis syndrome, Invitrogen Cdkn2a antibody (Thermoscientific, PA1-30670) was used in immunohistochemistry - paraffin section on mouse samples. Nat Med (2015) ncbi
Abcam
mouse monoclonal (2D9A12)
  • IHC-P; human
In order to study the clinical and pathological findings of two unusual cases of Bowen's disease, Abcam Cdkn2a antibody (Abcam, 2D9A12) was used in immunohistochemistry - paraffin section on human samples. J Dermatol (2015) ncbi
mouse monoclonal (2D9A12)
  • WB; human
Abcam Cdkn2a antibody (Abcam, ab54210) was used in western blot on human samples. Age (Dordr) (2013) ncbi
not indicated
  • WB; mouse
Abcam anti-p19(ARF) antibody was used in western blotting to study the mechanism of Braf inactivation driving aneuploidy.Cancer Res (2010) ncbi
not indicated
  • WB; mouse
Abcam anti-Arf antibody was used to perform western blot in order to show that the loss of Faf1 resulted in aberrant NF-kB signaling and tumor progression.Proc Natl Acad Sci U S A (2009) ncbi
not indicated
  • WB; mouse
Abcam anti-p19ARF antibody was used for western blot in order to demonstrate that cold-inducible RNA-binding protein bypassed replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation.Mol Cell Biol (2009) ncbi
not indicated
  • IHC; mouse
Abcam p19ARF rabbit polyclonal antibody was used to perform immunohistochemistry in order to reveal the importance of Bmi1 for tumor cell expansion.PLoS ONE (2009) ncbi
not indicated
  • WB; mouse
AbCam rabbit polyclonal anti-p19Arf was used to perform western blot in order to demonstrate that Puma imposes a significant, and Noxa a minor barrier to c-Myc-driven lymphomagenesisCell Death Differ (2009) ncbi
  • WB; mouse
Abcam rabbit anti-CDKN2A/p19ARF polyclonal antibody (Catalog #: AB-80) was used to perform western blot assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth.Adv Drug Deliv Rev (2006) ncbi
not indicated
  • IC; mouse
Abcam anti-p19ARF antibody was used in immunocytochemistry to study the function of forkhead box M1 to regulate the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.Mol Cell Biol (2005) ncbi
  • WB; mouse
Abcam antibody which recognizes murine ARF was used in western blot to study that p400 is required for E1A to promote apoptosis.J Biol Chem (2005) ncbi
Proteintech Group
rabbit polyclonal
  • IHC-P; human; 1:1000
In order to develop and characterize patient-derived primary xenografts to a model of muscle invasive bladder cancer, Proteintech Group Cdkn2a antibody (Proteintech, 10883-1-AP) was used in immunohistochemistry - paraffin section on human samples at 1:1000. Oncotarget (2015) ncbi
Novus Biologicals
rat monoclonal (5-C3-1)
  • WB; mouse; fig s5d
Novus Biologicals Cdkn2a antibody (Novus, NB-200-174) was used in western blot on mouse samples (fig s5d). Oncotarget (2014) ncbi
Abbiotec
rabbit polyclonal
  • IHC; mouse; 1:100
Abbiotec Cdkn2a antibody (Abbiotec, 251543) was used in immunohistochemistry on mouse samples at 1:100. J Pathol (2014) ncbi
Cell Signaling Technology
not indicated
  • WB; mouse
Cell Signaling Technology anti-p16 antibody was used to carry out western blot analysis in order to investigate the effect of obesity-induced long-term activation of Akt-mTOR signaling on vascular senescence and cardiovascular disease.Sci Signal (2009) ncbi
not indicated
  • WB; mouse
Cell Signaling anti-p16 antibody was used to perform western blot in order to study the regulation of NANOG in G1 to S transition in human embryonic stem cells.J Cell Biol (2009) ncbi
others
not indicated
  • IHC; mouse
St. Crz Biotechnoogy anti-p16 antibody was used for immunohistochemistry in order to study the role of AKT in mammary tumorigenesis.PLoS ONE (2010) ncbi
Articles Reviewed
  1. Wolfgang Jäger et al. (2015). "Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies".PMID 26041878
  2. Olga Moiseeva et al. (2015). "Mutant lamin A links prophase to a p53 independent senescence program".PMID 26029982
  3. Karine Pozo et al. (2015). "Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis".PMID 25900242
  4. Kaitlen Samse et al. (2015). "Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells".PMID 25882843
  5. Samriddhi Shukla et al. (2015). "Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis".PMID 25813524
  6. Hayley Davis et al. (2015). "Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche".PMID 25419707
  7. Chao Kai Hsu et al. (2015). "Bowen's disease with features resembling myrmecia wart".PMID 25387725
  8. Kexiong Zhang et al. (2014). "Cellular senescence occurred widespread to multiple selective sites in the fetal tissues and organs of mice".PMID 25345622
  9. Garth Hamilton et al. (2014). "AKT regulates NPM dependent ARF localization and p53mut stability in tumors".PMID 25071014
  10. Abhita Malaviya et al. (2014). "Synergistic Antiproliferative Effects of Combined γ -Tocotrienol and PPAR γ Antagonist Treatment Are Mediated through PPAR γ -Independent Mechanisms in Breast Cancer Cells".PMID 24729783
  11. Yi Lin Yang et al. (2014). "Lung tumourigenesis in a conditional Cul4A transgenic mouse model".PMID 24648314
  12. Jean Philippe Guegan et al. (2014). "MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K".PMID 24501087
  13. Ya Wei Chen et al. (2013). "Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma".PMID 24301303
  14. Josie X Zhou et al. (2013). "Combined modulation of polycomb and trithorax genes rejuvenates β cell replication".PMID 24216481
  15. Jatinder Kaur et al. (2014). "S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia".PMID 24122701
  16. Awad Shamma et al. (2013). "ATM mediates pRB function to control DNMT1 protein stability and DNA methylation".PMID 23754744
  17. Bin Zhang et al. (2013). "SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway".PMID 23494737
  18. Tamihiro Kamata et al. (2010). "BRAF inactivation drives aneuploidy by deregulating CRAF".PMID 20978199
  19. Carmen Blanco-Aparicio et al. (2010). "Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models".PMID 20174572
  20. Jay P Reddy et al. (2010). "Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation".PMID 20133707
  21. Pablo J Fernandez-Marcos et al. (2010). "Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1".PMID 20090907
  22. Rene Rodriguez et al. (2009). "Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells".PMID 19308294
  23. Chao Yung Wang et al. (2009). "Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR".PMID 19293429
  24. Deborah A Altomare et al. (2009). "Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice".PMID 19223589
  25. Ana Artero-Castro et al. (2009). "Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation".PMID 19158277
  26. Matthias Becker et al. (2009). "Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer".PMID 19156217
  27. E M Michalak et al. (2009). "Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis".PMID 19148184
  28. Xin Zhang et al. (2009). "A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A".PMID 19139263
  29. Konstantinos J Mavrakis et al. (2008). "Tumorigenic activity and therapeutic inhibition of Rheb GTPase".PMID 18708578
  30. Anna Sergeeva et al. (2006). "Display technologies: application for the discovery of drug and gene delivery agents".PMID 17123658
  31. Patrice Delobel et al. (2006). "Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1".PMID 16507903
  32. I Ching Wang et al. (2005). "Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase".PMID 16314512
  33. Lakita G Cavin et al. (2005). "Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas".PMID 16046551
  34. Andrew V Samuelson et al. (2005). "p400 is required for E1A to promote apoptosis".PMID 15741165