This is a review about p300, based on 49 published articles (read how Labome selects the articles), using p300 antibody in all methods. It is aimed to help Labome visitors find the most suited p300 antibody.
p300 synonym: KAT3B; RSTS2; p300; E1A-associated protein p300; E1A-binding protein, 300kD; histone acetyltransferase p300; p300 HAT

Santa Cruz BiotechnologySanta Cruz Biotechnology p300 product
  • ChIP assayIn 2011, Lan Wang et al. applied Santa Cruz Biotechnology p300 antibody to perform western blot and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis [ncbi , more ]. Ming Yu et al. utilized Santa Cruz Biotechnology p300 antibody to study the molecular basis of CD4 regulation and provide a conceptual framework for understanding how the same regulatory elements can mediate both reversible and irreversible CD4 regulation [ncbi , more ] in 2008 and Min Huei Liang et al. used Santa Cruz Biotechnology p300 antibody to demonstrate that lithium suppresses Smad3/4-dependent TGF-beta-responsive gene transactivation [ncbi , more ]. In 2007, Sergey Denissov et al. utilized Santa Cruz Biotechnology p300 antibody to identify novel functional TBP-binding sites and general factor repertoires (catalog: sc-369) [ncbi , more ]. In 2006, M D Heitzer et al. utilized Santa Cruz Biotechnology p300 antibody to determine whether Hic-5/ARA55 interacts with other coactivator proteins at glucocorticoid-responsive promoters in A1 2 cells derived from the T47D human mammary carcinoma cells line [ncbi , more ]. In 2005, David G DeNardo et al. utilized Santa Cruz Biotechnology p300 antibody to study the affect of ER transcription factor cross talk on a genome-wide scale in Breast Cancer [ncbi , more ]. In 2004, Sarah E Aiyar et al. utilized Santa Cruz Biotechnology p300 antibody to examine the dynamic association of coactivator p300 with the ERalpha-responsive promoters in human T47D cells [ncbi , more ]. In 2003, Wu Guo Deng et al. employed Santa Cruz Biotechnology p300 antibody to study p300 in RAW 264.7 cells with wt p300 or p300 HAT deletion mutant transfection [ncbi , more ].
  • EMSAIn 2005, Shunbin Ning et al. used Santa Cruz Biotechnology p300 antibody to study the regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling [ncbi , more ].
  • immunocytochemistryIn 2007, Amanda J Ullman et al. used Santa Cruz Biotechnology p300 antibody to demonstrate that E4 ORF3 is critical to the replicative success of adenovirus during the IFN-induced antiviral state [ncbi , more ]. In 2002, Christy J Fryer et al. applied Santa Cruz Biotechnology p300 antibody to study that mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex [ncbi , more ].
  • immunohistochemistryIn 2003, Rui Hong et al. utilized Santa Cruz Biotechnology p300 antibody to detect p300 in HeLa cells (catalog: sc-585) [ncbi , more ].
  • immunoprecipitationIn 2007, Aymeric Ravel-Chapuis et al. applied Santa Cruz Biotechnology p300 antibody to demonstrate that neural agrin-dependent reprogramming of myonuclei involves chromatin remodelling, histone hyperacetylation and histone hyperphosphorylation [ncbi , more ]. Santa Cruz Biotechnology p300 antibody was used in 2005 to study aryl hydrocarbon receptor-mediated transcription in MCF-7 human breast carcinoma, T47D breast carcinoma cells, and HuH7 human liver carcinoma cells [ncbi , more ], to study that notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1 [ncbi , more ]and to investigate the regulation of ER alpha proteolysis and transcription [ncbi , more ]. In 2004, Kishor K Bhakat et al. applied Santa Cruz Biotechnology p300 antibody to study the acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity [ncbi , more ]. Wu Guo Deng et al. employed Santa Cruz Biotechnology p300 antibody to study p300 in RAW 264.7 cells with wt p300 or p300 HAT deletion mutant transfection [ncbi , more ] in 2003 and Rui Hong et al. used Santa Cruz Biotechnology p300 antibody to detect p300 in HeLa cells (catalog: sc-585) [ncbi , more ]. F Gizard et al. utilized Santa Cruz Biotechnology p300 antibody to study the Interaction of a novel zinc finger protein TReP-132 with CBP/p300 to regulate human CYP11A1 gene expression (catalog: sc-584) [ncbi , more ] in 2001 and R Mehra-Chaudhary et al. used Santa Cruz Biotechnology p300 antibody to study the down-regulation of Msx1 promoter through recruiting histone deacetylase by Msx3 protein (catalog: sc-584) [ncbi , more ].
  • western blotIn 2011, Lan Wang et al. applied Santa Cruz Biotechnology p300 antibody to perform western blot and ChIP assays in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis [ncbi , more ]. In 2010, Di Feng et al. applied Santa Cruz Biotechnology p300 antibody to perform western blot in order to show that IRF5 mediated the transcriptional induction of proinflammatory cytokine expression in conjunction with HATs and HDACs [ncbi , more ]. Santa Cruz Biotechnology p300 antibody was employed in 2009 to show that tumor suppressor PTEN can regulate ARE activation through chromatin modifications [ncbi , more ], to study the role of SATB1-CtBP1 interaction in the repression and derepression of SATB1 target genes during Wnt signaling in T cells [ncbi , more ], to introduce Brd4 as a coactivator of NF-kappa B via specific binding to acetylated RelA [ncbi , more ]and to demonstrate that an HDAC inhibitor induces apoptosis through the FoxO1 acetylation-Bim pathway [ncbi , more ]. Susan Nozell et al. utilized Santa Cruz Biotechnology p300 antibody to perform western blot in order to study the association between ING4 and the activity of NF-kappa B molecules bound with target gene promoters [ncbi , more ] in 2008 and Yong Li et al. used Santa Cruz Biotechnology p300 antibody to demonstrate that p300 plays a role in the activation of the MT-I gene [ncbi , more ]. Aymeric Ravel-Chapuis et al. applied Santa Cruz Biotechnology p300 antibody to demonstrate that neural agrin-dependent reprogramming of myonuclei involves chromatin remodelling, histone hyperacetylation and histone hyperphosphorylation [ncbi , more ] in 2007 and Amanda J Ullman et al. used Santa Cruz Biotechnology p300 antibody to demonstrate that E4 ORF3 is critical to the replicative success of adenovirus during the IFN-induced antiviral state [ncbi , more ]. In 2006, Yuan Liu et al. used Santa Cruz Biotechnology p300 antibody to study the role of BRMS1 in the metastasis of breast cancer [ncbi , more ]. Santa Cruz Biotechnology p300 antibody was used in 2005 to determine the mechanism underlying regulation of the insulin gene by Pdx-1 [ncbi , more ], to detect p300 in TSA-treated MIA PaCa-2 cells [ncbi , more ], to study Ciglitazone induced cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells (catalog: sc-585) [ncbi , more ], to study that notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1 [ncbi , more ]and to demonstrate p300 modulating ATF4 stability and transcriptional activity independently of its acetyltransferase domain [ncbi , more ]. Kishor K Bhakat et al. applied Santa Cruz Biotechnology p300 antibody to study the acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity [ncbi , more ] in 2004 and Maria Carla Motta et al. used Santa Cruz Biotechnology p300 antibody to detect p300 levels in human HEK293T cells (catalog: sc-585) [ncbi , more ]. Santa Cruz Biotechnology p300 antibody was used in 2003 to detect p300 in HeLa cells (catalog: sc-585) [ncbi , more ], to provide biochemical and genetic evidence to show that the HATs p300, CBP, and PCAF are regulators of E2A activity in B lymphocytes (catalog: sc-585) [ncbi , more ]and to study p300 in RAW 264.7 cells with wt p300 or p300 HAT deletion mutant transfection [ncbi , more ]. Santa Cruz Biotechnology p300 antibody was employed in 2002 to study the function of the HMG-I/Y-related protein p8 to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter by binding to p300 and Pax2 trans-activation domain-interacting protein (PTIP) [ncbi , more ], to study the different function of protein kinase A and glycogen synthase kinase-3b for the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D [ncbi , more ]and to study that mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex [ncbi , more ]. N Yamamoto et al. utilized Santa Cruz Biotechnology p300 antibody to study the role of deltex-1 as a transcriptional regulator downstream of the notch receptor [ncbi , more ] in 2001 and R Mehra-Chaudhary et al. used Santa Cruz Biotechnology p300 antibody to study the down-regulation of Msx1 promoter through recruiting histone deacetylase by Msx3 protein (catalog: sc-584) [ncbi , more ].
EMD MilliporeEMD Millipore p300 product
  • ChIP assayIn 2009, Hiroki Matsuda et al. employed EMD Millipore p300 antibody to perform ChIP assays in order to study the functions of protein arginine methyltransferase 1 [ncbi , more ]. In 2006, Catherine K Yang et al. applied EMD Millipore p300 antibody to perform ChIP assays in order to sthudy the function of coiled-coil coactivator's N-terminal in regulating transcriptional activation [ncbi , more ]. In 2003, Tamara Nowling et al. used EMD Millipore p300 antibody to study the regulation of the FGF-4 gene [ncbi , more ].
  • immunocytochemistryIn 2001, D J Adams et al. employed EMD Millipore p300 antibody to study the function of ZNF265 [ncbi , more ].
  • immunohistochemistryIn 2007, Guang Hua Peng et al. used EMD Millipore p300 antibody to demonstrate that Crx activates transcription by recruiting HAT-harboring co-activators to target gene promoters and promoting histone acetylation (catalog: 05-257) [ncbi , more ].
  • immunoprecipitationRui Hong et al. utilized EMD Millipore p300 antibody to detect p300 in HeLa cells [ncbi , more ] in 2003 and Tamara Nowling et al. used EMD Millipore p300 antibody to study the regulation of the FGF-4 gene [ncbi , more ].
  • western blotIn 2011, Lan Wang et al. applied EMD Millipore p300 antibody to perform western blot in order to show that acetylation of AML1-ETO fusion protein by p300 is critical for leukemogenesis [ncbi , more ]. In 2009, Carrie Hayes Sutter et al. applied EMD Millipore p300 antibody to study the effect of EGF receptor signaling on aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes [ncbi , more ]. In 2004, Enrique Lara-Pezzi et al. used EMD Millipore p300 antibody to study a role for STAG/Scc3 in transcriptional regulation by cohesins [ncbi , more ]. EMD Millipore p300 antibody was applied in 2003 to detect p300 in HeLa cells [ncbi , more ], to study the molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL [ncbi , more ], to study the regulation of the FGF-4 gene [ncbi , more ]and to study the DNA damage response and MCL-1 destruction initiating apoptosis in adenovirus-infected cells [ncbi , more ]. In 2002, Mate Tolnay et al. used EMD Millipore p300 antibody to study the different function of protein kinase A and glycogen synthase kinase-3b for the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D [ncbi , more ].
Life Technologies CorporationLife Technologies Corporation p300 product
  • immunoprecipitationIn 2003, Kiyoshi Higashi et al. used Life Technologies Corporation p300 antibody to study transforming growth factor-beta signaling [ncbi , more ].
AbcamAbcam p300 product
  • western blotIn 2009, Chandrima Das et al. used Abcam p300 antibody to carry out western blot analysis in order to determine the histone H3 lysine 56 acetylation by histone acetyl transferases CBP/p300 [ncbi , more ].
BD Biosciences
  • ChIP assayIn 2008, Fabián Arenas et al. employed BD Biosciences p300 antibody to study the role of the alternative expression from AE2 gene in the physiology and pathophysiology of the hepatobiliary tract [ncbi , more ].
  • immunoprecipitationIn 2003, Nianli Sang et al. used BD Biosciences p300 antibody to study the effects of MAPK signaling on the activity of hypoxia-inducible factors by promoting the formation of the HIF-p300/CBP complex and by modulating the transactivation activity of p300/CBP [ncbi , more ].
  • western blotIn 2008, Fabián Arenas et al. employed BD Biosciences p300 antibody to study the role of the alternative expression from AE2 gene in the physiology and pathophysiology of the hepatobiliary tract [ncbi , more ]. In 2003, Nianli Sang et al. used BD Biosciences p300 antibody to study the effects of MAPK signaling on the activity of hypoxia-inducible factors by promoting the formation of the HIF-p300/CBP complex and by modulating the transactivation activity of p300/CBP [ncbi , more ].
Articles Reviewed
  1. Lan Wang et al. (2011). "The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation".PMID 21764752
  2. Di Feng et al. (2010). "Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression".PMID 20935208
  3. Yang Yang et al. (2009). "Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment".PMID 19308286
  4. Chandrima Das et al. (2009). "CBP/p300-mediated acetylation of histone H3 on lysine 56".PMID 19270680
  5. Carrie Hayes Sutter et al. (2009). "EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes".PMID 19255421
  6. Kensuke Sakamoto et al. (2009). "Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications".PMID 19158375
  7. Prabhat Kumar Purbey et al. (2009). "Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1".PMID 19103759
  8. Bo Huang et al. (2009). "Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA".PMID 19103749
  9. Hiroki Matsuda et al. (2009). "Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis".PMID 19047371
  10. Susan Nozell et al. (2008). "The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes".PMID 18779315
  11. Yong Li et al. (2008). "Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1".PMID 18458062
  12. Ming Yu et al. (2008). "Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development".PMID 18322012
  13. Fabián Arenas et al. (2008). "Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells".PMID 18188457
  14. Min Huei Liang et al. (2008). "Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling".PMID 18077182
  15. Guang Hua Peng et al. (2007). "Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation".PMID 17656371
  16. Aymeric Ravel-Chapuis et al. (2007). "Postsynaptic chromatin is under neural control at the neuromuscular junction".PMID 17304221
  17. Amanda J Ullman et al. (2007). "Adenovirus E4 ORF3 protein inhibits the interferon-mediated antiviral response".PMID 17301128
  18. Sergey Denissov et al. (2007). "Identification of novel functional TBP-binding sites and general factor repertoires".PMID 17268553
  19. Yuan Liu et al. (2006). "Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis".PMID 17000776
  20. Catherine K Yang et al. (2006). "Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin".PMID 16931570
  21. Irina Lassot et al. (2005). "p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain".PMID 16219772
  22. M D Heitzer et al. (2006). "Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator".PMID 16141357
  23. Christopher C Valley et al. (2005). "Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus".PMID 15964799
  24. Jason Matthews et al. (2005). "Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters".PMID 15964790
  25. Tessy Iype et al. (2005). "Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes".PMID 15743769
  26. Shunbin Ning et al. (2005). "Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling".PMID 15664995
  27. Weiqi Huang et al. (2005). "Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex".PMID 15647279
  28. Fei Chen et al. (2005). "Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation".PMID 15618021
  29. Eri Ishiko et al. (2005). "Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1".PMID 15563463
  30. David G DeNardo et al. (2005). "Global gene expression analysis of estrogen receptor transcription factor cross talk in breast cancer: identification of estrogen-induced/activator protein-1-dependent genes".PMID 15514030
  31. Sarah E Aiyar et al. (2004). "Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor".PMID 15342491
  32. Kishor K Bhakat et al. (2004). "Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity".PMID 15175427
  33. Maria Carla Motta et al. (2004). "Mammalian SIRT1 represses forkhead transcription factors".PMID 14980222
  34. Wu Guo Deng et al. (2003). "Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation".PMID 14662860
  35. Enrique Lara-Pezzi et al. (2004). "Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3".PMID 14660624
  36. Andrea Cuconati et al. (2003). "DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells".PMID 14633975
  37. Rui Hong et al. (2003). "The human proliferating Cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression".PMID 12937166
  38. Kiyoshi Higashi et al. (2003). "Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3".PMID 12917425
  39. Dmitri Wiederschain et al. (2003). "Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL".PMID 12773566
  40. Nianli Sang et al. (2003). "MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300".PMID 12588875
  41. Tamara Nowling et al. (2003). "The co-activator p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene".PMID 12488456
  42. Curtis Bradney et al. (2003). "Regulation of E2A activities by histone acetyltransferases in B lymphocyte development".PMID 12435739
  43. Christy J Fryer et al. (2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex".PMID 12050117
  44. Albrecht Hoffmeister et al. (2002). "The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter".PMID 11940591
  45. Mate Tolnay et al. (2002). "Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion".PMID 11903055
  46. N Yamamoto et al. (2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor".PMID 11564735
  47. D J Adams et al. (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing".PMID 11448987
  48. F Gizard et al. (2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression".PMID 11349124
  49. R Mehra-Chaudhary et al. (2001). "Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter".PMID 11115394