This is a review about p16, based on 43 published articles (read how Labome selects the articles), using p16 antibody in all methods. It is aimed to help Labome visitors find the most suited p16 antibody.
p16 synonym: ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16; CDK4 inhibitor p16-INK4; cell cycle negative regulator beta; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); multiple tumor suppressor 1

Santa Cruz BiotechnologySanta Cruz Biotechnology p16 product
  • immunocytochemistryIn 2003, Easwar Natarajan et al. applied Santa Cruz Biotechnology p16 antibody to study the setting in which p16 is expressed and functions as a tumor suppressor in stratified squamous epithelia in vivo [ncbi , more ].
  • immunohistochemistryIn 2009, Therese M Becker et al. used Santa Cruz Biotechnology p16 antibody to study the association of the chromatin remodelling factor BRG1 with the tumor suppressor p16INK4a [ncbi , more ]. Dalit Barkan et al. utilized Santa Cruz Biotechnology p16 antibody to study the role for targeting the cytoskeleton in inhibition of metastatic outgrowth from single dormant tumor cells (catalog: Sc-1661) [ncbi , more ] in 2008 and Yelena Lyustikman et al. used Santa Cruz Biotechnology p16 antibody to perform western blot in order to study the role of Raf-1 in glioma formation [ncbi , more ]. In 2004, Xin Li et al. used Santa Cruz Biotechnology p16 antibody to study p16INK4A hypermethylation in hepatocellular carcinoma [ncbi , more ]. In 2003, Easwar Natarajan et al. applied Santa Cruz Biotechnology p16 antibody to study the setting in which p16 is expressed and functions as a tumor suppressor in stratified squamous epithelia in vivo [ncbi , more ].
  • immunoprecipitationIn 2006, Jianwei Ren et al. applied Santa Cruz Biotechnology p16 antibody to study the role for FAT10 in the regulation of chromosomal stability [ncbi , more ].
  • western blotAlejo Efeyan et al. employed Santa Cruz Biotechnology p16 antibody to suggest that ATM plays a role in oncogene-induced senescence or in p53-dependent tumor suppression [ncbi , more ] in 2009 and Therese M Becker et al. used Santa Cruz Biotechnology p16 antibody to study the association of the chromatin remodelling factor BRG1 with the tumor suppressor p16INK4a [ncbi , more ]. In 2007, Wei jian Guo et al. used Santa Cruz Biotechnology p16 antibody to study the regulation of cell proliferation and senescence by Mel-18 via transcriptional repression of Bmi-1 and c-Myc oncoproteins [ncbi , more ]. In 2006, Irina Groisman et al. employed Santa Cruz Biotechnology p16 antibody to study the role of CPEB in cellular senescence [ncbi , more ]. Santa Cruz Biotechnology p16 antibody was utilized in 2005 to study the role of Dmp1 in Ras-Raf-Arf signaling [ncbi , more ], to study the suppression of cyclic GMP-specific phosphodiesterase 5 promoting apoptosis and inhibiting growth in HT29 cells [ncbi , more ]and to study that p400 is required for E1A to promote apoptosis (catalog: sc-8340) [ncbi , more ]. Shadan Ali et al. employed Santa Cruz Biotechnology p16 antibody to detect the expression of p16 in tumor tissues from patients with squamous cell carcinoma of the head and neck (SCCHN) [ncbi , more ] in 2004 and Daniel J Weisenberger et al. used Santa Cruz Biotechnology p16 antibody to study the role of the DNA methyltransferase variant DNMT3b3 in DNA methylation [ncbi , more ]. In 2003, Hesham M Amin et al. employed Santa Cruz Biotechnology p16 antibody to 1:1000 to facilitate the establishment of an in vitro model that can be reliably used to study the pathogenesis of MCL [ncbi , more ]. Santa Cruz Biotechnology p16 antibody was used in 2002 to study the induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1 [ncbi , more ], to study the role of Tbx3 in p53 pathway [ncbi , more ], to study expression of p53, ErbB1, ErbB2, and Raf-1 in lung cancer [ncbi , more ], to study the role for integrins in regulating the apoptotic response to DNA damage [ncbi , more ]and to study the RB activation defect in tumor cell lines [ncbi , more ].
Novus BiologicalsNovus Biologicals p16 product
  • immunocytochemistryIn 2005, Andrew V Samuelson et al. applied Novus Biologicals p16 antibody to study that p400 is required for E1A to promote apoptosis (catalog: NB200-106) [ncbi , more ].
EMD MilliporeEMD Millipore p16 product
  • western blotIn 2002, Cynthia C Sprenger et al. utilized EMD Millipore p16 antibody to study the effects of over-expression of the potential tumor suppressor gene IGFBP-rP1/mac25 on cell-cycle kinetics in human prostate cancer cells [ncbi , more ].
Thermo Scientific Pierce ProductsThermo Scientific Pierce Products p16 product
  • immunocytochemistryIn 2007, Jing Wang et al. used Thermo Scientific Pierce Products p16 antibody to perform immunocytochemistry in order to investigate the relations between PI4P and GGA [ncbi , more ]. In 2003, Geza Acs et al. utilized Thermo Scientific Pierce Products p16 antibody to study the effect of hypoxia on erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its role in cervical carcinogenesis and tumor progression [ncbi , more ].
  • immunohistochemistryIn 2008, Zhenhua Song et al. utilized Thermo Scientific Pierce Products p16 antibody to investigate the expression of p16INK4a, p21WAF1/CIP1, p27KIP1, and p53 in human corneal endothelial cell (HCEC) senescence ex vivo at various donor ages [ncbi , more ]. Ching Hao Li et al. utilized Thermo Scientific Pierce Products p16 antibody to investigate the effect of mitochondrial stress on p21 expression and cell apoptosis [ncbi , more ] in 2005 and Gita Ohlsson et al. used Thermo Scientific Pierce Products p16 antibody to study the interaction of the loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) with progression of human urothelial carcinomas [ncbi , more ]. In 2003, Geza Acs et al. utilized Thermo Scientific Pierce Products p16 antibody to study the effect of hypoxia on erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its role in cervical carcinogenesis and tumor progression [ncbi , more ].
  • immunoprecipitationIn 2006, Laurence Bockstaele et al. utilized Thermo Scientific Pierce Products p16 antibody to study the role for cyclins and CDK "inhibitors" in Thr172 phosphorylation of CDK4 [ncbi , more ]. In 2003, Philip Ian Padilla et al. utilized Thermo Scientific Pierce Products p16 antibody to study the interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) [ncbi , more ].
  • western blotIn 2010, Hui Kuan Lin et al. employed Thermo Scientific Pierce Products p16 antibody to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence [ncbi , more ]. In 2006, Laurence Bockstaele et al. utilized Thermo Scientific Pierce Products p16 antibody to study the role for cyclins and CDK "inhibitors" in Thr172 phosphorylation of CDK4 [ncbi , more ]. Ching Hao Li et al. utilized Thermo Scientific Pierce Products p16 antibody to investigate the effect of mitochondrial stress on p21 expression and cell apoptosis [ncbi , more ] in 2005 and Mark W Jackson et al. used Thermo Scientific Pierce Products p16 antibody to study p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2 [ncbi , more ]. Yu Pan et al. applied Thermo Scientific Pierce Products p16 antibody to study the effect of MDM2 on MDMX [ncbi , more ] in 2003 and Philip Ian Padilla et al. used Thermo Scientific Pierce Products p16 antibody to study the interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) [ncbi , more ].
AbcamAbcam p16 product
  • immunohistochemistryIn 2010, Jay P Reddy et al. applied Abcam p16 antibody to show the importance of protection of the ATM-mediated DDR-p53 signaling pathway for breast cancer prevention [ncbi , more ]. In 2009, Wassim Chatoo et al. used Abcam p16 antibody to perform immunohistochemistry in order to illustrate that the Bmi1 functions on neurons oxidative metabolism are associated with repression of p53 pro-oxidant activity [ncbi , more ].
  • western blotIn 2010, Qiang Li et al. applied Abcam p16 antibody to perform western blot in order to study the role of polycomb CBX7 in H3K9me3 [ncbi , more ]. Alejo Efeyan et al. employed Abcam p16 antibody to suggest that ATM plays a role in oncogene-induced senescence or in p53-dependent tumor suppression [ncbi , more ] in 2009 and Jayasree S Nair et al. used Abcam p16 antibody to investigate the role of Aurora B in the regulation of postmitotic endoreduplication checkpoint [ncbi , more ].
Life Technologies Corporation
  • immunoprecipitationIn 2009, Therese M Becker et al. used Life Technologies Corporation p16 antibody to study the association of the chromatin remodelling factor BRG1 with the tumor suppressor p16INK4a [ncbi , more ].
BD BiosciencesBD Biosciences p16 product
  • immunocytochemistryIn 2003, Easwar Natarajan et al. applied BD Biosciences p16 antibody to study the setting in which p16 is expressed and functions as a tumor suppressor in stratified squamous epithelia in vivo [ncbi , more ].
  • immunohistochemistryIn 2011, Nicolas Stransky et al. applied BD Biosciences p16 antibody to perform immunohistochemistry in order to show the mutational spectrum of head and neck squamous cell carcinoma [ncbi , more ]. In 2004, David J Simpson et al. used BD Biosciences p16 antibody to study p16 methylation in nonadenomatous pituitaries from Cushing s disease patients [ncbi , more ]. In 2003, Easwar Natarajan et al. applied BD Biosciences p16 antibody to study the setting in which p16 is expressed and functions as a tumor suppressor in stratified squamous epithelia in vivo [ncbi , more ].
  • western blotIn 2007, S Uchiyama et al. employed BD Biosciences p16 antibody to investigate the expression and localization of H2RSP in normal, injured, and neoplastic human intestinal tissue [ncbi , more ]. In 2006, Mandar R Bhonde et al. employed BD Biosciences p16 antibody to study the effect of DNA damage-induced expression of p53 on mitotic checkpoint kinase hMps1 [ncbi , more ]. Devanand Sarkar et al. applied BD Biosciences p16 antibody to detect the expression of p16 in the human metastatic melanoma cell line HO-1 [ncbi , more ] in 2005 and Masanori Terai et al. used BD Biosciences p16 antibody to study the prolongation of life span of human umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) [ncbi , more ].
Dako
  • immunohistochemistryIn 2005, Hong Bing Ma et al. applied Dako p16 antibody to study cyclin D1, p16, and retinoblastoma protein expressions in gallbladder carcinoma [ncbi , more ].
ONCOGENE LABORATORIES
  • immunocytochemistryIn 2003, Frederick Y Wu et al. employed p16 antibody to detect p16 in the human PEL cell line BCBL1 [ncbi , more ].
  • western blotIn 2003, Frederick Y Wu et al. employed p16 antibody to detect p16 in the human PEL cell line BCBL1 [ncbi , more ].
Articles Reviewed
  1. Nicolas Stransky et al. (2011). "The mutational landscape of head and neck squamous cell carcinoma".PMID 21798893
  2. Qiang Li et al. (2010). "Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus".PMID 21060834
  3. Hui Kuan Lin et al. (2010). "Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence".PMID 20237562
  4. Jay P Reddy et al. (2010). "Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation".PMID 20133707
  5. Alejo Efeyan et al. (2009). "Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression".PMID 19421407
  6. Jayasree S Nair et al. (2009). "Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780".PMID 19225156
  7. Therese M Becker et al. (2009). "The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a".PMID 19149898
  8. Wassim Chatoo et al. (2009). "The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity".PMID 19144853
  9. Dalit Barkan et al. (2008). "Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton".PMID 18676848
  10. Yelena Lyustikman et al. (2008). "Constitutive activation of Raf-1 induces glioma formation in mice".PMID 18472967
  11. Zhenhua Song et al. (2008). "Expression of senescence-related genes in human corneal endothelial cells".PMID 18334933
  12. Jing Wang et al. (2007). "PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal".PMID 17494868
  13. Wei jian Guo et al. (2007). "Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins".PMID 17151361
  14. Irina Groisman et al. (2006). "Control of cellular senescence by CPEB".PMID 17015432
  15. S Uchiyama et al. (2007). "Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers".PMID 16809422
  16. Laurence Bockstaele et al. (2006). "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"".PMID 16782892
  17. Jianwei Ren et al. (2006). "FAT10 plays a role in the regulation of chromosomal stability".PMID 16495226
  18. Mandar R Bhonde et al. (2006). "DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis".PMID 16446370
  19. Devanand Sarkar et al. (2005). "Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence".PMID 16055741
  20. Ching Hao Li et al. (2005). "Chloramphenicol-induced mitochondrial stress increases p21 expression and prevents cell apoptosis through a p21-dependent pathway".PMID 15905168
  21. Mark W Jackson et al. (2005). "p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2".PMID 15827088
  22. Andrew V Samuelson et al. (2005). "p400 is required for E1A to promote apoptosis".PMID 15741165
  23. Gita Ohlsson et al. (2005). "Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas".PMID 15734831
  24. Hong Bing Ma et al. (2005). "Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma".PMID 15655836
  25. Masanori Terai et al. (2005). "Immortalization of human fetal cells: the life span of umbilical cord blood-derived cells can be prolonged without manipulating p16INK4a/RB braking pathway".PMID 15647378
  26. Ramesh Sreeramaneni et al. (2005). "Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor".PMID 15601844
  27. Xin Li et al. (2004). "p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma".PMID 15569978
  28. Bing Zhu et al. (2005). "Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells".PMID 15526282
  29. Shadan Ali et al. (2004). "Cytochrome p450 and glutathione transferase expression in squamous cell cancer".PMID 15240530
  30. David J Simpson et al. (2004). "Molecular pathology shows p16 methylation in nonadenomatous pituitaries from patients with Cushing's disease".PMID 15014032
  31. Daniel J Weisenberger et al. (2004). "Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation".PMID 14757847
  32. Frederick Y Wu et al. (2003). "Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1)".PMID 12885907
  33. Easwar Natarajan et al. (2003). "Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture".PMID 12875969
  34. Yu Pan et al. (2003). "MDM2 promotes ubiquitination and degradation of MDMX".PMID 12860999
  35. Geza Acs et al. (2003). "Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression".PMID 12759237
  36. Hesham M Amin et al. (2003). "Characterization of 4 mantle cell lymphoma cell lines".PMID 12683869
  37. Philip Ian Padilla et al. (2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506".PMID 12606707
  38. Cristina Broceño et al. (2002). "RB activation defect in tumor cell lines".PMID 12379745
  39. Jennifer A Benanti et al. (2002). "Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1".PMID 12370286
  40. Hanqian Carlson et al. (2002). "Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation".PMID 12032820
  41. Xiaodan Yu et al. (2002). "Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228".PMID 11929951
  42. Jean McArthur Lewis et al. (2002). "Integrins regulate the apoptotic response to DNA damage through modulation of p53".PMID 11904424
  43. Cynthia C Sprenger et al. (2002). "Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis".PMID 11791184