This is a review about eIF2alpha, based on 31 published articles (read how Labome selects the articles), using eIF2alpha antibody in all methods. It is aimed to help Labome visitors find the most suited eIF2alpha antibody.
eIF2alpha synonym: EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A; eIF-2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit alpha

Santa Cruz BiotechnologySanta Cruz Biotechnology eIF2alpha product
  • immunoprecipitationIn 2005, Nikolai A Timchenko et al. applied Santa Cruz Biotechnology eIF2alpha antibody to study the role of RNA CUG-binding protein 1 to 20-kDa isoform of CCAAT/enhancer-binding protein beta [ncbi , more ].
  • western blotSanta Cruz Biotechnology eIF2alpha antibody was used in 2009 to identify angiogenin and tRNA-derived stress-induced RNAs (tiRNAs) as components of a phospho-eIF2alpha-independent stress response program [ncbi , more ], to carry out western blot analysis in order to determine whether glucose would augment fatty acid-induced beta-cell ER stress though mTORC1 signaling [ncbi , more ]and to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2 (catalog: SC-101670) [ncbi , more ]. Eileen Connolly et al. employed Santa Cruz Biotechnology eIF2alpha antibody to study the mechanism of protein synthesis inhibition by hypoxia in human breast cancer cells [ncbi , more ] in 2006 and Susana Guerra et al. used Santa Cruz Biotechnology eIF2alpha antibody to study the effect of attenuated poxvirus vector NYVAC on apoptotic genes and NF-kappaB-responsive genes in infected HeLa cells [ncbi , more ]. In 2005, Nikolai A Timchenko et al. applied Santa Cruz Biotechnology eIF2alpha antibody to study the role of RNA CUG-binding protein 1 to 20-kDa isoform of CCAAT/enhancer-binding protein beta [ncbi , more ].
Cell Signaling TechnologyCell Signaling Technology eIF2alpha product
  • immunocytochemistryIn 2009, Kazuchika Nishitsuji et al. applied Cell Signaling Technology eIF2alpha antibody to study the effect of E693deletemutation in amyloid precursor protein on intracellular accumulation of amyloid beta oligomers and its role in causing endoplasmic reticulum stress-induced apoptosis in cultured cells [ncbi , more ].
  • western blotHui Kuan Lin et al. employed Cell Signaling Technology eIF2alpha antibody to perform western blot in order to clarify that Skp2 involved in the p19Arf-p53 pathway independent cellular senescence [ncbi , more ] in 2010 and Tomokazu Matsuda et al. used Cell Signaling Technology eIF2alpha antibody to investigate the role of C/EBPB in the regulation of ER stress and pancreatic beta cell failure [ncbi , more ]. Cell Signaling Technology eIF2alpha antibody was applied in 2009 to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2 [ncbi , more ], to carry out western blot analysis in order to determine whether glucose would augment fatty acid-induced beta-cell ER stress though mTORC1 signaling [ncbi , more ], to study the effect of E693deletemutation in amyloid precursor protein on intracellular accumulation of amyloid beta oligomers and its role in causing endoplasmic reticulum stress-induced apoptosis in cultured cells [ncbi , more ], to perform western blot in order to study the mechanism of the apoptosis induced by severe acute respiratory syndrome coronavirus [ncbi , more ], to perform western blot in order to show that protein kinase PKR can induce apoptosis and restrict the growth of phenotypes of C protein-deficient measles virus [ncbi , more ]and to perform western blot in order to study the cytotoxicity of timosaponin AIII towards tumor cells [ncbi , more ]. In 2008, Kenji Takeuchi et al. utilized Cell Signaling Technology eIF2alpha antibody to perform western blot in order to show that SeV C protein can limit generation of dsRNA to restrict PKR activation [ncbi , more ]. In 2007, Kristen L Shogren et al. utilized Cell Signaling Technology eIF2alpha antibody to perform western blot in order to study the function of double-stranded RNA-dependent protein kinase in 2-methoxyestradiol-mediated cell death [ncbi , more ]. Gang Chen et al. employed Cell Signaling Technology eIF2alpha antibody to detect the phosphorylated eIF2alpha in human SH-SY5Y cells and cerebellar granule neurons (CGNs) isolated from the rat cerebella of 7-day-old rat pups, Cell Signaling Technology antibody against eIF2alpha was used in western blot to detect eIF2alpha expression in expression of PACT/Rax, PKR, eIF2, and p-eIF2 in human embryonic kidney cell line HEK293 (293), human neuroblastoma SK-N-MC (MC), SH-SY5Y (5Y) cells, and rat cerebella [ncbi , more ] in 2006 and Krystyna Mazan-Mamczarz et al. used Cell Signaling Technology eIF2alpha antibody to carry out western blot analysis in order to investigate the role for TIAR-mediated inhibition of translation factor expression in the regulation of cells responding to stress [ncbi , more ]. In 2005, Chiara Gorrini et al. used Cell Signaling Technology eIF2alpha antibody to study the regulation of cap-dependent translation by fibronectin [ncbi , more ]. Cell Signaling Technology eIF2alpha antibody was utilized in 2004 to study the inhibitory effect of small interfering RNA urokinase silencing on the invasion and migration of human hepatocellular carcinoma cells [ncbi , more ], to detect phosphorylated eIF2 alpha in HEK 293 cells transfected with eIF2Bs [ncbi , more ]and to examine the expression levels of total and the phosphorylated forms of eukaryotic inhibition factor 2alpha in human colon cancer cell line DLD-1 [ncbi , more ]. In 2001, J H Connor et al. utilized Cell Signaling Technology eIF2alpha antibody to study GADD34-induced signaling complex [ncbi , more ].
Enzo Life SciencesEnzo Life Sciences eIF2alpha product
  • western blotIn 2009, Satoshi Yamasaki et al. used Enzo Life Sciences eIF2alpha antibody to identify angiogenin and tRNA-derived stress-induced RNAs (tiRNAs) as components of a phospho-eIF2alpha-independent stress response program [ncbi , more ].
Life Technologies CorporationLife Technologies Corporation eIF2alpha product
  • ELISAIn 2005, Rajasekhar N V S Suragani et al. applied Life Technologies Corporation eIF2alpha antibody to study the interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases [ncbi , more ].
  • western blotIn 2011, Pavel Tsaytler et al. applied Life Technologies Corporation eIF2alpha antibody to perform western blot in order to show that regulatory subunit of protein phosphatase 1 could be blocked by small molecule selectively [ncbi , more ]. Michael L Whitney et al. used Life Technologies Corporation eIF2alpha antibody to demonstrate that REDD1 expression is upregulated during ER stress through a mechanism involving activation of PERK, phosphorylation of eIF2alpha, and increased ATF4 expression [ncbi , more ] in 2009 and Verena Krähling et al. used Life Technologies Corporation eIF2alpha antibody to carry out western blot analysis in order to investigate the mechanism of SARS coronavirus activating PKR and PERK and overcome the inhibitory effects of phosphorylated eIF2-alpha on viral mRNA translation [ncbi , more ]. J T Jamison et al. applied Life Technologies Corporation eIF2alpha antibody to study the mechanism of persistent translation arrest [ncbi , more ] in 2008 and Scot R Kimball et al. used Life Technologies Corporation eIF2alpha antibody to perform western blot in order to study the response of the mTORC1 signaling after the inhibition of protein synthesis [ncbi , more ]. In 2006, Eileen Connolly et al. employed Life Technologies Corporation eIF2alpha antibody to study the mechanism of protein synthesis inhibition by hypoxia in human breast cancer cells [ncbi , more ]. In 2002, Zsolt Talloczy et al. employed Life Technologies Corporation eIF2alpha antibody to demonstrate that autophagy is a novel evolutionarily conserved function of the eIF2alpha kinase pathway that is targeted by viral virulence gene products [ncbi , more ]. Y He et al. utilized Life Technologies Corporation eIF2alpha antibody to study the effect of NS5A inhibition of PKR [ncbi , more ] in 2001 and A H Wong et al. used Life Technologies Corporation eIF2alpha antibody to study the novel function of STAT1 as an inhibitor of PKR activation and eIF-2alpha phosphorylation [ncbi , more ].
AbcamAbcam eIF2alpha product
  • western blotIn 2011, Pavel Tsaytler et al. applied Abcam eIF2alpha antibody to perform western blot in order to show that regulatory subunit of protein phosphatase 1 could be blocked by small molecule selectively [ncbi , more ]. In 2008, Kenji Takeuchi et al. utilized Abcam eIF2alpha antibody to perform western blot in order to show that SeV C protein can limit generation of dsRNA to restrict PKR activation [ncbi , more ]. In 2005, Chenhao Fan et al. used Abcam eIF2alpha antibody to study the role of eIF-4E and eIF-2 in the cardiac hypertrophy observed in CCH-treated mice [ncbi , more ].
EDWARD HENSHAW
  • western blotIn 2004, Jing Deng et al. employed eIF2alpha antibody to study translational repression mediating activation of nuclear factor kappa B by phosphorylated translation initiation factor 2 [ncbi , more ].
Articles Reviewed
  1. Pavel Tsaytler et al. (2011). "Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis".PMID 21385720
  2. Hui Kuan Lin et al. (2010). "Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence".PMID 20237562
  3. Tomokazu Matsuda et al. (2010). "Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice".PMID 19955657
  4. Frank W King et al. (2009). "Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress".PMID 19789631
  5. Megan E Spurgeon et al. (2009). "The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection".PMID 19605483
  6. Satoshi Yamasaki et al. (2009). "Angiogenin cleaves tRNA and promotes stress-induced translational repression".PMID 19332886
  7. Etti Bachar et al. (2009). "Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1".PMID 19305497
  8. Kazuchika Nishitsuji et al. (2009). "The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells".PMID 19164507
  9. Michael L Whitney et al. (2009). "ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression".PMID 19114033
  10. Verena Krähling et al. (2009). "Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity".PMID 19109397
  11. Ann M Toth et al. (2009). "Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus".PMID 19004947
  12. Kenji Takeuchi et al. (2008). "Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA".PMID 18684815
  13. J T Jamison et al. (2008). "Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion".PMID 18456413
  14. Scot R Kimball et al. (2008). "Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis".PMID 18070882
  15. Kristen L Shogren et al. (2007). "Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells".PMID 17014383
  16. Eileen Connolly et al. (2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells".PMID 16648488
  17. Gang Chen et al. (2006). "Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons".PMID 16574643
  18. Krystyna Mazan-Mamczarz et al. (2006). "Translational repression by RNA-binding protein TIAR".PMID 16537914
  19. Susana Guerra et al. (2006). "Host response to the attenuated poxvirus vector NYVAC: upregulation of apoptotic genes and NF-kappaB-responsive genes in infected HeLa cells".PMID 16379000
  20. Rajasekhar N V S Suragani et al. (2005). "Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases".PMID 16288713
  21. Chiara Gorrini et al. (2005). "Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways".PMID 15961545
  22. Chenhao Fan et al. (2005). "Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia".PMID 15928208
  23. Nikolai A Timchenko et al. (2005). "RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2".PMID 15788409
  24. Jing Deng et al. (2004). "Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2".PMID 15542827
  25. Hirotaka Kato et al. (2004). "High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases".PMID 15534108
  26. Alessandro Salvi et al. (2004). "Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells".PMID 15210852
  27. Wei Li et al. (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways".PMID 15060152
  28. Zsolt Talloczy et al. (2002). "Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway".PMID 11756670
  29. J H Connor et al. (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1".PMID 11564868
  30. Y He et al. (2001). "Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A".PMID 11333890
  31. A H Wong et al. (2001). "Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR".PMID 11278865