Beta Actin Antibody Review and FAQs
Mary Johnson (mary at labome dot com)
Synatom Research, Princeton, New Jersey, United States
last modified : 2015-04-27; original version : 2013-03-21
Cite as
MATER METHODS 2013;3:179

A comprehensive review of beta actin antibodies as a Western blot internal control, with detailed discussion about one of most cited anti-beta actin clones: AC-15.

Beta Actin Antibody

This is a review about beta actin antibodies (mainly as an internal loading control for Western blot), based on 156 published articles as of April 27, 2015 in randomly selected publications that Labome has surveyed systematically. Labome is continuously curating antibodies cited in formal publications. There are numerous publications using beta actin antibodies; our systematic and random sampling ensures that our results and conclusions are representative. This review aims to facilitate Labome visitors in locating the best-suited beta actin antibodies. Beta actin antibodies from different suppliers are linked below or can be searched here. The article also addresses some of commonly asked questions about beta actin antibodies.

Beta actin is one of the most commonly used loading controls for Western blot, in addition to tubulin and GAPDH.

Beta Actin Antibody Review and FAQs figure 1
Figure 1. A typical application of beta actin antibody as the Western blot loading control, from [1].
Beta actin

The actin family of proteins are involved in muscle contraction and cytoskeleton structure. Beta and gamma forms are the only two non-muscle members. They play important rules in basic cellular processes, and are expressed in all cell types. Their sequences are highly conserved across species. Beta actin proteins are identical in human, mouse, and chicken.

Beta actin antibody as a Western blot loading control

Beta-actin antibody is the most commonly used loading control for western blot (see Labome's dedicated discussion on loading control for western blot). Table 1 lists the major providers of anti-beta actin antibodies among the publications Labome has surveyed.

Santa Cruz Biotechnology25
EMD Millipore/Calbiochem8
Cell Signaling6
Thermo Fisher3
Table 1. Major suppliers of beta actin antibodies used in western blot and their numbers of publications among the cohort of publications surveyed by Labome, as of April 27, 2015.
Actin antibody clones

The most cited anti-beta actin antibody clone is AC-15. It is cited in 11 publications among a total of 16 publications that indicate a clone or catalog number. Majority of publications do not indicate any clone number or catalog number. The clone AC-15 was used in Western blot in order to study wild type Cas, CasY253F, or Cas118423 [2], oogenic processes [3], apoptosis [4], Barrett's metaplasia [5], NF-kappaB signaling [6], retinal axon development [7], the role of sFLT-1 in the maintenance of the avascular photoreceptor layer in mouse models [8], a novel phosphoinositide-binding protein in modulating tight junctions and cell migration [9], rational drug design [10], synaptic plasticity [11] and the role for miR-196a in brown adipogenesis [12].

AC-15 clone was characterized and reported by Dr. J. Victor Small's lab at Institute for molecular biology, Austrian Academy of Sciences in their 1994 publications [13, 14]. AC-15 belongs to subclass IgG1, and was raised in mice against the N-terminal synthetic peptide of beta actin, with the sequence of AcD-D-D-I-A-A-L-V-I-D-N-G-S-G-K coupled to keyhole limpet hemocyanin. The clone specifically targets the beta isoform, with no cross reactivity against the other 5 isoforms of actin family. This clone is available from most antibody suppliers.

  • Dr. Mario Gimona, then a Ph.D. student in Dr. Small lab has kindly provided the following account of history about the clone AC-15 to this article.

    "While conducting experiments in 1993 at the Weizmann Institute of Science in Rehovot, Israel, I was invited to visit the facilities of BIOMAKOR, a company focusing on the development of monoclonal antibodies. Dr. Harry Langbeheim and Dr. Zeev Lando of BIOMAKOR instructed me on their latest developments that included isoform specific actin antibodies (at that time excellent probes for muscle actins and pan-actin Abs were available, but a beta-isoform specific probe was lacking). I was given the chance to take some of the putative beta actin specific probes (AC 15 and AC 74) back to Salzburg to test the Ab in our then lab in Salzburg.

    With the help of Prof. Small and Dr. Alison North in Salzburg, and together with our collaborator, the actin isoform expert Prof. Joel Vandekerckhove from the University of Ghent, Belgium, we characterized the Ab by light and electron microscopy, as well as 1D and 2D Western Blotting (on whole cell lysates and on isoform specific peptides).

    The probe demonstrated excellent specificity and worked well in all techniques and fixation methods used.

    Dr. Langebheim, Dr. Lando and BIOMAKOR generously granted us the publication of 2 initial papers in 1994 and provided us with a generous supply of the AC-15 Ab for many years.

    To my knowledge the company BIOMAKOR later on went to become part of SIGMA.

Due to the prevalence of anti-actin antibodies in Western blot as a loading control and the prevalence of Western blot analysis in the overall body of literature, this beta-actin clone is likely the mosted cited antibody clone among all antibody clones in literature.

Beta actin may not be a suitable internal loading control for low abundance proteins, or for samples at diseased states

It must be noted that beta-actin is not an appropriate Western blot loading control in some circumstances. At a higher total protein loading level, beta-actin specific antibodies may not be able to detect the differences of protein loading levels [15]. This is likely due to that beta actin is one of the dominant cellular proteins. This problem may not be alleviated by diluting anybody working solution or shortening the incubation time [15].

In addition, beta actin expression might change during growth and differentiation, or in disease states [16], or in different tissues and in different portions of same sample tissues [17]. It is important to evaluate the consistency of beta actin expression over, for example, the total protein, among different samples.

Frequently asked questions about beta actin antibody

Some of the commonly asked questions about beta actin antibody are addressed below.

There is no beta actin band during Western blot.

There are a number of reasons. The first one to check is whether the anti-beta actin antibody is effective. One way to accomplish that is to reduce the dilution of the anti-beta actin antibody, and check to see whether there is still any band at all, and/or try to use anti-beta actin antibodies from high quality suppliers. The second thing to check is whether the anti-beta actin anybody is suitable for Western blot; some of the anti-actin antibodies are good for immunocytochemistry or immunohistochemistry, but not for Western blot. The third thing to check is whether the proteins are transferred evenly from the gel to the membrane. This can be checked through Ponseau S staining. The fourth thing to check is whether beta actin is expressed in the sample tissue or cells; this should happen very rarely, since beta actin is one of most important housekeeping genes for all cell types. In addition, it should be examined whether beta actin is preferentially degraded (an unlikely event). Another thing to be checked is whether the secondary antibody matches is suitable for the anti-beta actin antibody.

Can an antibody for the target protein and an antibody for beta actin be incubated together to detect the target protein and beta actin at the same time?

This is not advisable. The best approach is to detect the target protein first, then use western blot stripping buffer to remove the target protein antibody and the secondary antibody, and then to incubate with an anti-beta actin antibody. The reason is that it is difficult to adjust the incubation and developing parameters for two different antibodies and it is also difficult to prevent cross-reactivity among different antibodies.

What is the best dilution for a given anti-beta actin antibody?

The easy way to find the best diltion is to check any information sheet that usually comes with the product. Another approach is to contact the antibody supplier; the supplier usually has optimized the dilution. Regardless, if the suggested dilution does not work, different dilutions should be tested to find the optimal one.

With different Western blot experiments, the same sample at the same loading volume gave very different beta actin signal intensities.

Multiple experimental procedures may affect this. It could be that the loading solution becomes more sticky, or the transfer is uneven.

Do I still need to do the internal control if the ratio of a phosphorylated target protein against its total protein is obtained?

Yes. The internal control not only ensures sample loading, but also checks the transfer, incubation, and signal development.

The target protein has the same molecular weight as beta actin.

Beta actin can still be used as an internal control. After the detection of the target protein, the blot should be completely stripped and checked for any signal before incubation with a beta actin antibody. Alternatively, another protein can be used as an internal control, such as tubulin or GAPDH.

Can I use beta actin as a loading control for nuclear samples?

No. The nucleus may contain some actin, but its level is dynamic and it should not serve as a control. See Labome's detailed discussion on different loading controls for nulear sample controls.

There are several beta actin positive bands, all of them are smaller than 43 kD.

There are several reasons: 1) Secondary antibody may not be very specific; 2) The loading buffer is not effective; 3) The beta actin antibody is not specific; 4) Beta actin is degraded.

Labome survey results

A detailed breakdown of the literature analyzed by Labome citing beta-actin antibodies is provided here. It is organized according to the suppliers. Whenever possible, the clonality and host species are also provided.

Santa Cruz Biotechnology

Santa Cruz Biotechnology goat anti-actin polyclonal antibody [18-20], mouse anti-beta-actin antibody [21], and rabbit anti-human actin antibody [22] were used in Western blot. ChIP [23] and immunoprecipitation [24] experiments were also cited. Santa Cruz Biotechnology beta-actin was used in Western blot to study activin receptor [25], hoxd4 gene repression [26], Id2 [27], anthracycline chemotherapy [28], androgen receptor silencing [29], human telomerase reverse transcriptase [30], tumor suppressor SMAR1 [31], Smad1 and p38 kinase [32], cortical neurons [33], C3 transferase. [34], PMA stimulation [35], B lymphocytes from patients [36], 293T cells [37], Faf1 deficiency [38], adiponectin haploinsufficiency [39], ILK [40], Prdx1 [41], nitric oxide function [42], BMP-6 [43], and MMS19 [44]. Santa Cruz Biotechnologies anti-beta-actin antibody was used to explore the regulation of a sexually transferred steroid hormone and a female protein in the oogenesis in the Malaria Mosquito Anopheles gambiae [45].


Monoclonal Abcam beta-actin antibody was used in western blot to study tumor necrosis factor alpha translation [46], phosphorylation of claudin-3 at threonine 192 [47], VHL status [48], Bmi1 functions [49], retinal axon development [7], and the function of sFLT-1 (ab6276) [8]. Abcam actin antibody was also used to study ABCA1 and ABCG1 in human macrophages [50], HIF-1 stabilization and degradation [51], melanoma-associated antigens [52], ubiquitination pathway [53], and TRiC/CCT functions [54].

EMD Millipore

Chemicon monoclonal anti-actin antibody was used in western blot to study heregulin-dependent BRCA1 phosphorylation [55], polycystin 2 [56], and human astrocyte [57]. Chemicon anti-actin antibody was used to study NMT1-1 and NMT2-4 siRNA [58], alpha-synuclein degradation by serine protease neurosin [59], the role of CDON in regulating tumor cell survival [60]. Oncogene Research Products and Calbiochem (both are now part of EMD Millipore) anti-actin antibodies were used in western blot to study galectin-3 phosphorylation [61] and interleukin-11 receptor alpha-chain [62], respectively.

Thermo Fisher

Zymed Laboratories, Ambion, Neomarkers, Biovision (all are now part of Thermo Fisher) anti-actin antibodies were used in western blot to study HER-2 down-regulation [63], histone demethylases [64], p130/p107/p105Rb-dependent transcriptional repression [65], and the regulatory effect of HILDA complex on VEGF-A expression [66], respectively.


Rockland actin antibody was used in western blot to study the effect of MDM2-dependent inhibition of p53 on EBV growth transformation of B-cell and infected-cell survival [67].

Novus Bio

Novus anti-beta-actin antibody was used for western blot to investigate the roles of MutSalpha and MutLalpha in ATR-Chk1 pathway [68].

US Biological

US Biological beta-actin antibody was used in western blot to study Zinc-induced PTEN protein degradation [69].


Cytoskeleton goat anti-human actin antibody was used in western blot as a loading control to study the effect of P2Y2 nucleotide receptors on alpha-secretase-dependent amyloid precursor protein processing [70].


The catalog numbers cited among the surveyed articles include A5441 (for AC-15 clone) [2, 9], AC-15 clone [4, 5, 10, 71, 72], AC-74 clone [73], rabbit anti-actin antibody A5060 [74] and A5316 for ChIP assay [75]. Most of publications citing Sigma beta actin antibodies are for Western blot; a few of them indicate immunoprecipitation [76-79], ELISA [80], and immunocytochemistry [81-83].

Monoclonal Sigma anti-actin antibodies were used in Western blot to study p53, WAF1, and MDM2 [84], von Hippel Lindau tumor suppressor [85], DNA methylation [86], ULBP5/RAET1G isoforms [87], iron accumulation [88], microtubule-associated protein 1S [89], SHIP [90], laminins [91], copper/zinc superoxide dismutase [92], H2AX [93], human astrocytoma cell line 1321N1 [94], Dnmt1 promoter [95], SRPK1 [96], Tsc/mTORC1 signaling [97], VAMP8/Endobrevin [98], nitric oxide synthase isoforms [99], Parkinson disease pathology [100], and Luc and NudC [101].

Polyclonal Sigma anti-beta-actin antibodies [102], from rabbit [103-105], were used in Western blot to investigate PR3-mediated p21 cleavage, Cu/Zn-superoxide dismutase mutant-induced motoneuronal cell death, the role for proepithelin in prostate carcinogenesis and the role of IRAK-1 blockade in immuno-tolerance.

Other publications cited Sigma anti-beta actin antibodies in western blot include [11, 12, 106-152].

MP Biochemicals

Monoclonal ICN Biomedicals anti-actin antibody was used in western blot to study Vav3 [153], LNCaP and PC-3 cells [154], and cystatin M [155]. Its antibodies against beta-actin were used to study lin-4 miRNA in C. elegans [156], and transforming growth factor-beta 1 [157].

Cell Signaling Technology

Cell Signaling anti-beta-actin antibodies [158-160], including that from rabbit [161], were used to perform western blot to investigate ETB and AT1 receptor, ATM-mediated DDR-p53 signaling pathway, androgen receptor signaling and ING1a. Cell Signaling Technologies anti-beta-actin was used to study the mechanism by which de-differentiation confers multidrug resistance [162] and the role of ALK7 signaling in catecholamine resistance in obesity [163].


Roche Molecular Biochemicals monoclonal anti-actin antibody was used in western blot as a loading control [164].

BD Bioscience

Transduction Laboratories rabbit polyclonal anti-beta-actin antibody was used in western blot to ensure equal loading [165].

  1. Kim S, Lu H, Alano C. Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture. PLoS ONE. 2011;6:e14731 pubmed publisher
  2. Goldberg G, Alexander D, Pellicena P, Zhang Z, Tsuda H, Miller W. Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J Biol Chem. 2003;278:46533-40 pubmed
  3. Su Y, Sugiura K, Sun F, Pendola J, Cox G, Handel M, et al. MARF1 regulates essential oogenic processes in mice. Science. 2012;335:1496-9 pubmed publisher
  4. Samuelson A, Narita M, Chan H, Jin J, de Stanchina E, McCurrach M, et al. p400 is required for E1A to promote apoptosis. J Biol Chem. 2005;280:21915-23 pubmed
  5. Wong N, Wilding J, Bartlett S, Liu Y, Warren B, Piris J, et al. CDX1 is an important molecular mediator of Barrett's metaplasia. Proc Natl Acad Sci U S A. 2005;102:7565-70 pubmed
  6. Shembade N, Ma A, Harhaj E. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science. 2010;327:1135-9 pubmed publisher
  7. Lin A, Tan C, Lin C, Strochlic L, Huang Y, Richter J, et al. Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development. Neural Dev. 2009;4:8 pubmed publisher
  8. Luo L, Uehara H, Zhang X, Das S, Olsen T, Holt D, et al. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. elife. 2013;2:e00324 pubmed publisher
  9. Rousseau A, McEwen A, Poussin-Courmontagne P, Rognan D, Nominé Y, Rio M, et al. TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. PLoS Biol. 2013;11:e1001726 pubmed publisher
  10. Balbas M, Evans M, Hosfield D, Wongvipat J, Arora V, Watson P, et al. Overcoming mutation-based resistance to antiandrogens with rational drug design. elife. 2013;2:e00499 pubmed publisher
  11. Kempf A, Tews B, Arzt M, Weinmann O, Obermair F, Pernet V, et al. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol. 2014;12:e1001763 pubmed publisher
  12. Mori M, Nakagami H, Rodriguez-Araujo G, Nimura K, Kaneda Y. Essential role for miR-196a in brown adipogenesis of white fat progenitor cells. PLoS Biol. 2012;10:e1001314 pubmed publisher
  13. North A, Gimona M, Lando Z, Small J. Actin isoform compartments in chicken gizzard smooth muscle cells. J Cell Sci. 1994;107:445-55 pubmed
  14. Gimona M, Vandekerckhove J, Goethals M, Herzog M, Lando Z, Small J. Beta-actin specific monoclonal antibody. Cell Motil Cytoskeleton. 1994;27:108-16 pubmed
  15. Dittmer A, Dittmer J. Beta-actin is not a reliable loading control in Western blot analysis. Electrophoresis. 2006;27:2844-5 pubmed
  16. Ruan W, Lai M. Actin, a reliable marker of internal control?. Clin Chim Acta. 2007;385:1-5 pubmed
  17. Eaton S, Roche S, Llavero Hurtado M, Oldknow K, Farquharson C, Gillingwater T, et al. Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting. PLoS ONE. 2013;8:e72457 pubmed publisher
  18. Benanti J, Williams D, Robinson K, Ozer H, Galloway D. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Mol Cell Biol. 2002;22:7385-97 pubmed
  19. Gao C, Guo H, Downey L, Marroquin C, Wei J, Kuo P. Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. Carcinogenesis. 2003;24:1871-8 pubmed
  20. Hwang S, Yu S, Ryu J, Jeon H, Yoo Y, Eom S, et al. Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin. J Biol Chem. 2005;280:12758-65 pubmed
  21. Nishihara H, Kizaka-Kondoh S, Insel P, Eckmann L. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A. 2003;100:8921-6 pubmed
  22. Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, et al. Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. J Biol Chem. 2001;276:39027-36 pubmed
  23. Cao S, Fernandez-Zapico M, Jin D, Puri V, Cook T, Lerman L, et al. KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling. J Biol Chem. 2005;280:1901-10 pubmed
  24. Williams K, Lich J, Duncan J, Reed W, Rallabhandi P, Moore C, et al. The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem. 2005;280:39914-24 pubmed
  25. Simon D, Vadakkadath Meethal S, Wilson A, Gallego M, Weinecke S, Bruce E, et al. Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. Neoplasia. 2009;11:365-76 pubmed
  26. Tan Y, Zhang B, Wu T, Skogerbø G, Zhu X, Guo X, et al. Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells. BMC Mol Biol. 2009;10:12 pubmed publisher
  27. Meng Y, Gu C, Wu Z, Zhao Y, Si Y, Fu X, et al. Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors. BMC Cancer. 2009;9:75 pubmed publisher
  28. Lee K, Qian D, Rey S, Wei H, Liu J, Semenza G. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A. 2009;106:2353-8 pubmed publisher
  29. Liao X, Tang S, Thrasher J, Griebling T, Li B. Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol Cancer Ther. 2005;4:505-15 pubmed
  30. Wang J, Feng H, Huang X, Xiang H, Mao Y, Liu J, et al. Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway. J Biol Chem. 2005;280:22776-87 pubmed
  31. Rampalli S, Pavithra L, Bhatt A, Kundu T, Chattopadhyay S. Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. Mol Cell Biol. 2005;25:8415-29 pubmed
  32. Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, Nokubi T, et al. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell. 2003;14:545-55 pubmed
  33. Bhakar A, Howell J, Paul C, Salehi A, Becker E, Said F, et al. Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad. J Neurosci. 2003;23:11373-81 pubmed
  34. Anwar K, Fazal F, Malik A, Rahman A. RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65. J Immunol. 2004;173:6965-72 pubmed
  35. Granja A, Nogal M, Hurtado C, Vila V, Carrascosa A, Salas M, et al. The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway. J Biol Chem. 2004;279:53736-46 pubmed
  36. Robinson-White A, Hundley T, Shiferaw M, Bertherat J, Sandrini F, Stratakis C. Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2. Hum Mol Genet. 2003;12:1475-84 pubmed
  37. Zhao J, Kong H, Li H, Huang B, Yang M, Zhu C, et al. IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J Biol Chem. 2006;281:10073-80 pubmed
  38. Altomare D, Menges C, Pei J, Zhang L, Skele-Stump K, Carbone M, et al. Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc Natl Acad Sci U S A. 2009;106:3420-5 pubmed publisher
  39. Lam J, Chow K, Xu A, Lam K, Liu J, Wong N, et al. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS ONE. 2009;4:e4968 pubmed publisher
  40. Gagné D, Groulx J, Benoit Y, Basora N, Herring E, Vachon P, et al. Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. J Cell Physiol. 2010;222:387-400 pubmed publisher
  41. Cao J, Schulte J, Knight A, Leslie N, Zagozdzon A, Bronson R, et al. Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J. 2009;28:1505-17 pubmed publisher
  42. Qu J, Liu G, Wu K, Han P, Wang P, Li J, et al. Nitric oxide destabilizes Pias3 and regulates sumoylation. PLoS ONE. 2007;2:e1085 pubmed
  43. Kersten C, Sivertsen E, Hystad M, Forfang L, Smeland E, Myklebust J. BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1. BMC Immunol. 2005;6:9 pubmed
  44. Stehling O, Vashisht A, Mascarenhas J, Jonsson Z, Sharma T, Netz D, et al. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science. 2012;337:195-9 pubmed publisher
  45. Baldini F, Gabrieli P, South A, Valim C, Mancini F, Catteruccia F. The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae. PLoS Biol. 2013;11:e1001695 pubmed publisher
  46. Galban S, Fan J, Martindale J, Cheadle C, Hoffman B, Woods M, et al. von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays. Mol Cell Biol. 2003;23:2316-28 pubmed
  47. D'Souza T, Agarwal R, Morin P. Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem. 2005;280:26233-40 pubmed
  48. Galban S, Martindale J, Mazan-Mamczarz K, Lopez de Silanes I, Fan J, Wang W, et al. Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol. 2003;23:7083-95 pubmed
  49. Chatoo W, Abdouh M, David J, Champagne M, Ferreira J, Rodier F, et al. The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci. 2009;29:529-42 pubmed publisher
  50. Mauerer R, Ebert S, Langmann T. High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages. Exp Mol Med. 2009;41:126-32 pubmed
  51. Moroz E, Carlin S, Dyomina K, Burke S, Thaler H, Blasberg R, et al. Real-time imaging of HIF-1alpha stabilization and degradation. PLoS ONE. 2009;4:e5077 pubmed publisher
  52. Lin J, Lin L, Thomas D, Greenson J, Giordano T, Robinson G, et al. Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. Clin Cancer Res. 2004;10:5708-16 pubmed
  53. Ramachandran S, Chahwan R, Nepal R, Frieder D, Panier S, Roa S, et al. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proc Natl Acad Sci U S A. 2010;107:809-14 pubmed publisher
  54. Kasembeli M, Lau W, Roh S, Eckols T, Frydman J, Chiu W, et al. Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol. 2014;12:e1001844 pubmed publisher
  55. Miralem T, Avraham H. Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus. Mol Cell Biol. 2003;23:579-93 pubmed
  56. Li Y, Wright J, Qian F, Germino G, Guggino W. Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. J Biol Chem. 2005;280:41298-306 pubmed
  57. John G, Chen L, Rivieccio M, Melendez-Vasquez C, Hartley A, Brosnan C. Interleukin-1beta induces a reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis. J Neurosci. 2004;24:2837-45 pubmed
  58. Ducker C, Upson J, French K, Smith C. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Mol Cancer Res. 2005;3:463-76 pubmed
  59. Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, et al. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum Mol Genet. 2003;12:2625-35 pubmed
  60. Delloye-Bourgeois C, Gibert B, Rama N, Delcros J, Gadot N, Scoazec J, et al. Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PLoS Biol. 2013;11:e1001623 pubmed publisher
  61. Yoshii T, Fukumori T, Honjo Y, Inohara H, Kim H, Raz A. Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest. J Biol Chem. 2002;277:6852-7 pubmed
  62. Kiessling S, Muller-Newen G, Leeb S, Hausmann M, Rath H, Strater J, et al. Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells. J Biol Chem. 2004;279:10304-15 pubmed
  63. Kuwada S, Kuang J, Li X. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. J Biol Chem. 2005;280:19027-35 pubmed
  64. Trojer P, Zhang J, Yonezawa M, Schmidt A, Zheng H, Jenuwein T, et al. Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem. 2009;284:8395-405 pubmed publisher
  65. Jackson M, Agarwal M, Yang J, Bruss P, Uchiumi T, Agarwal M, et al. p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2. J Cell Sci. 2005;118:1821-32 pubmed
  66. Yao P, Potdar A, Ray P, Eswarappa S, Flagg A, Willard B, et al. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS Biol. 2013;11:e1001635 pubmed publisher
  67. Forte E, Luftig M. MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival. J Virol. 2009;83:2491-9 pubmed publisher
  68. Liu Y, Fang Y, Shao H, Lindsey-Boltz L, Sancar A, Modrich P. Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. J Biol Chem. 2010;285:5974-82 pubmed publisher
  69. Wu W, Wang X, Zhang W, Reed W, Samet J, Whang Y, et al. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. J Biol Chem. 2003;278:28258-63 pubmed
  70. Camden J, Schrader A, Camden R, Gonzalez F, Erb L, Seye C, et al. P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing. J Biol Chem. 2005;280:18696-702 pubmed
  71. Yin J, Kwon Y, Varshavsky A, Wang W. RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum Mol Genet. 2004;13:2421-30 pubmed
  72. Valley C, Métivier R, Solodin N, Fowler A, Mashek M, Hill L, et al. Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus. Mol Cell Biol. 2005;25:5417-28 pubmed
  73. Li M, Zhou J, Ge Y, Matherly L, Wu G. The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem. 2003;278:41059-68 pubmed
  74. Cassimeris L, Morabito J. TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol Biol Cell. 2004;15:1580-90 pubmed
  75. Maston G, Zhu L, Chamberlain L, Lin L, Fang M, Green M. Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. elife. 2012;1:e00068 pubmed publisher
  76. Maine G, Mao X, Muller P, Komarck C, Klomp L, Burstein E. COMMD1 expression is controlled by critical residues that determine XIAP binding. Biochem J. 2009;417:601-9 pubmed publisher
  77. Tapinos N, Rambukkana A. Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli. Proc Natl Acad Sci U S A. 2005;102:9188-93 pubmed
  78. Wu J, Huen M, Lu L, Ye L, Dou Y, Ljungman M, et al. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol. 2009;29:849-60 pubmed publisher
  79. Wang X, Li H, Van Putten V, Winn R, Heasley L, Nemenoff R. Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Mol Biol Cell. 2009;20:791-800 pubmed publisher
  80. Benita Y, Kikuchi H, Smith A, Zhang M, Chung D, Xavier R. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009;37:4587-602 pubmed publisher
  81. Cartron P, Juin P, Oliver L, Martin S, Meflah K, Vallette F. Nonredundant role of Bax and Bak in Bid-mediated apoptosis. Mol Cell Biol. 2003;23:4701-12 pubmed
  82. Zhu J, Goldoni S, Bix G, Owens R, McQuillan D, Reed C, et al. Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem. 2005;280:32468-79 pubmed
  83. Master Z, Tran J, Bishnoi A, Chen S, Ebos J, Van Slyke P, et al. Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization. J Biol Chem. 2003;278:30170-9 pubmed
  84. Nakamura S, Roth J, Mukhopadhyay T. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. Mol Cell Biol. 2000;20:9391-8 pubmed
  85. Alberghini A, Recalcati S, Tacchini L, Santambrogio P, Campanella A, Cairo G. Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. J Biol Chem. 2005;280:30120-8 pubmed
  86. Suh E, Ha C, Rankin E, Toyota M, Traber P. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. J Biol Chem. 2002;277:35795-800 pubmed
  87. Eagle R, Flack G, Warford A, Martinez-Borra J, Jafferji I, Traherne J, et al. Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G. PLoS ONE. 2009;4:e4503 pubmed publisher
  88. Zhang A, West A, Wyman A, Bjorkman P, Enns C. Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells. J Biol Chem. 2005;280:33885-94 pubmed
  89. Orbán-Németh Z, Simader H, Badurek S, Trancikova A, Propst F. Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family. J Biol Chem. 2005;280:2257-65 pubmed
  90. Jiang X, Stuible M, Chalandon Y, Li A, Chan W, Eisterer W, et al. Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood. 2003;102:2976-84 pubmed
  91. Fujita M, Khazenzon N, Bose S, Sekiguchi K, Sasaki T, Carter W, et al. Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases. Breast Cancer Res. 2005;7:R411-21 pubmed
  92. Saito A, Hayashi T, Okuno S, Ferrand-Drake M, Chan P. Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. J Neurosci. 2003;23:1710-8 pubmed
  93. Ward I, Minn K, Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem. 2004;279:9677-80 pubmed
  94. Griffin B, Moynagh P. Persistent interleukin-1beta signaling causes long term activation of NFkappaB in a promoter-specific manner in human glial cells. J Biol Chem. 2006;281:10316-26 pubmed
  95. Zampieri M, Passananti C, Calabrese R, Perilli M, Corbi N, De Cave F, et al. Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity. PLoS ONE. 2009;4:e4717 pubmed publisher
  96. Zhong X, Ding J, Adams J, Ghosh G, Fu X. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009;23:482-95 pubmed publisher
  97. Adhikari D, Zheng W, Shen Y, Gorre N, Hamalainen T, Cooney A, et al. Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet. 2010;19:397-410 pubmed publisher
  98. Wang C, Ng C, Shi H, Liew H, Guo K, Zeng Q, et al. A role for VAMP8/endobrevin in surface deployment of the water channel aquaporin 2. Mol Cell Biol. 2010;30:333-43 pubmed publisher
  99. Ni J, McLoughlin R, Brodovitch A, Moulin P, Brouckaert P, Casadei B, et al. Nitric oxide synthase isoforms play distinct roles during acute peritonitis. Nephrol Dial Transplant. 2010;25:86-96 pubmed publisher
  100. Giaime E, Sunyach C, Druon C, Scarzello S, Robert G, Grosso S, et al. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ. 2010;17:158-69 pubmed publisher
  101. Aumais J, Williams S, Luo W, Nishino M, Caldwell K, Caldwell G, et al. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci. 2003;116:1991-2003 pubmed
  102. Kanekura K, Hashimoto Y, Kita Y, Sasabe J, Aiso S, Nishimoto I, et al. A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J Biol Chem. 2005;280:4532-43 pubmed
  103. Dublet B, Ruello A, Pederzoli M, Hajjar E, Courbebaisse M, Canteloup S, et al. Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site. J Biol Chem. 2005;280:30242-53 pubmed
  104. Monami G, Emiliozzi V, Bitto A, Lovat F, Xu S, Goldoni S, et al. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am J Pathol. 2009;174:1037-47 pubmed publisher
  105. Albrecht V, Hofer T, Foxwell B, Frankenberger M, Ziegler-Heitbrock L. Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. BMC Immunol. 2008;9:69 pubmed publisher
  106. Chae Y, Kang S, Kim M, Woo J, Lee J, Chang S, et al. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS ONE. 2008;3:e2594 pubmed publisher
  107. Arenas F, Hervias I, Uriz M, Joplin R, Prieto J, Medina J. Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J Clin Invest. 2008;118:695-709 pubmed publisher
  108. Lopes L, Furnish E, Komalavilas P, Flynn C, Ashby P, Hansen A, et al. Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. J Invest Dermatol. 2009;129:590-8 pubmed publisher
  109. Winklmeier A, Poser I, Hoek K, Bosserhoff A. Loss of full length CtBP1 expression enhances the invasive potential of human melanoma. BMC Cancer. 2009;9:52 pubmed publisher
  110. Basu S, Liu Q, Qiu Y, Dong F. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. Proc Natl Acad Sci U S A. 2009;106:1433-8 pubmed publisher
  111. Topisirovic I, Siddiqui N, Orolicki S, Skrabanek L, Tremblay M, Hoang T, et al. Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer. Mol Cell Biol. 2009;29:1152-62 pubmed publisher
  112. Hahn-Windgassen A, Nogueira V, Chen C, Skeen J, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005;280:32081-9 pubmed
  113. Tripathi M, Misra S, Khedkar S, Hamilton N, Irvin-Wilson C, Sharan C, et al. Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J Biol Chem. 2005;280:17163-71 pubmed
  114. Kaabeche K, Guenou H, Bouvard D, Didelot N, Listrat A, Marie P. Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. J Cell Sci. 2005;118:1223-32 pubmed
  115. Zhang J, Zhu J, Bu X, Cushion M, Kinane T, Avraham H, et al. Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Mol Biol Cell. 2005;16:824-34 pubmed
  116. West A, Moore D, Biskup S, Bugayenko A, Smith W, Ross C, et al. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A. 2005;102:16842-7 pubmed
  117. Wang H, Zhao L, Li K, Ling R, Li X, Wang L. Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer. BMC Cancer. 2006;6:91 pubmed
  118. Bonnal S, Pileur F, Orsini C, Parker F, Pujol F, Prats A, et al. Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA. J Biol Chem. 2005;280:4144-53 pubmed
  119. Vicent S, Garayoa M, Lopez-Picazo J, Lozano M, Toledo G, Thunnissen F, et al. Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients. Clin Cancer Res. 2004;10:3639-49 pubmed
  120. Lukong K, Larocque D, Tyner A, Richard S. Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression. J Biol Chem. 2005;280:38639-47 pubmed
  121. Li J, O'CONNOR K, Greeley G, Blackshear P, Townsend C, Evers B. Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway. J Biol Chem. 2005;280:8351-7 pubmed
  122. Umenishi F, Schrier R. Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene. J Biol Chem. 2003;278:15765-70 pubmed
  123. Samanta A, Huang H, Bast R, Liao W. Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. J Biol Chem. 2004;279:7576-83 pubmed
  124. Rosato R, Almenara J, Dai Y, Grant S. Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells. Mol Cancer Ther. 2003;2:1273-84 pubmed
  125. Ballestrero A, Nencioni A, Boy D, Rocco I, Garuti A, Mela G, et al. Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells. Clin Cancer Res. 2004;10:1463-70 pubmed
  126. Abid M, Schoots I, Spokes K, Wu S, Mawhinney C, Aird W. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J Biol Chem. 2004;279:44030-8 pubmed
  127. Choi S, Kim M, Kang C, Bae S, Cho C, Soh J, et al. Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells. J Biol Chem. 2006;281:7049-59 pubmed
  128. Naderi S, Gutzkow K, Låhne H, Lefdal S, Ryves W, Harwood A, et al. cAMP-induced degradation of cyclin D3 through association with GSK-3beta. J Cell Sci. 2004;117:3769-83 pubmed
  129. McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, et al. A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. J Clin Invest. 2003;111:51-60 pubmed
  130. Comi A, Hunt P, Vawter M, Pardo C, Becker K, Pevsner J. Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue. Pediatr Res. 2003;53:762-9 pubmed
  131. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006;281:7863-72 pubmed
  132. Noels H, Somers R, Liu H, Ye H, Du M, De Wolf-Peeters C, et al. Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma. PLoS ONE. 2009;4:e4822 pubmed publisher
  133. Kepp O, Gottschalk K, Churin Y, Rajalingam K, Brinkmann V, Machuy N, et al. Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection. PLoS Pathog. 2009;5:e1000348 pubmed publisher
  134. Addabbo F, Ratliff B, Park H, Kuo M, Ungvari Z, Csiszar A, et al. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am J Pathol. 2009;174:34-43 pubmed publisher
  135. Gonzalez-Navajas J, Fine S, Law J, Datta S, Nguyen K, Yu M, et al. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest. 2010;120:570-81 pubmed publisher
  136. Fujimoto T, Miyasaka K, Koyanagi M, Tsunoda T, Baba I, Doi K, et al. Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. PLoS ONE. 2009;4:e4240 pubmed publisher
  137. Lim S, Rogers T, Chan T, Whitney J, Kim J, Sodroski J, et al. TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys. PLoS Pathog. 2010;6:e1000738 pubmed publisher
  138. Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, et al. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest. 2010;120:115-26 pubmed publisher
  139. Mracek T, Gao D, Tzanavari T, Bao Y, Xiao X, Stocker C, et al. Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes. J Endocrinol. 2010;204:165-72 pubmed publisher
  140. Yang H, Grossniklaus H. Constitutive overexpression of pigment epithelium-derived factor inhibition of ocular melanoma growth and metastasis. Invest Ophthalmol Vis Sci. 2010;51:28-34 pubmed publisher
  141. Maier B, Wendt S, Vanselow J, Wallach T, Reischl S, Oehmke S, et al. A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes Dev. 2009;23:708-18 pubmed publisher
  142. Yang Z, MacQuarrie K, Analau E, Tyler A, Dilworth F, Cao Y, et al. MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state. Genes Dev. 2009;23:694-707 pubmed publisher
  143. Marlin J, Eaton A, Montano G, Chang Y, Jakobi R. Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death. Neoplasia. 2009;11:286-97 pubmed
  144. Pearce C, Hayden R, Bunce C, Khanim F. Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy. BMC Cell Biol. 2009;10:31 pubmed publisher
  145. Settembre C, Di Malta C, Polito V, Garcia Arencibia M, Vetrini F, Erdin S, et al. TFEB links autophagy to lysosomal biogenesis. Science. 2011;332:1429-33 pubmed publisher
  146. Purvis J, Karhohs K, Mock C, Batchelor E, Loewer A, Lahav G. p53 dynamics control cell fate. Science. 2012;336:1440-4 pubmed publisher
  147. Lee I, Kawai Y, Fergusson M, Rovira I, Bishop A, Motoyama N, et al. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science. 2012;336:225-8 pubmed publisher
  148. Kalyuga M, Gallego-Ortega D, Lee H, Roden D, Cowley M, Caldon C, et al. ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biol. 2012;10:e1001461 pubmed publisher
  149. Wang F, He L, Huangyang P, Liang J, Si W, Yan R, et al. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biol. 2014;12:e1001819 pubmed publisher
  150. Sancho R, Blake S, Tendeng C, Clurman B, Lewis J, Behrens A. Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol. 2013;11:e1001586 pubmed publisher
  151. Lundgaard I, Luzhynskaya A, Stockley J, Wang Z, Evans K, Swire M, et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol. 2013;11:e1001743 pubmed publisher
  152. Zhou H, Kaplan T, Li Y, Grubisic I, Zhang Z, Wang P, et al. Dual functions of TAF7L in adipocyte differentiation. elife. 2013;2:e00170 pubmed publisher
  153. Charvet C, Canonigo A, Billadeau D, Altman A. Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. J Biol Chem. 2005;280:15289-99 pubmed
  154. Yang C, Lin H, Chen C, Yang Y, Tseng P, Rangnekar V, et al. Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells. J Biol Chem. 2003;278:25872-8 pubmed
  155. Zhang J, Shridhar R, Dai Q, Song J, Barlow S, Yin L, et al. Cystatin m: a novel candidate tumor suppressor gene for breast cancer. Cancer Res. 2004;64:6957-64 pubmed
  156. Holtz J, Pasquinelli A. Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans. RNA. 2009;15:400-5 pubmed publisher
  157. Haller D, Holt L, Kim S, Schwabe R, Sartor R, Jobin C. Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. J Biol Chem. 2003;278:23851-60 pubmed
  158. Rajarajacholan U, Thalappilly S, Riabowol K. The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. PLoS Biol. 2013;11:e1001502 pubmed publisher
  159. Vander Griend D, D'Antonio J, Gurel B, Antony L, DeMarzo A, Isaacs J. Cell-autonomous intracellular androgen receptor signaling drives the growth of human prostate cancer initiating cells. Prostate. 2010;70:90-9 pubmed publisher
  160. Reddy J, Peddibhotla S, Bu W, Zhao J, Haricharan S, Du Y, et al. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A. 2010;107:3728-33 pubmed publisher
  161. Dimitrijevic I, Edvinsson M, Chen Q, Malmsjo M, Kimblad P, Edvinsson L. Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease. BMC Cardiovasc Disord. 2009;9:40 pubmed publisher
  162. Del Vecchio C, Feng Y, Sokol E, Tillman E, Sanduja S, Reinhardt F, et al. De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling. PLoS Biol. 2014;12:e1001945 pubmed publisher
  163. Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat K, et al. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. elife. 2014;3:e03245 pubmed publisher
  164. Werner A, de Vries E, Tait S, Bontjer I, Borst J. Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax. J Biol Chem. 2002;277:22781-8 pubmed
  165. Dai Y, Rahmani M, Corey S, Dent P, Grant S. A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2. J Biol Chem. 2004;279:34227-39 pubmed
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