This is a review about Shc, based on 18 published articles (read how Labome selects the articles), using Shc antibody in all methods. It is aimed to help Labome visitors find the most suited Shc antibody.
Shc synonym: SHC; SHCA; SH2 domain protein C1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A

Cell Signaling TechnologyCell Signaling Technology Shc product
  • immunoprecipitationIn 2009, Francesco E Boccalatte et al. utilized Cell Signaling Technology Shc antibody to perform to western blot and immunoprecipitation in order to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma [ncbi , more ].
  • western blotIn 2012, Shira Knafo et al. employed Cell Signaling Technology Shc antibody to perform western blot in order to study the effect of the facilitation of AMPA receptor synaptic delivery on cognitive enhancement [ncbi , more ]. In 2011, Iakovos Lazaridis et al. utilized Cell Signaling Technology Shc antibody to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors [ncbi , more ]. In 2009, Francesco E Boccalatte et al. utilized Cell Signaling Technology Shc antibody to perform to western blot and immunoprecipitation in order to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma [ncbi , more ]. Tushar B Deb et al. utilized Cell Signaling Technology Shc antibody to perform western blot in order to study the role of calmodulin kinase in ligand-independent EGFR degradation in pregnancy [ncbi , more ] in 2008 and Linda Yu et al. used Cell Signaling Technology Shc antibody to study the role for expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in mediating uterine leiomyoma growth [ncbi , more ].
EMD MilliporeEMD Millipore Shc product
  • immunoprecipitationIn 2005, Patrick A Kiely et al. applied EMD Millipore Shc antibody to study cells with mutant IGF-I receptor at tyrosines 1250 and 1251 [ncbi , more ]. In 2001, X Pesesse et al. employed EMD Millipore Shc antibody to study inositol 5-phosphatase SHIP2 recruitment in EGF-stimulated COS-7 cells [ncbi , more ].
  • western blotIn 2008, Takashi Nakakuki et al. utilized EMD Millipore Shc antibody to study the role of PAX4 in the beta-cell differentiation of human embryonic stem cells [ncbi , more ]. In 2005, Patrick A Kiely et al. applied EMD Millipore Shc antibody to study cells with mutant IGF-I receptor at tyrosines 1250 and 1251 [ncbi , more ]. In 2004, Dayanand D Deo et al. used EMD Millipore Shc antibody to study the role for the activation of the PAF receptor in inducing a specific receptor-associated pertussis toxin-insensitive G q protein in HUVECs [ncbi , more ]. In 2002, Maya Groysman et al. used EMD Millipore Shc antibody to study the interaction of Vav1 and Ly-GDI function as signal transducers in T cell antigen receptor-induced pathways [ncbi , more ]. In 2001, X Pesesse et al. employed EMD Millipore Shc antibody to study inositol 5-phosphatase SHIP2 recruitment in EGF-stimulated COS-7 cells [ncbi , more ].
R and D SystemsR and D Systems Shc product
  • western blotIn 2006, Wataru Matsuyama et al. utilized R and D Systems Shc antibody to study the effect of discoidin domain receptor 1 on the survival of lung fibroblast in idiopathic pulmonary fibrosis in human lung fibroblasts [ncbi , more ].
Thermo Scientific Pierce ProductsThermo Scientific Pierce Products Shc product
  • western blotIn 2001, X Pesesse et al. employed Thermo Scientific Pierce Products Shc antibody to study inositol 5-phosphatase SHIP2 recruitment in EGF-stimulated COS-7 cells [ncbi , more ].
Santa Cruz BiotechnologySanta Cruz Biotechnology Shc product
  • immunohistochemistryIn 2008, Hiroshi Honda et al. employed Santa Cruz Biotechnology Shc antibody to perform immunohistochemistry in dilution 1:300 in order to show that AXL and SHC1 expression disregulation may be associated with pathogenesis of endometriosis [ncbi , more ].
  • western blotIn 2002, Mihail S Iordanov et al. used Santa Cruz Biotechnology Shc antibody to study the association of the activated EGFR with ShcA, Grb2, and a p55 PI3K [ncbi , more ].
BD Biosciences
  • immunoprecipitationIn 2005, Yan Ling et al. employed BD Biosciences Shc antibody to study SHPS-1 in the regulation of insulin-like growth factor I which stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells [ncbi , more ]. Yu Li et al. utilized BD Biosciences Shc antibody to detect Shc in CHO cell expressing the IR and IRS-1 transfected with MOR [ncbi , more ] in 2003 and Olexandr Voytyuk et al. used BD Biosciences Shc antibody to study the biological function of c-Kit [ncbi , more ]. In 2001, C Sweeney et al. employed BD Biosciences Shc antibody to study growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors [ncbi , more ].
  • western blotYan Ling et al. employed BD Biosciences Shc antibody to study SHPS-1 in the regulation of insulin-like growth factor I which stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells [ncbi , more ] in 2005 and Patrick A Kiely et al. used BD Biosciences Shc antibody to study cells with mutant IGF-I receptor at tyrosines 1250 and 1251 [ncbi , more ]. Yu Li et al. utilized BD Biosciences Shc antibody to detect Shc in CHO cell expressing the IR and IRS-1 transfected with MOR [ncbi , more ] in 2003 and Olexandr Voytyuk et al. used BD Biosciences Shc antibody to study the biological function of c-Kit [ncbi , more ]. N J Hellyer et al. utilized BD Biosciences Shc antibody to detect the presence of Shc in ErbB3 immunoprecipitates from COS7 cells [ncbi , more ] in 2001 and C Sweeney et al. used BD Biosciences Shc antibody to study growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors [ncbi , more ].
Articles Reviewed
  1. Shira Knafo et al. (2012). "Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement".PMID 22363206
  2. Iakovos Lazaridis et al. (2011). "Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis".PMID 21541365
  3. Hiroshi Honda et al. (2008). "Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis".PMID 19055724
  4. Francesco E Boccalatte et al. (2009). "The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL".PMID 18845790
  5. Tushar B Deb et al. (2008). "Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation".PMID 18562482
  6. Takashi Nakakuki et al. (2008). "Topological analysis of MAPK cascade for kinetic ErbB signaling".PMID 18335053
  7. Linda Yu et al. (2008). "Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas".PMID 18231572
  8. Wataru Matsuyama et al. (2006). "Discoidin domain receptor 1 contributes to the survival of lung fibroblast in idiopathic pulmonary fibrosis".PMID 16507902
  9. Yan Ling et al. (2005). "Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells".PMID 15888547
  10. Patrick A Kiely et al. (2005). "RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251".PMID 15611085
  11. Dayanand D Deo et al. (2004). "Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells".PMID 14617636
  12. Yu Li et al. (2003). "Morphine induces desensitization of insulin receptor signaling".PMID 12917346
  13. Olexandr Voytyuk et al. (2003). "Src family kinases are involved in the differential signaling from two splice forms of c-Kit".PMID 12511554
  14. Maya Groysman et al. (2002). "Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways".PMID 12386169
  15. Mihail S Iordanov et al. (2002). "The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor".PMID 12101233
  16. N J Hellyer et al. (2001). "Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor".PMID 11546794
  17. X Pesesse et al. (2001). "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells".PMID 11349134
  18. C Sweeney et al. (2001). "Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors".PMID 11297548