This is a review about STAT2, based on 10 published articles (read how Labome selects the articles), using STAT2 antibody in all methods. It is aimed to help Labome visitors find the most suited STAT2 antibody.
STAT2 synonym: ISGF-3; P113; STAT113; interferon alpha induced transcriptional activator; signal transducer and activator of transcription 2

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Santa Cruz BiotechnologySanta Cruz Biotechnology STAT2 product
  • EMSAIn 2006, Mariko Tomita et al. employed Santa Cruz Biotechnology STAT2 antibody to study the effect of Jak-Stat pathway on cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells [ncbi , more ].
  • immunocytochemistryIn 2003, Omar Tliba et al. utilized Santa Cruz Biotechnology STAT2 antibody to study airway smooth muscle function modulation [ncbi , more ].
  • immunoprecipitationOmar Tliba et al. utilized Santa Cruz Biotechnology STAT2 antibody to study airway smooth muscle function modulation [ncbi , more ] in 2003 and Joe F Lau et al. used Santa Cruz Biotechnology STAT2 antibody to study interferon (IFN) induced signal transduction and transcription activation complex [ncbi , more ]. In 2001, D M Stewart et al. utilized Santa Cruz Biotechnology STAT2 antibody to study the effects of IFNtau on signal transducer and activator of transcription (STAT) activation, expression, DNA binding, and transcriptional activation using an ovine endometrial epithelial cell line (catalog: sc-476) [ncbi , more ].
  • western blotIn 2009, Oliver H Kramer et al. utilized Santa Cruz Biotechnology STAT2 antibody to investigate the role of phosphorylation-acetylation switch in the regulation of STAT1 signaling [ncbi , more ]. In 2008, Aparna Ramachandran et al. used Santa Cruz Biotechnology STAT2 antibody to demonstrate that STAT2 is a primary target for measles virus V protein-mediated Alpha/Beta interferon signaling inhibition [ncbi , more ]. In 2006, Limin Shang et al. used Santa Cruz Biotechnology STAT2 antibody to study the role for heat shock protein 90-CDC37 chaperone complex in types I and II interferon pathways [ncbi , more ]. In 2005, Masato Moriguchi et al. utilized Santa Cruz Biotechnology STAT2 antibody to study CXCL12 signaling [ncbi , more ]. Omar Tliba et al. utilized Santa Cruz Biotechnology STAT2 antibody to study airway smooth muscle function modulation [ncbi , more ] in 2003 and Joe F Lau et al. used Santa Cruz Biotechnology STAT2 antibody to study interferon (IFN) induced signal transduction and transcription activation complex [ncbi , more ].
EMD MilliporeEMD Millipore STAT2 product
  • western blotIn 2008, Eva K Pauli et al. utilized EMD Millipore STAT2 antibody to perform western blot in order to show that IFN signaling could be inhibited by influenza A viruses through SOCS3 upregulation by NF-kappaB [ncbi , more , fig ]. In 2006, Limin Shang et al. used EMD Millipore STAT2 antibody to study the role for heat shock protein 90-CDC37 chaperone complex in types I and II interferon pathways [ncbi , more ]. In 2001, A H Wong et al. used EMD Millipore STAT2 antibody to study the novel function of STAT1 as an inhibitor of PKR activation and eIF-2alpha phosphorylation [ncbi , more ].
Figure
Upstate anti-phospho-STAT2 was used to perform western blot in order to show that IFN signaling could be inhibited by influenza A viruses through SOCS3 upregulation by NF-kappaB.
STAT2 antibody western blot EMD Millipore
HEK293 cells were transfected with 500 ng plasmid DNA for expression of viral NP, M, NS.48 h post transfection cells were stimulated with human IFNbeta (500 U/ml) for 15 minutes. Total protein lysates were subjected to Western blot analysis using anti-phospho-STAT1, anti-phospho-STAT2, anti-STAT1 antibodies. Expression of influenza viral proteins was monitored with antibodies against NP, M1, NS1
Eva K Pauli et al. (2008). "Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression".PMID 18989459
Articles Reviewed
  1. Oliver H Kramer et al. (2009). "A phosphorylation-acetylation switch regulates STAT1 signaling".PMID 19171783
  2. Eva K Pauli et al. (2008). "Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression".PMID 18989459
  3. Aparna Ramachandran et al. (2008). "STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition".PMID 18579593
  4. Mariko Tomita et al. (2006). "Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells".PMID 16603085
  5. Limin Shang et al. (2006). "The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons".PMID 16280321
  6. Masato Moriguchi et al. (2005). "CXCL12 signaling is independent of Jak2 and Jak3".PMID 15611059
  7. Omar Tliba et al. (2003). "Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta".PMID 14519761
  8. Joe F Lau et al. (2003). "Role of metazoan mediator proteins in interferon-responsive transcription".PMID 12509459
  9. A H Wong et al. (2001). "Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR".PMID 11278865
  10. D M Stewart et al. (2001). "Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells".PMID 11145571