This is a review about SHP-2, based on 30 published articles (read how Labome selects the articles), using SHP-2 antibody in all methods. It is aimed to help Labome visitors find the most suited SHP-2 antibody.
SHP-2 synonym: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; PTP-2C; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C

Santa Cruz Biotechnology
mouse monoclonal (B-1)
  • WB; human
In order to study the role of Src homology phosphotyrosyl phosphatase 2 (SHP2) in triple negative breast cancers, Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, SC-7384) was used in western blot on human samples. BMC Cancer (2015) ncbi
mouse monoclonal (NS1-23-1)
  • WB; dog
In order to study cell tropism and virus spread in vivo is with an influenza virus expressing a reporter gene, Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, sc-130568) was used in western blot on dog samples. PLoS ONE (2015) ncbi
mouse monoclonal (NS1-23-1)
  • WB; human; fig 1
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz, sc-130568) was used in western blot on human samples (fig 1). J Virol (2015) ncbi
rabbit polyclonal (C-18)
  • WB; human
In order to identify binding partners ANKHD1 in leukemia cells, Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, sc-280) was used in western blot on human samples. Biochim Biophys Acta (2015) ncbi
rabbit polyclonal (C-18)
  • WB; human
Santa Cruz Biotechnology SHP-2 antibody (Santa, sc-280) was used in western blot on human samples. J Biol Chem (2014) ncbi
mouse monoclonal (B-1)
  • WB; human
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, sc-7384) was used in western blot on human samples. Proteomics (2015) ncbi
mouse monoclonal (NS1-23-1) Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz, sc-130568) was used . Virus Res (2014) ncbi
rabbit polyclonal (C-18)
  • IP; human
  • WB; human
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, SC-280) was used in immunoprecipitation on human samples and in western blot on human samples. PLoS ONE (2014) ncbi
mouse monoclonal (B-1)
  • WB; human
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz, sc-7384) was used in western blot on human samples. J Biol Chem (2013) ncbi
rabbit polyclonal (C-18)
  • IP; mouse
  • WB; mouse
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, SC280) was used in immunoprecipitation on mouse samples and in western blot on mouse samples. Int J Oncol (2013) ncbi
mouse monoclonal (NS1-23-1)
  • WB; Influenza A virus; 1:2000
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz, sc-130568) was used in western blot on Influenza A virus samples at 1:2000. PLoS ONE (2012) ncbi
not indicated
  • WB; human
Santa Cruz Biotechnology polyclonal anti-Shp2 antibody was used to perform western blot in order to study Notch signaling auto-amplification in macrophages which was regulated by TLR and RBP-J.J Immunol (2010) ncbi
not indicated
  • WB; human
Santa Cruz Biotechnology anti-SHP-2 polyclonal antibody was used in western blot in order to demonstrate that Lyn can inhibit osteoclast formation.Proc Natl Acad Sci U S A (2009) ncbi
mouse monoclonal (B-1)
  • WB; human
Santa Cruz Biotechnology SHP2 antibody was used for western blot in order to investigate the role of phosphorylation-acetylation switch in the regulation of STAT1 signaling.Genes Dev (2009) ncbi
rabbit polyclonal (C-18)
  • WB; human
Santa Cruz Biotechnology SHP-2 antibody (Santa Cruz Biotechnology, sc-280) was used in western blot on human samples. J Immunol (2007) ncbi
not indicated
  • WB; human
  • IP; human
Santa Cruz Biotechnology SHP-2 antibody was used in western blot and immunoprecipitation to demonstrate that KLRG1 differentially regulates NK cell and T cell functions.Int Immunol (2007) ncbi
not indicated
  • WB; human
Santa Cruz anti-SHP-2 antibody was used in western blot to study the role of leukocyte-associated Ig-like receptor-1.Eur J Immunol (2006) ncbi
not indicated
  • WB; human
SCBT monoclonal Shp-2 antibody was used in western blot to investigate the induction of IL-8 by the Helicobacter pylori CagA proteinProc Natl Acad Sci U S A (2005) ncbi
not indicated
  • WB; human
  • IP; human
Santa Cruz Biotechnology SHP2 antibody was used in western blot and immunoprecipitation to show that the liver is a major site of the peripheral action of PTP1B in regulating glucose homeostasis.J Biol Chem (2005) ncbi
EMD Millipore
not indicated
  • WB; human
Upstate SHP-2 antibody was used in western blot to study the association of ILT2 and murine MHC class I molecules in vivo.Eur J Immunol (2006) ncbi
not indicated
  • WB; human
Upstate Biotechnology anti-Shp-2 polyclonal antibody was used in western blot to study cells with mutant IGF-I receptor at tyrosines 1250 and 1251J Biol Chem (2005) ncbi
Cell Signaling Technology
rabbit monoclonal (D66F10)
  • WB; mouse; 1:1000; fig 4
In order to study phosphorylation events at sites of adhesion, Cell Signaling Technology SHP-2 antibody (Cell Signaling Technology, 5431S) was used in western blot on mouse samples at 1:1000 (fig 4). Nat Commun (2015) ncbi
rabbit polyclonal
  • WB; human
In order to identify binding partners ANKHD1 in leukemia cells, Cell Signaling Technology SHP-2 antibody (Cell Signaling Technology, 3751S) was used in western blot on human samples. Biochim Biophys Acta (2015) ncbi
rabbit polyclonal
  • WB; human
Cell Signaling Technology SHP-2 antibody (Cell Signaling, 3751) was used in western blot on human samples. Cancer Res (2013) ncbi
rabbit monoclonal (D50F2)
  • WB; human
Cell Signaling Technology SHP-2 antibody (Cell Signaling, 3397) was used in western blot on human samples. Am J Physiol Renal Physiol (2013) ncbi
not indicated
  • FC; human
Cell Signaling Technology anti-Shp2 (pY580) was used in 2ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry.Science (2011) ncbi
not indicated
  • WB; human
  • IP; human
Cell Signaling Technology rabbit anti-SHP2 (1:1000) and anti-phospho-SHP2 (Tyr 542) (1:1000) antibodies were used to perform to western blot and immunoprecipitation in order to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma.Blood (2009) ncbi
BD Biosciences
mouse monoclonal (79/PTP1D/SHP2)
  • WB; common platanna; fig s12
In order to investigate the role of cardiac transcription factor CASTOR (CASZ1) in heart development, BD Biosciences SHP-2 antibody (BD Transduction Laboratories, 610622) was used in western blot on common platanna samples (fig s12). Development (2014) ncbi
mouse monoclonal (79/PTP1D/SHP2)
  • WB; human
BD Biosciences mouse anti-SHP-2 antibody was used to perform western blot in order to investigate the role of PVRL4 in tumor progression.elife (2013) ncbi
not indicated
  • WB; human
BD Biosciences anti-Shp2 monoclonal antobody was used in western blot in order to study the function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clustersBMC Neurosci (2008) ncbi
not indicated
  • WB; human
BD Transduction Labs anti-SHP-2 antibody was used in western blot to study positive and negative signaling by the natural killer cell receptor 2B4 (CD244).Blood (2005) ncbi
Articles Reviewed
  1. Hua Zhao et al. (2015). "Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment".PMID 25885600
  2. Sarah De Baets et al. (2015). "A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody".PMID 25816132
  3. Joseph Robertson et al. (2015). "Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling".PMID 25677187
  4. Shih Feng Hsu et al. (2015). "A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication".PMID 25589657
  5. João Agostinho Machado-Neto et al. (2015). "ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells".PMID 25523139
  6. Ceren Ozek et al. (2014). "Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling".PMID 25288805
  7. Nerea Osinalde et al. (2015). "Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics".PMID 25142963
  8. Stephen Sojka et al. (2014). "Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity".PMID 24993940
  9. Alejandra Lara-Sampablo et al. (2014). "Transfection of influenza A virus nuclear export protein induces the expression of tumor necrosis factor alpha".PMID 24657783
  10. Toshikage Nagao et al. (2014). "Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera".PMID 24404189
  11. Barbara S Paugh et al. (2013). "Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas".PMID 23970477
  12. Xiaoming Zhou et al. (2013). "High NaCl-induced inhibition of PTG contributes to activation of NFAT5 through attenuation of the negative effect of SHP-1".PMID 23720348
  13. Natalya N Pavlova et al. (2013). "A role for PVRL4-driven cell-cell interactions in tumorigenesis".PMID 23682311
  14. Vittorio Abbonante et al. (2013). "Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions".PMID 23530036
  15. Nan Wu et al. (2013). "PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells".PMID 23233201
  16. Yun Hsiang Chen et al. (2012). "Methamphetamine reduces human influenza A virus replication".PMID 23139774
  17. Sean C Bendall et al. (2011). "Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum".PMID 21551058
  18. Julia Foldi et al. (2010). "Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1".PMID 20870935
  19. Hyun Ju Kim et al. (2009). "The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo".PMID 19171907
  20. Oliver H Kramer et al. (2009). "A phosphorylation-acetylation switch regulates STAT1 signaling".PMID 19171783
  21. Francesco E Boccalatte et al. (2009). "The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL".PMID 18845790
  22. Yueping K Qian et al. (2008). "The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters".PMID 18647419
  23. Nicola Tamassia et al. (2007). "The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4".PMID 17513785
  24. Marlowe S Tessmer et al. (2007). "KLRG1 binds cadherins and preferentially associates with SHIP-1".PMID 17307799
  25. Siyuan Liang et al. (2006). "Human ILT2 receptor associates with murine MHC class I molecules in vivo and impairs T cell function".PMID 16897816
  26. Annelies Verbrugge et al. (2006). "Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase".PMID 16380958
  27. Sabine Brandt et al. (2005). "NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein".PMID 15972330
  28. Philipp Eissmann et al. (2005). "Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)".PMID 15713798
  29. Fawaz G Haj et al. (2005). "Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice".PMID 15699041
  30. Patrick A Kiely et al. (2005). "RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251".PMID 15611085