This is a review about SHP-2, based on 30 published articles (read how Labome selects the articles), using SHP-2 antibody in all methods. It is aimed to help Labome visitors find the most suited SHP-2 antibody.
SHP-2 synonym: BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; PTP-2C; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; tyrosine-protein phosphatase non-receptor type 11

Santa Cruz BiotechnologySanta Cruz Biotechnology SHP-2 product
  • immunocytochemistryIn 2004, Charng Jui Chen et al. used Santa Cruz Biotechnology SHP-2 antibody to study the IL-2 production and proliferation in human T cells inhibited by the cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 [ncbi , more ].
  • immunoprecipitationIn 2007, Marlowe S Tessmer et al. employed Santa Cruz Biotechnology SHP-2 antibody to demonstrate that KLRG1 differentially regulates NK cell and T cell functions [ncbi , more ]. In 2005, Fawaz G Haj et al. employed Santa Cruz Biotechnology SHP-2 antibody to show that the liver is a major site of the peripheral action of PTP1B in regulating glucose homeostasis [ncbi , more ]. In 2004, Matthew L Jones et al. applied Santa Cruz Biotechnology SHP-2 antibody to study regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus [ncbi , more ]. In 2002, Runxiang Zhao et al. employed Santa Cruz Biotechnology SHP-2 antibody to study the role for cell surface glycoprotein PZR in concanavalin A-induced cell signaling [ncbi , more ]. In 2001, S Yamasaki et al. utilized Santa Cruz Biotechnology SHP-2 antibody to study the T cell receptor signaling regulation by docking protein Gab2 [ncbi , more ].
  • western blotIn 2010, Julia Foldi et al. applied Santa Cruz Biotechnology SHP-2 antibody to perform western blot in order to study Notch signaling auto-amplification in macrophages which was regulated by [ncbi , more ]. Hyun Ju Kim et al. utilized Santa Cruz Biotechnology SHP-2 antibody to demonstrate that Lyn can inhibit osteoclast formation [ncbi , more ] in 2009 and Oliver H Kramer et al. used Santa Cruz Biotechnology SHP-2 antibody to investigate the role of phosphorylation-acetylation switch in the regulation of STAT1 signaling (catalog: sc-7384) [ncbi , more ]. In 2007, Marlowe S Tessmer et al. employed Santa Cruz Biotechnology SHP-2 antibody to demonstrate that KLRG1 differentially regulates NK cell and T cell functions [ncbi , more ]. In 2006, Annelies Verbrugge et al. utilized Santa Cruz Biotechnology SHP-2 antibody to study the role of leukocyte-associated Ig-like receptor-1 [ncbi , more ]. Sabine Brandt et al. employed Santa Cruz Biotechnology SHP-2 antibody to investigate the induction of IL-8 by the Helicobacter pylori CagA protein [ncbi , more ] in 2005 and Fawaz G Haj et al. used Santa Cruz Biotechnology SHP-2 antibody to show that the liver is a major site of the peripheral action of PTP1B in regulating glucose homeostasis [ncbi , more ]. Matthew L Jones et al. applied Santa Cruz Biotechnology SHP-2 antibody to study regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus [ncbi , more ] in 2004 and April N Meyer et al. used Santa Cruz Biotechnology SHP-2 antibody to study a novel effector of fibroblast growth factor receptor 3 activation [ncbi , more ]. In 2003, Naoko Kogata et al. applied Santa Cruz Biotechnology SHP-2 antibody to detect SHP-2 in HAECs with adenovirus infection and 293T cells with plasmid DNA transfection [ncbi , more ]. Christine Guntermann et al. employed Santa Cruz Biotechnology SHP-2 antibody to study a potential role for tyrosine phosphatases [ncbi , more ] in 2002 and Armelle Yart et al. used Santa Cruz Biotechnology SHP-2 antibody to study the role of phosphoinositide 3-kinase beta lipid products in LPA-induced Ras activation [ncbi , more ]. Santa Cruz Biotechnology SHP-2 antibody was used in 2001 to study the T cell receptor signaling regulation by docking protein Gab2 [ncbi , more ], to characterize SH2D1A missense mutations in X-linked lymphoproliferative disease patients [ncbi , more ], to study Rap1 signaling activation in endosomes by nerve growth factor [ncbi , more ], to detect SHP-2 in U937 cells retrovirally infected with either empty vector or with Flag-tagged MIS [ncbi , more ]and to detect SHP-2 in the clonal lines of H-35 cells expressing G-CSFR-gp130 containing either 133 residues of the cytoplasmic domain of wild type gp130 [ncbi , more ].
Cell Signaling TechnologyCell Signaling Technology SHP-2 product
  • immunoprecipitationIn 2009, Francesco E Boccalatte et al. utilized Cell Signaling Technology SHP-2 antibody to perform to western blot and immunoprecipitation in order to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma [ncbi , more ].
  • western blotIn 2009, Francesco E Boccalatte et al. utilized Cell Signaling Technology SHP-2 antibody to perform to western blot and immunoprecipitation in order to study the role of ALK in the pathogenesis and the treatment of anaplastic large cell lymphoma [ncbi , more ].
EMD MilliporeEMD Millipore SHP-2 product
  • immunoprecipitationIn 2001, S Yamasaki et al. utilized EMD Millipore SHP-2 antibody to study the T cell receptor signaling regulation by docking protein Gab2 [ncbi , more ].
  • western blotIn 2006, Siyuan Liang et al. used EMD Millipore SHP-2 antibody to study the association of ILT2 and murine MHC class I molecules in vivo [ncbi , more ]. In 2005, Patrick A Kiely et al. applied EMD Millipore SHP-2 antibody to study cells with mutant IGF-I receptor at tyrosines 1250 and 1251 [ncbi , more ]. In 2001, S Yamasaki et al. utilized EMD Millipore SHP-2 antibody to study the T cell receptor signaling regulation by docking protein Gab2 [ncbi , more ].
BD Biosciences
  • immunoprecipitationIn 2004, Margaret S Sozio et al. employed BD Biosciences SHP-2 antibody to study the PTPH1 as a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor subunit [ncbi , more ]. S Yamasaki et al. utilized BD Biosciences SHP-2 antibody to study the T cell receptor signaling regulation by docking protein Gab2 [ncbi , more ] in 2001 and C Sweeney et al. used BD Biosciences SHP-2 antibody to study growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors [ncbi , more ].
  • western blotIn 2008, Yueping K Qian et al. applied BD Biosciences SHP-2 antibody to study the function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters [ncbi , more ]. In 2005, Philipp Eissmann et al. used BD Biosciences SHP-2 antibody to study positive and negative signaling by the natural killer cell receptor 2B4 (CD244) [ncbi , more ]. Andrew S J Marshall et al. utilized BD Biosciences SHP-2 antibody to describe the identification and characterization of a myeloid inhibitory C-type lectin-like receptor (MICL) that is a negative regulator of granulocyte and monocyte function [ncbi , more ] in 2004 and Margaret S Sozio et al. used BD Biosciences SHP-2 antibody to study the PTPH1 as a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor subunit [ncbi , more ]. In 2003, Samir Ali et al. applied BD Biosciences SHP-2 antibody to study the function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways [ncbi , more ]. In 2002, Johan Duchene et al. used BD Biosciences SHP-2 antibody to study the role for the interaction between G protein-coupled receptor and the phosphatase SHP-2 in bradykinin-induced inhibition of cell proliferation [ncbi , more ]. BD Biosciences SHP-2 antibody was used in 2001 to study growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors [ncbi , more ], to study the effect of SNT1 on ERK activation and neuronal differentiation in PC12 cells [ncbi , more ]and to study the T cell receptor signaling regulation by docking protein Gab2 [ncbi , more ].
Articles Reviewed
  1. Julia Foldi et al. (2010). "Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1".PMID 20870935
  2. Hyun Ju Kim et al. (2009). "The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo".PMID 19171907
  3. Oliver H Kramer et al. (2009). "A phosphorylation-acetylation switch regulates STAT1 signaling".PMID 19171783
  4. Francesco E Boccalatte et al. (2009). "The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL".PMID 18845790
  5. Yueping K Qian et al. (2008). "The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters".PMID 18647419
  6. Marlowe S Tessmer et al. (2007). "KLRG1 binds cadherins and preferentially associates with SHIP-1".PMID 17307799
  7. Siyuan Liang et al. (2006). "Human ILT2 receptor associates with murine MHC class I molecules in vivo and impairs T cell function".PMID 16897816
  8. Annelies Verbrugge et al. (2006). "Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase".PMID 16380958
  9. Sabine Brandt et al. (2005). "NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein".PMID 15972330
  10. Philipp Eissmann et al. (2005). "Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)".PMID 15713798
  11. Fawaz G Haj et al. (2005). "Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice".PMID 15699041
  12. Patrick A Kiely et al. (2005). "RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251".PMID 15611085
  13. Matthew L Jones et al. (2004). "Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus".PMID 15269224
  14. April N Meyer et al. (2004). "The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation".PMID 15105428
  15. Charng Jui Chen et al. (2004). "The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells by association with Src homology protein-1 and down-regulates IL-2 receptor".PMID 15004155
  16. Andrew S J Marshall et al. (2004). "Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes".PMID 14739280
  17. Margaret S Sozio et al. (2004). "PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit".PMID 14672952
  18. Samir Ali et al. (2003). "SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor".PMID 14522994
  19. Naoko Kogata et al. (2003). "Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells".PMID 12972546
  20. Johan Duchene et al. (2002). "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation".PMID 12177051
  21. Christine Guntermann et al. (2002). "CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases".PMID 11970985
  22. Armelle Yart et al. (2002). "A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid".PMID 11916960
  23. Runxiang Zhao et al. (2002). "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling".PMID 11751924
  24. F Blanchard et al. (2001). "Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms".PMID 11602599
  25. S Yamasaki et al. (2001). "Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules".PMID 11572860
  26. M Morra et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients".PMID 11477068
  27. C Wu et al. (2001). "Nerve growth factor activates persistent Rap1 signaling in endosomes".PMID 11466412
  28. C Sweeney et al. (2001). "Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors".PMID 11297548
  29. T Ulyanova et al. (2001). "Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2".PMID 11278955
  30. H Xu et al. (2001). "Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells".PMID 11278583