This is a review about PSEN2, based on 5 published articles (read how Labome selects the articles), using PSEN2 antibody in all methods. It is aimed to help Labome visitors find the most suited PSEN2 antibody.
PSEN2 synonym: AD3L; AD4; CMD1V; PS2; STM2; AD3LP; AD5; Alzheimer disease 4; E5-1; PS-2; STM-2

Knockout validation
Abcamrabbit monoclonal (EP1515Y)
  • WB (knockout); mouse; fig 6a
In order to assess the effects of presenilin dosage on cortical neuron survival in mice, Abcam PSEN2 antibody (Abcam, ab51249) was used in western blot (knockout) on mouse samples (fig 6a). J Neurosci (2014) ncbi
Abcam
rabbit monoclonal (EP1515Y)
  • WB (knockout); mouse; fig 6a
In order to assess the effects of presenilin dosage on cortical neuron survival in mice, Abcam PSEN2 antibody (Abcam, ab51249) was used in western blot (knockout) on mouse samples (fig 6a). J Neurosci (2014) ncbi
Cell Signaling Technology
rabbit monoclonal (D30G3)
  • WB; human
In order to investigate presenilin assembly and catalytic activity, Cell Signaling Technology PSEN2 antibody (Cell Signaling, D30G3) was used in western blot on human samples. J Biol Chem (2015) ncbi
rabbit polyclonal
  • IHC-P; rat; 1:1000
  • WB; rat; 1:1000
Cell Signaling Technology PSEN2 antibody (Cell Signaling Technology, 2192S) was used in immunohistochemistry - paraffin section on rat samples at 1:1000 and in western blot on rat samples at 1:1000. Mol Neurobiol (2016) ncbi
rabbit polyclonal
  • IHC; rat
Cell Signaling Technology PSEN2 antibody (Cell Signaling Technology, 2192S) was used in immunohistochemistry on rat samples. Toxicol Sci (2015) ncbi
not indicated
  • WB; human
Cell Signaling rabbit anti-PS2 antibody was used in western blot to study Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell deathJ Biol Chem (2005) ncbi
Articles Reviewed
  1. Claudia Marinangeli et al. (2015). "Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex".PMID 25614624
  2. Shailendra Kumar Maurya et al. (2016). "Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators".PMID 25575682
  3. Hirotaka Watanabe et al. (2014). "Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex".PMID 25429133
  4. Anushruti Ashok et al. (2015). "Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats".PMID 25288670
  5. Kohsuke Kanekura et al. (2005). "A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death".PMID 15579468