This is a review about PKR, based on 20 published articles (read how Labome selects the articles), using PKR antibody in all methods. It is aimed to help Labome visitors find the most suited PKR antibody.
PKR synonym: EIF2AK1; PKR; PRKR; P1/eIF-2A protein kinase; double stranded RNA activated protein kinase; eIF-2A protein kinase 2; interferon-induced, double-stranded RNA-activated protein kinase; interferon-inducible elF2alpha kinase; p68 kinase; protein kinase, interferon-inducible double stranded RNA dependent; tyrosine-protein kinase EIF2AK2

EpitomicsEpitomics PKR product
  • immunoprecipitationIn 2009, Bianca Dauber et al. employed Epitomics PKR antibody to show that the antiviral kinase PKR can be activated by influenza B virus ribonucleoprotein [ncbi , more ].
  • western blotEpitomics PKR antibody was utilized in 2009 to carry out western blot analysis in order to investigate the mechanism for vaccinia virus double-stranded RNA binding protein E3 inhibiting the expression of cytokines [ncbi , more ], to carry out western blot analysis in order to investigate the mechanism of SARS coronavirus activating PKR and PERK and overcome the inhibitory effects of phosphorylated eIF2-alpha on viral mRNA translation [ncbi , more ], to perform western blot in order to study the mechanism of the apoptosis induced by severe acute respiratory syndrome coronavirus [ncbi , more ]and to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2 (catalog: 1120-1) [ncbi , more ]. In 2008, Kenji Takeuchi et al. utilized Epitomics PKR antibody to perform western blot in order to show that SeV C protein can limit generation of dsRNA to restrict PKR activation [ncbi , more ].
Cell Signaling TechnologyCell Signaling Technology PKR product
  • immunoprecipitationIn 2009, Bianca Dauber et al. employed Cell Signaling Technology PKR antibody to show that the antiviral kinase PKR can be activated by influenza B virus ribonucleoprotein [ncbi , more ].
  • western blotMegan E Spurgeon et al. used Cell Signaling Technology PKR antibody to perform western blot in order to investigate the relations between E1B-55K/E4orf6 and eIF2 [ncbi , more ] in 2009 and Chad Myskiw et al. used Cell Signaling Technology PKR antibody to carry out western blot analysis in order to investigate the mechanism for vaccinia virus double-stranded RNA binding protein E3 inhibiting the expression of cytokines [ncbi , more ]. In 2006, Gang Chen et al. utilized Cell Signaling Technology PKR antibody to detect the phosphorylated PKR in human SH-SY5Y cells and cerebellar granule neurons (CGNs) isolated from the rat cerebella of 7-day-old rat pups, Cell Signaling Technology antibody against PKR was used in western blot to examine total PKR in human embryonic kidney cell line HEK293, human neuroblastoma SK-N-MC, SH-SY5Y cells, and rat cerebellar granule neurons [ncbi , more ]. In 2004, Alessandro Salvi et al. used Cell Signaling Technology PKR antibody to study the inhibitory effect of small interfering RNA urokinase silencing on the invasion and migration of human hepatocellular carcinoma cells [ncbi , more ].
EMD MilliporeEMD Millipore PKR product
  • western blotIn 2006, Qiaozhu Su et al. used EMD Millipore PKR antibody to study the role for tyrosine phosphorylation in full-scale activation of the eIF2alpha RNA-dependent protein kinase [ncbi , more ].
Life Technologies CorporationLife Technologies Corporation PKR product
  • immunoprecipitationIn 2001, A L Peel et al. applied Life Technologies Corporation PKR antibody to investigate the preferential binding of PKR to Huntington s disease (HD) transcripts [ncbi , more ].
  • western blotIn 2009, Satoshi Kakugawa et al. used Life Technologies Corporation PKR antibody to perform western blot in order to study the role of RSK2 in the cellular antiviral response [ncbi , more ]. In 2006, Susana Guerra et al. utilized Life Technologies Corporation PKR antibody to study the effect of attenuated poxvirus vector NYVAC on apoptotic genes and NF-kappaB-responsive genes in infected HeLa cells [ncbi , more ]. In 2001, A L Peel et al. applied Life Technologies Corporation PKR antibody to investigate the preferential binding of PKR to Huntington s disease (HD) transcripts [ncbi , more ].
Santa Cruz BiotechnologySanta Cruz Biotechnology PKR product
  • immunocytochemistryIn 2006, Alessandra Spaziani et al. utilized Santa Cruz Biotechnology PKR antibody to detect PKR in HepG2 cells [ncbi , more ]. In 2002, Takenori Takizawa et al. used Santa Cruz Biotechnology PKR antibody to study its interaction with apoptosis signal-regulating kinase 1 [ncbi , more ].
  • immunoprecipitationIn 2006, Alessandra Spaziani et al. utilized Santa Cruz Biotechnology PKR antibody to detect PKR in HepG2 cells [ncbi , more ].
  • western blotIn 2010, Maikel L Colli et al. used Santa Cruz Biotechnology PKR antibody to investigate the roles of MDA5 and PTPN2 in the regulation of pancreatic cell responses to the viral by-product double-stranded RNA [ncbi , more ]. Satoshi Kakugawa et al. used Santa Cruz Biotechnology PKR antibody to perform western blot in order to study the role of RSK2 in the cellular antiviral response [ncbi , more ] in 2009 and Ann M Toth et al. used Santa Cruz Biotechnology PKR antibody to perform western blot in order to show that protein kinase PKR can induce apoptosis and restrict the growth of phenotypes of C protein-deficient measles virus [ncbi , more ]. In 2008, Kenji Takeuchi et al. utilized Santa Cruz Biotechnology PKR antibody to perform western blot in order to show that SeV C protein can limit generation of dsRNA to restrict PKR activation [ncbi , more ]. Jongdae Lee et al. employed Santa Cruz Biotechnology PKR antibody to perform western blot in order to study the mechanism of anti-HCV by TLR7 [ncbi , more ] in 2006 and Alessandra Spaziani et al. used Santa Cruz Biotechnology PKR antibody to detect PKR in HepG2 cells [ncbi , more ]. In 2005, Pedro Gonzalez-Alegre et al. applied Santa Cruz Biotechnology PKR antibody to support the potential use of viral-mediated RNAi as a therapy for DYT1 dystonia and establish the basis for preclinical testing in animal models of the disease [ncbi , more ]. Takenori Takizawa et al. used Santa Cruz Biotechnology PKR antibody to study its interaction with apoptosis signal-regulating kinase 1 [ncbi , more ] in 2002 and Constantinos Koumenis et al. used Santa Cruz Biotechnology PKR antibody to study the expression of PKR in 3T3 cells [ncbi , more ].
BD Biosciences
  • western blotVerena Krähling et al. applied BD Biosciences PKR antibody to carry out western blot analysis in order to investigate the mechanism of SARS coronavirus activating PKR and PERK and overcome the inhibitory effects of phosphorylated eIF2-alpha on viral mRNA translation [ncbi , more ] in 2009 and Michael A Beazely et al. used BD Biosciences PKR antibody to perform western blot in order to study the mechanism of the apoptosis induced by severe acute respiratory syndrome coronavirus [ncbi , more ].
ARA HOVANESSIAN
  • immunoprecipitationIn 2002, Takenori Takizawa et al. used PKR antibody to study its interaction with apoptosis signal-regulating kinase 1 [ncbi , more ].
RIBOGENE
  • immunoprecipitationIn 2009, Bianca Dauber et al. employed PKR antibody to show that the antiviral kinase PKR can be activated by influenza B virus ribonucleoprotein [ncbi , more ].
GE Healthcare Life Biosciences
  • immunoprecipitationIn 2001, A H Wong et al. used GE Healthcare Life Biosciences PKR antibody to study the novel function of STAT1 as an inhibitor of PKR activation and eIF-2alpha phosphorylation [ncbi , more ].
  • western blotIn 2001, A H Wong et al. used GE Healthcare Life Biosciences PKR antibody to study the novel function of STAT1 as an inhibitor of PKR activation and eIF-2alpha phosphorylation [ncbi , more ].
Articles Reviewed
  1. Maikel L Colli et al. (2010). "MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA".PMID 19825843
  2. Megan E Spurgeon et al. (2009). "The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection".PMID 19605483
  3. Bianca Dauber et al. (2009). "Influenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKR".PMID 19521506
  4. Chad Myskiw et al. (2009). "Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways".PMID 19369349
  5. Satoshi Kakugawa et al. (2009). "Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection".PMID 19129453
  6. Verena Krähling et al. (2009). "Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity".PMID 19109397
  7. Michael A Beazely et al. (2009). "Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons".PMID 19106110
  8. Ann M Toth et al. (2009). "Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus".PMID 19004947
  9. Kenji Takeuchi et al. (2008). "Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA".PMID 18684815
  10. Gang Chen et al. (2006). "Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons".PMID 16574643
  11. Jongdae Lee et al. (2006). "Activation of anti-hepatitis C virus responses via Toll-like receptor 7".PMID 16446426
  12. Alessandra Spaziani et al. (2006). "Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1".PMID 16446363
  13. Susana Guerra et al. (2006). "Host response to the attenuated poxvirus vector NYVAC: upregulation of apoptotic genes and NF-kappaB-responsive genes in infected HeLa cells".PMID 16379000
  14. Qiaozhu Su et al. (2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase".PMID 16373505
  15. Pedro Gonzalez-Alegre et al. (2005). "Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia".PMID 16280588
  16. Alessandro Salvi et al. (2004). "Small interfering RNA urokinase silencing inhibits invasion and migration of human hepatocellular carcinoma cells".PMID 15210852
  17. Takenori Takizawa et al. (2002). "Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways".PMID 12473108
  18. Constantinos Koumenis et al. (2002). "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha".PMID 12370288
  19. A L Peel et al. (2001). "Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue".PMID 11468270
  20. A H Wong et al. (2001). "Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR".PMID 11278865