This is a review about PDX-1, based on 27 published articles (read how Labome selects the articles), using PDX-1 antibody in all methods. It is aimed to help Labome visitors find the most suited PDX-1 antibody.
PDX-1 synonym: GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1; IPF-1; IUF-1; glucose-sensitive factor; insulin promoter factor 1, homeodomain transcription factor; insulin upstream factor 1; islet/duodenum homeobox-1; pancreatic-duodenal homeobox factor 1; somatostatin transcription factor 1; somatostatin-transactivating factor 1

Abcam
rabbit polyclonal
  • WB; rat; 1:2000
In order to determine if Reg3alpha improves islet engraftment, Abcam PDX-1 antibody (Abcam, ab47267) was used in western blot on rat samples at 1:2000. Mol Med (2014) ncbi
rabbit polyclonal
  • IHC; mouse; 1:500; fig 2, 4, 5
Abcam PDX-1 antibody (Abcam, ab47267) was used in immunohistochemistry on mouse samples at 1:500 (fig 2, 4, 5). J Biol Chem (2015) ncbi
rabbit polyclonal
  • IHC-F; mouse
Abcam PDX-1 antibody (abcam, ab47267) was used in immunohistochemistry - frozen section on mouse samples. PLoS ONE (2014) ncbi
goat polyclonal
  • IHC-F; human
  • IHC-F; mouse
  • WB; human; 1:1000
Abcam PDX-1 antibody (Abcam, ab47383) was used in immunohistochemistry - frozen section on human samples and on mouse samples and in western blot on human samples at 1:1000. J Biol Chem (2014) ncbi
rabbit polyclonal
  • WB; mouse
Abcam PDX-1 antibody (Abcam, ab47267) was used in western blot on mouse samples. PLoS ONE (2014) ncbi
rabbit polyclonal
  • IHC-P; mouse
In order to examine the role of the LIM homeodomain transcription factor Isl1 in pyloric development, Abcam PDX-1 antibody (Abcam, ab47267) was used in immunohistochemistry - paraffin section on mouse samples. BMC Biol (2014) ncbi
rabbit polyclonal
  • IHC-P; mouse
Abcam PDX-1 antibody (Abcam, ab47267) was used in immunohistochemistry - paraffin section on mouse samples. J Leukoc Biol (2014) ncbi
rabbit polyclonal
  • WB; human
In order to evaluate the prognostic value of fascin in pancreatic cancer, Abcam PDX-1 antibody (Abcam, ab47267) was used in western blot on human samples. Gastroenterology (2014) ncbi
rabbit polyclonal
  • IHC-P; mouse
Abcam PDX-1 antibody (Abcam, AB47267) was used in immunohistochemistry - paraffin section on mouse samples. PLoS ONE (2013) ncbi
goat polyclonal
  • IHC-P; human
Abcam PDX-1 antibody (Abcam, ab47383) was used in immunohistochemistry - paraffin section on human samples. PLoS ONE (2013) ncbi
goat polyclonal
  • IHC-P; mouse; 1:1500
Abcam PDX-1 antibody (Abcam, ab47383) was used in immunohistochemistry - paraffin section on mouse samples at 1:1500. Int J Physiol Pathophysiol Pharmacol (2013) ncbi
goat polyclonal
  • IC; mouse; 1:50000
Abcam PDX-1 antibody (Abcam, ab47383) was used in immunocytochemistry on mouse samples at 1:50000. Hepatology (2013) ncbi
guinea pigs polyclonal
  • IHC; mouse; 1:1000
Abcam PDX-1 antibody (Abcam, ab47308) was used in immunohistochemistry on mouse samples at 1:1000. PLoS ONE (2013) ncbi
Santa Cruz Biotechnology
goat polyclonal (A-17)
  • IC; mouse; 1:100
Santa Cruz Biotechnology PDX-1 antibody (Santa Cruz Biotechnology, sc-14664) was used in immunocytochemistry on mouse samples at 1:100. Ups J Med Sci (2015) ncbi
goat polyclonal (A-17)
  • FC; human; 1:100
  • IC; human; 1:100; fig 3
Santa Cruz Biotechnology PDX-1 antibody (Santa Cruz, SC-14664) was used in flow cytometry on human samples at 1:100 and in immunocytochemistry on human samples at 1:100 (fig 3). Methods Mol Biol (2016) ncbi
goat polyclonal (A-17)
  • IHC; mouse; 1:200; fig s3
Santa Cruz Biotechnology PDX-1 antibody (Santa Cruz, sc-14664) was used in immunohistochemistry on mouse samples at 1:200 (fig s3). Nat Biotechnol (2014) ncbi
goat polyclonal (A-17)
  • WB; mouse; 1:200
In order to investigate the function of islet-1 in the pancreas, Santa Cruz Biotechnology PDX-1 antibody (Santa, sc-14664) was used in western blot on mouse samples at 1:200. Diabetes (2014) ncbi
goat polyclonal (N-18)
  • EMSA; mouse
  • EMSA; rat
In order to study the upregulation of pancreatic beta cell ARAP1 by a functional regulatory DNA variant at a type 2 diabetes locus, Santa Cruz Biotechnology PDX-1 antibody (Santa Cruz Biotechnology, sc-14662X) was used in EMSA on mouse samples and on rat samples. Am J Hum Genet (2014) ncbi
goat polyclonal (N-18)
  • EMSA; mouse
Santa Cruz Biotechnology PDX-1 antibody (Santa Cruz Biotechnologies, sc-14662) was used in EMSA on mouse samples. Nat Genet (2014) ncbi
not indicated
  • WB; human
Santa Cruz Pdx1 antibody was used in western blot in order to study the role of Gsk-3beta in control of beta-cell mass in insulin-resistant diabetic modelsPLoS Biol (2008) ncbi
not indicated
  • EMSA; human
Santa Cruz Biotechnology anti-PDX-1 antibody was used in emsa to determine factors regulating INGAP expression.J Endocrinol (2006) ncbi
not indicated
  • ChIP; human
Santa Cruz Biotechnology goat anti-PDX-1 antibody was used in ChIP assay to study the effect of sterol regulatory element-binding proteins on insulin gene promoterJ Biol Chem (2005) ncbi
R and D Systems
goat polyclonal
  • IC; human; 1:1000
In order to report the generation of human fibroblast-derived hepatocytes that can be used to repopulate mouse livers, R and D Systems PDX-1 antibody (R&D, AF2419) was used in immunocytochemistry on human samples at 1:1000. Nature (2014) ncbi
goat polyclonal
  • IHC-F; human
  • IHC-F; mouse
In order to study the diabetic-like lack of glucose kinase activity of pancreatic beta cells produced from induced pluripotent stem cells derived from a diabetic donor, R and D Systems PDX-1 antibody (R&D Systems, AF2419) was used in immunohistochemistry - frozen section on human samples and on mouse samples. J Clin Invest (2013) ncbi
goat polyclonal
  • IC; human; 1:500
R and D Systems PDX-1 antibody (R&D Systems, AF2419) was used in immunocytochemistry on human samples at 1:500. Cell Stem Cell (2013) ncbi
EMD Millipore
rabbit polyclonal
  • IC; mouse; 1:1000
EMD Millipore PDX-1 antibody (Millipore, 06-1379) was used in immunocytochemistry on mouse samples at 1:1000. Exp Cell Res (2013) ncbi
not indicated
  • WB; human
Chemicon International rabbit anti-PDX-1 antibody was used in western blot to determine factors regulating INGAP expression.J Endocrinol (2006) ncbi
Individual Researcher
not indicated
  • WB; human
Dr. M. German (University of California, San Francisco) rabbit polyclonal Pdx-1 antibody was used in western blot to determine the mechanism underlying regulation of the insulin gene by Pdx-1.J Biol Chem (2005) ncbi
others
not indicated
  • IHC; human
Joel Habener Pdx-1 antibody was used in immunohistochemistry in order to study the role of Gsk-3beta in control of beta-cell mass in insulin-resistant diabetic modelsPLoS Biol (2008) ncbi
Articles Reviewed
  1. Guangxiang Zang et al. (2015). "Activated pancreatic stellate cells can impair pancreatic islet function in mice".PMID 25854824
  2. Ying Ding et al. (2014). "Reg3α Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome".PMID 25826674
  3. Bipasha Bose et al. (2016). "In Vitro Differentiation of Pluripotent Stem Cells into Functional β Islets Under 2D and 3D Culture Conditions and In Vivo Preclinical Validation of 3D Islets".PMID 25783769
  4. Steven E Trasino et al. (2015). "Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass".PMID 25451926
  5. Weida Li et al. (2014). "Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells".PMID 25402613
  6. Haruka Nagasaki et al. (2014). "Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb".PMID 25397325
  7. Jimmy Masjkur et al. (2014). "Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release".PMID 25371201
  8. Benjamin N Ediger et al. (2014). "Islet-1 Is essential for pancreatic β-cell function".PMID 25028525
  9. Chaoqun Wang et al. (2014). "Long-term supranutritional supplementation with selenate decreases hyperglycemia and promotes fatty liver degeneration by inducing hyperinsulinemia in diabetic db/db mice".PMID 24983750
  10. Yushan Li et al. (2014). "LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3".PMID 24674670
  11. Kristin A Sauter et al. (2014). "Pleiotropic effects of extended blockade of CSF1R signaling in adult mice".PMID 24652541
  12. Saiyong Zhu et al. (2014). "Mouse liver repopulation with hepatocytes generated from human fibroblasts".PMID 24572354
  13. Ang Li et al. (2014). "Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes".PMID 24462734
  14. Jennifer R Kulzer et al. (2014). "A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell".PMID 24439111
  15. Michael N Weedon et al. (2014). "Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis".PMID 24212882
  16. Yaiza Diaz-De-Durana et al. (2013). "IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes".PMID 24205242
  17. Rémy Bonnavion et al. (2013). "Both PAX4 and MAFA are expressed in a substantial proportion of normal human pancreatic alpha cells and deregulated in patients with type 2 diabetes".PMID 24013263
  18. Haiqing Hua et al. (2013). "iPSC-derived β cells model diabetes due to glucokinase deficiency".PMID 23778137
  19. Ronald J Pérez et al. (2013). "Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation".PMID 23756134
  20. Mary M Feng et al. (2013). "An autocrine γ-aminobutyric acid signaling system exists in pancreatic β-cell progenitors of fetal and postnatal mice".PMID 23750307
  21. Frank Dipaola et al. (2013). "Identification of intramural epithelial networks linked to peribiliary glands that express progenitor cell markers and proliferate after injury in mice".PMID 23703727
  22. Asmin Tulpule et al. (2013). "Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction".PMID 23602541
  23. Siyeon Rhee et al. (2013). "Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development".PMID 23554936
  24. Katsuya Tanabe et al. (2008). "Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance".PMID 18288891
  25. David A Taylor-Fishwick et al. (2006). "PDX-1 can repress stimulus-induced activation of the INGAP promoter".PMID 16522740
  26. Michiyo Amemiya-Kudo et al. (2005). "Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47".PMID 16055439
  27. Tessy Iype et al. (2005). "Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes".PMID 15743769