This is a review about MK2, based on 22 published articles (read how Labome selects the articles), using MK2 antibody in all methods. It is aimed to help Labome visitors find the most suited MK2 antibody.
MK2 synonym: MAPKAP-K2; MK-2; MK2; MAPK-activated protein kinase 2; MAPKAP kinase 2

Santa Cruz Biotechnology
rabbit polyclonal (Thr 334)
  • WB; rat; 1:100; fig 4
Santa Cruz Biotechnology MK2 antibody (Santa Cruz Inc, sc-101729) was used in western blot on rat samples at 1:100 (fig 4). Int Urol Nephrol (2014) ncbi
rabbit polyclonal (H-66)
  • WB; rat; 1:100; fig 4
Santa Cruz Biotechnology MK2 antibody (Santa Cruz Inc, sc-7871) was used in western blot on rat samples at 1:100 (fig 4). Int Urol Nephrol (2014) ncbi
Invitrogen
rabbit polyclonal
  • WB; mouse; 1:2000; fig s3
In order to explore the regulatory functions of the BMP and Wnt pathways in early tooth development, Invitrogen MK2 antibody (Thermo, PA5-12619) was used in western blot on mouse samples at 1:2000 (fig s3). Development (2015) ncbi
EMD Millipore
not indicated
  • WB; human
Upstate polyclonal anti-MAPKAP kinase 2 (MK2) antibody was used in human HeLa cells and in western blot to study the role for the effects of MK2 on the regulation of HSF1 in inhibiting transcriptional activity and promotes HSP90 binding.J Biol Chem (2006) ncbi
Enzo Life Sciences
not indicated
  • WB; human
Assay Designs anti-MK2 antibody was used to carry out western blot analysis in order to investigate the role for p38 MAPKAPK2 kinase cascade in yolk cell movement process by regulating the activity of F-actin.PLoS Genet (2009) ncbi
Cell Signaling Technology
rabbit polyclonal
  • WB; human; fig s2
Cell Signaling Technology MK2 antibody (Cell Signaling, 3042) was used in western blot on human samples (fig s2). PLoS ONE (2015) ncbi
not indicated
  • WB; human
Anti-MK2 antibody was used for Western blotting, in order to study the mechanism by which MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy.elife (2015) ncbi
rabbit polyclonal
  • WB; mouse; 1:1000
In order to investigate the role of membrane-anchored versus soluble CX3CL1 in regulating the microglia-mediated amelioration of Abeta pathology, Cell Signaling Technology MK2 antibody (Cell Signaling Technology, 3041L) was used in western blot on mouse samples at 1:1000. J Neurosci (2014) ncbi
rabbit polyclonal
  • WB; human
Cell Signaling Technology MK2 antibody (Cell Signaling, 3041) was used in western blot on human samples. Biochem J (2014) ncbi
rabbit polyclonal
  • WB; mouse; fig 1, 2
In order to demonstrate that p38MAPK activation elevates mitochondrial ROS levels, Cell Signaling Technology MK2 antibody (Cell Signaling Technology, 3042) was used in western blot on mouse samples (fig 1, 2). Cell Commun Signal (2014) ncbi
rabbit monoclonal (27B7)
  • WB; mouse
Cell Signaling Technology MK2 antibody (Cell Signaling Technology Inc, 3007) was used in western blot on mouse samples. Br J Pharmacol (2013) ncbi
rabbit monoclonal (9A7)
  • WB; mouse; 1:1 000
Cell Signaling Technology MK2 antibody (CST, 3316) was used in western blot on mouse samples at 1:1 000. Cell Res (2013) ncbi
not indicated
  • FC; human
Cell Signaling Technology anti-MAPKAPK 2 (pT334) was used in 1ug/ml to perform mass cytometry in order to show that different stimulation effect of human hematopoietic cells could be analysized by single-cell mass cytometry.Science (2011) ncbi
rabbit monoclonal (9A7)
  • WB; human
Cell Signaling Technology MK2 antibody (Cell Signaling Technology, 3316) was used in western blot on human samples. Cell Death Differ (2010) ncbi
not indicated
  • WB; human
Cell Signaling Technology anti-phospho-MK2 (Thr334) and anti-MK2 antibodies were used to carry out western blot analysis in order to investigate the mechanism for vaccinia virus double-stranded RNA binding protein E3 inhibiting the expression of cytokines.J Virol (2009) ncbi
not indicated
  • WB; human
  • IC; human
Cell Signaling Technology antibodies against MK2 were used to investigate the role of p38alpha MAPK in the regulation of macrophage apoptosis.J Clin Invest (2009) ncbi
not indicated
  • WB; human
Cell Signaling anti-phospho-MK2 antibody was used to carry out western blot analysis in order to investigate the role for p38 MAPKAPK2 kinase cascade in yolk cell movement process by regulating the activity of F-actin.PLoS Genet (2009) ncbi
not indicated
  • WB; human
Cell Signaling anti-phospho-MK2 antibody was used for western blot in order to investigate the role of MK2 in the regulation of actin polymerization and vascular leakPLoS ONE (2009) ncbi
not indicated
  • WB; human
Cell Signaling Technology anti-MK2 and anti-phospho-MK2 antibodies were used in western blot to demonstrate the critical role of hypoxia in activating p38 MAPK and androgen independent androgen receptor stabilization and activity, causing increased aggressiveness of LNCaP cells.Oncogene (2009) ncbi
not indicated
  • WB; human
Cell Signaling Technology anti-phospho-MK2 antibody was used for western blot in order to investigate the role of Ser326 phosphorylation of Plk1 in the regulation of its functions during mitotic progression.Oncogene (2008) ncbi
not indicated
  • WB; human
Cell Signaling rabbit polyclonal anti-MAPKAPK-2 antibody (1:1000) was used in western blot in order to demonstrate that human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) induces cell cycle G2 arrest through a Srk1/MK2-mediated mechanism.J Virol (2008) ncbi
not indicated
  • IC; human
Cell Signaling Technologies rabbit phospho-MAPKAPK2 (Thr334) antibody was used in immunocytochemistry at a dilution of 1:100 to investigate whether CCM2 is expressed during mouse preimplantation development and to determine whether this scaffolding protein is associated with p38 MAPK activation following exposure of preimplantation embryos to hyperosmotic environments.BMC Dev Biol (2007) ncbi
not indicated
  • WB; human
Cell Signaling polyclonal anti-phospho-MK2 (Thr-334) antibody was used in human HeLa cells and in western blot to study the role for the effects of MK2 on the regulation of HSF1 in inhibiting transcriptional activity and promotes HSP90 binding.J Biol Chem (2006) ncbi
not indicated
  • WB; human
Cell Signaling phospho-MAPKAPK2 antibody was used in western blot to investigate regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.Mol Cell Biol (2005) ncbi
not indicated
  • WB; human
  • ELISA; human
Cell Signaling Technology phospho-MAPKAPK-2 antibody was used in western blot to study IL-1 beta-inducd MAPKAPK-2 phosphorylation in rat ATII cells.J Biol Chem (2005) ncbi
Articles Reviewed
  1. Peggy Prickaerts et al. (2015). "MK3 modulation affects BMI1-dependent and independent cell cycle check-points".PMID 25853770
  2. Yongjie Wei et al. (2015). "The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation".PMID 25693418
  3. Guohua Yuan et al. (2015). "The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development".PMID 25428587
  4. Sungho Lee et al. (2014). "Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway".PMID 25209291
  5. Anzhou Xia et al. (2014). "Roles of MAPKAPK-2 and HSP27 in the reduction of renal ischemia-reperfusion injury by ischemic postconditioning in rats".PMID 24927932
  6. Hanneke L D M Willemen et al. (2014). "A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia".PMID 24517375
  7. Muhammad Imtiaz Ashraf et al. (2014). "A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury".PMID 24423080
  8. Riku Korhonen et al. (2013). "Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1".PMID 23849041
  9. Xinxiu Xu et al. (2013). "Stress-mediated p38 activation promotes somatic cell reprogramming".PMID 23044805
  10. Sean C Bendall et al. (2011). "Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum".PMID 21551058
  11. J K Son et al. (2010). "TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1".PMID 20168333
  12. Chad Myskiw et al. (2009). "Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways".PMID 19369349
  13. Tracie A Seimon et al. (2009). "Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice".PMID 19287091
  14. Beth A Holloway et al. (2009). "A novel role for MAPKAPK2 in morphogenesis during zebrafish development".PMID 19282986
  15. Mahendra Damarla et al. (2009). "Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury".PMID 19240800
  16. L Khandrika et al. (2009). "Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer".PMID 19151763
  17. J Tang et al. (2008). "Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression".PMID 18695677
  18. Sylvain Huard et al. (2008). "Human immunodeficiency virus type 1 Vpr induces cell cycle G2 arrest through Srk1/MK2-mediated phosphorylation of Cdc25".PMID 18160429
  19. Barry Fong et al. (2007). "Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation".PMID 17214902
  20. XiaoZhe Wang et al. (2006). "Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding".PMID 16278218
  21. Guillaume Bossis et al. (2005). "Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation".PMID 16055710
  22. Jeremie Roux et al. (2005). "Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway".PMID 15755725