This is a review about MEK2, based on 16 published articles (read how Labome selects the articles), using MEK2 antibody in all methods. It is aimed to help Labome visitors find the most suited MEK2 antibody.
MEK2 synonym: MAPKK2; MEK2; MKK2; PRKMK2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45

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Cell Signaling TechnologyCell Signaling Technology MEK2 product
  • immunoprecipitationIn 2009, Jianrong Wang et al. used Cell Signaling Technology MEK2 antibody to study the role of Beclin 1 in the regulation of autophagy [ncbi , more ].
  • western blotIn 2010, David L Moyes et al. applied Cell Signaling Technology MEK2 antibody to perform western blot in order to study the discrimination between the yeast and hyphal forms of C. albicans in epithelial cells via a biphasic MAPK response [ncbi , more ]. Jianrong Wang et al. used Cell Signaling Technology MEK2 antibody to study the role of Beclin 1 in the regulation of autophagy [ncbi , more ] in 2009 and Vladimir L Gabai et al. used Cell Signaling Technology MEK2 antibody to study the role for Hsp72 in suppression of the oncogene-induced senescence [ncbi , more ]. In 2008, Sean R Werner et al. employed Cell Signaling Technology MEK2 antibody to study the role for MMP-28 in myelination (catalog: 4377S) [ncbi , more ]. In 2006, Anna Moshnikova et al. utilized Cell Signaling Technology MEK2 antibody to detect MEK expression in human A549 lung adenocarcinoma cells [ncbi , more ]. In 2005, Charles E Ducker et al. applied Cell Signaling Technology MEK2 antibody to detect phospho-MEK2 in HT-29 cells treated with NMT1-1 siRNA or NMT2-4 siRNA [ncbi , more ]. Fang Yan et al. employed Cell Signaling Technology MEK2 antibody to study the role of KSR1 in regulating intestinal cell fate during cytokine-mediated inflammation [ncbi , more ] in 2004 and Susana Castro-Obregon et al. used Cell Signaling Technology MEK2 antibody to study SP/NK1R-induced cell death mediated by a MAP kinase activation pathway involving Raf-1, MEK2, and extracellular signal-regulated protein kinase 2 (ERK2) [ncbi , more ]. Fuminori Umenishi et al. employed Cell Signaling Technology MEK2 antibody to study the expression of hypertonicity-induced aquaporin-1 (AQP1) which is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene [ncbi , more ] in 2003 and Pramod P Naranatt et al. used Cell Signaling Technology MEK2 antibody to study the role for PI 3-kinase in HHV-8 entry into the target cells and the role for PKC-zeta, MEK, and ERK at a post-viral entry stage of infection [ncbi , more ]. In 2001, S H Hong et al. utilized Cell Signaling Technology MEK2 antibody to identify arsenic trioxide as a potent inhibitor of the interaction of SMRT corepressor with its transcription factor partners such as T3Rs and RARs in human acute promyelocytic leukemia [ncbi , more ].
Santa Cruz BiotechnologySanta Cruz Biotechnology MEK2 product
  • western blotIn 2004, Lenin Mahimainathan et al. applied Santa Cruz Biotechnology MEK2 antibody to study the role of PTEN in PDGF-induced DNA synthesis [ncbi , more ]. In 2002, Mihail S Iordanov et al. utilized Santa Cruz Biotechnology MEK2 antibody to study the inhibition of ERK phosphorylation by UVB [ncbi , more ].
Abgent
  • western blotIn 2007, Jinghua Jin et al. employed Abgent MEK2 antibody to identify novel mitochondrial proteins affected by rotenone in dopaminergic cells [ncbi , more ].
BD Biosciences
  • western blotIn 2009, Adriana S Hemerly et al. applied BD Biosciences MEK2 antibody to demonstrate that the copy numbers of centriole and centrosome were regulated by Orc1 in human cells [ncbi , more ]. In 2008, Laure Voisin et al. utilized BD Biosciences MEK2 antibody to perform western blot in order to show that MEK1 or MEK2 activation is sufficient for metastatic tumor formation [ncbi , more , fig ].
Figure
Transduction Laboratories anti-MEK2 was used to perform western blot in order to show that MEK1 or MEK2 activation is sufficient for metastatic tumor formation.
MEK2 antibody western blot BD Biosciences
Immunoblot analysis of MEK1, MEK2 and phospho-MEK1/2 expression in the human colon carcinoma cell lines HCT116, HT-29 and SW480, and in the breast adenocarcinoma line MDA-MB-231. Lysates were prepared from cells deprived of serum for 24 h (c), restimulated with serum for 5 min (+), or proliferating exponentially (exp).
Laure Voisin et al. (2008). "Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors".PMID 19014680
Articles Reviewed
  1. David L Moyes et al. (2010). "A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells".PMID 20833374
  2. Jianrong Wang et al. (2009). "A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1".PMID 19520853
  3. Adriana S Hemerly et al. (2009). "Orc1 controls centriole and centrosome copy number in human cells".PMID 19197067
  4. Laure Voisin et al. (2008). "Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors".PMID 19014680
  5. Vladimir L Gabai et al. (2009). "Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells".PMID 19001088
  6. Sean R Werner et al. (2008). "MMP-28 as a regulator of myelination".PMID 18778487
  7. Jinghua Jin et al. (2007). "Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells".PMID 17705834
  8. Anna Moshnikova et al. (2006). "The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway".PMID 16421102
  9. Charles E Ducker et al. (2005). "Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis".PMID 16123142
  10. Fang Yan et al. (2004). "Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation".PMID 15520859
  11. Susana Castro-Obregon et al. (2004). "Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77".PMID 14769794
  12. Lenin Mahimainathan et al. (2004). "Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase".PMID 14718524
  13. Fuminori Umenishi et al. (2003). "Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene".PMID 12600999
  14. Pramod P Naranatt et al. (2003). "Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity".PMID 12502866
  15. Mihail S Iordanov et al. (2002). "The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor".PMID 12101233
  16. S H Hong et al. (2001). "Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia".PMID 11585900