This is a review about LRRK2, based on 12 published articles (read how Labome selects the articles), using LRRK2 antibody in all methods. It is aimed to help Labome visitors find the most suited LRRK2 antibody.
LRRK2 synonym: AURA17; DARDARIN; PARK8; RIPK7; ROCO2; augmented in rheumatoid arthritis 17

Knockout validation
Epitomicsrabbit monoclonal
  • IHC (knockout); mouse; fig 1
  • IHC (knockout); rat; fig 1
Epitomics LRRK2 antibody (Epitomics, 3514-1) was used in immunohistochemistry (knockout) on mouse samples (fig 1) and on rat samples (fig 1). J Comp Neurol (2014) ncbi
Abcamrabbit monoclonal (MJFF2 (c41-2))
  • IHC-Free; mouse; fig 4
  • IHC-Free; rat; fig 6
  • IHC (knockout); mouse; fig 4
  • IHC (knockout); rat; fig 6
  • WB (knockout); mouse; fig 1, s2
  • WB; human; fig 1
Abcam LRRK2 antibody (Abcam, ab133474) was used in immunohistochemistry - free floating section on mouse samples (fig 4) and on rat samples (fig 6), in immunohistochemistry (knockout) on mouse samples (fig 4) and on rat samples (fig 6), in western blot (knockout) on mouse samples (fig 1, s2), and in western blot on human samples (fig 1). Biochem J (2013) ncbi
Neuromabmouse monoclonal (N241A/34)
  • IHC (knockout); mouse; fig 1
  • IHC (knockout); rat; fig 1
  • WB (knockout); human; fig 7
  • WB (knockout); mouse; fig 6
Neuromab LRRK2 antibody (NeuroMab, 73-253) was used in immunohistochemistry (knockout) on mouse samples (fig 1) and on rat samples (fig 1) and in western blot (knockout) on human samples (fig 7) and on mouse samples (fig 6). J Comp Neurol (2014) ncbi
Neuromabmouse monoclonal (N241A/34)
  • IHC (knockdown); rat; fig 6
  • IC (knockout); mouse; fig s3
  • WB (knockout); mouse; fig 1, s2
  • WB (knockout); rat; fig 5
  • WB; human; fig 1
  • IP; human; fig 2
  • IP; mouse; fig 2
Neuromab LRRK2 antibody (Neuromab, N241A/34) was used in immunohistochemistry (knockdown) on rat samples (fig 6), in immunocytochemistry (knockout) on mouse samples (fig s3), in western blot (knockout) on mouse samples (fig 1, s2) and on rat samples (fig 5), and in immunoprecipitation on human samples (fig 2) and on mouse samples (fig 2). Biochem J (2013) ncbi
Epitomics
rabbit monoclonal
  • WB; mouse; fig s5
Epitomics LRRK2 antibody (Epitomics, 5099-1) was used . Sci Transl Med (2015) ncbi
rabbit monoclonal
  • WB; mouse; fig s5
Epitomics LRRK2 antibody (Epitomics, 3514-1) was used . Sci Transl Med (2015) ncbi
rabbit monoclonal
  • IHC-P; mouse; 1:50
Epitomics LRRK2 antibody (Epitomics, 3514-1) was used in immunohistochemistry - paraffin section on mouse samples at 1:50. PLoS Genet (2014) ncbi
rabbit monoclonal
  • IHC-F; rat; 1:500
In order to examine the p.G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) and it's role in Parkinson's disease, Epitomics LRRK2 antibody (Epitomics, 3514-1) was used in immunohistochemistry - frozen section on rat samples at 1:500. J Parkinsons Dis (2014) ncbi
rabbit monoclonal
  • WB; rat; 1:2000
In order to determine how leucine-rich repeat kinase 2 contributes to diabetic neuropathy using Purkinje cells, Epitomics LRRK2 antibody (Epitomics, 3516) was used in western blot on rat samples at 1:2000. Cell Death Dis (2014) ncbi
rabbit monoclonal
  • IHC (knockout); mouse; fig 1
  • IHC (knockout); rat; fig 1
Epitomics LRRK2 antibody (Epitomics, 3514-1) was used in immunohistochemistry (knockout) on mouse samples (fig 1) and on rat samples (fig 1). J Comp Neurol (2014) ncbi
rabbit monoclonal
  • WB; human
Epitomics LRRK2 antibody (Epitomics, 3514-1) was used in western blot on human samples. Biochem Biophys Res Commun (2013) ncbi
Abcam
rabbit monoclonal (MJFF2 (c41-2))
  • WB; human
In order to elucidate the relationship between LRRK2 and Rab5b, Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on human samples. J Biochem (2015) ncbi
rabbit monoclonal (MJFF2 (c41-2))
  • WB; human; 1:1000
Abcam LRRK2 antibody (Abcam, ab133474) was used in western blot on human samples at 1:1000. Biomed Res Int (2014) ncbi
rabbit monoclonal (MJFF2 (c41-2))
  • IHC-Free; mouse; fig 4
  • IHC-Free; rat; fig 6
  • IHC (knockout); mouse; fig 4
  • IHC (knockout); rat; fig 6
  • WB (knockout); mouse; fig 1, s2
  • WB; human; fig 1
Abcam LRRK2 antibody (Abcam, ab133474) was used in immunohistochemistry - free floating section on mouse samples (fig 4) and on rat samples (fig 6), in immunohistochemistry (knockout) on mouse samples (fig 4) and on rat samples (fig 6), in western blot (knockout) on mouse samples (fig 1, s2), and in western blot on human samples (fig 1). Biochem J (2013) ncbi
EMD Millipore
mouse monoclonal (8G10)
  • FC; rat
EMD Millipore LRRK2 antibody (Millipore, 8G10) was used in flow cytometry on rat samples. Biomaterials (2014) ncbi
BioLegend
mouse monoclonal (MC.028.83.76.242)
  • IP; mouse; fig 2
  • WB; human; fig 1
BioLegend LRRK2 antibody (biolegend, 808201) was used in immunoprecipitation on mouse samples (fig 2) and in western blot on human samples (fig 1). Biochem J (2013) ncbi
Santa Cruz Biotechnology
not indicated
  • IC; human
Santa Cruz Biotechnology LRRK2 rabbit polyclonal antibody was used to stain endogenous LRRK2 protein in order to determine the localization of endogenous LRRK2Proc Natl Acad Sci U S A (2009) ncbi
Neuromab
mouse monoclonal (N241A/34) Neuromab LRRK2 antibody (NeuroMab, 75-253) was used . Sci Transl Med (2015) ncbi
mouse monoclonal (N241A/34)
  • IHC (knockout); mouse; fig 1
  • IHC (knockout); rat; fig 1
  • WB (knockout); human; fig 7
  • WB (knockout); mouse; fig 6
Neuromab LRRK2 antibody (NeuroMab, 73-253) was used in immunohistochemistry (knockout) on mouse samples (fig 1) and on rat samples (fig 1) and in western blot (knockout) on human samples (fig 7) and on mouse samples (fig 6). J Comp Neurol (2014) ncbi
mouse monoclonal (N241A/34)
  • IHC (knockdown); rat; fig 6
  • IC (knockout); mouse; fig s3
  • WB (knockout); mouse; fig 1, s2
  • WB (knockout); rat; fig 5
  • WB; human; fig 1
  • IP; human; fig 2
  • IP; mouse; fig 2
Neuromab LRRK2 antibody (Neuromab, N241A/34) was used in immunohistochemistry (knockdown) on rat samples (fig 6), in immunocytochemistry (knockout) on mouse samples (fig s3), in western blot (knockout) on mouse samples (fig 1, s2) and on rat samples (fig 5), and in immunoprecipitation on human samples (fig 2) and on mouse samples (fig 2). Biochem J (2013) ncbi
Individual Researcher
not indicated
  • IHC; human
Dr. Valina L. Dawson (Johns Hopkins University) LRRK2 antibody was used in immunohistochemistry to study the localization of LRRK2 to membranous and vesicular structures in mammalian brain.Ann Neurol (2006) ncbi
Articles Reviewed
  1. Reina N Fuji et al. (2015). "Effect of selective LRRK2 kinase inhibition on nonhuman primate lung".PMID 25653221
  2. Hye Jin Yun et al. (2015). "An early endosome regulator, Rab5b, is an LRRK2 kinase substrate".PMID 25605758
  3. Panojot Bifsha et al. (2014). "Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra".PMID 25501001
  4. Dong Hwan Ho et al. (2014). "Increased DJ-1 in urine exosome of Korean males with Parkinson's disease".PMID 25478574
  5. Matthew D Walker et al. (2014). "Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging".PMID 25000966
  6. Archana V Boopathy et al. (2014). "The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation".PMID 24974008
  7. S Yang et al. (2014). "Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model".PMID 24810053
  8. Andrew B West et al. (2014). "Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents".PMID 24633735
  9. Claudia Manzoni et al. (2013). "Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation".PMID 24211199
  10. Paul Davies et al. (2013). "Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies".PMID 23560750
  11. Han Seok Ko et al. (2009). "CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity".PMID 19196961
  12. Saskia Biskup et al. (2006). "Localization of LRRK2 to membranous and vesicular structures in mammalian brain".PMID 17120249