This is a review about IL-6R, based on 15 published articles (read how Labome selects the articles), using IL-6R antibody in all methods. It is aimed to help Labome visitors find the most suited IL-6R antibody.
IL-6R synonym: CD126; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ; gp80; CD126 antigen; IL-6 receptor subunit alpha; IL-6R 1; membrane glycoprotein 80

Santa Cruz Biotechnology
rabbit polyclonal (C-20)
  • IC; mouse; 1:200
Santa Cruz Biotechnology IL-6R antibody (Santa Cruz, Sc-661) was used in immunocytochemistry on mouse samples at 1:200. Cancer Res (2015) ncbi
rabbit polyclonal (C-20)
  • IHC-P; human; 1:100
Santa Cruz Biotechnology IL-6R antibody (Santa Cruz, sc-661) was used in immunohistochemistry - paraffin section on human samples at 1:100. APMIS (2015) ncbi
rabbit polyclonal (H-300)
  • WB; mouse
Santa Cruz Biotechnology IL-6R antibody (Santa Cruz Biotechnology, sc-13947) was used in western blot on mouse samples. Mol Cell Endocrinol (2014) ncbi
rabbit polyclonal (C-20)
  • WB; human
Santa Cruz Biotechnology anti-gp80 antibody was used in western blot in order to study the role of vIL-6 in the growth and survival of cells latently infected with HHV-8.J Virol (2009) ncbi
not indicated
  • WB; human
Santa Cruz rabbit polyclonal anti-IL-6R antibody was used to detect IL-6R in western blot in order to demonstrate that the MAPK/CREB cascade and the STAT-3 signaling pathway mediate H-IL-6-activated neurogenesis and gliogenesisMol Biol Cell (2009) ncbi
not indicated
  • WB; human
Santa Cruz Biotechnology anti-IL-6R antibody was used in western blot to detect IL-6R in C2C12 cells.J Biol Chem (2006) ncbi
Invitrogen
mouse monoclonal (B-R6)
  • FC; human
In order to assess the effects of cytokines on integrin expression and mast cell adhesion, Invitrogen IL-6R antibody (Biosource, B-R6) was used in flow cytometry on human samples. J Invest Dermatol (2003) ncbi
mouse monoclonal (B-N12)
  • FC; human; fig 1
In order to assess the antitumor effects of IL-6 on hepatocarcinoma HepG2 cells, Invitrogen IL-6R antibody (Biosource, clone B-N12) was used in flow cytometry on human samples (fig 1). Eur J Cancer (2001) ncbi
mouse monoclonal (B-R6)
  • FC; human; fig 2
In order to examine the role of role of neutrophil-derived serine proteases in traumatic brain injuries, Invitrogen IL-6R antibody (Biosource, B-R-6) was used in flow cytometry on human samples (fig 2). J Interferon Cytokine Res (1999) ncbi
mouse monoclonal (B-N12)
  • FC; human; fig 2
In order to examine the role of role of neutrophil-derived serine proteases in traumatic brain injuries, Invitrogen IL-6R antibody (Biosource, B-N12) was used in flow cytometry on human samples (fig 2). J Interferon Cytokine Res (1999) ncbi
mouse monoclonal (B-R6)
  • ELISA; human; fig 1
In order to study human herpesvirus 8 interleukin 6, Invitrogen IL-6R antibody (Biosource, clone B-R6) was used in ELISA on human samples (fig 1). AIDS (1999) ncbi
R and D Systems
mouse monoclonal (17506)
  • ELISA; human
In order to optimize a method to distinguish benign prostatic hypertrophy from prostate cancer, R and D Systems IL-6R antibody (R&D Systems, MAB227) was used in ELISA on human samples. PLoS ONE (2015) ncbi
BioLegend
mouse monoclonal (UV4)
  • FC; human; 1:50
BioLegend IL-6R antibody (BioLegend, 352803) was used in flow cytometry on human samples at 1:50. Mol Cancer Res (2015) ncbi
not indicated
  • IP; human
Biolegend anti-IL-6R antibody was used in immunoprecipitation to immunoprecipitate IRS-1 in C2C12 cells transfected with IRS-1 and stimulated with mouse recombinant IL-6.J Biol Chem (2006) ncbi
LifeSpan Biosciences
mouse monoclonal (B-R6)
  • IHC-F; human
LifeSpan Biosciences IL-6R antibody (LifeSpan BioSciences, LS-C45194) was used in immunohistochemistry - frozen section on human samples. Clin Exp Immunol (2012) ncbi
BD Biosciences
not indicated
  • FC; human
BD antibody against IL-6R was used for flow cytometry in order to demonstrate IL-6 promotes antibody production through increased IL-21 production.J Exp Med (2009) ncbi
not indicated
  • FC; human
BD Biosciences R-phycoerythrin-conjugated mouse anti-human IL-6 receptor monoclonal antibody was used in flow cytometry to study TGF-beta1 signalingJ Biol Chem (2005) ncbi
Articles Reviewed
  1. Jesse V Jokerst et al. (2015). "A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers".PMID 26421725
  2. Ganga Gopinathan et al. (2015). "Interleukin-6 Stimulates Defective Angiogenesis".PMID 26081809
  3. Simon Andreasen et al. (2015). "Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gland".PMID 26061266
  4. Patrick M Perrigue et al. (2015). "The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines".PMID 25652587
  5. Emmelie Cansby et al. (2014). "Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained".PMID 24976178
  6. M M Suttle et al. (2012). "Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor".PMID 22861371
  7. Oliver Dienz et al. (2009). "The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells".PMID 19139170
  8. Daming Chen et al. (2009). "Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6".PMID 18987143
  9. Omedul Islam et al. (2009). "Interleukin-6 and neural stem cells: more than gliogenesis".PMID 18971377
  10. Cora Weigert et al. (2006). "Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells".PMID 16418171
  11. Xiao Liang Zhang et al. (2005). "Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling".PMID 15661740
  12. Dagmar Schoeler et al. (2003). "Interleukin-6 enhances whereas tumor necrosis factor alpha and interferons inhibit integrin expression and adhesion of human mast cells to extracellular matrix proteins".PMID 12713584
  13. M Cervello et al. (2001). "Downregulation of wild-type beta-catenin expression by interleukin 6 in human hepatocarcinoma HepG2 cells: a possible role in the growth-regulatory effects of the cytokine?".PMID 11267862
  14. U Bank et al. (1999). "Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation".PMID 10574621
  15. J R Gage et al. (1999). "Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line".PMID 10513642