This is a review about IKK alpha, based on 42 published articles (read how Labome selects the articles), using IKK alpha antibody in all methods. It is aimed to help Labome visitors find the most suited IKK alpha antibody.
IKK alpha synonym: IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16; I-kappa-B kinase 1; I-kappa-B kinase-alpha; IKK-a kinase; IkB kinase alpha subunit; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; inhibitor of nuclear factor kappa-B kinase subunit alpha; transcription factor 16

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Santa Cruz BiotechnologySanta Cruz Biotechnology IKK alpha product
  • ChIP assayIn 2008, Alessio Iannetti et al. used Santa Cruz Biotechnology IKK alpha antibody to identify NF-kappaB target genes involved in thyroid cancer [ncbi , more ].
  • immunocytochemistryIn 2002, Ryouichi Horie et al. employed Santa Cruz Biotechnology IKK alpha antibody to study the intracellular localization of tumor necrosis factor (TNF) receptor associated factor (TRAF) proteins in H-RS cells [ncbi , more ].
  • immunohistochemistryIn 2005, Zhanguo Gao et al. used Santa Cruz Biotechnology IKK alpha antibody to study the coactivators and corepressors of NF-kappa B in I kappa B alpha gene promoter [ncbi , more ]. In 2004, Susan E McNulty et al. applied Santa Cruz Biotechnology IKK alpha antibody to study the expression pattern of NFkappaB family members in human melanocytic cells of normal skin, benign intradermal naevus, and metastatic melanoma tissues [ncbi , more ]. In 2002, Ryouichi Horie et al. employed Santa Cruz Biotechnology IKK alpha antibody to study the intracellular localization of tumor necrosis factor (TNF) receptor associated factor (TRAF) proteins in H-RS cells [ncbi , more ].
  • immunoprecipitationIn 2007, Hittu Matta et al. utilized Santa Cruz Biotechnology IKK alpha antibody to study the K13-induced NF-B and JNK activation and re-examine the role of TRAFs in these processes [ncbi , more ]. Ling Chi Wang et al. applied Santa Cruz Biotechnology IKK alpha antibody to study tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells [ncbi , more ] in 2005 and Hua Cheng et al. used Santa Cruz Biotechnology IKK alpha antibody to study the role for hTid-1 in the regulation of NF-kappaB activity and suppression of tumor growth [ncbi , more ]. In 2004, Holger Buss et al. utilized Santa Cruz Biotechnology IKK alpha antibody to study the effect of multiple protein kinases and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription on constitutive and interleukin-1-inducible phosphorylation of p65 NF- B at serine 536 [ncbi , more ]. In 2002, Zhanguo Gao et al. utilized Santa Cruz Biotechnology IKK alpha antibody to study the effect of inhibitor kappaB kinase complex on insulin receptor substrate 1 [ncbi , more ].
  • western blotIn 2011, Shaun Rosebeck et al. used Santa Cruz Biotechnology IKK alpha antibody to perform western blot in order to study that cleveage of NIK leads to noncanonical NF- kB activation (catalog: sc-949) [ncbi , more ]. In 2010, Bruce S Hostager et al. used Santa Cruz Biotechnology IKK alpha antibody to perform western blot in order to indicate an important role for the ubiquitin ligase activity of HOIP in CD40 signaling [ncbi , more ]. In 2009, DaMing Gao et al. used Santa Cruz Biotechnology IKK alpha antibody to perform western blot in order to show that Skp2 phosphorylation by Akt1 promotes Skp2 to localize in cytoplasm and impairs APCCdh1-mediated Skp2 destruction (catalog: SC-7184) [ncbi , more ]. Santa Cruz Biotechnology IKK alpha antibody was used in 2008 to demonstrate that NF-kappaB dictates the degradation pathway of IkappaBalpha [ncbi , more ], to study the role of TLR2 in CCL5 secretion in response to M. bovis BCG [ncbi , more ]and to demonstrate that CARD11 can recruit signaling cofactors independently of one another in a signal-inducible manner (catalog: sc-7606) [ncbi , more ]. In 2007, Y H Kim et al. employed Santa Cruz Biotechnology IKK alpha antibody to investigate the effect of TA on early inflammation and vascular leakage in the retina of STZ-induced hyperglycemic rats [ncbi , more ]. Santa Cruz Biotechnology IKK alpha antibody was applied in 2005 to study I{kappa}B kinase signaling regulated by PP2A [ncbi , more ], to study the role of endothelin-1 in increaseing total peripheral resistance (TPR) and decreaseing organ blood flow [ncbi , more ], to characterize a NIK and IKKbeta binding protein [ncbi , more ], to study the coactivators and corepressors of NF-kappa B in I kappa B alpha gene promoter [ncbi , more ], to study the inhibition effect of sphingosine-1-phosphate on nuclear factor kappa B activation and germ cell apoptosis in the human testis independently of its receptors (catalog: sc-847) [ncbi , more ], to study the role for hTid-1 in the regulation of NF-kappaB activity and suppression of tumor growth [ncbi , more ]and to detect IKKalpha in the PAK4 knockdown cells treated with TNFalpha+CHX [ncbi , more ]. Santa Cruz Biotechnology IKK alpha antibody was used in 2004 to study the effect of multiple protein kinases and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription on constitutive and interleukin-1-inducible phosphorylation of p65 NF- B at serine 536 [ncbi , more ], to study precise mechanism by which TGase 2 promotes inflammation [ncbi , more ]and to study the effect of tumor necrosis factor alpha receptor complex-targeted MEKK3 on NF-kappaB in receptor-interacting protein-deficient cells [ncbi , more ]. Santa Cruz Biotechnology IKK alpha antibody was used in 2003 to study the regulatory mechanisms for the phosphorylation of p65 on Ser-536 under physiological conditions [ncbi , more ], to study the induction of ICAM-1 expression in human aortic endothelial cells by Chlamydophila pneumoniae via protein kinase C dependent activation of nuclear factor-kappa B [ncbi , more ], to study the role of IKK alpha in mitogenic signaling [ncbi , more ]and to study the role of RelB serine 368 for dimerization and p100 stabilization [ncbi , more ]. Santa Cruz Biotechnology IKK alpha antibody was employed in 2002 to study the effect of human herpes virus 8-encoded viral FLICE inhibitory protein on Ikappa B kinase complex (catalog: SC-7182) [ncbi , more ], to study the formation of the TRAF6-TAB2-TAK1 complex [ncbi , more ]and to study the effect of inhibitor kappaB kinase complex on insulin receptor substrate 1 [ncbi , more ]. K Tada et al. used Santa Cruz Biotechnology IKK alpha antibody to study the role of TRAF2 and TRAF5 in tumor necrosis factor-induced NF- B activation and protection from cell death [ncbi , more ] in 2001 and Y H Choi et al. used Santa Cruz Biotechnology IKK alpha antibody to study the function of FLASH in NF-kappaB Activity [ncbi , more ].
EMD MilliporeEMD Millipore IKK alpha product
  • western blotIn 2002, Kaoru Saijo et al. applied EMD Millipore IKK alpha antibody to study the phosphorylation of IKKalpha [ncbi , more ].
Cell Signaling TechnologyCell Signaling Technology IKK alpha product
  • immunoprecipitationIn 2002, Kaoru Saijo et al. applied Cell Signaling Technology IKK alpha antibody to study the phosphorylation of IKKalpha [ncbi , more ].
  • western blotIn 2010, Nicholas Matluk et al. employed Cell Signaling Technology IKK alpha antibody to perform western blotting in order to determine the role of NRAGE in regulating NF-kappaB activity [ncbi , more ]. Thomas J Cremer et al. used Cell Signaling Technology IKK alpha antibody to perform western blot in order to study the role of F.n. induced MiR-155 in enhanced pro-inflammatory cytokine response and SHIP down-regulation [ncbi , more , fig ] in 2009 and Sagar Ghosh et al. used Cell Signaling Technology IKK alpha antibody to study the regulation of aromatase transcription and estrogen biosynthesis in adipose stromal cells (ASCs) [ncbi , more ]. In 2008, Sara M Reyna et al. utilized Cell Signaling Technology IKK alpha antibody to carry out western blot analysis in order to examine whether insulin-resistant patients have abnormal TLR4 expression and TLR4-driven signaling in skeletal muscle [ncbi , more ]. In 2006, Sohini Mukherjee et al. employed Cell Signaling Technology IKK alpha antibody to study inhibition of MAPK and NFkappaB signaling pathways through preventing activation of the family of MAPK kinases (MAPKK) [ncbi , more ]. Arlene E Kray et al. employed Cell Signaling Technology IKK alpha antibody to study I{kappa}B kinase signaling regulated by PP2A [ncbi , more ] in 2005 and Wen Hui Hu et al. used Cell Signaling Technology IKK alpha antibody to characterize a NIK and IKKbeta binding protein [ncbi , more ]. Andrew M F Liu et al. applied Cell Signaling Technology IKK alpha antibody to detect total IKKalpha and activated IKKalpha/beta in human Reh and HEK 293 cells [ncbi , more ] in 2004 and Jongmin Lee et al. used Cell Signaling Technology IKK alpha antibody to study precise mechanism by which TGase 2 promotes inflammation [ncbi , more ]. In 2002, Christopher J Howe et al. employed Cell Signaling Technology IKK alpha antibody to study the phosphorylation of IKK [ncbi , more ].
WILEX Inc.
  • western blotIn 2009, Keiko Kawauchi et al. employed WILEX Inc. IKK alpha antibody to perform western blot in order to prove that the catalytic activity of IKK modified with O-GlcNAc in p53-deficient cells is enhanced [ncbi , more ].
ProSci
  • immunoprecipitationIn 2010, Padmam Puneet et al. applied ProSci IKK alpha antibody to carry out immunoprecipitation assay and western blot analysis in order to investigate the role for SphK1 in regulating endotoxin signaling and sepsis-induced inflammatory responses [ncbi , more ].
  • western blotIn 2010, Padmam Puneet et al. applied ProSci IKK alpha antibody to carry out immunoprecipitation assay and western blot analysis in order to investigate the role for SphK1 in regulating endotoxin signaling and sepsis-induced inflammatory responses [ncbi , more ].
BD Biosciences
  • western blotIn 2008, Tomoyasu Higashimoto et al. applied BD Biosciences IKK alpha antibody to perform western blot in order to study the funtion of phosphorylation of gamma-binding domain of IkB kinase beta [ncbi , more ]. Arlene E Kray et al. employed BD Biosciences IKK alpha antibody to study I{kappa}B kinase signaling regulated by PP2A [ncbi , more ] in 2005 and Ling Chi Wang et al. used BD Biosciences IKK alpha antibody to study tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells [ncbi , more ]. In 2003, Chris Albanese et al. used BD Biosciences IKK alpha antibody to study the role of IKK alpha in mitogenic signaling [ncbi , more ].
GE Healthcare Life Biosciences
  • western blotIn 2004, Andrew M F Liu et al. applied GE Healthcare Life Biosciences IKK alpha antibody to detect total IKKalpha and activated IKKalpha/beta in human Reh and HEK 293 cells [ncbi , more ].
Figure
Cell Signaling rabbit anti-pIKKalpha antibody was used to perform western blot in order to study the role of F.n. induced MiR-155 in enhanced pro-inflammatory cytokine response and SHIP down-regulation.
IKK alpha antibody western blot Cell Signaling Technology
Cell lysates from WT and TLR2 macrophage mutants infected with F. tularensis novicida for various time were analyzed by Western blotting for pIKKalpha, pNFkappaBp65, and actin.
Thomas J Cremer et al. (2009). "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response".PMID 20041145
Articles Reviewed
  1. Shaun Rosebeck et al. (2011). "Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation".PMID 21273489
  2. Bruce S Hostager et al. (2010). "HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex".PMID 20614026
  3. Padmam Puneet et al. (2010). "SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis".PMID 20522778
  4. Nicholas Matluk et al. (2010). "A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway".PMID 20100315
  5. Thomas J Cremer et al. (2009). "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response".PMID 20041145
  6. DaMing Gao et al. (2009). "Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction".PMID 19270695
  7. Sagar Ghosh et al. (2009). "IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells".PMID 19221050
  8. Keiko Kawauchi et al. (2009). "Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification".PMID 19202066
  9. Tomoyasu Higashimoto et al. (2008). "Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1".PMID 18957422
  10. Alessio Iannetti et al. (2008). "The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells".PMID 18768801
  11. Sara M Reyna et al. (2008). "Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects".PMID 18633101
  12. Ryan R McCully et al. (2008). "The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association".PMID 18625728
  13. Erika Mathes et al. (2008). "NF-kappaB dictates the degradation pathway of IkappaBalpha".PMID 18401342
  14. Patricia Méndez-Samperio et al. (2008). "Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways".PMID 17989335
  15. Y H Kim et al. (2007). "Triamcinolone acetonide protects the rat retina from STZ-induced acute inflammation and early vascular leakage".PMID 17881007
  16. Hittu Matta et al. (2007). "Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation".PMID 17597077
  17. Sohini Mukherjee et al. (2006). "Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation".PMID 16728640
  18. Xiaofan Li et al. (2005). "PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor".PMID 16227624
  19. Arlene E Kray et al. (2005). "Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A".PMID 16126728
  20. Rongqian Wu et al. (2005). "Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1".PMID 16018991
  21. Wen Hui Hu et al. (2005). "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation".PMID 15951441
  22. Zhanguo Gao et al. (2005). "Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter".PMID 15811852
  23. Laura Suomalainen et al. (2005). "Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors".PMID 15743789
  24. Ling Chi Wang et al. (2005). "Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK".PMID 15611081
  25. Hua Cheng et al. (2005). "Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth".PMID 15601829
  26. Marzenna Blonska et al. (2004). "Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells".PMID 15572679
  27. Holger Buss et al. (2004). "Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK".PMID 15489227
  28. Andrew M F Liu et al. (2004). "G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling".PMID 15485865
  29. Jongmin Lee et al. (2004). "Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia".PMID 15471861
  30. Susan E McNulty et al. (2004). "Comparative expression of NFkappaB proteins in melanocytes of normal skin vs. benign intradermal naevus and human metastatic melanoma biopsies".PMID 15016307
  31. Harald Jakob Maier et al. (2003). "Critical role of RelB serine 368 for dimerization and p100 stabilization".PMID 12874295
  32. Hiroaki Sakurai et al. (2003). "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway".PMID 12842894
  33. Silvana A Vielma et al. (2003). "Chlamydophila pneumoniae induces ICAM-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-kappaB".PMID 12714566
  34. Chris Albanese et al. (2003). "IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf".PMID 12589056
  35. Zhanguo Gao et al. (2002). "Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex".PMID 12351658
  36. Kaoru Saijo et al. (2002). "Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha".PMID 12070292
  37. Christopher J Howe et al. (2002). "Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes".PMID 12063265
  38. Ryouichi Horie et al. (2002). "Cytoplasmic aggregation of TRAF2 and TRAF5 proteins in the Hodgkin-Reed-Sternberg cells".PMID 12000717
  39. Li Liu et al. (2002). "The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex".PMID 11830587
  40. Junko Mizukami et al. (2002). "Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6".PMID 11809792
  41. K Tada et al. (2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death".PMID 11479302
  42. Y H Choi et al. (2001). "FLASH coordinates NF-kappa B activity via TRAF2".PMID 11340079