This is a review about Cdk5, based on 28 published articles (read how Labome selects the articles), using Cdk5 antibody in all methods. It is aimed to help Labome visitors find the most suited Cdk5 antibody.
Cdk5 synonym: LIS7; PSSALRE; TPKII catalytic subunit; cell division protein kinase 5; protein kinase CDK5 splicing; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit

Knockout validation
Invitrogenmouse monoclonal (DC34)
  • IC (knockout); mouse; fig 2
In order to demonstrate that the Cdk5-Foxc2 interaction regulates lymphatic vessel development, Invitrogen Cdk5 antibody (Life Technologies, AHZ0492) was used in immunocytochemistry (knockout) on mouse samples (fig 2). Nat Commun (2015) ncbi
Santa Cruz Biotechnology
rabbit polyclonal (C-8)
  • WB; rat; 1:200
In order to investigate the involvement of microRNA-195 in the effect of chronic brain hypoperfusion on rodent Cdk5/p25 and tau phosphorylation, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-173) was used in western blot on rat samples at 1:200. J Neurochem (2015) ncbi
rabbit polyclonal (C-8)
  • WB; mouse; fig 4
In order to test the effects of high fat diet using a mouse model of familial Alzheimer disease, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz biotech, Sc-173) was used in western blot on mouse samples (fig 4). Biochim Biophys Acta (2015) ncbi
rabbit polyclonal (C-8)
  • WB; human
In order to identify small-molecules that inhibit the interaction between CDK5 and p25, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-173) was used in western blot on human samples. Chem Biol (2015) ncbi
mouse monoclonal (J-3)
  • WB; rat
  • IP; rat
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz, sc-6247) was used in western blot on rat samples and in immunoprecipitation on rat samples. PLoS ONE (2015) ncbi
rabbit polyclonal (C-8)
  • WB; mouse; 1:1000; fig 10
In order to characterize cognitive and neuropathological Alzheimer's disease markers in a novel mouse model, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotech, sc-173) was used in western blot on mouse samples at 1:1000 (fig 10). Age (Dordr) (2015) ncbi
mouse monoclonal (DC 17)
  • WB; human; fig 1
In order to identify CDK4 binding partners, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz, DC-17) was used in western blot on human samples (fig 1). Cell Cycle (2014) ncbi
rabbit polyclonal (C-8)
  • WB; mouse; 1:400
In order to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz, sc-173) was used in western blot on mouse samples at 1:400. Neurobiol Aging (2015) ncbi
rabbit polyclonal (C-8)
  • IHC-P; human; 1:200
  • IP; human
  • WB; human
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-173) was used in immunohistochemistry - paraffin section on human samples at 1:200, in immunoprecipitation on human samples, and in western blot on human samples. J Cell Biol (2014) ncbi
rabbit polyclonal (Tyr 15)
  • WB; human
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-12918-R) was used in western blot on human samples. J Cell Biol (2014) ncbi
mouse monoclonal (J-3)
  • IHC-P; human; 1:200
  • WB; human
  • IP; human
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-6247) was used in immunohistochemistry - paraffin section on human samples at 1:200, in western blot on human samples, and in immunoprecipitation on human samples. J Cell Biol (2014) ncbi
mouse monoclonal (DC 17)
  • WB; human; 1:2000; fig 7c
In order to study the initiation and regulation of radial migration, Santa Cruz Biotechnology Cdk5 antibody (Santa, sc-249) was used in western blot on human samples at 1:2000 (fig 7c). Nat Commun (2014) ncbi
mouse monoclonal (J-3)
  • IC; mouse; 1:100; fig 4
In order to elucidate the molecular mechanisms of dilation formation and nuclear elongation, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz, sc-6247) was used in immunocytochemistry on mouse samples at 1:100 (fig 4). Development (2014) ncbi
rabbit polyclonal (C-8)
  • WB; mouse
In order to investigate the abnormalites in hippocampal energy metabolism in the pathogenesis of Alzheimer disease, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz biotech, Sc-173) was used in western blot on mouse samples. Biochim Biophys Acta (2014) ncbi
mouse monoclonal (DC 17)
  • WB; mouse
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, DC17) was used in western blot on mouse samples. J Neurosci (2014) ncbi
goat polyclonal (Tyr 15)
  • WB; African green monkey
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-12918) was used in western blot on African green monkey samples. J Biol Chem (2014) ncbi
goat polyclonal (Ser 159)
  • WB; human
  • WB; mouse
In order to study the lack of involvementof GSK3-alpha/beta in the elevated tau phosphorylation observed in Tau.P30L hypothermic mice, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz, sc-12919) was used in western blot on human samples and on mouse samples. Eur J Neurosci (2014) ncbi
rabbit polyclonal (Ser 159)
  • IHC; mouse; 1:200
Santa Cruz Biotechnology Cdk5 antibody (Santa cruz, sc-12919-R) was used in immunohistochemistry on mouse samples at 1:200. PLoS ONE (2014) ncbi
mouse monoclonal (J-3)
  • WB; human
  • WB; rat
  • IC; human
In order to investigate the role of MiR-26b in cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-6247) was used in western blot on human samples and on rat samples and in immunocytochemistry on human samples. J Neurosci (2013) ncbi
rabbit polyclonal (C-8)
  • WB; human
  • WB; rat
  • IC; human
In order to investigate the role of MiR-26b in cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-173) was used in western blot on human samples and on rat samples and in immunocytochemistry on human samples. J Neurosci (2013) ncbi
rabbit polyclonal (C-8)
  • WB; mouse; 1:500
  • IP; mouse; 1:500
Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-173) was used in western blot on mouse samples at 1:500 and in immunoprecipitation on mouse samples at 1:500. J Biol Chem (2013) ncbi
not indicated
  • WB; human
Santa Cruz Biotechnology anti-Cdk5 (SC-173), Cdk5-pTyr-15 (SC-12918), and Cdk5-pSer-159 (SC-12919) antibodies were used to perform western blot in order to investigate the molecular mechanisms underlying CRMP2 function in CXCL12-induced T lymphocyte migration.J Biol Chem (2009) ncbi
rabbit polyclonal (C-8)
  • IHC-F; mouse
In order to exmaine the role of Cdk5 in the neurnal migration in the developing spinal cord, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz Biotechnology, sc-173) was used in immunohistochemistry - frozen section on mouse samples. J Comp Neurol (2007) ncbi
not indicated
  • WB; human
Santa Cruz Biotechnology anti-Cdk5 monoclonal antibody (J-3) was used in western blot to study retinoblastoma phosphorylation in neuronal cell deathJ Cell Sci (2005) ncbi
rabbit polyclonal (C-8)
  • WB; human
In order to describe a signal transduction pathway in which Fyn and Cdk5 mediate neuronal guidance regulated by Sema3A, Santa Cruz Biotechnology Cdk5 antibody (Santa Cruz, C-8) was used in western blot on human samples. Neuron (2002) ncbi
Invitrogen
mouse monoclonal (DC34)
  • IC (knockout); mouse; fig 2
In order to demonstrate that the Cdk5-Foxc2 interaction regulates lymphatic vessel development, Invitrogen Cdk5 antibody (Life Technologies, AHZ0492) was used in immunocytochemistry (knockout) on mouse samples (fig 2). Nat Commun (2015) ncbi
mouse monoclonal (DC34)
  • WB; human; 1:100; fig 1
In order to demonstrate that cyclin-dependent kinase 2 and 5 regulate neoangiogenesis, Invitrogen Cdk5 antibody (Molecular Probes, AHZ0492) was used in western blot on human samples at 1:100 (fig 1). J Cell Physiol (2013) ncbi
Abcam
rabbit monoclonal (EP715Y)
  • WB; rat; 1:2000
Abcam Cdk5 antibody (Abcam, ab40773) was used in western blot on rat samples at 1:2000. Brain Res Bull (2014) ncbi
mouse monoclonal (4E4)
  • IHC-F; rat; 1:200
  • IP; rat
  • WB; rat
Abcam Cdk5 antibody (Abcam, ab115812) was used in immunohistochemistry - frozen section on rat samples at 1:200, in immunoprecipitation on rat samples, and in western blot on rat samples. PLoS ONE (2012) ncbi
rabbit monoclonal (EP715Y)
  • IHC-F; rat; 1:200
  • WB; rat
  • IP; rat
Abcam Cdk5 antibody (Abcam, ab40773) was used in immunohistochemistry - frozen section on rat samples at 1:200, in western blot on rat samples, and in immunoprecipitation on rat samples. PLoS ONE (2012) ncbi
EMD Millipore
mouse monoclonal (1H3)
  • WB; rat; 1:1000
EMD Millipore Cdk5 antibody (Millipore, MABS50) was used in western blot on rat samples at 1:1000. Neuroreport (2014) ncbi
mouse monoclonal
  • WB; human
EMD Millipore Cdk5 antibody (Upstate Biotechnology, 05-364) was used in western blot on human samples. Evid Based Complement Alternat Med (2012) ncbi
not indicated
  • WB; human
Upstate Biotechnology cdk5 antibody was used in western blot to study the role of cdk5 in the regulation of breast cancer cell proliferation and apoptosis.Exp Mol Pathol (2007) ncbi
Articles Reviewed
  1. Li hua Sun et al. (2015). "Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation".PMID 26118667
  2. Johanna Liebl et al. (2015). "Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2".PMID 26027726
  3. Dmitry Petrov et al. (2015). "High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents".PMID 26003667
  4. Caroline Corbel et al. (2015). "Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation".PMID 25865311
  5. Bo S Kim et al. (2015). "Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia".PMID 25831123
  6. D Porquet et al. (2015). "Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8)".PMID 25663420
  7. Siwanon Jirawatnotai et al. (2014). "The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis".PMID 25486477
  8. Elisabetta Lauretti et al. (2015). "Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor".PMID 25457549
  9. Brajendra K Tripathi et al. (2014). "CDK5 is a major regulator of the tumor suppressor DLC1".PMID 25452387
  10. Tao Ye et al. (2014). "Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex".PMID 25189171
  11. Yoshiaki V Nishimura et al. (2014). "Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons".PMID 25183872
  12. Kai Li et al. (2014). "Epigenetic upregulation of Cdk5 in the dorsal horn contributes to neuropathic pain in rats".PMID 25055140
  13. Ignacio Pedrós et al. (2014). "Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease".PMID 24887203
  14. Jing Tang et al. (2014). "Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition".PMID 24872548
  15. Hiroyuki Kobayashi et al. (2014). "Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5".PMID 24872417
  16. Xiaojie Liu et al. (2014). "Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-D-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord".PMID 24769228
  17. Hervé Maurin et al. (2014). "Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β".PMID 24754737
  18. Xiaoqin Zhang et al. (2014). "ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity".PMID 24498195
  19. Sabrina Absalon et al. (2013). "MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons".PMID 24027266
  20. Xuemei Zhang et al. (2013). "Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models".PMID 23737518
  21. Mei Chih Chen et al. (2012). "Retinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 Overactivation".PMID 23304206
  22. Hong hai Zhang et al. (2012). "Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats".PMID 23056393
  23. Filomena de Nigris et al. (2013). "Osteosarcoma cells induce endothelial cell proliferation during neo-angiogenesis".PMID 23042366
  24. Michel Varrin-Doyer et al. (2009). "Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration".PMID 19276087
  25. Yee Ping Yip et al. (2007). "Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord".PMID 17492640
  26. Shaun Goodyear et al. (2007). "Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5".PMID 17081516
  27. Malika Hamdane et al. (2005). "p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death".PMID 15741232
  28. Yukio Sasaki et al. (2002). "Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex".PMID 12372285