This is a review about Cdk4, based on 43 published articles (read how Labome selects the articles), using Cdk4 antibody in experiments. It is aimed to help Labome visitors find the most suited Cdk4 antibody.
Cdk4 synonym: CMM3; PSK-J3; cell division protein kinase 4

  • Santa Cruz polyclonal rabbit anti-CDK4 was used in 1:500 dilution to perform western blot in order to show the mechanism of cancer cell proliferation and invasion inhibition by PCDGF/GEP blockadencbi, more , figure 1
  • Figure 1
    Cdk4 antibody western blot Santa Cruz Biotechnology
    Cdk4 antibody western blot Santa Cruz Biotechnology
    cyclin D1 and CDK4 decreased after antisense PCDGF construct transfection in SW626 cells, which paralleled with the proliferation and invasion capability.
    Yulan Liu et al. (2007). "Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2".PMID 17261172
  • Santa Cruz Biotechnology CDK4 antibody (1:200 dilution) was used in western blot in order to study molecular mechanisms underlying TSH-secreting pituitary tumors (TSHomas) (catalog: sc-260) ncbi, more
  • Santa Cruz Biotechnology CDK4 antibody (1:100) was used in western blot to study the role of an unliganded TRbeta mutant in pituitary tumorigenesis in vivo. (catalog: sc-260) ncbi, more
  • Santa Cruz Biotechnology mouse monoclonal anti-cdk4 antibody was used for western blot in order to investigate the role of Aurora B in the regulation of postmitotic endoreduplication checkpoint.ncbi, more
  • Santa Cruz anti-CDK4 antibody was used to perform western blot in order to study the regulation of NANOG in G1 to S transition in human embryonic stem cells.ncbi, more
  • Santa Cruz Biotechnology CDK4 antibody was used in western blot in order to show that Hsp90 co-chaperone CDC37 can maintain the oncogenic protein kinase clients.ncbi, more
  • Santa Cruz Biotechnology polyclonal anti-CDK4 antibody C-22 was used in human cells (T98G, IMR-90 cells) and in western blot to study the role for cyclins and CDK "inhibitors" in Thr172 phosphorylation of CDK4.ncbi, more
  • suppliernumreagent linkcited catalog
    Santa Cruz Biotechnology27Cdk4 antibodysc-260
    EMD Millipore3Cdk4 antibody
    Thermo Scientific Pierce Products1Cdk4 antibody
    Cell Signaling Technology6Cdk4 antibody
    BD Biosciences2Cdk4 antibody
    Sigma-Aldrich1
    Table 1. Cdk4 antibody western blot.
  • Santa Cruz Biotechnology Cdk2 antibody was used in western blot to study the roles of ATF3 in both cell death and cell cycle regulation.ncbi, more
  • SCBT anti-CDK4 (C-22) antibody was used in western blot to investigate the regulation of Cdc6 protein stability by p53.ncbi, more
  • SCBT anti-CDK4 (C-22) antibody was used in immunoprecipitation to investigate the role of ORC2 in CDK2 activationncbi, more
  • Santa Cruz Biotechnology antibody against cdk4 (product C-22) was used in immunoprecipitation to isolate cdk4 and in western blot to detect cdk4 in human primary effusion lymphoma (PEL) cell line BC3ncbi, more
  • Santa Cruz Biotechnologies Cdk4 antibody was used in western blot to study COLO-357 cell growth inhibition by TGF beta1ncbi, more
  • suppliernumreagent link
    Santa Cruz Biotechnology12Cdk4 antibody
    Table 2. Cdk4 antibody immunoprecipitation.
  • Santa Cruz Biotechnology rabbit polyclonal Cdk4 (C-22) antibody was used in western blot to study retinoblastoma phosphorylation in neuronal cell deathncbi, more
  • Santa Cruz Biotechnology rabbit polyclonal anti-CDK4 antibody was used in western blot and immunoprecipitation to detect CDK4 in NIH 3T3 cells transiently transfected with vector, RACK1, or mutant RACK1.ncbi, more
  • Santa Cruz Biotechnology anti-CDK4 antibody was used in western blot and immunoprecipitation to detect CDK4 in Reh cells transfected with expression vectors encoding wild type His-cyclin D3 or mutant His-cyclin D3.ncbi, more
  • Santa Cruz Biotechnology anti-CDK 4 antibody (sc-749) was used in human MCF7 cells and in western blot to study the effect of DRF 3188 on the cell cycle of MCF 7 breast cancer cells.ncbi, more
  • Santa Cruz Biotechnology anti-cdk4 (C-22 or H-22) was used in immunoprecipitation and western blot to isolate and detect cdk4 from the lysates of human WI-38 fibroblastsncbi, more
  • suppliernumreagent link
    Santa Cruz Biotechnology2Cdk4 antibody
    Table 3. Cdk4 antibody immunohistochemistry.
  • Santa Cruz Biotechnology CDK4 antibody was used in western blot to study the role of AMF/PGI in the regulation of cell proliferation.ncbi, more
  • Santa Cruz Biotechnology anti-Cdk4 antibody (H-22) was used in immunoprecipitation and western blot to the correlation of phosphorylation of p16INK4A with Cdk4 association.ncbi, more
  • Santa Cruz Biotechnology anti-Cdk4 antibody was used in immunoprecipitation to study that extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.ncbi, more
  • Santa Cruz Biotechnology anti-CDK4 antibody (C-22) was used in MCF-7S human breast cancer cells and in immunoprecipitation, western blot to study the mechanism by which IGF-I induces the activation of the cyclin D1-CDK4 complex.ncbi, more
  • Santa Cruz Biotechnology polyclonal CDK4 antibody was used in western blot to study the expression of CDK2-NLS immunocomplexes in transfected IIC9 cells.ncbi, more
  • Santa Cruz Biotechnologies anti-cdk4 antibody C-22 was used in immunohistochemistry to study the effect of expression of nuclear cdk2 and cdk4 in neurons on reactivation of herpes simplex virus.ncbi, more
  • Santa Cruz Biotechnology rabbit anti-CDK4 antibody was used in immunoprecipitation and western blot to study the physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulating the phosphorylation of retinoblastoma protein.ncbi, more
  • Santa Cruz Biotechnology antibody against Cdk4 was used in immunoprecipitation to study the different p27Kip1 phosphorylation patterns during cell cycle progression in human epithelial cells resistant to transforming growth factor beta-mediated G1 arrest.ncbi, more
  • Santa Cruz anti-CDK4 antibody was used in western blot and immunoprecipitation to identify the BCL6 as an inhibitor of anti-proliferative p19ARF-p53 signaling by a senescence rescue screen.ncbi, more
  • Santa Cruz Biotechnology anti-Cdk4 antibody (C-22) was used in human cells and in western blot to study the effects of SF/HGF, c-myc, p27, Cdk2, or E2F1 on glioblastoma cell cycle progression.ncbi, more
  • Santa Cruz Biotechnologies anti-cyclin-dependent kinases (cdk) 4 antibody was used in western blot to study the effects of over-expression of the potential tumor suppressor gene IGFBP-rP1/mac25 on cell-cycle kinetics in human prostate cancer cells.ncbi, more
  • Santa Cruz Biotechnology 1.5 g anti-Cdk4 antibody was used in western blot and immunoprecipitation to stduy the mechanism (s) by which Cdk4 activity is regulated in MCF-7 cells.ncbi, more
  • Santa Cruz Biotechnology goat polyclonal anti-CDK4 antibody was used in western blot and immunohistochemistry to detect CDK4 in the patients' tumor and adjacent normal testicular tissue.ncbi, more
  • Santa Cruz Biotechnology rabbit polyclonal cdk4 antibodies were used in western blot to demonstrate a cyclin D1/cyclin-dependent kinase 4 binding site within the C domain of the retinoblastoma protein.ncbi, more
  • Millipore anti-CDK4 antibody was used to perform western blot in order to study the roles of the fragile X mental retardation protein during the regulations of the proliferation and differentiation of adult neural stem/progenitor cells.ncbi, more
  • Upstate Biotechnology cdk4 antibody was used in western blot to study the role of cdk5 in the regulation of breast cancer cell proliferation and apoptosis.ncbi, more
  • Calbiochem anti-Cdk4 (Ab-2) antibody was used in western blot to identify cyclin E as a target of WT1 transcriptional repression.ncbi, more
Thermo Scientific Pierce ProductsThermo Scientific Pierce Products Cdk4 product
  • NeoMarkers anti-Cdk4 antibody was used in human T-cell leukemia cell lines and in western blot to study the effect of Jak-Stat pathway on cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.ncbi, more
  • Cell Signalling Technolgies mouse anti-CDK4 antibody (catalog no:2906) was used in western blot to combine computational simulations, experimental testing of simulation results, and finally reverse engineering of a protein interaction network to define potential therapeutic strategies for de novo trastuzumab resistant breast cancerncbi, more
  • Cell Signaling Technology anti-phospho-specific-CDK4 (Thr172) antibody was used in human (T98G, IMR-90) cells and in western blot to study the role for cyclins and CDK "inhibitors" in Thr172 phosphorylation of CDK4.ncbi, more
  • Cell Signaling anti-CDK4 antibody was used in western blot to study that tumor suppressor SMAR1 mediates Cyclin D1 repression by recruitment of the SIN3/Histone deacetylase 1 complex.ncbi, more
  • Cell Signaling anti-CDK4 antibody was used in western blot to detect CDK4 in HT-29 cells treated with NMT1-1 siRNA or NMT2-4 siRNA.ncbi, more
  • Cell Signaling anti-Cdk4 (catalog no. 2906) antibody was used in western blot to study tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cellsncbi, more
  • New England Biolabs polyclonal anti-CDK4 antibody was used in western blot to study that disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression.ncbi, more
  • BD PharMingen anti-CDK4 antibody was used in western blot in order to demonstrate that sulindac suppresses beta-catenin expression in human cancer cellsncbi, more
  • BD PharMingen polyclonal CDK4 antibody was used in western blot to study the PCNA multiprotein complexesncbi, more
Sigma-Aldrich
  • Sigma mouse anti-CDK4 antibody (C8218) was used in western blot to study the association of the chromatin remodelling factor BRG1 with the tumor suppressor p16INK4ancbi, more
Articles Reviewed
  1. Yuping Luo et al. (2010). "Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells".PMID 20386739
  2. Jayasree S Nair et al. (2009). "Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780".PMID 19225156
  3. Therese M Becker et al. (2009). "The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a".PMID 19149898
  4. Xin Zhang et al. (2009). "A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A".PMID 19139263
  5. Ozgur Sahin et al. (2009). "Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance".PMID 19118495
  6. J R Smith et al. (2009). "Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors".PMID 18931700
  7. Changxue Lu et al. (2008). "Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors".PMID 18356276
  8. Anjia Han et al. (2008). "Sulindac suppresses beta-catenin expression in human cancer cells".PMID 18291362
  9. Yulan Liu et al. (2007). "Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2".PMID 17261172
  10. Shaun Goodyear et al. (2007). "Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5".PMID 17081516
  11. Laurence Bockstaele et al. (2006). "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"".PMID 16782892
  12. Mariko Tomita et al. (2006). "Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells".PMID 16603085
  13. Dan Lu et al. (2006). "Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis".PMID 16469745
  14. Shravanti Rampalli et al. (2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex".PMID 16166625
  15. Charles E Ducker et al. (2005). "Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis".PMID 16123142
  16. Anja Duursma et al. (2005). "p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation".PMID 16055707
  17. Yuichi J Machida et al. (2005). "Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation".PMID 15944161
  18. Rukiyah Van Dross et al. (2005). "Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells".PMID 15870436
  19. Nichole Boyer Arnold et al. (2005). "Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein".PMID 15811853
  20. Malika Hamdane et al. (2005). "p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death".PMID 15741232
  21. Ling Chi Wang et al. (2005). "Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK".PMID 15611081
  22. Hiroko Furumoto et al. (2005). "An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis".PMID 15601836
  23. Vidya Mamidipudi et al. (2004). "RACK1 regulates G1/S progression by suppressing Src kinase activity".PMID 15254245
  24. Soheil Naderi et al. (2004). "cAMP-induced degradation of cyclin D3 through association with GSK-3beta".PMID 15252116
  25. Chitkala Satyanarayana et al. (2004). "DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells".PMID 15207007
  26. Sung Kwon Moon et al. (2004). "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression".PMID 15175338
  27. Christina R Kahl et al. (2004). "Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I".PMID 14754892
  28. Soichi Tsutsumi et al. (2003). "Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling".PMID 12783864
  29. Jay Gump et al. (2003). "Phosphorylation of p16INK4A correlates with Cdk4 association".PMID 12529334
  30. Tiho Miralem et al. (2003). "Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus".PMID 12509456
  31. Irene H L Hamelers et al. (2002). "Insulin-like growth factor I triggers nuclear accumulation of cyclin D1 in MCF-7S breast cancer cells".PMID 12364325
  32. Nathan H Lents et al. (2002). "Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2".PMID 12359725
  33. Luis M Schang et al. (2002). "Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4".PMID 12097586
  34. Kerstin Haller et al. (2002). "Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein".PMID 11971966
  35. Sandra Ciarallo et al. (2002). "Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest".PMID 11940657
  36. David M Loeb et al. (2002). "Cyclin E is a target of WT1 transcriptional repression".PMID 11919196
  37. Avi Shvarts et al. (2002). "A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling".PMID 11914273
  38. Kevin A Walter et al. (2002). "Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription".PMID 11909963
  39. Cynthia C Sprenger et al. (2002). "Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis".PMID 11791184
  40. Andrew J Skildum et al. (2002). "The cyclin-dependent kinase inhibitor p21WAF1/Cip1 is an antiestrogen-regulated inhibitor of Cdk4 in human breast cancer cells".PMID 11741909
  41. B A Schmidt et al. (2001). "Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors".PMID 11358847
  42. W Pan et al. (2001). "A cyclin D1/cyclin-dependent kinase 4 binding site within the C domain of the retinoblastoma protein".PMID 11306463
  43. Y Takasaki et al. (2001). "Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation".PMID 11254741