This is a review about CDK2, based on 52 published articles (read how Labome selects the articles), using CDK2 antibody in all methods. It is aimed to help Labome visitors find the most suited CDK2 antibody.
CDK2 synonym: p33(CDK2); cdc2-related protein kinase; cell devision kinase 2; cell division protein kinase 2; p33 protein kinase

Santa Cruz BiotechnologySanta Cruz Biotechnology CDK2 product
  • immunohistochemistryIn 2002, Luis M Schang et al. used Santa Cruz Biotechnology CDK2 antibody to study the effect of expression of nuclear cdk2 and cdk4 in neurons on reactivation of herpes simplex virus [ncbi , more ]. In 2001, B A Schmidt et al. applied Santa Cruz Biotechnology CDK2 antibody to detect CDK2 in the patients' tumor and adjacent normal testicular tissue [ncbi , more ].
  • immunoprecipitationIn 2009, C Elizabeth Caldon et al. used Santa Cruz Biotechnology CDK2 antibody to show that cyclin D1 is essential for estrogen regulation of cyclin E2 [ncbi , more ]. In 2006, Jason W Upton et al. applied Santa Cruz Biotechnology CDK2 antibody to determine the contribution of v-cyclin-mediated cell cycle regulation to the viral life cycle [ncbi , more ]. Santa Cruz Biotechnology CDK2 antibody was used in 2005 to isolate cdk2 and in western blot to detect cdk2 in human primary effusion lymphoma (PEL) cell line BC3 [ncbi , more ], to study the role of the cell cycle-regulated kinase cyclin A/Cdk2 in progesterone receptor (PR) action [ncbi , more ]and to detect the expression of CDK2 in the human metastatic melanoma cell line HO-1 and in immunoprecipitation to isolate CDK2 from HO-1 cells [ncbi , more ]. Santa Cruz Biotechnology CDK2 antibody was utilized in 2004 to study cyclin A1 is a transcriptional target of the Six1 homeoprotein [ncbi , more ], to isolate and detect cdk2 from the lysates of human WI-38 fibroblasts [ncbi , more ]and to detect CDK2 in NIH 3T3 cells transiently transfected with vector, RACK1, or mutant RACK1 [ncbi , more ]. In 2003, Jeanho Yun et al. utilized Santa Cruz Biotechnology CDK2 antibody to study the association of cdk2 with NF-YA in HEK293 cells were co-transfected with a FLAG-YA plasmid and a dominant negative mutant of cdc2 (cdc2D146N), cdk2 (cdk2D145N), or cdk4 (cdk4D158N) (catalog: SC-163) [ncbi , more ]. Santa Cruz Biotechnology CDK2 antibody was utilized in 2002 to study the role of association of TSG101 with p21Cip1/WAF1 in regulating of cell growth and differentiation [ncbi , more ], to study the effects of SF/HGF, c-myc, p27, Cdk2, or E2F1 on glioblastoma cell cycle progression [ncbi , more ], to isolate cdk2 from human HT29 colon carcinoma sublines U9 and HD3 [ncbi , more ]and to study the physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulating the phosphorylation of retinoblastoma protein [ncbi , more ]. D Y Huang et al. used Santa Cruz Biotechnology CDK2 antibody to study interaction of human thymidine kinase 1 with p21Waf1 [ncbi , more ] in 2001 and C Hall et al. used Santa Cruz Biotechnology CDK2 antibody to characterize HIRA [ncbi , more ].
  • western blotHyungshin Yim et al. applied Santa Cruz Biotechnology CDK2 antibody to perform western blot in order to study the role of cdc6 in chromosomal segregation mediated by cdk1 and separase [ncbi , more ] in 2010 and Veronique Marsaud et al. used Santa Cruz Biotechnology CDK2 antibody to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma (catalog: sc-6248) [ncbi , more ]. Marie Hélene Perrard et al. employed Santa Cruz Biotechnology CDK2 antibody to perform western blot in order to show that cytostatic factor proteins and beta-nerve growth factor can increases Mos levels [ncbi , more ] in 2009 and Jayasree S Nair et al. used Santa Cruz Biotechnology CDK2 antibody to investigate the role of Aurora B in the regulation of postmitotic endoreduplication checkpoint [ncbi , more ]. Laurence Bockstaele et al. utilized Santa Cruz Biotechnology CDK2 antibody to study the role for cyclins and CDK "inhibitors" in Thr172 phosphorylation of CDK4 [ncbi , more ] in 2006 and Dan Lu et al. used Santa Cruz Biotechnology CDK2 antibody to study the roles of ATF3 in both cell death and cell cycle regulation [ncbi , more ]. Santa Cruz Biotechnology CDK2 antibody was employed in 2005 to detect the expression of CDK2 in the human metastatic melanoma cell line HO-1 and in immunoprecipitation to isolate CDK2 from HO-1 cells [ncbi , more ], to investigate the regulation of Cdc6 protein stability by p53 [ncbi , more ], to study Cdk2-dependent inhibition of p21 stability [ncbi , more ], to investigate the role of ORC2 in CDK2 activation [ncbi , more ], to isolate cdk2 and in western blot to detect cdk2 in human primary effusion lymphoma (PEL) cell line BC3 [ncbi , more ], to study COLO-357 cell growth inhibition by TGF beta1 [ncbi , more ], to study retinoblastoma phosphorylation in neuronal cell death [ncbi , more ], to study the role of DGK in the mTOR pathway [ncbi , more ], to study the role of the cell cycle-regulated kinase cyclin A/Cdk2 in progesterone receptor (PR) action [ncbi , more ]and to study the function of forkhead box M1 to regulate the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase [ncbi , more ]. Santa Cruz Biotechnology CDK2 antibody was used in 2004 to detect CDK2 in NIH 3T3 cells transiently transfected with vector, RACK1, or mutant RACK1 [ncbi , more ], to isolate and detect cdk2 from the lysates of human WI-38 fibroblasts [ncbi , more ]and to study the role for SCFSkp2 ubiquitin ligase in modulating type 1 IFN signaling by controlling UBP43 protein levels [ncbi , more ]. Philippe Coulombe et al. applied Santa Cruz Biotechnology CDK2 antibody to study the rapid turnover of extracellular signal-regulated kinase 3 which defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation [ncbi , more ] in 2003 and Soichi Tsutsumi et al. used Santa Cruz Biotechnology CDK2 antibody to study the role of AMF/PGI in the regulation of cell proliferation [ncbi , more ]. Santa Cruz Biotechnology CDK2 antibody was applied in 2002 to study the association of RUNX1/AML1 and RUNX2/Cbfa1 with stationary subnuclear domains [ncbi , more ], to study the physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulating the phosphorylation of retinoblastoma protein [ncbi , more ], to study the role of association of TSG101 with p21Cip1/WAF1 in regulating of cell growth and differentiation [ncbi , more ], to study the different p27Kip1 phosphorylation patterns during cell cycle progression in human epithelial cells resistant to transforming growth factor beta-mediated G1 arrest [ncbi , more ], to identify cyclin E as a target of WT1 transcriptional repression [ncbi , more ], to study the effects of SF/HGF, c-myc, p27, Cdk2, or E2F1 on glioblastoma cell cycle progression [ncbi , more ], to demonstrate that pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity (catalog: SC-163) [ncbi , more ], to study the role for LATS1 tumor suppressor in regulating G2/M transition and apoptosis in human cells [ncbi , more ], to study the effects of over-expression of the potential tumor suppressor gene IGFBP-rP1/mac25 on cell-cycle kinetics in human prostate cancer cells [ncbi , more ]and to study the expression of CDK2-NLS immunocomplexes in transfected IIC9 cells [ncbi , more ]. T Samuel et al. utilized Santa Cruz Biotechnology CDK2 antibody to study the effect of the interaction between G2/M regulator 14-3-3delta and Bax on apoptosis [ncbi , more ] in 2001 and B A Schmidt et al. used Santa Cruz Biotechnology CDK2 antibody to detect CDK2 in the patients' tumor and adjacent normal testicular tissue [ncbi , more ].
Cell Signaling TechnologyCell Signaling Technology CDK2 product
  • western blotIn 2004, Sung Kwon Moon et al. utilized Cell Signaling Technology CDK2 antibody to study that disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression [ncbi , more ]. In 2002, Nathan H Lents et al. used Cell Signaling Technology CDK2 antibody to study the Thr-160 phosphorylation of CDK2-NLS in transfected IIC9 cells [ncbi , more ].
Enzo Life SciencesEnzo Life Sciences CDK2 product
  • western blotIn 2005, Bing Zhu et al. applied Enzo Life Sciences CDK2 antibody to study the suppression of cyclic GMP-specific phosphodiesterase 5 promoting apoptosis and inhibiting growth in HT29 cells [ncbi , more ].
EMD MilliporeEMD Millipore CDK2 product
  • block or activateIn 2002, Cristina Broceño et al. employed EMD Millipore CDK2 antibody to study the CDK Activition in tumor cell lines [ncbi , more ].
  • western blotIn 2007, Shaun Goodyear et al. used EMD Millipore CDK2 antibody to study the role of cdk5 in the regulation of breast cancer cell proliferation and apoptosis [ncbi , more ].
BD Biosciences
  • immunohistochemistryIn 2009, Wei Qin Jiang et al. applied BD Biosciences CDK2 antibody to perform immunohistochemistry in order to study the function of HP1 proteins in the alternative lengthening of telomeres-associated PML bodies by p53/p21 [ncbi , more ]. In 2002, Jose L Donato et al. employed BD Biosciences CDK2 antibody to prove human HTm4 is a hematopoietic cell cycle regulator through confirming that HTm4 binds to KAP-CDK2 complexes in immune complexes derived from U937 lysate [ncbi , more ].
  • immunoprecipitationAlex C Minella et al. applied BD Biosciences CDK2 antibody to investigate the regulatoin of Fbw7-mediated cyclin E proteolysis by Ras [ncbi , more ] in 2005 and Ayumi Kudoh et al. used BD Biosciences CDK2 antibody to study the effect of Epstein-Barr virus lytic replication on ATM checkpoint signal transduction [ncbi , more ]. In 2002, Jose L Donato et al. employed BD Biosciences CDK2 antibody to prove human HTm4 is a hematopoietic cell cycle regulator through confirming that HTm4 binds to KAP-CDK2 complexes in immune complexes derived from U937 lysate [ncbi , more ].
  • western blotIn 2009, Ozgur Sahin et al. used BD Biosciences CDK2 antibody to combine computational simulations, experimental testing of simulation results, and finally reverse engineering of a protein interaction network to define potential therapeutic strategies for de novo trastuzumab resistant breast cancer [ncbi , more ]. BD Biosciences CDK2 antibody was employed in 2005 to demonstrate that mutation of Cys105 inhibits dimerization of p12CDK2-AP1 [ncbi , more ], to study the effect of Epstein-Barr virus lytic replication on ATM checkpoint signal transduction [ncbi , more ]and to investigate the regulatoin of Fbw7-mediated cyclin E proteolysis by Ras [ncbi , more ]. In 2004, Nozomi Sugimoto et al. used BD Biosciences CDK2 antibody to study the efffect of Cdt1 phosphorylation by cyclin A-dependent kinases [ncbi , more ]. In 2002, Jose L Donato et al. employed BD Biosciences CDK2 antibody to prove human HTm4 is a hematopoietic cell cycle regulator through confirming that HTm4 binds to KAP-CDK2 complexes in immune complexes derived from U937 lysate [ncbi , more ].
Articles Reviewed
  1. Hyungshin Yim et al. (2010). "Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase".PMID 21041660
  2. Veronique Marsaud et al. (2010). "Cyclin K and cyclin D1b are oncogenic in myeloma cells".PMID 20459741
  3. Marie Hélene Perrard et al. (2009). "Cytostatic factor proteins are present in male meiotic cells and beta-nerve growth factor increases mos levels in rat late spermatocytes".PMID 19802389
  4. C Elizabeth Caldon et al. (2009). "Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc".PMID 19564413
  5. Wei Qin Jiang et al. (2009). "Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins".PMID 19468068
  6. Jayasree S Nair et al. (2009). "Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780".PMID 19225156
  7. Ozgur Sahin et al. (2009). "Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance".PMID 19118495
  8. Shaun Goodyear et al. (2007). "Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5".PMID 17081516
  9. Jason W Upton et al. (2006). "Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin".PMID 17005668
  10. Laurence Bockstaele et al. (2006). "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"".PMID 16782892
  11. Dan Lu et al. (2006). "Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis".PMID 16469745
  12. I Ching Wang et al. (2005). "Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase".PMID 16314512
  13. Devanand Sarkar et al. (2005). "Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence".PMID 16055741
  14. Anja Duursma et al. (2005). "p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation".PMID 16055707
  15. Alex C Minella et al. (2005). "Ras activity regulates cyclin E degradation by the Fbw7 pathway".PMID 15980150
  16. Hongyan Zhu et al. (2005). "Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif".PMID 15964852
  17. Yuichi J Machida et al. (2005). "Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation".PMID 15944161
  18. Rukiyah Van Dross et al. (2005). "Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells".PMID 15870436
  19. Yong Kim et al. (2005). "Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect".PMID 15840587
  20. Nichole Boyer Arnold et al. (2005). "Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein".PMID 15811853
  21. Malika Hamdane et al. (2005). "p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death".PMID 15741232
  22. Antonia Avila-Flores et al. (2005). "Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid".PMID 15632115
  23. Ayumi Kudoh et al. (2005). "Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment".PMID 15611093
  24. Ramesh Narayanan et al. (2005). "Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator".PMID 15601848
  25. Bing Zhu et al. (2005). "Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells".PMID 15526282
  26. Sara Tokarz et al. (2004). "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase".PMID 15342634
  27. Vidya Mamidipudi et al. (2004). "RACK1 regulates G1/S progression by suppressing Src kinase activity".PMID 15254245
  28. Sung Kwon Moon et al. (2004). "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression".PMID 15175338
  29. Ricardo D Coletta et al. (2004). "The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1".PMID 15123840
  30. Nozomi Sugimoto et al. (2004). "Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding".PMID 14993212
  31. Christina R Kahl et al. (2004). "Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I".PMID 14754892
  32. Jeanho Yun et al. (2003). "Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway".PMID 12857729
  33. Philippe Coulombe et al. (2003). "Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation".PMID 12808096
  34. Soichi Tsutsumi et al. (2003). "Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling".PMID 12783864
  35. Cristina Broceño et al. (2002). "RB activation defect in tumor cell lines".PMID 12379745
  36. Nathan H Lents et al. (2002). "Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2".PMID 12359725
  37. Kimberly S Harrington et al. (2002). "Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains".PMID 12356919
  38. Luis M Schang et al. (2002). "Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4".PMID 12097586
  39. Kerstin Haller et al. (2002). "Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein".PMID 11971966
  40. Hyesun Oh et al. (2002). "Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1)".PMID 11943869
  41. Sandra Ciarallo et al. (2002). "Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest".PMID 11940657
  42. David M Loeb et al. (2002). "Cyclin E is a target of WT1 transcriptional repression".PMID 11919196
  43. Kevin A Walter et al. (2002). "Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription".PMID 11909963
  44. Rebecca G Carey et al. (2002). "Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity".PMID 11880488
  45. Hong Xia et al. (2002). "LATS1 tumor suppressor regulates G2/M transition and apoptosis".PMID 11850843
  46. Cynthia C Sprenger et al. (2002). "Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis".PMID 11791184
  47. Zhongfa Yan et al. (2002). "Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1".PMID 11784716
  48. Jose L Donato et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator".PMID 11781350
  49. T Samuel et al. (2001). "The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax".PMID 11574543
  50. D Y Huang et al. (2001). "Interaction of human thymidine kinase 1 with p21(Waf1)".PMID 11389691
  51. B A Schmidt et al. (2001). "Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors".PMID 11358847
  52. C Hall et al. (2001). "HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression".PMID 11238922