This is a review about BACE, based on 7 published articles (read how Labome selects the articles), using BACE antibody in experiments. It is aimed to help Labome visitors find the most suited BACE antibody.
BACE synonym: ASP2; BACE; HSPC104; APP beta-secretase; asp 2; aspartyl protease 2; beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site APP cleaving enzyme 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; memapsin-2; membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2

  • Santa Cruz anti-BACE1 was used in 1:1,000 dilution to perform western blot in order to show that new BACE1 substrates were identified by quantitative proteomics.ncbi, more , figure 1
  • Figure 1
    BACE antibody western blot Santa Cruz Biotechnology
    BACE antibody western blot Santa Cruz Biotechnology
    BACE1 was shed by metalloproteases, but not affected by beta-secretase activity. Left panels are from cell lysates, and right panels are from conditioned medium.
    Matthew L Hemming et al. (2009). "Identification of beta-secretase (BACE1) substrates using quantitative proteomics".PMID 20041192
  • Santa Cruz Biotechnology polyclonal BACE antibody (1:200) was used for western blot in order to indentify new biomarker of Alzheimer's disease.ncbi, more
  • Chemicon monoclonal anti-BACE antibody was used in western blot in order to study the role of NGF or BDNF signaling in neuronal apoptotic deathncbi, more
  • Calbiochem rabbit antibodies recognizing the proregion of immature BACE (AA 26 45) and the NH2-terminal end of mature BACE (AA 46 65) were used in western blot to study lysosomal BACE degradationncbi, more
  • Chemicon anti-BACE antibody (against the C-terminus) was used in immunoprecipitation to study BACE (secretase) phosphorylation and its interaction with GGA1ncbi, more
  • Calbiochem rabbit anti-BACE antibody (against the C-terminus) was used in western blot to study BACE (secretase) phosphorylation and its interaction with GGA1ncbi, more
Thermo Scientific Pierce ProductsThermo Scientific Pierce Products BACE product
  • Affinity BioReagents anti-BACE1 antibody (PA1 757) was used in human cells and in western blot to study the role for ubiquilin 1 in modulating amyloid precursor protein trafficking and Abeta secretion.ncbi, more
  • suppliernumreagent link
    EMD Millipore3BACE antibody
    Thermo Scientific Pierce Products2BACE antibody
    Santa Cruz Biotechnology2BACE antibody
    Covance1
    Table 1. BACE antibody western blot.
  • Affinity Bioreagents rabbit anti-BACE COOH-terminal antibody was used in western blot to study lysosomal BACE degradationncbi, more
Covance
  • Covance antibody B280 that recognizes residues 191-207 of human BACE1 was used in western blot to study BACE2 functions as an alternative alpha-secretase in cells.ncbi, more
suppliernumreagent link
EMD Millipore1BACE antibody
Table 2. BACE antibody immunoprecipitation.
Articles Reviewed
  1. Matthew L Hemming et al. (2009). "Identification of beta-secretase (BACE1) substrates using quantitative proteomics".PMID 20041192
  2. Weiping Qin et al. (2009). "S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10".PMID 19159013
  3. Carmela Matrone et al. (2008). "NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons".PMID 18728191
  4. Mikko Hiltunen et al. (2006). "Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion".PMID 16945923
  5. Young Ho Koh et al. (2005). "BACE is degraded via the lysosomal pathway".PMID 16033761
  6. Christine A F von Arnim et al. (2004). "Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy".PMID 15466887
  7. R Yan et al. (2001). "BACE2 functions as an alternative alpha-secretase in cells".PMID 11423558