This is a review about Akt, based on 354 published articles (read how Labome selects the articles), using Akt antibody in all methods. It is aimed to help Labome visitors find the most suited Akt antibody.
Akt synonym: AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; PKB alpha; RAC-PK-alpha; RAC-alpha serine/threonine-protein kinase; protein kinase B alpha; proto-oncogene c-Akt; rac protein kinase alpha

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Cell Signaling TechnologyCell Signaling Technology Akt product
  • flow cytometryIn 2009, Yaron Vagima et al. applied Cell Signaling Technology Akt antibody to study the role of MT1-MMP and RECK for the motility, adhesion, and mobilization of human hematopoietic progenitor cells [ncbi , more ].
  • immunocytochemistryIn 2012, Devendra Singh et al. used Cell Signaling Technology Akt antibody to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients [ncbi , more ]. In 2009, Tracie A Seimon et al. employed Cell Signaling Technology Akt antibody to investigate the role of p38alpha MAPK in the regulation of macrophage apoptosis [ncbi , more ]. In 2007, Faiyaz Ahmad et al. utilized Cell Signaling Technology Akt antibody to study the role of PDE3B and its interaction with PKB for regulation of specific cAMP pools and signalling pathways by insulin [ncbi , more ]. In 2005, Chang Shi Chen et al. utilized Cell Signaling Technology Akt antibody to study the effect of the interaction between histone deacetylase inhibitors and protein phosphatase 1 complexes on Akt in human U87MG cells and PC-3 cells [ncbi , more ]. Makoto Hiromura et al. used Cell Signaling Technology Akt antibody to study the effect of peptide spanning the A strand of the proto-oncogene TCL1 on Akt kinase activity [ncbi , more ] in 2004 and Azucena Kakazu et al. used Cell Signaling Technology Akt antibody to detect phospho-Akt in human corneal epithelial (HCE) stimulated with HGF for different times [ncbi , more ].
  • immunohistochemistryIn 2012, Devendra Singh et al. used Cell Signaling Technology Akt antibody to perform immunohistochemistry and immunocytochemistry in order to show that FGFR-TACC fusion happened in specific GBM patients [ncbi , more ]. In 2010, Mehrnoosh Saghizadeh et al. utilized Cell Signaling Technology Akt antibody to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas [ncbi , more ]. Cell Signaling Technology Akt antibody was employed in 2009 to perform immunohistochemistry in order to show the role of CK2B in apoptosis resistance and cell proliferation in endometrial carcinoma [ncbi , more ], to perform immunohistochemistry in order to study the function of the fixative in the immunohistochemical detection of phosphoproteins [ncbi , more ], to perform immunohistochemistry in order to study the regulation of ubiquitin-conjugating enzyme H7 in S phase of the cell cycle [ncbi , more ], to perform immunofluorescence and western blot in order to investigate the earliest events in the commitment of human epidermal keratinocytes to terminal differentiation [ncbi , more ]and to illustrate epidermal growth factor receptor (EGFR) mutations are frequently associated with tumor occurs, investigate the mechanism of Akt mediate the sterol regulatory element-binding protein 1 (SREBP-1) cleavage and nuclear translocation induced by EGFR, found out a new therapeutic approaches to glioblastomas which activated by EGFR [ncbi , more ]. Cell Signaling Technology Akt antibody was used in 2008 to identify genetic mechanisms of hepatocarcinogenesis in paraffin sections from human tissue [ncbi , more ], to demonstrate that NS3 acts in serotonergic neurons to regulate insulin signaling and thus exert global growth control [ncbi , more ], to investigate the expressions of EGFR and pEGFR and their correlation with overall and disease-free survival, clinicopathological parameters and biological markers of invasion and angiogenesis [ncbi , more ], to perform immunohistochemistry in order to investigate the expression alteration of dickkopfs (Dkks) and kremen2 (Krm2) in gastrointestinal cancer [ncbi , more ], to study the role of decreased endothelial GSH in the age-related loss of vascular endothelial function [ncbi , more ], to study the role for expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in mediating uterine leiomyoma growth in sections from human tissue [ncbi , more ], to perform immunohistochemistry in order to study the genetic evidence of the relation between perivascular epithelioid cell tumour (PEComa) and angiomyolipoma and the alteration of chromosome 16p in PEComa [ncbi , more ]and to perform immunohistochemistry in dilution 1:50 in order to show that AXL and SHC1 expression disregulation may be associated with pathogenesis of endometriosis [ncbi , more ]. In 2007, Shawn D Larson et al. utilized Cell Signaling Technology Akt antibody to determine the incidence of patients with thyroid cancer and associated HT [ncbi , more ]. In 2006, Nabeel Bardeesy et al. utilized Cell Signaling Technology Akt antibody to perform mmunohistochemistry assays in order to investigate the molecular regulation mechanisms of Smad4 in the process of normal pancreas development and pancreatic ductal adenocarcinomas (PDAC) growth [ncbi , more ]. Yen Chung Chen et al. applied Cell Signaling Technology Akt antibody to investigate the activation of phosphatidylinositol 3-kinase/Akt and transformation by NBS1 [ncbi , more ] in 2005 and Federico Cappuzzo et al. used Cell Signaling Technology Akt antibody to study epidermal growth factor receptor gene and protein and gefitinib sensitivity in non small-cell lung cancer [ncbi , more ]. Cell Signaling Technology Akt antibody was applied in 2004 to study HER2/neu overexpression in breast cancer patients [ncbi , more ], to study the role of activated Akt expression in prognosis of pancreatic ductal adenocarcinoma [ncbi , more ]and to study the effect of peptide spanning the A strand of the proto-oncogene TCL1 on Akt kinase activity [ncbi , more ]. Yuichi Oike et al. employed Cell Signaling Technology Akt antibody to study the role of AGF in epidermal keratinocytes [ncbi , more ] in 2003 and Nobuo Noshita et al. used Cell Signaling Technology Akt antibody to study copper-zinc superoxide dismutase during transient mouse focal cerebral ischemia [ncbi , more ]. Shazli N Malik et al. used Cell Signaling Technology Akt antibody to study the expression of phospho-specific Akt in human prostate cancer [ncbi , more ] in 2002 and Hong Wang et al. used Cell Signaling Technology Akt antibody to study endometrial tumorigenesis in Pten heterozygous mice [ncbi , more ].
  • immunoprecipitationCell Signaling Technology Akt antibody was applied in 2009 to evaluate the potential relevance of ApoER2 for APC cell signaling mechanisms [ncbi , more ], to demonstrate that oncogenic K-Ras can increase proliferation and decrease cell junctions [ncbi , more ]and to carry out western blot analysis and immunoprecipitation assays in order to investigate the regulation of adipocyte glucose transport by ClipR-59 mediated Akt cellular compartmentalization [ncbi , more ]. Mei Hua Gao et al. used Cell Signaling Technology Akt antibody to perform immunoprecipitation in order to study the Akt activity and phospholamban phosphorylation increased by adenylyl cyclase type VI [ncbi , more ] in 2008 and Jiaxu Wang et al. used Cell Signaling Technology Akt antibody to study the role of Jab1 in mediating EGFR signaling [ncbi , more ]. In 2006, Celso Caruso-Neves et al. applied Cell Signaling Technology Akt antibody to study the role for PKB and megalin in the survival or death of renal proximal tubule cells [ncbi , more ]. In 2005, Kin Yip Lo et al. utilized Cell Signaling Technology Akt antibody to study the effect of SLAM-associated protein in Trk signaling [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2004 to study interleukin 7 effects on T cell acute lymphoblastic leukemia cells [ncbi , more ], to study the molecular mechanisms downstream of BTC involved in mediating vascular remodeling [ncbi , more ], to detect phospho-Akt1 in human ejaculate spermatozoa [ncbi , more ]and to isolate Akt from human Ishikawa cells, in western blot to determine the total amount of Akt in Ishikawa cells, Cell Signaling Technologies rabbit polyclonal phospho-Akt antibody was used in western blot to detect the phosphorylation of Akt in Ishikawa cells [ncbi , more ]. In 2003, Madhavi J Rane et al. utilized Cell Signaling Technology Akt antibody to isolate Akt from human neutrophils and in western blot to detect Akt expression in the neutrophils isolated from venous blood obtained from healthy volunteers, Cell Signaling anti-phospho-Ser-473-Akt was used in western blot to detect the phosphorylation of Akt in neutrophils [ncbi , more ]. In 2002, Thomas Jahn et al. used Cell Signaling Technology Akt antibody to study the biological roles of Grb10 in the activation of Akt [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2001 to study activation of ER by the PI 3-kinase/AKT survival pathways [ncbi , more ], to study activation of p38-dependent MK2 in human neutrophils [ncbi , more ]and to study the role of Hgs/Hrs and its interacting proteins in signaling for cytokine-mediated c-fos induction [ncbi , more ].
  • western blotDaniel Thomas et al. applied Cell Signaling Technology Akt antibody to perform western blot to study the role of phosphoinositide 3-kinase in the regulation of cytokine-dependent cell survival [ncbi , more ] in 2013 and Uma Karthika Rajarajacholan et al. used Cell Signaling Technology Akt antibody to perform western blot in order to study how ING1a induced senescence [ncbi , more ]. Cell Signaling Technology Akt antibody was employed in 2011 to perform western blot in order to show that hypoglycemia in humans could be caused by activating mutant AKT2 [ncbi , more ], to perform western blot in order to show that lysosomal biogenesis could be induced by TFEB and lead to autophagy [ncbi , more ], to perform western blot in order to study the interaction between dehydroepiandrosterone and nerve growth factor (NGF) receptors [ncbi , more ]and to perform western blot in order to show that vacuolar H+-ATPase is involved in mTOR pathway for mTORC1 translocation and activating [ncbi , more ]. Cell Signaling Technology Akt antibody was employed in 2010 to perform western blot in order to study the role of microRNA-7 in tongue squamous cell carcinoma cells [ncbi , more ], to carry out western blot analysis in order to investigate the role for Sfrp5 as anti-inflammatory adipokine in the modulation of metabolic dysfunction in obesity [ncbi , more ], to perform western blot in order to study the role of LMP2A in the nasopharyngeal carcinoma progression [ncbi , more ], to carry out western blot analysis in order to investigate the precise contribution of 4E-BPs to mTORC1 signaling [ncbi , more ], to perform western blot in order to show the role of cyclin K and cyclin D1b in multiple myeloma [ncbi , more ], to perform western blot in order to study the role of SPRR3 in colorectal tumorigenesis [ncbi , more ], to show that CP1 can activate TSC2 and repress mTOR [ncbi , more ], to perform western blot in order to study how carboxy terminal tail of polycystin-1 repress mTOR signaling via regulating the subcellular localization of TSC2 [ncbi , more ], to research the molecular mechanism of Interferon gamma (IFN) contributing to angiogenesis and the role of PI3K/mTOR/translational pathway in this process in human retinal pigmented epithelial cells [ncbi , more ], to carry out western blot analysis in order to investigate the regulation of Notch signaling and cell differentiation by mTOR signaling [ncbi , more ], to investigate the role of Tsc/mTORC1 signaling in the regulation of the quiescence and activation of primordial follicles [ncbi , more ], to investigate the role of PKCdelta in the regulation of CHL1 expression in cultured astrocytes. [ncbi , more ]and to reveal the effect of slit2 on eosinophil and neutrophil during lung inflammation [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2009 to perform western blot in order to show that autophagy is induced by stent-eluting drugs sirolimus and paclitaxel to suppress healing of the endothelium [ncbi , more ], to perform western blot in order to study the cytotoxicity of timosaponin AIII towards tumor cells [ncbi , more ], to deduce that calcineurin activity and apoptosis of leukemic lymphocytes can be modulated by GC-mediated upregulation of RCAN1-1 [ncbi , more ], to characterize the role of ERBB4 mutations in melanoma [ncbi , more ], to perform western blot in order to study the important role of GRK4 in D3 receptor's signaling in human proximal tubule cells [ncbi , more ], to investigate the role of rpS6 phosphorylation in the regulation of myofiber growth and energy content [ncbi , more ], to investigate the role of sproutys in the regulation angiogenesis and ischemia in mice [ncbi , more ], to investigate the role of ARIA in the regulation of endothelial apoptosis and angiogenesis [ncbi , more ], to investigate the role of PTEN in the regulation of prostate lesion growth [ncbi , more ], to investigate the role of Prdx1 in the regulation of tumorigenesis [ncbi , more ], to show that adiponectin haploinsufficiency can promote mammary tumorigenesis through inhibition of PTEN activity and activation of PI3K/Akt signalling pathway [ncbi , more ], to perform western blot in order to show that JNK1 can suppresses the expression of LPS-induced MMP-9 [ncbi , more ], to investigate the roles of STAT3 and caveolin-3 in the regulation of the development of the catecholamine-induced cardiac hypertrophy [ncbi , more ], to investigate the role of p38alpha MAPK in the regulation of macrophage apoptosis [ncbi , more ], to perform western blot in order to show that Skp2 phosphorylation by Akt1 promotes Skp2 to localize in cytoplasm and impairs APCCdh1-mediated Skp2 destruction [ncbi , more ], to investigate the role of NDRG2 in the regulation of TCF/beta-catenin signaling in human colon carcinoma [ncbi , more ], to study the role for IGF-1 in the growth of myeloma cell lines and the association of the expression of its receptor with prognosis [ncbi , more ], to carry out western blot analysis in order to investigate the role for AEG1 in regulating Hepatocellular carcinoma pathogenesis [ncbi , more ], to investigate the role of PTEN phosphorylation in the regulation of ATP-sensitive K+ channels [ncbi , more ], to investigate the role of purinergic in the regulation of endothelial nitric oxide synthase activity in endothelial cells [ncbi , more ], to investigate the role of the Snail1 in the regulation of three-dimensional invasion by mesenchymal cells [ncbi , more ], to study the role for proepithelin in stimulating the migration, proliferation, and anchorage-independent growth of prostate cancer cells [ncbi , more ], to suggest that ZEB-1 can inhibit semaphorin 3F tumor suppressor gene in lung cancer cells [ncbi , more ], to perform western blot in order to find out the consequences of expression of activated PIK3CA in ovarian surface epithelium [ncbi , more ], to perform immunoblotting in order to study the regulation of BAD phosphorylation involved in beta-arrestin-2 mediates anti-apoptotic effects [ncbi , more ], to demonstrate that Lyn can inhibit osteoclast formation [ncbi , more ], to study the effect of gC1qR on RIG-I and MDA5-dependent antiviral response at mitochondria [ncbi , more ], to carry out western blot analysis in order to investigate the role of PIP5K1alpha in extracellular calcium induced generation of the second messengers IP3 and keratinocyte differentiation [ncbi , more ], to show that tumor suppressor PTEN can regulate ARE activation through chromatin modifications [ncbi , more ], to investigate the role of KRAP in the regulation of energy homeostasis and diet-induced obesity in mice [ncbi , more ], to perform western blot in order to show that rapamycin treatment can lead to the transactivation of the EGFR [ncbi , more ], to carry out western blot analysis in order to investigate the role of PI3k/Akt pathway in macrophage-mediated antibody-dependent cell-mediated cytotoxicity [ncbi , more ], to perform western blot in order to study the roles of S100B protein during the astrocyte shape and migration [ncbi , more ], to carry out western blot analysis and immunoprecipitation assays in order to investigate the regulation of adipocyte glucose transport by ClipR-59 mediated Akt cellular compartmentalization [ncbi , more ], to evaluate the potential relevance of ApoER2 for APC cell signaling mechanisms [ncbi , more ], to study the role for PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations [ncbi , more ], to carry out western blot analysis in order to investigate the functionality of platelet TLR2 in the immune and inflammatory response [ncbi , more ], to investigate whether the PI3K/PTEN pathway may be important in regulating Fas-induced apoptosis in type I and type II cells [ncbi , more ], to carry out western blot analysis in order to investigate the regulation of insulin-induced translational activation of TOP mRNAs by TSC-mTOR pathway [ncbi , more ], to carry out western blot analysis in order to investigate whether FGFR4 plays a role in promoting the progression of hepatocellular carcinoma [ncbi , more ], to study the role for Hsp72 in suppression of the oncogene-induced senescence [ncbi , more ], to investigate potential links between decreased BRCA1 levels and responses to Tam in ER-positive human breast cancer cell lines (T47D and ZR-75-1) [ncbi , more ], to analyze the functional domains of Epstein-Barr Virus Glycoprotein B [ncbi , more ], to carry out western blot analysis in order to investigate the role for myogenic Akt signaling in promoting the expression of utrophin and sarcolemma stability in muscular dystrophy [ncbi , more ], to show that Hsp90 co-chaperone CDC37 can maintain the oncogenic protein kinase clients [ncbi , more ], to perform western blot in order to study the oncogenic behavior of the RON receptor tyrosine kinase in breast epithelial cells [ncbi , more ], to perform immunofluorescence and western blot in order to investigate the earliest events in the commitment of human epidermal keratinocytes to terminal differentiation [ncbi , more ]and to generate monoclonal antibodies to evaluate therapeutic potential of targeting EphA2 in pancreatic tumor [ncbi , more ]. Cell Signaling Technology Akt antibody was employed in 2008 to investigate the role of ICAM-2 in the mediation of membrane-actin link in neuroblastoma [ncbi , more ], to investigate the role of hypoxia-induced energy stress in the regulation of mTOR pathway in head and neck squamous cell carcinoma1 [ncbi , more ], to perform western blot in order to show that PTEN-null tumors is promoted to autophagy and more sensitive to lysosomotropic agents after Akt inhibition [ncbi , more ], to study the efficacy of lapatinib for preventing the outgrowth of breast cancer cells in the brain in a mouse xenograft model of brain metastasis [ncbi , more ], to study the pathogenesis of Joubert syndrome and the role of the Ahi1-Hap1 complex in early brain development [ncbi , more ], to study the role for human AQP5 in the progression of chronic myelogenous leukemia [ncbi , more ], to demonstrate that increased AA and insulin availability causes changes in anabolic signaling and amounts of enzymes of the ubiquitin-proteasome pathway [ncbi , more ], to study the role of acetylation and extra-cellular location of heat shock protein 90alpha in tumor cell invasion [ncbi , more ], to study the role of MMP-2 inhibition in tumor cells by targeting angiogenic components of tumor growth [ncbi , more ], to perform western blot in order to show that VHL tumor supppressor gene has endothelial function through fibroblast growth factor receptor signaling [ncbi , more ], to study the synergistic effect of green tea (-) epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor on inhibition of head and neck tumor growth [ncbi , more ], to examine the subcellular signaling pathways activated by heat stress [ncbi , more ], to study the role of Jab1 in mediating EGFR signaling [ncbi , more ], to test the hypothesis that HGF suppresses renal inflammation by inhibiting proinflammatory cytokine expression [ncbi , more ], to perform western blot in order to study the role of Raf-1 in glioma formation [ncbi , more ], to identify the pathway and mechanism by which AAs signal to hVps34 to stimulate mTOR complex1 signaling [ncbi , more ], to investigate the roles of PI3K/Akt and MAPK pathways in the regulation of Myc-mediated transcription [ncbi , more ], to perform western blot in order to show that periodontal ligament fibroblasts can maintain an equilibrium of the plasminogen activator system in the presence of platelet-derived growth factor isoforms [ncbi , more ], to study the effect of human herpesvirus 8 chemokines on endothelial survival and virus replication [ncbi , more ], to study the role for endocytosis in the regulation of signaling by the Kaposi's sarcoma-associated herpesvirus K1 protein [ncbi , more ], to perform western blot in order to study how genistein regulate tumor suppressor genes in prostate cancer cells [ncbi , more ], to study the regulation and the role of NAG-1 expression in VES-treated PC-3 human prostate carcinoma cells [ncbi , more ], to study the mechanisms by which GH and/or IGF-1 regulate sodium and water balance remain [ncbi , more ], to perform western blot in order to study the effect of TG2 on FAK/AKT cell survival signaling [ncbi , more ], to study molecular mechanisms underlying TSH-secreting pituitary tumors (TSHomas) [ncbi , more ], to study the role of Gsk-3beta in control of beta-cell mass in insulin-resistant diabetic models [ncbi , more ], to study the role of trefoil factor 3 (TFF3) in beta-cell replication [ncbi , more ], to study the role for expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in mediating uterine leiomyoma growth in sections from human tissue [ncbi , more ], to test the hypothesis that exposure of mice to fever-like temperatures abrogates neutrophil recruitment and NF-kappaB activation in a mouse model of skin inflammation [ncbi , more ], to demonstrate that PM cholesterol influences PIP2-regulated cytoskeletal structure essential for insulin-regulated GLUT4 translocation and glucose transport [ncbi , more ], to demonstrate that lithium suppresses Smad3/4-dependent TGF-beta-responsive gene transactivation [ncbi , more ], to perform immunoblotting in order to study the molecular mechanisms of autoactivation happened in the catalytic domain of anaplastic lymphoma kinase [ncbi , more ], to perform western blot in order to investigate the role of the mTOR signaling pathway in the synthesis of human muscle protein [ncbi , more ], to study the role of the VLDLR in inhibiting cell division [ncbi , more ], to investigate the effects of CB2 receptor agonists on TNF-alpha-induced proliferation, migration, and signal transduction [ncbi , more ], to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma [ncbi , more ], to study the role of birc1 in suppressing apoptosis in the uterus [ncbi , more ]and to perform western blot in order to show that thioredoxin is an IFN-gamma-induced factor and plays a role for cytokine production [ncbi , more , fig ]. Cell Signaling Technology Akt antibody was utilized in 2007 to study the role of acetylation, one of the main post-translational regulatory mechanisms, in regulating Fli1 activity in human dermal fibroblast [ncbi , more ], to assesse the effects of cryptotanshinone on macrophage chemotaxis [ncbi , more ], to demonstrate that Ulk1/2 proteins regulate filopodia extension and neurite branching during sensory axon outgrowth [ncbi , more ], to study the role of PDE3B and its interaction with PKB for regulation of specific cAMP pools and signalling pathways by insulin [ncbi , more ], to demonstrate enhanced DcR3 expression upon EBV reactivation in P3HR1 cells and in EBV-infected 293 cells [ncbi , more ], to study the role of PDCD4 in retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells [ncbi , more ], to examine whether the malignant potential of endometrial cancer enhanced by P-LAP/IRAP is due to increased glucose uptake via the P-LAP/IRAP-mediated activation of insulin signaling [ncbi , more ], to demonstrate that the Src-mediated activation of PI 3-kinase and its downstream effector Akt is a critical event in the transduction of RV signaling in human airway epithelial cells [ncbi , more ]and to perform western blot in order to investigate a novel means of regulating AGL levels and some of the signals that regulate this process [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2006 to study the role for PKB and megalin in the survival or death of renal proximal tubule cells [ncbi , more ], to study the role for the effect of H-REV107-1 on mitogenic signaling in growth in human non-small cell lung carcinomas [ncbi , more ], to investigate the activation of Akt by FGF19 promoter in human CE cells [ncbi , more ], to study the role for the effect of receptor tyrosine kinase on lymphatic endothelial cells in therapy of colon cancer lymph node metastasis [ncbi , more ], to study the interaction of ADAM22 with all 14-3-3 protein family members expressed in the brain in HEK 293T cells [ncbi , more ], to perform western blot in order to investigate the molecular mechanisms of HGF-induced cell scattering [ncbi , more ], to study the antagonizing of the receptor-type protein tyrosine phosphatase J for effects of RET-derived oncoproteins [ncbi , more ], to study the mechanism of protein synthesis inhibition by hypoxia in human breast cancer cells [ncbi , more ], to verify that CA-Akt can selectively induce GLT-1 expression [ncbi , more ], to analyze biology and drug responsiveness of human breast cancer [ncbi , more ], to study the link between the PI3K-Akt pathway and the cigarette smoke (CS) stimulated epidermal growth factor receptor-mediated FRA-1 induction in non-oncogenic HBE cells [ncbi , more ], to study the identification and characterization of a novel regulatory subunit of PI3K [ncbi , more ], to characterize the antiangiogenic and antitumor activity of the hydroxamic derivative LBH589 [ncbi , more ], to detect Akt and phosphorylated Akt levels in human renal carcinoma ACHN cells [ncbi , more ], to detect Akt expression and Akt phosphorylation status in human A549 lung adenocarcinoma cells [ncbi , more ], to detect phospho-Akt in cell extracts of L6 myotubes stimulated with rat recombinant IL-6 [ncbi , more ], to study the effect of up-regulation of PTEN on p38 MAPK stress signal-induced inhibition of insulin signaling [ncbi , more ], to study the role for the effect of HER-2/neu on RECK expression in promoting cell invasion [ncbi , more ], to determine the levels of Akt and phosphorylated AKT in HeLa cells [ncbi , more ], to investigate whether the signals generated by Ras proteins were affected by microlocalization and its important biological outcomes [ncbi , more ], to detect the amount of phospho-Akt in mouse Ba/F3 cells and human Hep3B cells [ncbi , more ], to domenstrate that proline 326 in the c terminus of murine cx3cr1 prevents G-protein and phosphatidylinositol 3-kinase-dependent stimulation of akt and extracellular signal-regulated kinase in Chinese hamster ovary cells [ncbi , more ]and to study the expression and role of Nrdp1 in cancer [ncbi , more ]. Cell Signaling Technology Akt antibody was employed in 2005 to study the role of CCN in ovarian carcinomas [ncbi , more ], to study the effect of SLAM-associated protein in Trk signaling [ncbi , more ], to study the effect of the interaction between histone deacetylase inhibitors and protein phosphatase 1 complexes on Akt in human U87MG cells and PC-3 cells [ncbi , more ], to study amino acids mediate mTOR activation by signaling through class 3 PI3K, hVps34 [ncbi , more ], to study whether SCH66336 inhibits angiogenesis of aerodigestive tract cancer cells [ncbi , more ], to study the function of protein phosphatase subunit G5PR in B cell receptor induced apoptosis [ncbi , more ], to investigate regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation [ncbi , more ], to investigate the repression of RNA polymerase I transcription by PTEN [ncbi , more ], to investigate the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway by semaphorin 4D/plexin-B1 [ncbi , more ], to investigate the activation of phosphatidylinositol 3-kinase/Akt and transformation by NBS1 [ncbi , more ], to investigate the interaction among Akt, mTOR, and AMPK [ncbi , more ], to study the role of akt in the subcellular localization of JFC1 [ncbi , more ], to study the changes of retinal gene expression in proliferative vitreoretinopathy [ncbi , more ], to study the induction of neuroblastoma cell apoptosis by TrkA [ncbi , more ], to study regulation of the integrin-linked kinase (ILK) level, cell shape, and survival signaling through the LIM1-mediated interaction with ILK [ncbi , more ], to study the relationship between FPR expression and the biologic behavior of glioma cells [ncbi , more ], to investigate the down-regulation of phospholipase D2 in the EWS-Fli1-knocked down TC-135 cells [ncbi , more ], to investigate the role of integrin-linked kinase in Akt phosphorylation and fibroblast survival [ncbi , more ], to identify S6 Kinase 1 as a mTOR-phosphorylating Kinase [ncbi , more ], to study the effect of activation of vascular endothelial growth factor receptor 3 on endothelial function and infection [ncbi , more ], to demonstrate that Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L [ncbi , more ], to study the beta-ig-h3-mediated keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha-3, beta-1, and the phosphatidylinositol 3-kinase/Akt signaling pathway [ncbi , more ], to study CXC chemokine receptor 4 expression in non-small cell lung cancer cells [ncbi , more ], to study the role for the effect of p38 kinase on transactivation of the epidermal growth factor receptor in dedifferentiation of renal epithelial cells after oxidant injury [ncbi , more ], to study the biological function of NAG-1 expression in LNCaP cells [ncbi , more ], to study the biological function of TRAIL induced apoptosis in human colon cells (catalog: 9271S) [ncbi , more ], to study galectin-8 signalling pathway [ncbi , more ], to study the inhibition effect of sphingosine-1-phosphate on nuclear factor kappa B activation and germ cell apoptosis in the human testis independently of its receptors [ncbi , more ], to study the role for phosphoinositide 3-kinase in accelerating postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis [ncbi , more ], to study the inducing of platelet-derived growth factor C to liver fibrosis, steatosis, and hepatocellular carcinoma [ncbi , more ], to study the interaction of Grb10 with 14-3-3 [ncbi , more ], to the angiogenic phenotype regulation by mitochondrial H2O2 via PTEN oxidation [ncbi , more ], to study the biological function of Rac-MKK3/6-p38 pathway [ncbi , more ], to study the effect of flow shear stress on Gab1, protein kinase B, and endothelial nitric-oxide synthase in endothelial cells [ncbi , more ], to study VEGF mRNA stability in DU145 prostate carcinoma [ncbi , more ], to study the negative regulation of the mammalian target of rapamycin pathway by the stress-inducted proteins RTP801 and RTP801L [ncbi , more ], to study that kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via akt-glycogen synthase kinase-3 and akt-bad 14-3-3 signaling pathways [ncbi , more ], to study Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death [ncbi , more ], to study the role for the interleukins 2 and 15 in regulating Ets1 expression in human natural killer cells [ncbi , more ], to study the biological function of protein kinase B/Akt phosphorylation [ncbi , more ], to study gene regulation by anti-HER2 antibody [ncbi , more ], to study the physiological role of ER palmitoylation in the receptor localization to the cell membrane and in the regulation of the E2-induced cell proliferation [ncbi , more ], to study the mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells [ncbi , more ]and to investigate the regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation (EMT) [ncbi , more ]. Cell Signaling Technology Akt antibody was employed in 2004 to study the role of KSR1 in regulating intestinal cell fate during cytokine-mediated inflammation [ncbi , more ], to evaluate therapeutic potential of the combination of IGFBP-3 and SCH66336 [ncbi , more ], to study the effect of peptide spanning the A strand of the proto-oncogene TCL1 on Akt kinase activity [ncbi , more ], to study interleukin 7 effects on T cell acute lymphoblastic leukemia cells [ncbi , more ], to study the role for Sp1 in Akt-mediated induction of VEGF expression [ncbi , more ], to detect phospho-Akt in human coronary artery endothelial cells (HCAEC) treated with or without VEGF [ncbi , more ], to demonstrate that IGF-1 and its receptor in regulate post-translational changes in RUNX2 to activate DNA binding in proliferating EC [ncbi , more ], to study GCP in vitro and in vivo for potential utility as a prostate cancer chemopreventative agent in human prostate cancer cell line [ncbi , more ], to detect phospho-PKB in HeLa cells with FTI treatment [ncbi , more ], to study the role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis [ncbi , more ], to study the levels of phosphorylated Akt (p-Akt-ser473) and total Akt in response to upstream signals in the beta 1 integrin/PI3K/Akt signal pathway [ncbi , more ], to study the molecular mechanisms downstream of BTC involved in mediating vascular remodeling [ncbi , more ], to study the coordination between apoptotic and Ub-P'some systems [ncbi , more ], to study interaction between thioredoxin and Txnip as an important mechanism for vascular oxidative stress in diabetes mellitus [ncbi , more ], to study the role of activated Akt expression in prognosis of pancreatic ductal adenocarcinoma [ncbi , more ], to detect phospho-AKT in Panc-1 cells [ncbi , more ], to study akt-dependent cell survival by the regulating of ezrin/radixin/moesin Proteins [ncbi , more ], to study tumor invasion activity in PANC-1, P/ARK, DLD-1, D/ARK, and SW480 cells [ncbi , more ], to detect Akt and phospho-Akt in ET-1-treated lung fibroblasts from open lung biopsy specimens from SSc patients [ncbi , more ], to detect phospho-Akt1 in human ejaculate spermatozoa [ncbi , more ], to detect Akt and phospho-Akt in U251 human glioma cells treated in normoxic or hypoxic conditions in the presence or absence of TPT, LY294002, and rapamycin [ncbi , more ], to study neuroprotective role of PRAS and NGF in apoptotic neuronal cell death after stroke [ncbi , more ], to detect phospho-Akt in NR6 WT cells and NR6 c'973 cells [ncbi , more ], to study the role of PTEN in PDGF-induced DNA synthesis [ncbi , more ], to detect Akt and phospho-Akt in rat cardiac myocytes infected with recombinant adenoviruses containing human wild type or mutant cDNA of RasGAP, Akt or ILK [ncbi , more ], to study the functional expression of the interleukin-11 receptor alpha-Chain and evidence of antiapoptotic effects in human colonic epithelial cells [ncbi , more ], to detect pAkt in U373 cells with human MEKK3 stable transfection [ncbi , more ], to study the role of Hu1D10 in human chronic lymphocytic leukemia cells [ncbi , more ], to detect AKT kinase and phospho-AKT kinase in neutrophils isolated from citrated blood of healthy single donors [ncbi , more ], to study the role of adiponectin in angiogenesis [ncbi , more ]and to isolate Akt from human Ishikawa cells, in western blot to determine the total amount of Akt in Ishikawa cells, Cell Signaling Technologies rabbit polyclonal phospho-Akt antibody was used in western blot to detect the phosphorylation of Akt in Ishikawa cells [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2003 to study the inhibition of lysophosphatidic acid acyltransferase beta on proliferative and survival signals in normal cells and apoptosis of tumor cells [ncbi , more ], to study the role of tyrosine phosphorylation in Reelin-stimulated activation of Akt and Src family kinases [ncbi , more ], to detect Akt and phopho-Akt in SK-LMS-1 cells and MDA-MB-231 cells with human TSP1 transfection [ncbi , more ], to detect AKT and phospho-Akt in Hela cells transfected with pUSEamp (+) /myr-Akt1 or pFLAG-PINCH-2 [ncbi , more ], to detect Akt and phospho-Akt in CHO cell expressing the IR and IRS-1 transfected with MOR [ncbi , more ], to study the inhibitory effect of the angiotensin II type 2 receptor on VEGF-induced migration and in vitro tube formation of human endothelial cells [ncbi , more ], to study the effect of adrenomedullin on myocardial infarction and apoptosis after ischemia and reperfusion [ncbi , more ], to study the expression, function, and signaling pathways of PCDGF in human MM [ncbi , more ], to study Akt1 activation [ncbi , more ], to detect total and phospho-AKT in HeLa Tet-on cells, HeLa Tet-on-inducible FOXO4 stable cells (15-14), and BJAB cells or RCC4 cell stably transfected with a wild-type human VHL expression plasmid [ncbi , more ], to study Zinc-induced PTEN protein degradation [ncbi , more ], to isolate Akt from human neutrophils and in western blot to detect Akt expression in the neutrophils isolated from venous blood obtained from healthy volunteers, Cell Signaling anti-phospho-Ser-473-Akt was used in western blot to detect the phosphorylation of Akt in neutrophils [ncbi , more ], to study copper-zinc superoxide dismutase during transient mouse focal cerebral ischemia [ncbi , more ], to detect Akt and phospho-Akt in LNCaP and PC-3 cells [ncbi , more ], to study the effects of activated G q on p110 phosphatidylinositol 3-kinase and Akt [ncbi , more ], to study that transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation [ncbi , more ], to study that resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells [ncbi , more ], to study interleukin-6-dependent insulin resistance in hepatocytes by suppressor of cytokine signaling-3 (SOCS-3) [ncbi , more ], to study that extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus [ncbi , more ], to study the role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite [ncbi , more ]and to study the production of interleukin 15 by human colon cancer cells associated with induction of mucosal hyperplasia, angiogenesis, and metastasis [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2002 to study induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species [ncbi , more ], to study the role of SAP in murine CD150 (SLAM) mediated T-cell proliferation and interferon gamma production [ncbi , more ], to investigate Akt phosphorylation in human microvascular endothelial cells isolated by enzymatic digestion of blood vessels taken from the mesentery of the small bowel (designated MM1 cells) [ncbi , more ], to determine if IGFBP-3 might enhance IGF action by influencing intracellular signaling events downstream of the IGF receptor [ncbi , more ], to examine PKB phosphorylation in H69 human SCLC cells [ncbi , more ], to study 3-phosphoinositide-dependent protein kinase-1 activity regulation [ncbi , more ], to study the biological characteristics of insulin/insulin-like growth factor I hybrid receptors [ncbi , more ], to study the Akt activity and Akt phosphorylation [ncbi , more ], to study the phosphorylation state of EGFR, ERK, and PKB/Akt1 [ncbi , more ], to further elucidate the activation mechanism for intracellular signaling mediated by interaction between Dok1 and phosphorylated RET [ncbi , more ], to study the phosphorylation of PTEN [ncbi , more ], to study the role for IGF-1 in this delay of the onset of apoptosis through activation of the AKT signaling pathway [ncbi , more ], to study the phosphorylation of Akt [ncbi , more ], to determine the actions of FSH and IGF-I on PI3K/AKT protein kinase signaling in immature rat Sertoli cells [ncbi , more ], to study the effect of VIIa/tissue factor interaction [ncbi , more ], to study the effect of insulin-like growth factor I on mannitol-induced degradation of focal adhesion kinase and Akt [ncbi , more ], to study cell survival by GLP-2R signaling [ncbi , more ], to study the characterization of beta-catenin signaling in CaP [ncbi , more ], to study the role of phosphoinositide 3-kinase beta lipid products in LPA-induced Ras activation [ncbi , more ], to detect phospho-Akt in D5 and vector HEK293 cells untreated or treated with insulin [ncbi , more ], to detect Akt and phospho-Akt in A549 cells [ncbi , more ], to investigate a novel mechanism for the regulation of Rac activity and lamellipodia formation by RET tyrosine kinase [ncbi , more ], to study the role for ANGPTL3 in endothelial cell adhesion and migration and blood vessel formation in Vivo in human cells [ncbi , more ], to study the expression of FKHR, FKHRL1, and AFX genes in the rodent ovary [ncbi , more ], to study the role for vitamin D in arresting thyroid carcinoma cell growth and inducing p27 dephosphorylation and accumulation [ncbi , more ], to study the inhibition of UVB-induced apoptosis of human keratinocytes by hepatocyte growth factor/satter factor [ncbi , more ], to study the mechanism by which WISP-1 promotes tumorigenicity [ncbi , more ], to study the effects of black tea polyphenols on IGF-I signal transduction pathways in normal prostate epithelial cells and Du145 prostate carcinoma cells [ncbi , more ], to study the effect of Akt on collagenase gene expression during replicative senescence in human fibroblasts [ncbi , more ], to study insulin receptor catalytic activity inhibition [ncbi , more ]and to study the expression of Akt in the Eker renal tumors [ncbi , more ]. Cell Signaling Technology Akt antibody was utilized in 2001 to detect phosphorylated Akt in MDCK cells and human SKBR-3 and BT20 cells [ncbi , more ], to demonstrate the causal relationship between PTEN loss and overexpression of Bcl-2 in prostate cancer [ncbi , more ], to study the HGF/SF-c-Met signaling pathways for cell survival and DNA repair regulated by Gab1 (catalog: 9271S) [ncbi , more ], to study the role of Hgs/Hrs and its interacting proteins in signaling for cytokine-mediated c-fos induction [ncbi , more ], to study the regulation of Ca2+/Calmodulin-dependent eNOS activity by the phosphorylation of eNOS Thr495 [ncbi , more ], to study the MV interference with Akt activation during immunosuppression [ncbi , more ], to demonstrate caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells [ncbi , more ], to study growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors [ncbi , more ], to study the effect of XIAP on Akt activity during cisplatin-induced apoptosis in human ovarian epithelial cancer cells [ncbi , more ], to study the mechanisms of Raf-1 activation [ncbi , more ], to investigate erythropoietin effect on neuronal apoptosis after cerebral ischemia and metabolic stress [ncbi , more ], to study the effect of SH2-containing inositol phosphatase 2 in 3T3-L1 adipocytes [ncbi , more ], to study activation of ER by the PI 3-kinase/AKT survival pathways [ncbi , more ], to study activation of endothelial nitric-oxide synthase induced by estrogen in vascular endothelial cells [ncbi , more ], to study cd19-dependent activation of Akt kinase in B-lymphocytes [ncbi , more ]and to study the effect of CCI-779 on the proliferation of a panel of breast cancer cell lines [ncbi , more ].
EMD MilliporeEMD Millipore Akt product
  • EMSAIn 2002, Matt Y Liu et al. employed EMD Millipore Akt antibody to establish the presence of functional and overlapping 14-3-3 and Akt recognition site (s) in tuberin [ncbi , more ].
  • flow cytometryIn 2002, Shyra Gardai et al. utilized EMD Millipore Akt antibody to study the role of oxidants and Lyn in SHIP regulation [ncbi , more ].
  • immunocytochemistryIn 2004, Justin D Topp et al. employed EMD Millipore Akt antibody to demonstrate that alsin is a Rab5 and Rac1 guanine nucleotide exchange factor [ncbi , more ]. In 2001, J M Paramio et al. applied EMD Millipore Akt antibody to study the effects of inhibition of protein kinase B (PKB) and PKC zeta on keratin k10-induced cell cycle arrest [ncbi , more ].
  • immunohistochemistryIn 2010, Heather L Chandler et al. applied EMD Millipore Akt antibody to perform immunohistochemistry in order to study the function of pAkt on posterior capsule [ncbi , more ]. In 2001, K Kurose et al. employed EMD Millipore Akt antibody to study the correlation between PTEN and Akt, p27, cyclin D1 in primary epithelial ovarian carcinomas [ncbi , more ].
  • immunoprecipitationIn 2009, Jixin Ding et al. used EMD Millipore Akt antibody to carry out western blot analysis and immunoprecipitation assays in order to investigate the regulation of adipocyte glucose transport by ClipR-59 mediated Akt cellular compartmentalization [ncbi , more ]. In 2005, Eijiro Yamada et al. employed EMD Millipore Akt antibody to study phosphorylation of Synip by Akt2 to regulate docking and fusion of GLUT4-containing vesicles [ncbi , more ]. Bryan A Ballif et al. applied EMD Millipore Akt antibody to study the role of tyrosine phosphorylation in Reelin-stimulated activation of Akt and Src family kinases [ncbi , more ] in 2003 and Maria Chiara Deregibus et al. used EMD Millipore Akt antibody to study the endothelial cell survival and in vitro angiogenesis mediating by CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway [ncbi , more ]. EMD Millipore Akt antibody was employed in 2002 to study the molecular mechanisms through which HIV-1-Tat protein inhibits vincristine-induced apoptosis of KS cells [ncbi , more ], to study the effect of Akt on collagenase gene expression during replicative senescence in human fibroblasts [ncbi , more ]and to isolate Protein kinase B from H69 human SCLC cells, and in western blot to detect PKB in H69 SCLC cells [ncbi , more ]. In 2001, X Pesesse et al. employed EMD Millipore Akt antibody to study inositol 5-phosphatase SHIP2 recruitment in EGF-stimulated COS-7 cells [ncbi , more ].
  • western blotJixin Ding et al. used EMD Millipore Akt antibody to carry out western blot analysis and immunoprecipitation assays in order to investigate the regulation of adipocyte glucose transport by ClipR-59 mediated Akt cellular compartmentalization [ncbi , more ] in 2009 and Timo Liebig et al. used EMD Millipore Akt antibody to study the role for RhoE in keratinocyte differentiation and stratification [ncbi , more ]. M R Hoda et al. utilized EMD Millipore Akt antibody to demonstrate that leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells [ncbi , more ] in 2007 and James G Greger et al. used EMD Millipore Akt antibody to study the role of MNAR in 17beta-estradiol (E2) induced activation of the phosphatidylinositol 3-kinase (PI3K) /Akt pathway [ncbi , more ]. EMD Millipore Akt antibody was utilized in 2005 to study the role of akt in the subcellular localization of JFC1 [ncbi , more ], to study synaptic localization of a functional NADPH oxidase in the mouse hippocampus [ncbi , more ], to study gene regulation by anti-HER2 antibody [ncbi , more ]and to study the function of the mammalian scribble polarity protein to regulate epithelial cell adhesion and migration through E-cadherin [ncbi , more ]. EMD Millipore Akt antibody was applied in 2004 to detect phospho-Akt in human corneal epithelial (HCE) stimulated with HGF for different times [ncbi , more ], to examine the ability of calcineurin-deficient mice to undergo skeletal muscle hypertrophic growth following mechanical overload (MOV) stimulation or insulin-like growth factor-1 (IGF-1) stimulation [ncbi , more ], to study the cooperation of Dock180 and ELMO1 proteins to promote evolutionarily conserved rac-dependent cell migration [ncbi , more ]and to examine Rac expression in human SNB19 and U87 cells [ncbi , more ]. EMD Millipore Akt antibody was employed in 2003 to demonstrate that p85 alpha and p85 beta modulate PI 3-kinase-dependent signaling by multiple mechanisms and transmit signals independent of PI 3-kinase activation [ncbi , more ], to study CD44 interaction with p115RhoGEF in human metastatic breast tumor cells [ncbi , more ], to study the endothelial cell survival and in vitro angiogenesis mediating by CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway [ncbi , more ], to study the role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite [ncbi , more ]and to study the differential activation of phosphatidylinositol 3-kinase signaling during proliferation and differentiation of lens epithelial cells [ncbi , more ]. EMD Millipore Akt antibody was utilized in 2002 to determine if IGFBP-3 might enhance IGF action by influencing intracellular signaling events downstream of the IGF receptor [ncbi , more ], to isolate Protein kinase B from H69 human SCLC cells, and in western blot to detect PKB in H69 SCLC cells [ncbi , more ], to study the phosphorylation of PTEN [ncbi , more ], to study the molecular mechanisms through which HIV-1-Tat protein inhibits vincristine-induced apoptosis of KS cells [ncbi , more ], to study the effect of Akt on collagenase gene expression during replicative senescence in human fibroblasts [ncbi , more ], to study the role of oxidants and Lyn in SHIP regulation [ncbi , more ]and to establish the presence of functional and overlapping 14-3-3 and Akt recognition site (s) in tuberin [ncbi , more ]. In 2001, X Pesesse et al. employed EMD Millipore Akt antibody to study inositol 5-phosphatase SHIP2 recruitment in EGF-stimulated COS-7 cells [ncbi , more ].
Santa Cruz BiotechnologySanta Cruz Biotechnology Akt product
  • flow cytometryIn 2010, Qiaoling Liang et al. used Santa Cruz Biotechnology Akt antibody to perform flow cytometry in order to study the signaling mechanism in the resistance of T cells from asthmatic patients against suppression by TGFbeta and IL-10 [ncbi , more ]. In 2002, Shyra Gardai et al. utilized Santa Cruz Biotechnology Akt antibody to study the role of oxidants and Lyn in SHIP regulation [ncbi , more ].
  • immunocytochemistryIn 2008, Alok Sharma et al. employed Santa Cruz Biotechnology Akt antibody to demonstrate that the phosphorylation of p130Cas initiates Rac activation and membrane ruffling [ncbi , more ]. In 2001, J M Paramio et al. applied Santa Cruz Biotechnology Akt antibody to study the effects of inhibition of protein kinase B (PKB) and PKC zeta on keratin k10-induced cell cycle arrest [ncbi , more ].
  • immunohistochemistryIn 2010, Mehrnoosh Saghizadeh et al. employed Santa Cruz Biotechnology Akt antibody to perform immunohistochemistry in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas (catalog: sc-7985-R) [ncbi , more ]. In 2008, Krisztina Kovács de Ostrovich et al. employed Santa Cruz Biotechnology Akt antibody to study the role for paracrine overexpression of insulin-like growth factor-1 in mammary tumorigenesis in Vivo in formalin-fixed sections from mammary glands of BK5.IGF-1 transgenic mice [ncbi , more ]. In 2004, Mario Schiffer et al. employed Santa Cruz Biotechnology Akt antibody to study the role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis [ncbi , more ]. In 2002, Shazli N Malik et al. used Santa Cruz Biotechnology Akt antibody to study the expression of phospho-specific Akt in human prostate cancer [ncbi , more ].
  • immunoprecipitationIn 2003, Alessandra Trencia et al. utilized Santa Cruz Biotechnology Akt antibody to study the phosphorylation of PED/PEA-15 by Akt in 293 cells were stimulated with insulin [ncbi , more ]. Hiroyuki Sano et al. applied Santa Cruz Biotechnology Akt antibody to detect Akt1 in D5 and vector HEK293 cells untreated or treated with insulin [ncbi , more ] in 2002 and Thomas Jahn et al. used Santa Cruz Biotechnology Akt antibody to study the biological roles of Grb10 in the activation of Akt [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was employed in 2001 to study the MV interference with Akt activation during immunosuppression [ncbi , more ], to study the effect of SH2-containing inositol phosphatase 2 in 3T3-L1 adipocytes [ncbi , more ]and to study the effects of inhibition of protein kinase B (PKB) and PKC zeta on keratin k10-induced cell cycle arrest [ncbi , more ].
  • western blotJianhui Ma et al. applied Santa Cruz Biotechnology Akt antibody to carry out western blot analysis in order to investigate the regulation of Notch signaling and cell differentiation by mTOR signaling [ncbi , more ] in 2010 and Eric N Churchill et al. used Santa Cruz Biotechnology Akt antibody to investigate the role of Ischaemic preconditioning in the regulation of proteasomal activity and the degradation of PKCdelta during reperfusion [ncbi , more ]. Helenia Ansuini et al. employed Santa Cruz Biotechnology Akt antibody to generate monoclonal antibodies to evaluate therapeutic potential of targeting EphA2 in pancreatic tumor [ncbi , more ] in 2009 and Omedul Islam et al. used Santa Cruz Biotechnology Akt antibody to detect phospho-AKT in western blot in order to demonstrate that the MAPK/CREB cascade and the STAT-3 signaling pathway mediate H-IL-6-activated neurogenesis and gliogenesis [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was applied in 2008 to perform western blot in order to show that VHL tumor supppressor gene has endothelial function through fibroblast growth factor receptor signaling [ncbi , more ], to study the role of the tumor suppressor genes, TSC1 and TSC2, and other members of this pathway in tumorigenesis of OSCC [ncbi , more ], to examine the effects of combining a proteasome inhibitor with an HDAC inhibitor in GBM cell lines [ncbi , more ], to study the effect of human herpesvirus 8 chemokines on endothelial survival and virus replication [ncbi , more ], to study the potential binding partners to Cot and their region of association by separating proteins that were pulled-down with various Cot constructs following immunoprecipiation in human HEK293 cells and Hela cells [ncbi , more ]and to perform western blot in order to show that vascular integrity and angiogenesis are regulated by miR-126 [ncbi , more ]. In 2007, James G Greger et al. applied Santa Cruz Biotechnology Akt antibody to study the role of MNAR in 17beta-estradiol (E2) induced activation of the phosphatidylinositol 3-kinase (PI3K) /Akt pathway [ncbi , more ]. Florian Hohla et al. employed Santa Cruz Biotechnology Akt antibody to study the effect of antagonists of growth hormone-releasing hormone (GHRH) MZ-J-7-138 and JV-1-92 on H460 human non-small cell lung carcinoma (NSCLC) xenografted orthotopically into nude mice [ncbi , more ] in 2006 and Weihua Wan et al. used Santa Cruz Biotechnology Akt antibody to study the role for anaplastic lymphoma kinase activity in proliferation and survival of anaplastic large-cell lymphoma cells [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was used in 2005 to study the interaction of Grb10 with 14-3-3 [ncbi , more ], to study the physiological role of ER palmitoylation in the receptor localization to the cell membrane and in the regulation of the E2-induced cell proliferation [ncbi , more ]and to study the effect of down-regulation of BRCA2 expression by collagen type I [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was utilized in 2004 to detect Akt in human corneal epithelial (HCE) stimulated with HGF for different times [ncbi , more ], to study the role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis [ncbi , more ], to study akt-dependent cell survival by the regulating of ezrin/radixin/moesin Proteins [ncbi , more ]and to evaluate therapeutic potential of the combination of IGFBP-3 and SCH66336 [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was applied in 2003 to study the inhibition of lysophosphatidic acid acyltransferase beta on proliferative and survival signals in normal cells and apoptosis of tumor cells [ncbi , more ], to demonstrate that p85 alpha and p85 beta modulate PI 3-kinase-dependent signaling by multiple mechanisms and transmit signals independent of PI 3-kinase activation [ncbi , more ], to study the interaction of calcium/calmodulin-dependent protein kinase II with Raf-1 and the effect of it on integrin-stimulated ERK activation [ncbi , more ], to study the phosphorylation of PED/PEA-15 by Akt in 293 cells were stimulated with insulin [ncbi , more ], to study the effects of activated G q on p110 phosphatidylinositol 3-kinase and Akt [ncbi , more ], to study the role of Lipocalin-type prostaglandin D2 synthase (L-PGDS) in maintaining the proper equilibrium between proliferation and apoptosis [ncbi , more ], to study the pathway for platelet-derived growth factor to induce the beta-gamma-secretase-mediated cleavage of alzheimer's amyloid precursor protein [ncbi , more ], to study the endothelial cell survival and in vitro angiogenesis mediating by CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway [ncbi , more ], to study the role of EWS/FLI-1 in the alteration of mesodermal cell differentiation [ncbi , more ]and to study the production of interleukin 15 by human colon cancer cells associated with induction of mucosal hyperplasia, angiogenesis, and metastasis [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was utilized in 2002 to study the effect of VIIa/tissue factor interaction [ncbi , more ], to study the molecular mechanisms through which HIV-1-Tat protein inhibits vincristine-induced apoptosis of KS cells [ncbi , more ], to detect Akt1 in D5 and vector HEK293 cells untreated or treated with insulin [ncbi , more ], to study insulin receptor catalytic activity inhibition [ncbi , more ], to study the role of oxidants and Lyn in SHIP regulation [ncbi , more ]and to study the phosphorylation state of EGFR, ERK, and PKB/Akt1 [ncbi , more ]. Santa Cruz Biotechnology Akt antibody was employed in 2001 to study the MV interference with Akt activation during immunosuppression [ncbi , more ], to study the effect of SH2-containing inositol phosphatase 2 in 3T3-L1 adipocytes [ncbi , more ]and to study the effects of inhibition of protein kinase B (PKB) and PKC zeta on keratin k10-induced cell cycle arrest [ncbi , more ].
Life Technologies CorporationLife Technologies Corporation Akt product
  • immunohistochemistryIn 2001, D Camper-Kirby et al. applied Life Technologies Corporation Akt antibody to study the difference between sexes in myocardial activation of Akt [ncbi , more ].
  • western blotIn 2006, Michael Holinstat et al. utilized Life Technologies Corporation Akt antibody to study the key role of FAK activation as a negative feedback mechanism that maintains endothelial barrier function by p190RhoGAP-mediated suppression of RhoA activity [ncbi , more ]. In 2003, Dong Yu et al. utilized Life Technologies Corporation Akt antibody to study the contributions of the different downstream pathways of IGF-IR to IGF-IR-mediated radioresistance [ncbi , more ]. In 2001, D Camper-Kirby et al. applied Life Technologies Corporation Akt antibody to study the difference between sexes in myocardial activation of Akt [ncbi , more ].
R and D SystemsR and D Systems Akt product
  • western blotIn 2003, DiAnna L Hynds et al. employed R and D Systems Akt antibody to study the role of Rit in human neuroblastoma cells for MEK-independent neurite branching [ncbi , more ].
AbcamAbcam Akt product
  • western blotIn 2008, Yidi Wu et al. employed Abcam Akt antibody to show that ILK can regulate airway smooth muscle differentiation [ncbi , more ].
BD BiosciencesBD Biosciences Akt product
  • immunoprecipitationIn 2001, Y Sasaki et al. applied BD Biosciences Akt antibody to study the role of Hgs/Hrs and its interacting proteins in signaling for cytokine-mediated c-fos induction [ncbi , more ].
  • western blotIn 2010, Mehrnoosh Saghizadeh et al. employed BD Biosciences Akt antibody to perform western blot in order to study the roles of MMP-10 and CTSF in impaired wound healing in diabetic corneas (catalog: 610860) [ncbi , more ]. BD Biosciences Akt antibody was applied in 2009 to investigate the role of PTEN phosphorylation in the regulation of ATP-sensitive K+ channels [ncbi , more ], to combine computational simulations, experimental testing of simulation results, and finally reverse engineering of a protein interaction network to define potential therapeutic strategies for de novo trastuzumab resistant breast cancer (catalog: 610860) [ncbi , more ]and to investigate the roles of STAT3 and caveolin-3 in the regulation of the development of the catecholamine-induced cardiac hypertrophy [ncbi , more ]. In 2008, Taghi Manshouri et al. employed BD Biosciences Akt antibody to perform western blot in order to study the JAK kinase inhibitor reduces the growth of human polycythemia vera cells [ncbi , more ]. In 2006, Silvia Goicoechea et al. used BD Biosciences Akt antibody to study the role of Palladin in the rapid and transient remodeling of the actin cytoskeleton [ncbi , more ]. In 2005, Bruno Canguilhem et al. utilized BD Biosciences Akt antibody to study RhoB protective effect from UVB-induced apoptosis in human keratinocytes [ncbi , more ]. Julien Mazieres et al. used BD Biosciences Akt antibody to detect AKT in Panc-1 cells [ncbi , more ] in 2004 and Andrew P Mone et al. used BD Biosciences Akt antibody to study the role of Hu1D10 in human chronic lymphocytic leukemia cells [ncbi , more ]. In 2003, DiAnna L Hynds et al. employed BD Biosciences Akt antibody to study the role of Rit in human neuroblastoma cells for MEK-independent neurite branching [ncbi , more ]. In 2001, Y Sasaki et al. applied BD Biosciences Akt antibody to study the role of Hgs/Hrs and its interacting proteins in signaling for cytokine-mediated c-fos induction [ncbi , more ].
Sigma-AldrichSigma-Aldrich Akt product
  • immunohistochemistryIn 2008, Tadateru Maehata et al. applied Sigma-Aldrich Akt antibody to perform immunohistochemistry in order to investigate the expression alteration of dickkopfs (Dkks) and kremen2 (Krm2) in gastrointestinal cancer [ncbi , more ].
  • western blotIn 2005, Rinat Arbel-Goren et al. used Sigma-Aldrich Akt antibody to study galectin-8 signalling pathway [ncbi , more ]. In 2004, Debra L Bemis et al. applied Sigma-Aldrich Akt antibody to study GCP in vitro and in vivo for potential utility as a prostate cancer chemopreventative agent in human prostate cancer cell line [ncbi , more ].
BIOLABS
  • immunocytochemistryIn 2001, J M Paramio et al. applied Akt antibody to study the effects of inhibition of protein kinase B (PKB) and PKC zeta on keratin k10-induced cell cycle arrest [ncbi , more ].
Promega
  • immunocytochemistryIn 2002, Chang Yu Wang et al. used Promega Akt antibody to study the effect of glial cell line-derived neurotrophic factor and neurturin on neuromuscular synapse development [ncbi , more ].
  • western blotIn 2002, David Decraene et al. applied Promega Akt antibody to study the role for IGF-1 in this delay of the onset of apoptosis through activation of the AKT signaling pathway [ncbi , more ].
Covance
  • western blotIn 2009, Ozgur Sahin et al. used Covance Akt antibody to combine computational simulations, experimental testing of simulation results, and finally reverse engineering of a protein interaction network to define potential therapeutic strategies for de novo trastuzumab resistant breast cancer [ncbi , more ].
UBI
  • western blotIn 2004, Lenin Mahimainathan et al. applied UBI Akt antibody to study the role of PTEN in PDGF-induced DNA synthesis [ncbi , more ].
Figure
Cell Signaling anti-Akt and anti-p-Akt were used to perform western blot in order to show that thioredoxin is an IFN-gamma-induced factor and plays a role for cytokine production.
Akt antibody western blot Cell Signaling Technology
Analysis of Jak, Akt, and MAPK pathways during IFN-gamma signal transduction in THP1 cells. THP1 cells (1 x 106) were treated with media alone or IFN-gamma under serum-free conditions for the indicated times. The total cell lysates were then prepared and analyzed by Western blot to determine the activation status of Jak1/Stat1, Akt, and MAPKs as described in the text.
Seol Hee Kim et al. (2008). "Identification of human thioredoxin as a novel IFN-gamma-induced factor: mechanism of induction and its role in cytokine production".PMID 18983687
Articles Reviewed
  1. Daniel Thomas et al. (2013). "Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival".PMID 23526884
  2. Uma Karthika Rajarajacholan et al. (2013). "The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway".PMID 23472054
  3. Devendra Singh et al. (2012). "Transforming fusions of FGFR and TACC genes in human glioblastoma".PMID 22837387
  4. Roberto Zoncu et al. (2011). "mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase".PMID 22053050
  5. K Hussain et al. (2011). "An activating mutation of AKT2 and human hypoglycemia".PMID 21979934
  6. Carmine Settembre et al. (2011). "TFEB links autophagy to lysosomal biogenesis".PMID 21617040
  7. Iakovos Lazaridis et al. (2011). "Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis".PMID 21541365
  8. Heather L Chandler et al. (2010). "The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model".PMID 21139685
  9. Bu Qing Ye et al. (2010). "Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation".PMID 20944010
  10. Qiaoling Liang et al. (2010). "IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma".PMID 20926789
  11. Lu Jiang et al. (2010). "MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells".PMID 20819078
  12. Noriyuki Ouchi et al. (2010). "Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity".PMID 20558665
  13. Qing Li Kong et al. (2010). "Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma".PMID 20532215
  14. Ryan J O Dowling et al. (2010). "mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs".PMID 20508131
  15. Veronique Marsaud et al. (2010). "Cyclin K and cyclin D1b are oncogenic in myeloma cells".PMID 20459741
  16. Dong Hyung Cho et al. (2010). "Upregulation of SPRR3 promotes colorectal tumorigenesis".PMID 20379613
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