This is a review about APC, based on 31 published articles (read how Labome selects the articles), using APC antibody in all methods. It is aimed to help Labome visitors find the most suited APC antibody.
APC synonym: BTPS2; DP2; DP2.5; DP3; PPP1R46; adenomatosis polyposis coli tumor suppressor; deleted in polyposis 2.5; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli

Knockout validation
Abcamrabbit polyclonal
  • IHC (knockout); mouse; 1:100; fig 5
Abcam APC antibody (Abcam, ab15270) was used in immunohistochemistry (knockout) on mouse samples at 1:100 (fig 5). PLoS ONE (2012) ncbi
EMD Millipore
mouse monoclonal
  • IHC; mouse; 1:50
EMD Millipore APC antibody (CalBiochem, OP80-100UG) was used in immunohistochemistry on mouse samples at 1:50. J Neurosci (2015) ncbi
mouse monoclonal
  • IHC-Free; mouse; 1:400
In order to assess using recombinant adeno-associated virus rhesus-10 as a gene therapy vector in the central nervous system, EMD Millipore APC antibody (EMD Bioscience, OP80-100UG) was used in immunohistochemistry - free floating section on mouse samples at 1:400. Mol Neurobiol (2015) ncbi
mouse monoclonal
  • IHC-F; rat; 1:400
In order to characterize the incidence, distribution, and cellular composition of the ectopic colonies arising from transplanted fetal neuronal stem cells in the nervous system, EMD Millipore APC antibody (EMD Millipore, OP-80) was used in immunohistochemistry - frozen section on rat samples at 1:400. J Neurosci (2014) ncbi
mouse monoclonal
  • IHC-F; mouse; 1:50
EMD Millipore APC antibody (EMD Biosciences, OP80-100UG) was used in immunohistochemistry - frozen section on mouse samples at 1:50. J Neurosci (2014) ncbi
mouse monoclonal
  • IHC-F; rat; 1:400
In order to evaluate the long distance growth and connectivity of neural stem cells after neural stem cell transplantation, EMD Millipore APC antibody (Oncogene, OP80-100UG) was used in immunohistochemistry - frozen section on rat samples at 1:400. Exp Neurol (2014) ncbi
mouse monoclonal (CC-1)
  • IC; mouse
EMD Millipore APC antibody (Calbiochem, AP-7/CC-1) was used in immunocytochemistry on mouse samples. J Neurosci (2014) ncbi
mouse monoclonal
  • IHC-F; rat; 1:200
EMD Millipore APC antibody (Millipore, OP80-100UG) was used in immunohistochemistry - frozen section on rat samples at 1:200. J Comp Neurol (2014) ncbi
mouse monoclonal (CC-1)
  • IHC; mouse; 1:100
In order to confirm the role of PTEN signaling in Olig2 expressing neural progenitor cells and oligodendrocytes, EMD Millipore APC antibody (Calbiochem, CC1) was used in immunohistochemistry on mouse samples at 1:100. Stem Cells (2014) ncbi
mouse monoclonal
  • IHC-F; mouse; 1:200
EMD Millipore APC antibody (EMD, OP80-100UG) was used in immunohistochemistry - frozen section on mouse samples at 1:200. Hum Mol Genet (2014) ncbi
mouse monoclonal
  • IHC-Free; mouse; 1:40
  • IC; mouse; 1:200
EMD Millipore APC antibody (Millipore, OP-80) was used in immunohistochemistry - free floating section on mouse samples at 1:40 and in immunocytochemistry on mouse samples at 1:200. J Neurosci (2013) ncbi
not indicated
  • IC; human
Calbiochem anti-APC was used to perform immunocytochemistry in order to show that MRP protein plays an important role in adherens junction formation and tumorigenesisPLoS ONE (2009) ncbi
Santa Cruz Biotechnology
rabbit polyclonal (H-56)
  • WB; human
In order to study the impact of TNF-alpha and IL-1beta on the inflammatory phenotype of cancer-associated fibroblasts and mesenchymal stem/stromal cells, Santa Cruz Biotechnology APC antibody (Santa Cruz Biotechnology, sc-135069) was used in western blot on human samples. Stem Cell Res Ther (2015) ncbi
rabbit polyclonal (C-20)
  • IHC-Free; rat; 0.1 ug/ul
Santa Cruz Biotechnology APC antibody (Santa Cruz, sc-896) was used in immunohistochemistry - free floating section on rat samples at 0.1 ug/ul. J Comp Neurol (2015) ncbi
rabbit polyclonal (H-290)
  • IC; human; 1:200
In order to study how DLC2 regulates cell junction maintenance and planar spindle positioning, Santa Cruz Biotechnology APC antibody (Santa, sc7930) was used in immunocytochemistry on human samples at 1:200. Nat Commun (2014) ncbi
rabbit polyclonal (C-20)
  • WB; human; 1:100
Santa Cruz Biotechnology APC antibody (Santa Cruz Biotechnology, sc-896) was used in western blot on human samples at 1:100. elife (2014) ncbi
rabbit polyclonal (H-290)
  • WB; human; 1:500; fig 3c
Santa Cruz Biotechnology APC antibody (Santa, sc-7930) was used in western blot on human samples at 1:500 (fig 3c). Oncotarget (2014) ncbi
rabbit polyclonal (C-20)
  • IHC-P; mouse
In order to study the pathogenesis of prostate cance, Santa Cruz Biotechnology APC antibody (Santa Cruz, sc-896) was used in immunohistochemistry - paraffin section on mouse samples. Prostate (2014) ncbi
rabbit polyclonal (C-20)
  • IHC; human
Santa Cruz Biotechnology APC antibody (Santa Cruz, sc896) was used in immunohistochemistry on human samples. Eur J Hum Genet (2014) ncbi
rabbit polyclonal (C-20)
  • WB; mouse
Santa Cruz Biotechnology APC antibody (Santa Cruz Biotechnology, sc-896) was used in western blot on mouse samples. J Biol Chem (2013) ncbi
rabbit polyclonal (C-20)
  • IHC; mouse; 1:100
  • IC; human; 1:100
  • WB; mouse; 1:1000
In order to study the mechanisms by which the the gut tumor suppressor APC regulates the development of oligodendroglia, Santa Cruz Biotechnology APC antibody (Santa Cruz Biotechnology, sc-896) was used in immunohistochemistry on mouse samples at 1:100, in immunocytochemistry on human samples at 1:100, and in western blot on mouse samples at 1:1000. J Neurosci (2013) ncbi
not indicated
  • WB; human
Santa Cruz Biotechnology rabbit polyclonal antibody to the N-terminus of APC antibody was used for western blot in order to investigate the role Wnt/beta-catenin pathway in the regulation of both physiological and pathophysiological conditions.PLoS Genet (2010) ncbi
not indicated
  • WB; human
  • IHC; human
Santa Cruz Biotechnology rabbit anti-human-APC antibody(N-15 1:200, C-20 1:20) was used to perform western blot and immunohistochemistry in order to study promoter methylation and protein expression of APC in HCC.J Cancer Res Clin Oncol (2008) ncbi
Abcam
mouse monoclonal (CC-1)
  • IHC-P; rat; 1:1000
Abcam APC antibody (Abcam, ab16794) was used in immunohistochemistry - paraffin section on rat samples at 1:1000. Cell Death Dis (2015) ncbi
mouse monoclonal (CC-1)
  • IHC-P; mouse
Abcam APC antibody (Abcam, ab16794) was used in immunohistochemistry - paraffin section on mouse samples. J Neurosci (2014) ncbi
rabbit polyclonal
  • IHC-P; mouse; 1:100
Abcam APC antibody (Abcam, 15270) was used in immunohistochemistry - paraffin section on mouse samples at 1:100. Am J Physiol Gastrointest Liver Physiol (2014) ncbi
mouse monoclonal (CC-1)
  • IHC-F; mouse; 1:20
In order to use a SIP1-EGFP reporter mouse to study brain development, Abcam APC antibody (Abcam, ab16794) was used in immunohistochemistry - frozen section on mouse samples at 1:20. Genesis (2014) ncbi
mouse monoclonal (ALi 12-28)
  • IC; dog; 1:200
In order to study the role of Kif3a in microtubular dynamics, migration and lumen formation of MDCK cells, Abcam APC antibody (Abcam, AB58) was used in immunocytochemistry on dog samples at 1:200. PLoS ONE (2013) ncbi
rabbit polyclonal
  • IHC (knockout); mouse; 1:100; fig 5
Abcam APC antibody (Abcam, ab15270) was used in immunohistochemistry (knockout) on mouse samples at 1:100 (fig 5). PLoS ONE (2012) ncbi
mouse monoclonal (CC-1)
  • IHC-F; rat; 1:400
Abcam APC antibody (Abcam, ab16794) was used in immunohistochemistry - frozen section on rat samples at 1:400. J Comp Neurol (2008) ncbi
eBioscience
rat monoclonal (AFKJS-9)
  • FC; mouse
eBioscience APC antibody (ebioscience, 17-6988-80) was used in flow cytometry on mouse samples. Exp Parasitol (2014) ncbi
BD Biosciences
not indicated
  • FC; human
Pharmingen anti-APC antibody was used to perform western blot in order to study the dependency on oxidative phosphorylation during transformation of human mesenchymal stem cells.Proc Natl Acad Sci U S A (2007) ncbi
Articles Reviewed
  1. Matthew L Kraushar et al. (2015). "Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes".PMID 26245956
  2. Yansu Guo et al. (2015). "A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord".PMID 26050084
  3. Christina Katanov et al. (2015). "Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway".PMID 25928089
  4. S Liu et al. (2015). "Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death".PMID 25569099
  5. Kentaro Matsuzaki et al. (2015). "Aging attenuates acquired heat tolerance and hypothalamic neurogenesis in rats".PMID 25556765
  6. Elisa Vitiello et al. (2014). "The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion".PMID 25518808
  7. Taichi Isobe et al. (2014). "miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway".PMID 25406066
  8. Oswald Steward et al. (2014). "Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury".PMID 25319698
  9. Estefanía Martino-Echarri et al. (2014). "Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy".PMID 25301724
  10. Yifeng Lin et al. (2014). "Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice".PMID 25186761
  11. Kenneth C Valkenburg et al. (2014). "Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia".PMID 25175604
  12. Sarah Jane Bull et al. (2014). "Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes".PMID 25031414
  13. Anne E Powell et al. (2014). "Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis".PMID 24833705
  14. Kelli G Sharp et al. (2014). "A re-assessment of long distance growth and connectivity of neural stem cells after severe spinal cord injury".PMID 24747827
  15. Daniel E Lysko et al. (2014). "SDF1 reduces interneuron leading process branching through dual regulation of actin and microtubules".PMID 24695713
  16. Tarun Keswani et al. (2014). "Differential role of T regulatory and Th17 in Swiss mice infected with Plasmodium berghei ANKA and Plasmodium yoelii".PMID 24675415
  17. Juraj Sevc et al. (2014). "Evidence that the central canal lining of the spinal cord contributes to oligodendrogenesis during postnatal development and adulthood in intact rats".PMID 24659141
  18. Cecile L Maire et al. (2014). "Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy".PMID 24395742
  19. Yuriko Nishizaki et al. (2014). "SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse".PMID 24243579
  20. Hongyan Wang et al. (2014). "Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis".PMID 24108104
  21. B Rivera et al. (2014). "A novel AXIN2 germline variant associated with attenuated FAP without signs of oligondontia or ectodermal dysplasia".PMID 23838596
  22. Jason L Larabee et al. (2013). "Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE)".PMID 23775085
  23. Christopher Boehlke et al. (2013). "Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells".PMID 23658710
  24. Jordan Lang et al. (2013). "Adenomatous polyposis coli regulates oligodendroglial development".PMID 23407966
  25. Ci Di Chen et al. (2013). "The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS".PMID 23365232
  26. Yijing Chen et al. (2012). "Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain".PMID 22412988
  27. Michael Buchert et al. (2010). "Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo".PMID 20084116
  28. Alexander E Finlayson et al. (2009). "A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis".PMID 19924305
  29. Richa B Tripathi et al. (2008). "Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats".PMID 18615534
  30. Antal Csepregi et al. (2008). "APC promoter methylation and protein expression in hepatocellular carcinoma".PMID 17973119
  31. Juan M Funes et al. (2007). "Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production".PMID 17384149