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Human sVCAM-1 Platinum ELISA 10 x 96 tests
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quantity :
10 x 96 tests
price :
2,889.00 USD
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List Price :
2,889.00 USD
Size :
10 x 96 tests
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Product Description :
Human sVCAM-1 Platinum ELISA 10 x 96 tests
Also Known As :
Vascular cell adhesion protein 1, CD106 antigen
Reactivity/Species :
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Regulatory Status :
Conjugate :
Sensitivity :
0.6 ng/mL
Standard Curve :
3.15 - 100 ng/mL
Long Description :
The human sVCAM-1 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sVCAM-1. The human sVCAM-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures. The vascular cell adhesion molecule-1 (VCAM-1) or CD106 is a member of the immunoglobulin gene superfamily. The initial molecular cloning of VCAM-1 reported six extracellular Ig-like domains (6D VCAM-1). This 6D VCAM-1 arises due to alternative splicing from a seven-domain VCAM-1 (7D VCAM-1). 7D VCAM-1 is the dominant form expressed by cultured human endothelial cells. Domains 1 through 3 are highly homologous to domains 4 through 6, suggesting that they arose by gene duplication. VCAM-1 is not constitutively expressed on endothelium, but can be upregulated in vitro in response to LPS, TNF-a, and IL-1, as well as to IFN-gamma and IL-4. VCAM-1 is also present on tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts and myotubes. A soluble form of VCAM-1 (sVCAM-1) has been described. Soluble VCAM-1 levels have been found in the serum of healthy individuals and increased levels of sVCAM-1 can be detected in several diseases. Cancer: ovarian, gastric-intestinal, renal, bladder cancer, non-Hodgkin's lymphoma, breast cancer (cyst fluid). Autoimmune diseases: multiple sclerosis (cerebrospinal fluid), systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis. Infections: sepsis, meningitis, malaria. Inflammation: vasculitis, alcoholic cirrhosis, primary biliary cirrhosis, Wegener's granulomatosis.
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Parent application :
antigen :
CD106 (VCAM-1), sCD106 (sVCAM-1)
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10255 Science Center Drive
San Diego, CA 92121
headquarters: USA