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product name :
Anti-Human/Mouse ROR gamma (t) Purified 25 ug
catalog :
quantity :
25 ug
price :
139.00 USD
clonality :
host :
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
publications citing this reagent :
total: 49
  1. mouse (flow cytometry(1:200))
    Chatterjee S, Thyagarajan K, Kesarwani P, Song J, Soloshchenko M, Fu J, et al. Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors. Cancer Res. 2014;74:6048-59 pubmed publisher
  2. human (flow cytometry) : mouse (immunohistochemistry - frozen section)
    Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
  3. mouse (immunocytochemistry : flow cytometry)
    McGuire D, Rowse A, Li H, Peng B, Sestero C, Cashman K, et al. CD5 enhances Th17-cell differentiation by regulating IFN-γ response and RORγt localization. Eur J Immunol. 2014;44:1137-42 pubmed publisher
  4. Wong L, HATFIELD J, Brown M. Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem. 2013;288:35170-9 pubmed publisher
  5. Mielke L, Groom J, Rankin L, Seillet C, Masson F, Putoczki T, et al. TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation. J Immunol. 2013;191:4383-91 pubmed publisher
  6. Lina T, Pinchuk I, House J, Yamaoka Y, Graham D, Beswick E, et al. CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection. J Immunol. 2013;191:3838-46 pubmed publisher
  7. Monk J, Hou T, Turk H, McMurray D, Chapkin R. n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells. J Nutr. 2013;143:1501-8 pubmed publisher
  8. Edwards J, Fujii H, Zhou A, Creemers J, Unutmaz D, Shevach E. Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol. 2013;190:5506-15 pubmed publisher
  9. Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496:518-22 pubmed publisher
  10. Kathania M, Zadeh M, Lightfoot Y, Roman R, Sahay B, Abbott J, et al. Colonic immune stimulation by targeted oral vaccine. PLoS ONE. 2013;8:e55143 pubmed publisher
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product information
Catalog Number :
List Price :
139.00 USD
Size :
25 ug
Presku :
Product Type :
Product Description :
Anti-Human/Mouse ROR gamma (t) Purified 25 ug
Clone :
Host :
Isotype :
Also Known As :
Retinoid-Related Orphan Receptor gamma
Reactivity/Species :
Human , Mouse
Applications :
Immunoprecipitation , Western Blotting
Regulatory Status :
Conjugate :
Long Description :
The AJKJS-9 monoclonal antibody reacts with the mouse ROR (t) protein. ROR is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes ROR and ROR . ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. ROR is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, ROR t, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ Òdouble-positiveÓ thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs. The ROR t isoform differs from ROR by three unique amino acids at its amino terminus. Therefore, the AFKJS-9 antibody will react with both the ROR and ROR t isoforms.
Parent application :
antigen :
ROR gamma (t)
publications citing this reagent :
  1. Pinchuk I, Morris K, Nofchissey R, Earley R, Wu J, Ma T, et al. Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment. PLoS ONE. 2013;8:e53798 pubmed publisher
  2. McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed publisher
  3. Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R, Clerici M, et al. A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing. 2013;10:1 pubmed publisher
  4. Sciumè G, Hirahara K, Takahashi H, Laurence A, Villarino A, Singleton K, et al. Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med. 2012;209:2331-8 pubmed publisher
  5. Patakas A, Benson R, Withers D, Conigliaro P, McInnes I, Brewer J, et al. Th17 effector cells support B cell responses outside of germinal centres. PLoS ONE. 2012;7:e49715 pubmed publisher
  6. Peters J, Tjabringa G, Fasse E, de Oliveira V, Schalkwijk J, Koenen H, et al. Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations. J Dermatol Sci. 2013;69:44-53 pubmed publisher
  7. Russell S, Moore A, Fallon P, Walsh P. Soluble IL-2Rα (sCD25) exacerbates autoimmunity and enhances the development of Th17 responses in mice. PLoS ONE. 2012;7:e47748 pubmed publisher
  8. Larochelle C, Cayrol R, Kebir H, Alvarez J, Lécuyer M, Ifergan I, et al. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain. 2012;135:2906-24 pubmed publisher
  9. Sestero C, McGuire D, De Sarno P, Brantley E, Soldevila G, Axtell R, et al. CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012;189:2918-30 pubmed publisher
  10. Centuori S, Trad M, LaCasse C, Alizadeh D, Larmonier C, Hanke N, et al. Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells. J Leukoc Biol. 2012;92:987-97 pubmed publisher
  11. Kumar P, Thakar M, Ouyang W, Malarkannan S. IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol. 2013;6:69-82 pubmed publisher
  12. McGovern J, Nguyen D, Notley C, Mauri C, Isenberg D, Ehrenstein M. Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. Arthritis Rheum. 2012;64:3129-38 pubmed publisher
  13. Zielinski C, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, et al. Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. Nature. 2012;484:514-8 pubmed publisher
  14. Jurado J, Pasquinelli V, Alvarez I, Peña D, Rovetta A, Tateosian N, et al. IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukoc Biol. 2012;91:991-1002 pubmed publisher
  15. Rubinstein M, Cloud C, Garrett T, Moore C, Schwartz K, Johnson C, et al. Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. J Am Coll Surg. 2012;214:700-7; discussion 707-8 pubmed publisher
  16. Radulovic K, Manta C, Rossini V, Holzmann K, Kestler H, Wegenka U, et al. CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J Immunol. 2012;188:2001-13 pubmed publisher
  17. Hidalgo L, Martínez V, Valencia J, Hernández-López C, Vázquez M, Núñez J, et al. Expression of BMPRIA on human thymic NK cell precursors: role of BMP signaling in intrathymic NK cell development. Blood. 2012;119:1861-71 pubmed publisher
  18. LaCasse C, Janikashvili N, Larmonier C, Alizadeh D, Hanke N, Kartchner J, et al. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism. J Immunol. 2011;187:6310-7 pubmed publisher
  19. Ma J, Wang R, Fang X, Ding Y, Sun Z. Critical role of TCF-1 in repression of the IL-17 gene. PLoS ONE. 2011;6:e24768 pubmed publisher
  20. Prochazkova J, Pokorna K, Holan V. IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction. Immunobiology. 2012;217:74-82 pubmed publisher
  21. Svobodova E, Krulova M, Zajicova A, Pokorna K, Prochazkova J, Trosan P, et al. The role of mouse mesenchymal stem cells in differentiation of naive T-cells into anti-inflammatory regulatory T-cell or proinflammatory helper T-cell 17 population. Stem Cells Dev. 2012;21:901-10 pubmed publisher
  22. Lu Y, Malmhäll C, Sjöstrand M, Radinger M, O'Neil S, Lotvall J, et al. Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. PLoS ONE. 2011;6:e19889 pubmed publisher
  23. Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, et al. A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity. J Immunol. 2011;186:6287-95 pubmed publisher
  24. Gaddis D, Michalek S, Katz J. TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B. J Immunol. 2011;186:5772-83 pubmed publisher
  25. Kim S, Han S, Withers D, Gaspal F, Bae J, Baik S, et al. CD117⁺ CD3⁻ CD56⁻ OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues. Eur J Immunol. 2011;41:1563-72 pubmed publisher
  26. Moens E, Brouwer M, Dimova T, Goldman M, Willems F, Vermijlen D. IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17. J Leukoc Biol. 2011;89:743-52 pubmed publisher
  27. Lexberg M, Taubner A, Albrecht I, Lepenies I, Richter A, Kamradt T, et al. IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells. Eur J Immunol. 2010;40:3017-27 pubmed publisher
  28. Li L, Kim J, Boussiotis V. IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol. 2010;185:4148-53 pubmed publisher
  29. Nakatsukasa H, Tsukimoto M, Tokunaga A, Kojima S. Repeated gamma irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells but not by damaging lymphocytes directly. Radiat Res. 2010;174:313-24 pubmed publisher
  30. Purvis H, Stoop J, Mann J, Woods S, Kozijn A, Hambleton S, et al. Low-strength T-cell activation promotes Th17 responses. Blood. 2010;116:4829-37 pubmed publisher
  31. Ness-Schwickerath K, Jin C, Morita C. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol. 2010;184:7268-80 pubmed publisher
  32. Henry T, Kirimanjeswara G, Ruby T, Jones J, Peng K, Perret M, et al. Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. J Immunol. 2010;184:3755-67 pubmed publisher
  33. Lugering A, Ross M, Sieker M, Heidemann J, Williams I, Domschke W, et al. CCR6 identifies lymphoid tissue inducer cells within cryptopatches. Clin Exp Immunol. 2010;160:440-9 pubmed publisher
  34. Satoh-Takayama N, Lesjean-Pottier S, Vieira P, Sawa S, Eberl G, Vosshenrich C, et al. IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med. 2010;207:273-80 pubmed publisher
  35. Sanos S, Diefenbach A. Isolation of NK cells and NK-like cells from the intestinal lamina propria. Methods Mol Biol. 2010;612:505-17 pubmed publisher
  36. Mjösberg J, Berg G, Jenmalm M, Ernerudh J. FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua. Biol Reprod. 2010;82:698-705 pubmed publisher
  37. Satoh-Takayama N, Dumoutier L, Lesjean-Pottier S, Ribeiro V, Mandelboim O, Renauld J, et al. The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium. J Immunol. 2009;183:6579-87 pubmed publisher
  38. Kebir H, Ifergan I, Alvarez J, Bernard M, Poirier J, Arbour N, et al. Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Ann Neurol. 2009;66:390-402 pubmed publisher
  39. Poffenberger M, Straka N, El Warry N, Fang D, Shanina I, Horwitz M. Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis. PLoS ONE. 2009;4:e6207 pubmed publisher
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company information
10255 Science Center Drive
San Diego, CA 92121
headquarters: USA