NU 7026 | Tocris Bioscience 2828/50 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NU 7026

catalog :

2828/50

quantity :

50 mg

price :

842 USD

citations: 14

Reference
Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, et al. ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J. 2017;36:2161-2176 pubmed publisher
Dolman M, van der Ploeg I, Koster J, Bate Eya L, Versteeg R, Caron H, et al. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS ONE. 2015;10:e0145744 pubmed publisher
Allen C, Tinganelli W, Sharma N, Nie J, Sicard C, Natale F, et al. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Front Oncol. 2015;5:260 pubmed publisher
You R, Lu W, Shan M, Berlin J, Samuel E, Marcano D, et al. Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema. elife. 2015;4:e09623 pubmed publisher
Nakahara T, Tanaka K, Ohno S, Egawa N, Yugawa T, Kiyono T. Activation of NF-ÎºB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1. J Virol. 2015;89:5040-59 pubmed publisher
Rodgers W, Byrum J, Sapkota H, Rahman N, Cail R, Zhao S, et al. Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst). 2015;27:19-27 pubmed publisher
Yousefzadeh M, Wyatt D, Takata K, Mu Y, Hensley S, Tomida J, et al. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 2014;10:e1004654 pubmed publisher
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed publisher
Petruccelli L, Pettersson F, Del Rincón S, Guilbert C, Licht J, Miller W. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis. Mol Cancer Ther. 2013;12:1591-604 pubmed publisher
Sultana R, Abdel Fatah T, Abbotts R, Hawkes C, Albarakati N, Seedhouse C, et al. Targeting XRCC1 deficiency in breast cancer for personalized therapy. Cancer Res. 2013;73:1621-34 pubmed publisher
Ando K, Kernan J, Liu P, Sanda T, Logette E, Tschopp J, et al. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell. 2012;47:681-93 pubmed publisher
Tang J, Wang J, Parker L. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. Chembiochem. 2012;13:665-73 pubmed publisher
Kanai R, Rabkin S, Yip S, Sgubin D, Zaupa C, Hirose Y, et al. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells. J Natl Cancer Inst. 2012;104:42-55 pubmed publisher
Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, et al. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet. 2011;7:e1001381 pubmed publisher

product information

brand :

Tocris

master code :

2828

SKU :

2828/50

product name :

NU 7026

description :

Selective DNA-PK inhibitor

target :

DNA-dependent Protein Kinase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

281.31

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, 100 and 100 u M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

catalog number base :

2828

extended description :

Selective DNA-PK inhibitor

chemical name text :

2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one

formula :

C 17 H 15 NO 3

formula text :

C17H15NO3

cas num :

154447-35-5

USD 2021 :

788

USD 2022 :

842 USD

product details :

Selective DNA-PK inhibitor

storage :

Store at +4°C