DMNB | Tocris Bioscience 2088/50 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DMNB

catalog :

2088/50

quantity :

50 mg

price :

205 USD

product information

CHEMISTRY :

COC1=C(OC)C=C(C(C=O)=C1)[N+]([O-])=O

Stock Reference :

2088/50

Cat Number :

2088

Product Name :

DMNB

Cas Number :

[20357-25-9]

Unit Size :

50 mg

Size :

Unit :

USD :

205 USD

Primary Category :

Enzymes

Secondary Category :

Kinases

Tertiary Category :

DNA-dependent Protein Kinase

Primary Action :

DNA-PK inhibitor

Biological Description :

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 muM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

Storage :

Store at -20°C

Formula :

C9H9NO5

Molwt :

211.15

Minimum Purity :

> 98%

Solubility :

Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO

RTECS No :

not available