RXRB Monoclonal Antibody (MOK13-17) | Invitrogen MA3-812 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RXRB Monoclonal Antibody (MOK13-17)

catalog :

MA3-812

quantity :

100µg

price :

US 381.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MOK13-17

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse immunohistochemistry; mouse western blot; mouse	Miyazaki S, Taniguchi H, Moritoh Y, Tashiro F, Yamamoto T, Yamato E, et al. Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells. Diabetes. 2010;59:2854-61 pubmed publisher
	Jiang F, Li P, Fornace A, Nicosia S, Bai W. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. J Biol Chem. 2003;278:48030-40 pubmed
	Osburn D, Shao G, Seidel H, Schulman I. Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions. Mol Cell Biol. 2001;21:4909-18 pubmed
	Thompson P, Jurutka P, Haussler C, Whitfield G, Haussler M. Heterodimeric DNA binding by the vitamin D receptor and retinoid X receptors is enhanced by 1,25-dihydroxyvitamin D3 and inhibited by 9-cis-retinoic acid. Evidence for allosteric receptor interactions. J Biol Chem. 1998;273:8483-91 pubmed
	MacDonald P, Dowd D, Nakajima S, Galligan M, Reeder M, Haussler C, et al. Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene. Mol Cell Biol. 1993;13:5907-17 pubmed
	Segars J, Marks M, Hirschfeld S, Driggers P, Martinez E, Grippo J, et al. Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways. Mol Cell Biol. 1993;13:2258-68 pubmed
	Minucci S, Zand D, Dey A, Marks M, Nagata T, Grippo J, et al. Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells. Mol Cell Biol. 1994;14:360-72 pubmed
	Mangelsdorf D, Umesono K, Kliewer S, Borgmeyer U, Ong E, Evans R. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell. 1991;66:555-61 pubmed
	Hallenbeck P, Marks M, Lippoldt R, Ozato K, Nikodem V. Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation. Proc Natl Acad Sci U S A. 1992;89:5572-6 pubmed

product information

Product Type :

Antibody

Product Name :

RXRB Monoclonal Antibody (MOK13-17)

Catalog # :

MA3-812

Quantity :

100µg

Price :

US 381.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Gel Shift: Assay dependent, Immunofluorescence: Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 5 µg/mL

Species :

Human, Mouse

Clone :

MOK13-17

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Retinoid X receptors (RXRs) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. The RXR subfamily consists of at least three similar genes, RXR alpha, RXR beta and RXR gamma, all of which control transcription of target genes mediated by retinoids. RXR beta controls expression of many genes that respond to hormones and vitamins, including thyroid hormone, estrogen, retinoids and vitamin D. RXR beta, also known as RCoR1, controls a wide array of genes because of its ability to heterodimerize with other hormone receptors including the thyroid hormone receptor (THR), vitamin D receptor (VDR) and retinoic acid receptor (RAR). The corresponding gene for the retinoid X receptor beta is NR2B2.

Immunogen :

Recombinant human retinoic X receptor beta protein.

Format :

Liquid

Applications w/Dilutions :

Gel Shift: Assay dependent, Immunofluorescence: Assay dependent, Immunoprecipitation: Assay dependent, Western Blot: 5 µg/mL

Aliases :

RXR Beta, Retinoic acid receptor RXR-beta